메뉴 건너뛰기




Volumn 37, Issue 9, 2016, Pages 12203-12211

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

Author keywords

Endometrial cancer; EP4; Prostaglandin E2; SUMO 1; catenin

Indexed keywords

BETA CATENIN; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E SYNTHASE 2; PROSTAGLANDIN E2; SHORT HAIRPIN RNA; SUMO 1 PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84969988399     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-016-5087-x     Document Type: Article
Times cited : (45)

References (44)
  • 3
    • 84936943463 scopus 로고    scopus 로고
    • Annual report on status of cancer in china, 2011. Chinese journal of cancer research
    • PID: 25717220
    • Chen W, Zheng R, Zeng H, Zhang S, He J. Annual report on status of cancer in china, 2011. Chinese journal of cancer research. Chung-kuo yen cheng yen chiu. 2015;27:2–12.
    • (2015) Chung-kuo yen cheng yen chiu , vol.27 , pp. 2-12
    • Chen, W.1    Zheng, R.2    Zeng, H.3    Zhang, S.4    He, J.5
  • 4
    • 73749088151 scopus 로고    scopus 로고
    • Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances
    • COI: 1:CAS:528:DC%2BC3cXnsFarsA%3D%3D, PID: 19788928
    • Legler DF, Bruckner M, Uetz-von Allmen E, Krause P. Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol. 2010;42:198–201.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 198-201
    • Legler, D.F.1    Bruckner, M.2    Uetz-von Allmen, E.3    Krause, P.4
  • 6
    • 57349152156 scopus 로고    scopus 로고
    • Synergistic up-regulation of prostaglandin e synthase expression in breast cancer cells by 17β-estradiol and proinflammatory cytokines
    • COI: 1:CAS:528:DC%2BD1cXhsVGltrjN, PID: 18703630
    • Frasor J, Weaver AE, Pradhan M, Mehta K. Synergistic up-regulation of prostaglandin e synthase expression in breast cancer cells by 17β-estradiol and proinflammatory cytokines. Endocrinology. 2008;149:6272–9.
    • (2008) Endocrinology , vol.149 , pp. 6272-6279
    • Frasor, J.1    Weaver, A.E.2    Pradhan, M.3    Mehta, K.4
  • 7
    • 33845671788 scopus 로고    scopus 로고
    • Ovarian epithelial cancer: a role for pge2-synthesis and signalling in malignant transformation and progression
    • PID: 17107625
    • Rask K, Zhu Y, Wang W, Hedin L, Sundfeldt K. Ovarian epithelial cancer: a role for pge2-synthesis and signalling in malignant transformation and progression. Mol Cancer. 2006;5:62.
    • (2006) Mol Cancer , vol.5 , pp. 62
    • Rask, K.1    Zhu, Y.2    Wang, W.3    Hedin, L.4    Sundfeldt, K.5
  • 8
    • 84900035813 scopus 로고    scopus 로고
    • Activation of a positive feedback loop involving il-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment
    • COI: 1:CAS:528:DC%2BC2cXis1egtQ%3D%3D, PID: 24347287
    • Che Q, Liu BY, Liao Y, Zhang HJ, Yang TT, He YY, et al. Activation of a positive feedback loop involving il-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment. Int J Cancer. 2014;135:282–94.
    • (2014) Int J Cancer , vol.135 , pp. 282-294
    • Che, Q.1    Liu, B.Y.2    Liao, Y.3    Zhang, H.J.4    Yang, T.T.5    He, Y.Y.6    Xia, Y.H.7    Lu, W.8    He, X.Y.9    Chen, Z.10    Wang, F.Y.11    Wan, X.P.12
  • 9
    • 84930013827 scopus 로고    scopus 로고
    • Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis
    • PID: 25954856
    • Zhu M, Che Q, Liao Y, Wang H, Wang J, Chen Z, et al. Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis. Oncol Rep. 2015;34:129–38.
    • (2015) Oncol Rep , vol.34 , pp. 129-138
    • Zhu, M.1    Che, Q.2    Liao, Y.3    Wang, H.4    Wang, J.5    Chen, Z.6    Wang, F.7    Dai, C.8    Wan, X.9
  • 10
    • 79955478443 scopus 로고    scopus 로고
    • The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice
    • COI: 1:CAS:528:DC%2BC3MXlsFShtbo%3D, PID: 21419570
    • Takahashi T, Ogawa H, Izumi K, Uehara H. The soluble EP2 receptor FuEP2/Ex2 suppresses endometrial cancer cell growth in an orthotopic xenograft model in nude mice. Cancer Lett. 2011;306:67–75.
    • (2011) Cancer Lett , vol.306 , pp. 67-75
    • Takahashi, T.1    Ogawa, H.2    Izumi, K.3    Uehara, H.4
  • 11
    • 10344242948 scopus 로고    scopus 로고
    • Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway
    • COI: 1:CAS:528:DC%2BD2cXhtFSit7%2FO, PID: 15579767
    • Sales KJ, Battersby S, Williams AR, Anderson RA, Jabbour HN. Prostaglandin E2 mediates phosphorylation and down-regulation of the tuberous sclerosis-2 tumor suppressor (tuberin) in human endometrial adenocarcinoma cells via the Akt signaling pathway. J Clin Endocrinol Metab. 2004;89:6112–8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 6112-6118
    • Sales, K.J.1    Battersby, S.2    Williams, A.R.3    Anderson, R.A.4    Jabbour, H.N.5
  • 12
    • 84938781131 scopus 로고    scopus 로고
    • K-bZIP mediated sumo-2/3 specific modification on the KSHV genome negatively regulates lytic gene expression and viral reactivation
    • PID: 26197391
    • Yang WS, Hsu HW, Campbell M, Cheng CY, Chang PC. K-bZIP mediated sumo-2/3 specific modification on the KSHV genome negatively regulates lytic gene expression and viral reactivation. PLoS Pathog. 2015;11:e1005051.
    • (2015) PLoS Pathog , vol.11
    • Yang, W.S.1    Hsu, H.W.2    Campbell, M.3    Cheng, C.Y.4    Chang, P.C.5
  • 14
    • 77950868811 scopus 로고    scopus 로고
    • Sumo weighs in on polycomb-dependent gene repression
    • COI: 1:CAS:528:DC%2BC3cXms1amu7k%3D, PID: 20417594
    • Gill G. Sumo weighs in on polycomb-dependent gene repression. Mol Cell. 2010;38:157–9.
    • (2010) Mol Cell , vol.38 , pp. 157-159
    • Gill, G.1
  • 15
    • 15944406765 scopus 로고    scopus 로고
    • Sumo: a history of modification
    • COI: 1:CAS:528:DC%2BD2MXjt1Oit78%3D, PID: 15808504
    • Hay RT. Sumo: a history of modification. Mol Cell. 2005;18:1–12.
    • (2005) Mol Cell , vol.18 , pp. 1-12
    • Hay, R.T.1
  • 16
    • 0030455748 scopus 로고    scopus 로고
    • A novel ubiquitin-like modification modulates the partitioning of the ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
    • COI: 1:CAS:528:DyaK28XnsFGgtLs%3D, PID: 8978815
    • Matunis MJ, Coutavas E, Blobel G. A novel ubiquitin-like modification modulates the partitioning of the ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol. 1996;135:1457–70.
    • (1996) J Cell Biol , vol.135 , pp. 1457-1470
    • Matunis, M.J.1    Coutavas, E.2    Blobel, G.3
  • 17
    • 0030794729 scopus 로고    scopus 로고
    • The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer
    • COI: 1:CAS:528:DyaK2sXmsFWms7k%3D, PID: 9312010
    • Johnson ES, Schwienhorst I, Dohmen RJ, Blobel G. The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J. 1997;16:5509–19.
    • (1997) EMBO J , vol.16 , pp. 5509-5519
    • Johnson, E.S.1    Schwienhorst, I.2    Dohmen, R.J.3    Blobel, G.4
  • 18
    • 0030932134 scopus 로고    scopus 로고
    • A small ubiquitin-related polypeptide involved in targeting RsanGAP1 to nuclear pore complex protein RanBP2
    • COI: 1:CAS:528:DyaK2sXltF2isA%3D%3D, PID: 9019411
    • Mahajan R, Delphin C, Guan T, Gerace L, Melchior F. A small ubiquitin-related polypeptide involved in targeting RsanGAP1 to nuclear pore complex protein RanBP2. Cell. 1997;88:97–107.
    • (1997) Cell , vol.88 , pp. 97-107
    • Mahajan, R.1    Delphin, C.2    Guan, T.3    Gerace, L.4    Melchior, F.5
  • 19
    • 0033571214 scopus 로고    scopus 로고
    • SUMO-1 modification activates the transcriptional response of p53
    • COI: 1:CAS:528:DyaK1MXns1Ort74%3D, PID: 10562557
    • Rodriguez MS, Desterro JM, Lain S, Midgley CA, Lane DP, Hay RT. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 1999;18:6455–61.
    • (1999) EMBO J , vol.18 , pp. 6455-6461
    • Rodriguez, M.S.1    Desterro, J.M.2    Lain, S.3    Midgley, C.A.4    Lane, D.P.5    Hay, R.T.6
  • 20
    • 77954824975 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells
    • COI: 1:CAS:528:DC%2BC3cXns1Smtbg%3D, PID: 20351196
    • Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, et al. Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Mol Endocrinol. 2010;24:1175–86.
    • (2010) Mol Endocrinol , vol.24 , pp. 1175-1186
    • Miao, L.1    Shi, J.2    Wang, C.Y.3    Zhu, Y.4    Du, X.5    Jiao, H.6    Mo, Z.7    Klocker, H.8    Lee, C.9    Zhang, J.10
  • 21
    • 84941103776 scopus 로고    scopus 로고
    • PGE2 elevates IL-23 production in human dendritic cells via a camp dependent pathway
    • Shi Q, Yin Z, Zhao B, Sun F, Yu H, Yin X, et al. PGE2 elevates IL-23 production in human dendritic cells via a camp dependent pathway. Mediat Inflamm. 2015;2015:984690.
    • (2015) Mediat Inflamm , vol.2015 , pp. 984690
    • Shi, Q.1    Yin, Z.2    Zhao, B.3    Sun, F.4    Yu, H.5    Yin, X.6    Zhang, L.7    Wang, S.8
  • 22
    • 84947556958 scopus 로고    scopus 로고
    • Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase a in HCA-7 human colon cancer cells
    • COI: 1:CAS:528:DC%2BC2MXhslGksLbN, PID: 26518053
    • Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, et al. Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase a in HCA-7 human colon cancer cells. Eur J Pharmacol. 2015;768:149–59.
    • (2015) Eur J Pharmacol , vol.768 , pp. 149-159
    • Fujino, H.1    Seira, N.2    Kurata, N.3    Araki, Y.4    Nakamura, H.5    Regan, J.W.6    Murayama, T.7
  • 23
    • 77952309664 scopus 로고    scopus 로고
    • Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals
    • COI: 1:CAS:528:DC%2BC3cXlslShs78%3D, PID: 20026682
    • Leitao B, Jones MC, Fusi L, Higham J, Lee Y, Takano M, et al. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB J. 2010;24:1541–51.
    • (2010) FASEB J , vol.24 , pp. 1541-1551
    • Leitao, B.1    Jones, M.C.2    Fusi, L.3    Higham, J.4    Lee, Y.5    Takano, M.6    Goto, T.7    Christian, M.8    Lam, E.W.9    Brosens, J.J.10
  • 24
    • 33750806731 scopus 로고    scopus 로고
    • Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone
    • COI: 1:CAS:528:DC%2BD28Xht1WmsL3F, PID: 17053081
    • Jones MC, Fusi L, Higham JH, Abdel-Hafiz H, Horwitz KB, Lam EW, et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006;103:16272–7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16272-16277
    • Jones, M.C.1    Fusi, L.2    Higham, J.H.3    Abdel-Hafiz, H.4    Horwitz, K.B.5    Lam, E.W.6    Brosens, J.J.7
  • 27
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • COI: 1:CAS:528:DC%2BD1cXovV2mtbg%3D, PID: 18650914
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436–44.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 28
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 84920854543 scopus 로고    scopus 로고
    • Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/BCL-2 signaling pathway
    • PID: 25572805
    • Yang C, He L, He P, Liu Y, Wang W, He Y, et al. Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/BCL-2 signaling pathway. Med Oncol. 2015;32:352.
    • (2015) Med Oncol , vol.32 , pp. 352
    • Yang, C.1    He, L.2    He, P.3    Liu, Y.4    Wang, W.5    He, Y.6    Du, Y.7    Gao, F.8
  • 30
    • 84916006645 scopus 로고
    • On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)
    • von Euler US. On the specific vaso-dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J Physiol. 1936;88:213–34.
    • (1936) J Physiol , vol.88 , pp. 213-234
    • von Euler, U.S.1
  • 31
    • 77951157434 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome
    • COI: 1:CAS:528:DC%2BC3cXkslSrurw%3D, PID: 20353998
    • Kim JI, Lakshmikanthan V, Frilot N, Daaka Y. Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. Mol Cancer Res. 2010;8:569–77.
    • (2010) Mol. Cancer Res , vol.8 , pp. 569-577
    • Kim, J.I.1    Lakshmikanthan, V.2    Frilot, N.3    Daaka, Y.4
  • 32
    • 84924674617 scopus 로고    scopus 로고
    • Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2–Ep2 pathway
    • COI: 1:CAS:528:DC%2BC2MXpvFKhu74%3D, PID: 25625500
    • Li S, Xu X, Jiang M, Bi Y, Xu J, Han M. Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2–Ep2 pathway. Mol Med Rep. 2015;11:4454–62.
    • (2015) Mol Med Rep , vol.11 , pp. 4454-4462
    • Li, S.1    Xu, X.2    Jiang, M.3    Bi, Y.4    Xu, J.5    Han, M.6
  • 33
    • 0035008948 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression and prostaglandin e(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    • COI: 1:CAS:528:DC%2BD3MXjs1Omtbo%3D, PID: 11344234
    • Sales KJ, Katz AA, Davis M, Hinz S, Soeters RP, Hofmeyr MD, et al. Cyclooxygenase-2 expression and prostaglandin e(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. J Clin Endocrinol Metab. 2001;86:2243–9.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2243-2249
    • Sales, K.J.1    Katz, A.A.2    Davis, M.3    Hinz, S.4    Soeters, R.P.5    Hofmeyr, M.D.6    Millar, R.P.7    Jabbour, H.N.8
  • 36
    • 84871924774 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the vitamins and lifestyle (vital) cohort
    • COI: 1:CAS:528:DC%2BC38Xhs1Cjs7jL, PID: 23063765
    • Brasky TM, Moysich KB, Cohn DE, White E. Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the vitamins and lifestyle (vital) cohort. Gynecol Oncol. 2013;128:113–9.
    • (2013) Gynecol Oncol , vol.128 , pp. 113-119
    • Brasky, T.M.1    Moysich, K.B.2    Cohn, D.E.3    White, E.4
  • 37
    • 3943099375 scopus 로고    scopus 로고
    • Protein modification by SUMO
    • COI: 1:CAS:528:DC%2BD2cXmslags7k%3D, PID: 15189146
    • Johnson ES. Protein modification by SUMO. Annu Rev Biochem. 2004;73:355–82.
    • (2004) Annu Rev Biochem , vol.73 , pp. 355-382
    • Johnson, E.S.1
  • 38
    • 84943163720 scopus 로고    scopus 로고
    • SUMO-1 promotes Ishikawa cell proliferation and apoptosis in endometrial cancer by increasing SUMOylation of histone H4
    • PID: 26222483
    • Zheng J, Liu L, Wang S, Huang X. SUMO-1 promotes Ishikawa cell proliferation and apoptosis in endometrial cancer by increasing SUMOylation of histone H4. Int J Gynecol Cancer. 2015;25:1364–8.
    • (2015) Int. J. Gynecol. Cancer , vol.25 , pp. 1364-1368
    • Zheng, J.1    Liu, L.2    Wang, S.3    Huang, X.4
  • 39
    • 84864018984 scopus 로고    scopus 로고
    • Identification of estrogen receptor beta as a SUMO-1 target reveals a novel phosphorylated SUMOylation motif and regulation by glycogen synthase kinase 3β
    • COI: 1:CAS:528:DC%2BC38XhtVeqsbzL, PID: 22586270
    • Picard N, Caron V, Bilodeau S, Sanchez M, Mascle X, Aubry M, et al. Identification of estrogen receptor beta as a SUMO-1 target reveals a novel phosphorylated SUMOylation motif and regulation by glycogen synthase kinase 3β. Mol Cell Biol. 2012;32:2709–21.
    • (2012) Mol Cell Biol , vol.32 , pp. 2709-2721
    • Picard, N.1    Caron, V.2    Bilodeau, S.3    Sanchez, M.4    Mascle, X.5    Aubry, M.6    Tremblay, A.7
  • 42
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • COI: 1:CAS:528:DC%2BD2cXhtVejsr7I, PID: 15473860
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004;20:781–810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 43
    • 79952947661 scopus 로고    scopus 로고
    • Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges
    • COI: 1:CAS:528:DC%2BC3MXjs1yqsbc%3D, PID: 21421114
    • Nicholas MK, Lukas RV, Chmura S, Yamini B, Lesniak M, Pytel P. Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges. Semin Oncol. 2011;38:243–53.
    • (2011) Semin Oncol , vol.38 , pp. 243-253
    • Nicholas, M.K.1    Lukas, R.V.2    Chmura, S.3    Yamini, B.4    Lesniak, M.5    Pytel, P.6
  • 44
    • 84953280500 scopus 로고    scopus 로고
    • Expression patterns of the wnt pathway inhibitors Dickkopf3 and secreted frizzled-related proteins 1 and 4 in endometrial endometrioid adenocarcinoma: an NRG oncology/gynecologic oncology group study
    • PID: 26397159
    • Eskander RN, Ali S, Dellinger T, Lankes HA, Randall LM, Ramirez NC, et al. Expression patterns of the wnt pathway inhibitors Dickkopf3 and secreted frizzled-related proteins 1 and 4 in endometrial endometrioid adenocarcinoma: an NRG oncology/gynecologic oncology group study. Int J Gynecol Cancer. 2016;26:125–32.
    • (2016) Int. J. Gynecol. Cancer , vol.26 , pp. 125-132
    • Eskander, R.N.1    Ali, S.2    Dellinger, T.3    Lankes, H.A.4    Randall, L.M.5    Ramirez, N.C.6    Monk, B.J.7    Walker, J.L.8    Eisenhauer, E.9    Hoang, B.H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.