Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics

Journal of the Royal Society Interface

Volumn 13, Issue 117, 2016, Pages

  Herberg, Maria ^a,b   Glauche, Ingmar ^a   Zerjatke, Thomas ^a   Winzi, Maria ^a   Buchholz, Frank ^a   Roeder, Ingo ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Agent based modelling; Cellular genealogies; Flow cytometry; Nanog heterogeneity; Oscillations

Indexed keywords

AUTONOMOUS AGENTS; CELL PROLIFERATION; CELLS; COMPUTATIONAL METHODS; CYTOLOGY; DYNAMICS; FLOW CYTOMETRY; GENE EXPRESSION; HISTORY; MAMMALS; POPULATION STATISTICS; STEM CELLS; STOCHASTIC SYSTEMS; TRANSCRIPTION FACTORS;

AGENT-BASED MODELLING; CELLULAR GENEALOGIES; HETEROGENEOUS EXPRESSIONS; MOUSE EMBRYONIC STEM CELLS; NANOG HETEROGENEITY; OSCILLATIONS; STOCHASTIC FLUCTUATION; SUSTAINED OSCILLATIONS;

TRANSCRIPTION;

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR REX1; UNCLASSIFIED DRUG; NANOG PROTEIN, MOUSE; REX-1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL HETEROGENEITY; CELL INTERACTION; CELL POPULATION; CELL SELECTION; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; HEREDITY; MOUSE; MOUSE EMBRYONIC STEM CELL; NOISE; NONHUMAN; PLURIPOTENT STEM CELL; POPULATION GROWTH; PROTEIN EXPRESSION; STEM CELL SELF-RENEWAL; SYSTEMS BIOLOGY; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; MICE; MODELS, BIOLOGICAL; MOUSE EMBRYONIC STEM CELLS; NANOG HOMEOBOX PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84969980342     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2016.0167     Document Type: Article

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