Design, preparation, and in vitro characterization of a trimodally-targeted nanomagnetic onco-theranostic system for cancer diagnosis and therapy

International Journal of Pharmaceutics

Volumn 500, Issue 1-2, 2016, Pages 62-76

  Zarrin, Abdolhossein ^a   Sadighian, Somayeh ^b   Rostamizadeh, Kobra ^b   Firuzi, Omidreza ^a   Hamidi, Mehrdad ^b   Mohammadi Samani, Soliman ^c   Miri, Ramin ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Folate receptor targeting; Nanomagnetic onco diagnostic system; Nanomagnetic onco theranostic system; SPION

Indexed keywords

CHITOSAN; CONTRAST MEDIUM; DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; MAGNETIC NANOPARTICLE; NANOCARRIER; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; ANTINEOPLASTIC ANTIBIOTIC; FOLATE TRANSPORTER; MAGNETITE NANOPARTICLE;

ANIMAL CELL; ARTICLE; BREAST ADENOCARCINOMA; CANCER DIAGNOSIS; CANCER THERAPY; CELL VIABILITY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; EARLY CANCER; EMBRYO; ENDOCYTOSIS; GELATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MAGNETOMETRY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THERANOSTIC NANOMEDICINE; THERMOGRAVIMETRY; TRANSMISSION ELECTRON MICROSCOPY; TRIMODALLY TARGETED NANOMAGNETIC ONCOLOGY THERANOSTIC SYSTEM; TUMOR LOCALIZATION; VIBRATING SAMPLE MAGNETOMETRY; WHOLE BODY MRI; X RAY DIFFRACTION; ZETA POTENTIAL; 3T3 CELL LINE; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; DRUG FORMULATION; MAGNETISM; MCF-7 CELL LINE; METABOLISM; NEOPLASMS; PH; THERMOTHERAPY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; CHITOSAN; DOXORUBICIN; DRUG COMPOUNDING; DRUG DESIGN; DRUG LIBERATION; FOLIC ACID; FOLIC ACID TRANSPORTERS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTHERMIA, INDUCED; MAGNETIC PHENOMENA; MAGNETITE NANOPARTICLES; MCF-7 CELLS; MICE; NEOPLASMS; NIH 3T3 CELLS; THERANOSTIC NANOMEDICINE;

EID: 84970917669     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.12.051     Document Type: Article

References (37)

1. S. Arora, S. Lal, S. Kumar, M. Kumar, and M. Kumar Comparative degradation kinetic studies of three biopolymers: chitin, chitosan and cellulose Arch. Appl. Sci. Res. 3 2011 188 201
2. 4 nanoparticles as an MRI contrast agent eXPRESS Polym. Lett. 4 2010 329 338
3. A. Azadi, M. Hamidi, and M.R. Rouini Methotrextae-loaded chitosan nanogels as Trojan Horses for drug delivery to brain: preparation and in vitro/in vivo characterization Int. J. Biol. Macromol. 62 2013 523 530
4. M. Azadi, M.R. Rouini, and M. Hamidi Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels Int. J. Biol. Macromol. 79 2015 326 335
5. M. Azizmohammadi, M. Khoobi, A. Ramazani, S. Emami, A. Zarrin, O. Firuzi, R. Miri, and A. Shafiee 2-H chromene derivatives bearing thiazolidine-2,4-dione, rhodamine or hydantoin moieties as potential anticancer agents Eur. J. Med. Chem. 59 2013 15 22
6. M.A. Busquets, R. Sabaté, and J. Estelrich Potential applications of magnetic particles to detect and treat Alzheimer's disease Nanoscale Res. Lett. 9 2014 538 547
7. P. Calvo, C. Remunan-Lopez, J.L. Vila-Jato, and M.J. Alonso Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers J. Appl. Polym. Sci. 63 1997 125 132
8. J. Castello, M. Gallardo, M.A. Busquets, and J. Estelrich Chitosan (or alginate)-coated iron oxide nanoparticles: A comparative studyosan (or alginate)-coated iron oxide nanoparticles: A comparative study Colloids Surf. A Physicochem. Eng. Aspects 468 2015 151 158
9. M.F. Casula, A. Corrias, P. Arosio, A. Lascialfari, T. Sen, P. Floris, and I.J. Bruce Design of water-based ferrofluids as contrast agents for magnetic resonance imaging J. Colloids Interface Sci. 357 2011 50 55
10. Y. Chen, H. Chen, D. Zeng, Y. Tian, F. Chen, J. Feng, and J. Shi Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery ACS Nano 4 2010 6001 6013
11. S. David, H. Marchais, K. Hervé-Aubert, D. Bedin, A.S. Garin, C. Hoinard, and I. Chourpa Use of experimental design methodology for the development of new magnetic siRNA nanovectors (MSN) of experimental design methodology for the development of new magnetic siRNA nanovectors (MSN) Int. J. Pharm. 454 2013 660 667
12. D. Dube, M. Francis, J.-C. Leroux, and F. Winnik Preparation and tumor cell uptake of poly(n-isopropylacrylamide) folate conjugates Bioconjugate Chem. 13 2002 685 692
13. J. Funkhouser Reinventing pharma: the theranostic revolution Curr. Drug Discovery 2 2002 17 19
14. K.M. Gharpure, S.Y. Wu, C. Li, G. Lopez-Berestein, and A.K. Sood Nanotechnology: future of oncotherapy Clin. Cancer Res. 21 2015 3121 3130
15. S. Goodwin, C. Peterson, C. Hoh, and C. Bittner Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapyeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy J. Magn. Magn. Mater. 194 1-3 1999 132 139
16. I. Hajdu, G. Trencsenyi, M. Dodnar, M. Emri, G. Banfalvi, J. Sikula, T. Marian, J. Kollar, J. Vamosi, and J. Borbely Tumor-specific localization of self-assembled nanoparticle PET/MR modalities Anticancer Res. 34 2014 49 60
17. K. Kaaki, K. Hervé-Aubert, M. Chiper, A. Shkilnyy, M. Souce', R. Benoit, A. Paillard, P. Dubois, M.L. Saboungi, and I. Chourpa Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid: relation between coating structure surface properties, colloidal stability, and cancer cell targeting Langmuir 28 2012 1496 1505
18. C. Kaewsaneha, K. Jangpatarapongsa, T. Tangchaikeeree, D. Polpanich, and P. Tangboriboonrat Fluorescent chitosan functionalized magnetic polymeric nanoparticles: cytotoxicity and in vitro evaluation of cellular uptake J. Biomater. Appl. 29 2014 761 768
19. M. Khalkhali, K. Rostamizadeh, S. Sadighian, F. Khoeini, M. Naghibi, and M. Hamidi The impact of polymer coatings on magnetic nanoparticles performance as MRI contrast agents; a comparative study Daru 23 2015 45
20. M. Khalkhali, S. Sadighian, K. Rostamizadeh, F. Khoeini, M. Naghibi, N. Bayat, M. Habibzadeh, and M. Hamidi Synthesis and characterization of dextran coated magnetite nanoparticles for diagnostics and therapy Bioimpacts 5 2015 141 150
21. T.H. Kim, S. Lee, and X. Chen Nanotheranostics for personalized medicine Expert Rev. Mol. Diagn. 13 2013 257 269
22. N. Kohler, C. Sun, A. Fichtenholtz, J. Gunn, C. Fang, and M. Zhang Methotrexate immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery Small 2 2006 785 792
23. M. Kumar, G. Singh, V. Arora, S. Mewar, U. Sharma, N.R. Jagannathan, S. Sapra, A.K. Dinda, S. Kharbanda, and H. Singh Cellular interaction of folic acid conjugated superparamagnetic iron oxide nanoparticles and its use as contract agent for targeted magnetic imaging of tumor cells Int. J. Nanomed. 7 2012 3503 3516
24. 2 as a safe and targeting antitumor nanovehicle in vitro Nanoscale Res. Lett. 9 2014 146 156
25. J. Li, Y. He, W. Sun, Y. Luo, H. Cai, Y. Pan, M. Shen, J. Xia, and X. Shi Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging Bimaterials 35 2014 3666 3677
26. 4@Au composite nanoparticles for dual mode MR/CT imaging applications ACS Appl. Mater. Interfaces 5 2013 10357 10366
27. J. Li, L. Zheng, H. Cai, W. Sun, M. Shen, G. Zhang, and X. Shi Polyethyleneimine-mediated synthesis of folic acid-targeted iron oxide nanoparticles for in vivo tumor MR imaging Biomaterials 34 2013 8382 8392
28. L. Li, F. Gao, W. Jiang, X. Wu, Y. Cai, J. Tang, X. Gao, and F. Gao Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging Drug Deliv. 2015 1 8
29. P.S. Low, and S.A. Kularatne Folate-targeted therapeutic and imaging agents for cancer Curr. Opin. Chem. Biol. 13 2009 256 262
30. X. Ma, A. Gong, B. Chen, J. Zheng, T. Chen, Z. Shen, and A. Wu Exploring a new SPION-based MRI contrast agent with excellent water-dispersibility, high specificity to cancer cells and strong MR imaging efficacy Colloids Surf. B Biointerfaces 126 2015 44 49
31. B. Manocha, and A. Margaritis Controlled release of doxorubicin from doxorubicin/γ-polyglutamic acid ionic complex J. Nanomater. 780171 2010 1 9
32. S. Sadighian, K. Rostamizadeh, H. Hosseini-Monfared, and M. Hamidi Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery Colloids Surf. B Biointerfaces 117 2014 406 413
33. S. Sadighian, H. Hosseini-Monfared, K. Rostamizadeh, and M. Hamidi pH-Triggered magnetic-chitosan nanogels (MCNs) for doxorubicin delivery: physically vs: chemically cross linking approach Adv. Pharm. Bull. 5 2015 115 120
34. A. Senyei, K. Widder, and G. Czerlinski Magnetic guidance of drug-carrying microspheres J. Appl. Phys. 49 6 1978 3578 3583
35. A. Vora, A. Riga, D. Dollimore, and K. Alexander Thermal stability of folic acid in the solid state J. Therm. Anal. Calorim. 75 2004 709 717
36. W. Wu, Q. He, and C.H. Jiang Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies Nanoscale Res. Lett. 3 2008 397 415
37. S.K. Yen, P. Padmanabhan, and S.T. Selvan Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery Theranostics 3 2013 986 1003