Aerosol deposition in the lungs of spontaneously breathing rats using Gd-DOTA-based contrast agents and ultra-short echo time MRI at 1.5 Tesla

Magnetic Resonance in Medicine

Volumn 75, Issue 2, 2016, Pages 594-605

  Wang, Hongchen ^a   Sebrié, Catherine ^a   Ruaud, Jean Pierre ^a   Guillot, Geneviève ^a   Bouazizi Verdier, Khaoula ^a   Willoquet, Georges ^a   Maître, Xavier ^a   Darrasse, Luc ^a   De Rochefort, Ludovic ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

aerosol deposition; contrast enhancement; Gd DOTA; lung MRI; nebulization; ultra short echo

Indexed keywords

BIOLOGICAL ORGANS; CONTROLLED DRUG DELIVERY; DEPOSITION; MAGNETIC RESONANCE IMAGING; RATS; RESPIRATORY MECHANICS; TARGETED DRUG DELIVERY;

AEROSOL DEPOSITION; CONTRAST ENHANCEMENT; GD-DOTA; LUNG MRIS; NEBULIZATION; ULTRA-SHORT ECHO;

AEROSOLS;

GADOTERATE MEGLUMINE; AEROSOL; CONTRAST MEDIUM; GADOLINIUM 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETATE; HETEROCYCLIC COMPOUND; ORGANOMETALLIC COMPOUND;

AEROSOL; AEROSOL DEPOSITION; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG CLEARANCE; IMAGE ANALYSIS; LUNG PARENCHYMA; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PARTICLE SIZE; RAT; ANATOMY AND HISTOLOGY; ANIMAL; CINE MAGNETIC RESONANCE IMAGING; FEASIBILITY STUDY; IMAGE PROCESSING; INHALATIONAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; LUNG; PROCEDURES; WISTAR RAT;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRANASAL; AEROSOLS; ANIMALS; CONTRAST MEDIA; FEASIBILITY STUDIES; HETEROCYCLIC COMPOUNDS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUNG; MAGNETIC RESONANCE IMAGING, CINE; MALE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR;

EID: 84970925798     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25617     Document Type: Article

References (65)

1. Kleinstreuer C, Zhang Z, Donohue JF,. Targeted drug-aerosol delivery in the human respiratory system. Annu Rev Biomed Eng 2008; 10: 195-220.
2. Heyder J,. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 2004; 1: 315-320.
3. Sosnowski TR,. Importance of airway geometry and respiratory parameters variability for particle deposition in the human respiratory tract. J Thorac Dis 2011; 3: 153-155.
4. Byron PR, Hindle M, Lange CF, et al., In vivo-in vitro correlations: predicting pulmonary drug deposition from pharmaceutical aerosols. J Aerosol Med Pulm Drug Deliv 2010; 23 (Suppl 2): S59-S69.
5. El-Gendy N, Aillon KL, Berkland C,. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm 2010; 391: 305-312.
6. Aillon KL, El-Gendy N, Dennis C, Norenberg JP, McDonald J, Berkland C,. Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization. Mol Pharm 2010; 7: 1274-1282.
7. Bayat S, Dégrugilliers L, Albu G, Porra L, Petak F, Strengell S, Suortti P, Sovijarvi A, Habre W,. Aerosol deposition during acute bronchoconstriction studied by synchrotron radiation imaging in rabbits. Eur Respir J 2013; 42: 208.
8. Moller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Haussinger K, Kreyling WG,. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 2008; 177: 426-432.
9. Moller W, Felten K, Meyer G, Meyer P, Seitz J, Kreyling WG,. Corrections in dose assessment of 99mTc radiolabeled aerosol particles targeted to central human airways using planar gamma camera imaging. J Aerosol Med Pulm Drug Deliv 2009; 22: 45-54.
10. Eberl S, Chan HK, Daviskas E, Constable C, Young I,. Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. Eur J Nucl Med 2001; 28: 1365-1372.
11. Palko HA, Fung JY, Louie AY,. Positron emission tomography: a novel technique for investigating the biodistribution and transport of nanoparticles. Inhal Toxicol 2010; 22: 657-688.
12. Yi D, Price A, Panoskaltsis-Mortari A, Naqwi A, Wiedmann TS,. Measurement of the distribution of aerosols among mouse lobes by fluorescent imaging. Anal Biochem 2010; 403: 88-93.
13. Montgomery AB, Paajanen H, Brasch RC, Murray JF,. Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of extravascular lung water. Invest Radiol 1987; 22: 377-381.
14. Berthezene Y, Vexler V, Clement O, Muhler A, Moseley ME, Brasch RC,. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion. Radiology 1992; 183: 667-672.
15. Gobbo OL, Zurek M, Tewes F, Ehrhardt C, Cremillieux Y,. Manganese: a new contrast agent for lung imaging? Contrast Media Mol Imaging 2012; 7: 542-546.
16. Sood BG, Shen Y, Latif Z, Chen X, Sharp J, Neelavalli J, Joshi A, Slovis TL, Haacke EM,. Aerosol delivery in ventilated newborn pigs: an MRI evaluation. Pediatr Res 2008; 64: 159-164.
17. Haage P, Karaagac S, Adam G, Glowinski A, Gunther RW,. Comparison of aerosolized gadoteridol and gadopentetate dimeglumine for magnetic resonance ventilation imaging of the lung. Magn Reson Med 2001; 46: 803-806.
18. Suga K, Ogasawara N, Tsukuda T, Matsunaga N,. Assessment of regional lung ventilation in dog lungs with Gd-DTPA aerosol ventilation MR imaging. Acta Radiol 2002; 43: 282-291.
19. Hirsch W, Wenkel R, Eichler G, Paetzel V, Schluter A,. Pulmonary resorption of inhaled gadobutrol in an animal model: usage to determine lung diffusion in MRI examinations. Magn Reson Imaging 2004; 22: 489-493.
20. Suga K, Yuan Y, Ogasawara N, Tsukuda T, Matsunaga N,. Altered clearance of gadolinium diethylenetriaminepentaacetic acid aerosol from bleomycin-injured dog lungs-initial observations. Am J Respir Crit Care Med 2003; 167: 1704-1710.
21. Martin AR, Thompson RB, Finlay WH,. MRI measurement of regional lung deposition in mice exposed nose-only to nebulized superparamagnetic iron oxide nanoparticles. J Aerosol Med Pulm Drug Deliv 2008; 21: 335-342.
22. Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C,. Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging. Ann Biomed Eng 2013; 41: 967-978.
23. Sarracanie M, Martin A, Tardieu M, et al., In vivo 3D mapping of aerosol deposition in rat lungs. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012. Abstract 633.
24. Strobel K, Hoerr V, Schmid F, Wachsmuth L, Loffler B, Faber C,. Early detection of lung inflammation: exploiting T1-effects of iron oxide particles using UTE MRI. Magn Reson Med 2012; 68: 1924-1931.
25. Bianchi A, Lux F, Tillement O, Crémillieux Y,. Contrast enhanced lung MRI in mice using ultra-short echo time radial imaging and intratracheally administrated Gd-DOTA-based nanoparticles. Magn Reson Med 2013; 70: 1419-1426.
26. Al Faraj A, Lacroix G, Alsaid H, Elgrabi D, Stupar V, Robidel F, Gaillard S, Canet-Soulas E, Cremillieux Y,. Longitudinal 3He and proton imaging of magnetite biodistribution in a rat model of instilled nanoparticles. Magn Reson Med 2008; 59: 1298-1303.
27. Leong BK, Coombs JK, Sabaitis CP, Rop DA, Aaron CS,. Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats. J Appl Toxicol 1998; 18: 149-160.
28. Wong ST, Roos MS,. A strategy for sampling on a sphere applied to 3D selective RF pulse design. Magn Reson Med 1994; 32: 778-784.
29. Dempster AP, Laird NM, Rubin DB,. Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc Series B Stat Methodol 1977; 39: 1-38.
30. Lagarias J, Reeds J, Wright M, Wright P,. Convergence properties of the Nelder-Mead simplex method in low dimensions. SIAM J Optim 1998; 9: 112-147.
31. Schabel MC, Parker DL,. Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences. Phys Med Biol 2008; 53: 2345-2373.
32. Fram EK, Herfkens RJ, Johnson GA, Glover GH, Karis JP, Shimakawa A, Perkins TG, Pelc NJ,. Rapid calculation of T1 using variable flip angle gradient refocused imaging. Magn Reson Imaging 1987; 5: 201-208.
33. Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann H-J,. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005; 40: 715-724.
34. DeCarlo PF, Slowik JG, Worsnop DR, Davidovits P, Jimenez JL,. Particle morphology and density characterization by combined mobility and aerodynamic diameter measurements. Part 1: theory. Aerosol Sci Technol 2004; 38: 1185-1205.
35. Martin AR, Ang A, Katz IM, Haussermann S, Caillibotte G, Texereau J,. An in vitro assessment of aerosol delivery through patient breathing circuits used with medical air or a helium-oxygen mixture. J Aerosol Med Pulm Drug Deliv 2011; 24: 225-234.
36. Wang H, Xavier M, Ruaud J-P, Darrasse L, de Rochefort L,. Measurement precision of contrast agent with R2∗ (magnitude) and quantitative susceptibility mapping (phase). In Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, Utah, USA, 2013. Abstract 3841.
37. De Backer JW, Vos WG, Burnell P, Verhulst SL, Salmon P, De Clerck N, De Backer W,. Study of the variability in upper and lower airway morphology in Sprague-Dawley rats using modern micro-CT scan-based segmentation techniques. Anat Rec (Hoboken) 2009; 292: 720-727.
38. Shioya S, Haida M, Fukuzaki M, Ono Y, Tsuda M, Ohta Y, Yamabayashi H,. A 1-year time course study of the relaxation times and histology for irradiated rat lungs. Magn Reson Med 1990; 14: 358-368.
39. El-Khatib E, Lehnert S,. Lung density changes observed in vivo in rat lungs after irradiation: variations among and within individual lungs. Int J Radiat Oncol Biol Phys 1989; 16: 745-754.
40. Berthezene Y, Muhler A, Lang P, Shames DM, Clement O, Rosenau W, Kuwatsuru R, Brasch RC,. Safety aspects and pharmacokinetics of inhaled aerosolized gadolinium. J Magn Reson Imaging 1993; 3: 125-130.
41. Everard ML, Hardy JG, Milner AD,. Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation. Thorax 1993; 48: 1045-1046.
42. Mosbah K, Ruiz-Cabello J, Berthezene Y, Cremillieux Y,. Aerosols and gaseous contrast agents for magnetic resonance imaging of the lung. Contrast Media Mol Imaging 2008; 3: 173-190.
43. Apiou-Sbirlea G, Katz IM, Martonen TB,. The effects of simulated airway diseases and affected flow distributions on aerosol deposition. Respir Care 2010; 55: 707-718.
44. Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB,. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci 2000; 55: 24-35.
45. Lizio R, Westhof A, Lehr CM, Klenner T,. Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery. Lab Anim 2001; 35: 257-260.
46. Olsson B, Bondesson E, Borgström L, Edsbäcker S, Eirefelt S, Ekelund K, Gustavsson L, Hegelund-Myrbäck T,. Pulmonary drug metabolism, clearance, and absorption. In:, Smyth HDC, Hickey AJ, editors. Controlled pulmonary drug delivery, advances in delivery science and technology. New York: Springer; 2011. p 21-50.
47. Patton JS, Fishburn CS, Weers JG,. The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc 2004; 1: 338-344.
48. O'Doherty MJ, Peters AM,. Pulmonary technetium-99m diethylene triamine penta-acetic acid aerosol clearance as an index of lung injury. Eur J Nucl Med 1997; 24: 81-87.
49. Bondesson E, Bengtsson T, Nilsson LE, Wollmer P,. Site of deposition and absorption of an inhaled hydrophilic solute. Br J Clin Pharmacol 2007; 63: 722-731.
50. Donahue KM, Weisskoff RM, Burstein D,. Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging 1997; 7: 102-110.
51. Schlesinger RB, Gurman JL, Lippmann M,. Particle deposition within bronchial airways: comparisons using constant and cyclic inspiratory flows. Ann Occup Hyg 1982; 26: 47-64.
52. Martonen TB,. Deposition patterns of cigarette smoke in human airways. Am Ind Hyg Assoc J 1992; 53: 6-18.
53. Churg A, Vedal S,. Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: evidence for high particle concentration at airway carinas. Occup Environ Med 1996; 53: 553-558.
54. Balásházy I, Hofmann W, Heistracher T,. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol (1985) 2003; 94: 1719-1725.
55. Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C,. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol 2012; 112: 1921-1931.
56. Oakes JM, Marsden AL, Grandmont C, Shadden SC, Darquenne C, Vignon-Clementel IE,. Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments. Ann Biomed Eng 2014; 42: 899-914.
57. Burgel PR, Nadel JA,. Plugging (publicising) to prevent mucous plugging. Eur Respir J 2010; 36: 1236-1238.
58. Baumann D, Rudin M,. Quantitative assessment of rat kidney function by measuring the clearance of the contrast agent Gd(DOTA) using dynamic MRI. Magn Reson Imaging 2000; 18: 587-595.
59. Cutillo AG, Ailion DC,. Modeling the nuclear magnetic resonance behavior of lung: from electrical engineering to critical care medicine. Bioelectromagnetics 1999;(Suppl 4): 110-119.
60. Vignaud A, Maître X, Guillot G, Durand E, de Rochefort L, Robert P, Vivès V, Santus R, Darrasse L,. Magnetic susceptibility matching at the air-tissue interface in rat lung by using a superparamagnetic intravascular contrast agent: influence on transverse relaxation time of hyperpolarized helium-3. Magn Reson Med 2005; 54: 28-33.
61. Gossuin Y, Gillis P, Hocq A, Vuong QL, Roch A,. Magnetic resonance relaxation properties of superparamagnetic particles. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009; 1: 299-310.
62. Takahashi M, Togao O, Obara M, et al., Ultra-short echo time (UTE) MR imaging of the lung: comparison between normal and emphysematous lungs in mutant mice. J Magn Reson Imaging 2010; 32: 326-333.
63. Olsson LE, Lindahl M, Onnervik PO, Johansson LB, Palmer M, Reimer MK, Hultin L, Hockings PD,. Measurement of MR signal and T2∗ in lung to characterize a tight skin mouse model of emphysema using single-point imaging. J Magn Reson Imaging 2007; 25: 488-494.
64. Herborn CU, Honold E, Wolf M, Kemper J, Kinner S, Adam G, Barkhausen J,. Clinical safety and diagnostic value of the gadolinium chelate gadoterate meglumine (Gd-DOTA). Invest Radiol 2007; 42: 58-62.
65. Conolly S, Nishimura D, Macovski A, Glover G,. Variable-rate selective excitation. J Magn Reson (1969) 1988; 78: 440-458.