메뉴 건너뛰기




Volumn 1, Issue 2, 2015, Pages

Late-onset Alzheimer disease risk variants mark brain regulatory loci

Author keywords

[No Author keywords available]

Indexed keywords

C1QTNF4 PROTEIN; C20ORF43 PROTEIN; CASS4 PROTEIN; CR1 PROTEIN; FERMT2 PROTEIN; HLA DRB1 ANTIGEN; MEF2C PROTEIN; MTCH2 PROTEIN; PILRB PROTEIN; PROTEIN; RAPSN PROTEIN; SLC24A4 PROTEIN; UNCLASSIFIED DRUG; ZCWPW1 PROTEIN;

EID: 84969943555     PISSN: None     EISSN: 23767839     Source Type: Journal    
DOI: 10.1212/NXG.0000000000000012     Document Type: Article
Times cited : (56)

References (31)
  • 1
    • 70349558522 scopus 로고    scopus 로고
    • Genomewide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • Harold D, Abraham R, Hollingworth P, et al. Genomewide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009;41:1088-1093.
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3
  • 2
    • 77952307991 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic loci associated with Alzheimer disease
    • Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832-1840.
    • (2010) JAMA , vol.303 , pp. 1832-1840
    • Seshadri, S.1    Fitzpatrick, A.L.2    Ikram, M.A.3
  • 3
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011;43:436-441.
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3
  • 4
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    • Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011;43:429-435.
    • (2011) Nat Genet , vol.43 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3
  • 5
    • 84888317489 scopus 로고    scopus 로고
    • Metaanalysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Metaanalysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013;45:1452-1458.
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3
  • 6
    • 84895063050 scopus 로고    scopus 로고
    • Alternative approaches in gene discovery and characterization in Alzheimer's disease
    • Ertekin-Taner N, De Jager PL, Yu L, Bennett DA. Alternative approaches in gene discovery and characterization in Alzheimer's disease. Curr Genet Med Rep 2013;1:39-51.
    • (2013) Curr Genet Med Rep , vol.1 , pp. 39-51
    • Ertekin-Taner, N.1    De Jager, P.L.2    Yu, L.3    Bennett, D.A.4
  • 7
    • 84863722361 scopus 로고    scopus 로고
    • Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    • Allen M, Zou F, Chai HS, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology 2012;79:221-228.
    • (2012) Neurology , vol.79 , pp. 221-228
    • Allen, M.1    Zou, F.2    Chai, H.S.3
  • 9
    • 84887235001 scopus 로고    scopus 로고
    • ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status
    • Vasquez JB, Fardo DW, Estus S. ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status. Neurosci Lett 2013;556:58-62.
    • (2013) Neurosci Lett , vol.556 , pp. 58-62
    • Vasquez, J.B.1    Fardo, D.W.2    Estus, S.3
  • 10
    • 84888306100 scopus 로고    scopus 로고
    • Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
    • Chapuis J, Hansmannel F, Gistelinck M, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry 2013;18: 1225-1234.
    • (2013) Mol Psychiatry , vol.18 , pp. 1225-1234
    • Chapuis, J.1    Hansmannel, F.2    Gistelinck, M.3
  • 11
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the nincds-adrda work group under the auspices of department of health and human services task force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 12
    • 59149084048 scopus 로고    scopus 로고
    • Genetic variation in PCDH11X is associated with susceptibility to lateonset Alzheimer's disease
    • Carrasquillo MM, Zou F, Pankratz VS, et al. Genetic variation in PCDH11X is associated with susceptibility to lateonset Alzheimer's disease. Nat Genet 2009;41:192-198.
    • (2009) Nat Genet , vol.41 , pp. 192-198
    • Carrasquillo, M.M.1    Zou, F.2    Pankratz, V.S.3
  • 13
    • 84864066707 scopus 로고    scopus 로고
    • Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
    • Zou F, Chai HS, Younkin CS, et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet 2012;8: e1002707.
    • (2012) PLoS Genet , vol.8 , pp. e1002707
    • Zou, F.1    Chai, H.S.2    Younkin, C.S.3
  • 14
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82: 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 15
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009;41:1094-1099.
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3
  • 16
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575.
    • (2007) Am J Hum Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3
  • 17
    • 77956586071 scopus 로고    scopus 로고
    • LocusZoom: Regional visualization of genome-wide association scan results
    • Pruim RJ, Welch RP, Sanna S, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010;26:2336-2337.
    • (2010) Bioinformatics , vol.26 , pp. 2336-2337
    • Pruim, R.J.1    Welch, R.P.2    Sanna, S.3
  • 18
    • 84865712382 scopus 로고    scopus 로고
    • Annotation of functional variation in personal genomes using RegulomeDB
    • Boyle AP, Hong EL, Hariharan M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012;22:1790-1797.
    • (2012) Genome Res , vol.22 , pp. 1790-1797
    • Boyle, A.P.1    Hong, E.L.2    Hariharan, M.3
  • 19
    • 84921750431 scopus 로고    scopus 로고
    • Genetic variability in the regulation of gene expression in ten regions of the human brain
    • Ramasamy A, Trabzuni D, Guelfi S, et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci 2014;17:1418-1428.
    • (2014) Nat Neurosci , vol.17 , pp. 1418-1428
    • Ramasamy, A.1    Trabzuni, D.2    Guelfi, S.3
  • 20
    • 84876907931 scopus 로고    scopus 로고
    • Integrated systems approach identifies genetic nodes and networks in lateonset Alzheimer's disease
    • Zhang B, Gaiteri C, Bodea LG, et al. Integrated systems approach identifies genetic nodes and networks in lateonset Alzheimer's disease. Cell 2013;153:707-720.
    • (2013) Cell , vol.153 , pp. 707-720
    • Zhang, B.1    Gaiteri, C.2    Bodea, L.G.3
  • 21
    • 77955463899 scopus 로고    scopus 로고
    • Replication of CLU, CR1, and PICALM associations with Alzheimer disease
    • Carrasquillo MM, Belbin O, Hunter TA, et al. Replication of CLU, CR1, and PICALM associations with Alzheimer disease. Arch Neurol 2010;67:961-964.
    • (2010) Arch Neurol , vol.67 , pp. 961-964
    • Carrasquillo, M.M.1    Belbin, O.2    Hunter, T.A.3
  • 22
    • 77957909886 scopus 로고    scopus 로고
    • Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes
    • Jun G, Naj AC, Beecham GW, et al. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 2010;67:1473-1484.
    • (2010) Arch Neurol , vol.67 , pp. 1473-1484
    • Jun, G.1    Naj, A.C.2    Beecham, G.W.3
  • 23
    • 84856228504 scopus 로고    scopus 로고
    • Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
    • Brouwers N, Van Cauwenberghe C, Engelborghs S, et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol Psychiatry 2012;17:223-233.
    • (2012) Mol Psychiatry , vol.17 , pp. 223-233
    • Brouwers, N.1    Van Cauwenberghe, C.2    Engelborghs, S.3
  • 24
    • 84876340047 scopus 로고    scopus 로고
    • Blockage of CR1 prevents activation of rodent microglia
    • Crehan H, Hardy J, Pocock J. Blockage of CR1 prevents activation of rodent microglia. Neurobiol Dis 2013;54: 139-149.
    • (2013) Neurobiol Dis , vol.54 , pp. 139-149
    • Crehan, H.1    Hardy, J.2    Pocock, J.3
  • 26
    • 84860488892 scopus 로고    scopus 로고
    • A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline
    • Keenan BT, Shulman JM, Chibnik LB, et al. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet 2012;21:2377-2388.
    • (2012) Hum Mol Genet , vol.21 , pp. 2377-2388
    • Keenan, B.T.1    Shulman, J.M.2    Chibnik, L.B.3
  • 27
    • 84875808566 scopus 로고    scopus 로고
    • Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: A pilot study
    • AppersonML, Tian Y, Stamova B, et al. Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study. J Neuroimmunol 2013;257:90-96.
    • (2013) J Neuroimmunol , vol.257 , pp. 90-96
    • Apperson, M.L.1    Tian, Y.2    Stamova, B.3
  • 28
    • 84890215976 scopus 로고    scopus 로고
    • Association of Parkinson disease with structural and regulatory variants in the HLA region
    • Wissemann WT, Hill-Burns EM, Zabetian CP, et al. Association of Parkinson disease with structural and regulatory variants in the HLA region. Am J Hum Genet 2013;93:984-993.
    • (2013) Am J Hum Genet , vol.93 , pp. 984-993
    • Wissemann, W.T.1    Hill-Burns, E.M.2    Zabetian, C.P.3
  • 29
    • 55449112185 scopus 로고    scopus 로고
    • Genome-wide associations of gene expression variation in humans
    • Stranger BE, Forrest MS, Clark AG, et al. Genome-wide associations of gene expression variation in humans. PLoS Genet 2005;1:e78.
    • (2005) PLoS Genet , vol.1 , pp. e78
    • Stranger, B.E.1    Forrest, M.S.2    Clark, A.G.3
  • 30
    • 19844366096 scopus 로고    scopus 로고
    • Cis-acting expression quantitative trait loci in mice
    • Doss S, Schadt EE, Drake TA, Lusis AJ. Cis-acting expression quantitative trait loci in mice. Genome Res 2005;15: 681-691.
    • (2005) Genome Res , vol.15 , pp. 681-691
    • Doss, S.1    Schadt, E.E.2    Drake, T.A.3    Lusis, A.J.4
  • 31
    • 84874017631 scopus 로고    scopus 로고
    • Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk loci
    • Holton P, Ryten M, Nalls M, et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk loci. Ann Hum Genet 2013;77:85-105.
    • (2013) Ann Hum Genet , vol.77 , pp. 85-105
    • Holton, P.1    Ryten, M.2    Nalls, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.