Production of para-aminobenzoic acid from different carbon-sources in engineered Saccharomyces cerevisiae

Microbial Cell Factories

Volumn 15, Issue 1, 2016, Pages

  Averesch, Nils J H ^a   Winter, Gal ^a,b   Krömer, Jens O ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

Aromatics; Ethanol; Glycerol; PABA; Phenylethanol; Yeast

Indexed keywords

4 AMINOBENZOIC ACID; ALCOHOL; CHORISMIC ACID; GLUCOSE; GLYCEROL; CARBON; SACCHAROMYCES CEREVISIAE PROTEIN;

ABZ1 GENE; ABZ2 GENE; ARO7 GENE; ARTICLE; CARBON SOURCE; COMPUTER MODEL; CONTROLLED STUDY; FERMENTATION; FUNGAL METABOLISM; FUNGAL STRAIN; FUNGUS GROWTH; GENE; GENE DELETION; GENE OVEREXPRESSION; GENETIC ENGINEERING; IN VIVO STUDY; NONHUMAN; SACCHAROMYCES CEREVISIAE; TRP3 GENE; CHEMISTRY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLISM; PLASMID;

4-AMINOBENZOIC ACID; CARBON; ETHANOL; GLYCEROL; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; PLASMIDS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84969785107     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-016-0485-8     Document Type: Article

References (46)

1. Becker J, Wittmann C. Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angew Chem Int Ed Engl. 2015;54:3328-50.
2. Chen Y, Nielsen J. Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks. Curr Opin Biotechnol. 2013;24:965-72.
3. Jang YS, Kim B, Shin JH, Choi YJ, Choi S, Song CW, Lee J, Park HG, Lee SY. Bio-based production of C2-C6 platform chemicals. Biotechnol Bioeng. 2012;109:2437-59.
4. Li M, Borodina I. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2015;15(1):1-12.
5. Borodina I, Nielsen J. Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals. Biotechnol J. 2014;9:609-20.
6. Fletcher E, Krivoruchko A, Nielsen J. Industrial systems biology and its impact on synthetic biology of yeast cell factories. Biotechnol Bioeng. 2016;113(6):1164-70.
7. Hansen EH, Moller BL, Kock GR, Bunner CM, Kristensen C, Jensen OR, Okkels FT, Olsen CE, Motawia MS, Hansen J. De novo biosynthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae). Appl Environ Microbiol. 2009;75:2765-74.
8. Williams TC, Averesch NJ, Winter G, Plan MR, Vickers CE, Nielsen LK, Krömer JO. Quorum-sensing linked RNA interference for dynamic metabolic pathway control in Saccharomyces cerevisiae. Metab Eng. 2015;29:124-34.
9. Krömer JO, Nunez-Bernal D, Averesch NJ, Hampe J, Varela J, Varela C. Production of aromatics in Saccharomyces cerevisiae-a feasibility study. J Biotechnol. 2013;163:184-93.
10. Curran KA, Leavitt JM, Karim AS, Alper HS. Metabolic engineering of muconic acid production in Saccharomyces cerevisiae. Metab Eng. 2013;15:55-66.
11. Jendresen CB, Stahlhut SG, Li M, Gaspar P, Siedler S, Förster J, Maury J, Borodina I, Nielsen AT. Novel highly active and specific tyrosine ammonia-lyases from diverse origins enable enhanced production of aromatic compounds in bacteria and yeast. Appl Environ Microb. 2015;81:13.
12. Rodriguez A, Kildegaard KR, Li M, Borodina I, Nielsen J. Establishment of a yeast platform strain for production of p-coumaric acid through metabolic engineering of aromatic amino acid biosynthesis. Metab Eng. 2015;31:181-8.
13. Farlow A, Krömer JO. Reactions with aminobenzoic acids via dia-zonium salts open new routes to bio-derived aromatics. Int J Org Chem. 2016;6. doi: 10.4236/ijoc.2016.62010.
14. Global Bio-based Polyethylene Terephthalate (PET) Market http://www.grandviewresearch.com/industry-analysis/bio-based-polyethylene-terephthalate-pet-industry (access date 23/05/2016). Accessed 23 May 2016.
15. PET Packaging Industry News. http://www.smitherspira.com/news/2014/April/demand-for-pet-packaging-material-in-2019 (access date 23/05/2016). Accessed 23 May 2016.
16. H.J. Heinz Company. Driving Sustainable Growth. http://www.heinz.com/AR_2011/Heinz_Annual_Report_2010.pdf. 2011. Accessed 23 May 2016.
17. Burk MJ, Osterhout RE, Sun J. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid. Google Patents; 2012.
18. Osterhout RE, Burgard AP, Burk MJ. Microorganisms and processes for producing terephthalic acid and its salts. Google Patents; 2013.
19. Aramid Fibers (Para and Meta)-a Global Market Overview. http://www.researchandmarkets.com/research/5nwxtj/aramid_fibers (access date 23/05/2016). Accessed 23 May 2016.
20. Braus GH. Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway. Microbiol Rev. 1991;55:349-70.
21. Botet J, Mateos L, Revuelta JL, Santos MA. A chemogenomic screening of sulfanilamide-hypersensitive Saccharomyces cerevisiae mutants uncovers ABZ2, the gene encoding a fungal aminodeoxychorismate lyase. Eukaryot Cell. 2007;6:2102-11.
22. Lingens F, Goebel W, Uesseler H. Regulation der Biosynthese der aromatischen Aminosäuren in Saccharomyces cerevisiae. Eur J Biochem.1967;1:363-74.
23. Luttik MA, Vuralhan Z, Suir E, Braus GH, Pronk JT, Daran JM. Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: quantification of metabolic impact. Metab Eng. 2008;10:141-53.
24. Ambroset C, Petit M, Brion C, Sanchez I, Delobel P, Guérin C, Chiapello H, Nicolas P, Bigey F, Dequin S, Blondin B. Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach. G3. 2011;1:263-81.
25. Koma D, Yamanaka H, Moriyoshi K, Sakai K, Masuda T, Sato Y, Toida K, Ohmoto T. Production of P-aminobenzoic acid by metabolically engineered Escherichia coli. Biosci Biotechnol Biochem. 2014;78:350-7.
26. Clomburg JM, Gonzalez R. Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals. Trends Biotechnol. 2013;31:20-8.
27. da Silva GP, Mack M, Contiero J. Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnol Adv. 2009;27:30-9.
28. Presnyak V, Alhusaini N, Chen Y-H, Martin S, Morris N, Kline N, Olson S, Weinberg D, Baker KE, Graveley BR, Coller J. Codon optimality is a major determinant of mrna stability. Cell. 2015;160:1111-24.
29. Averesch NJH, Krömer JO. Tailoring strain construction strategies for muconic acid production in S. cerevisiae and E. coli. Metab Eng Commun. 2014;1:19-28.
30. Sumegi B, Sherry AD, Malloy CR. Channeling of TCA cycle intermediates in cultured Saccharomyces cerevisiae. Biochemistry. 1990;29:9106-10.
31. Winter G, Averesch NJ, Nunez-Bernal D, Krömer JO. In vivo instability of chorismate causes substrate loss during fermentative production of aromatics. Yeast. 2014;31:333-41.
32. Swinnen S, Klein M, Carrillo M, McInnes J, Nguyen HT, Nevoigt E. Re-evaluation of glycerol utilization in Saccharomyces cerevisiae: characterization of an isolate that grows on glycerol without supporting supplements. Biotechnol Biofuels. 2013;6:157.
33. Avbelj M, Zupan J, Kranjc L, Raspor P. Quorum-sensing kinetics in Saccharomyces cerevisiae: a symphony of ARO genes and aromatic alcohols. J Agr Food Chem. 2015;63:8544-50.
34. Terzer M, Stelling J. Large-scale computation of elementary flux modes with bit pattern trees. Bioinformatics. 2008;24:2229-35.
35. White S. Gene cloning principles and applications by Julia Lodge, Pete Lund, and Steve Minchin. Biochem Mol Biol Edu. 2008;36:170.
36. Güldener U, Heck S, Fielder T, Beinhauer J, Hegemann JH. A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 1996;24:2519-24.
37. Gietz RD, Woods RA. Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. Methods Enzymol. 2002;350:87-96.
38. Güldener U, Heinisch J, Koehler GJ, Voss D, Hegemann JH. A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast. Nucleic Acids Res. 2002;30:e23.
39. Partow S, Siewers V, Bjorn S, Nielsen J, Maury J. Characterization of different promoters for designing a new expression vector in Saccharomyces cerevisiae. Yeast. 2010;27:955-64.
40. Hegemann JH, Heick SB. Delete and repeat: a comprehensive toolkit for sequential gene knockout in the budding yeast Saccharomyces cerevisiae. Methods Mol Biol. 2011;765:189-206.
41. Mortimer RK, Johnston JR. Genealogy of principal strains of the yeast genetic stock center. Genetics. 1986;113:35-43.
42. Borneman AR, Forgan AH, Pretorius IS, Chambers PJ. Comparative genome analysis of a Saccharomyces cerevisiae wine strain. FEMS Yeast Res. 2008;8:1185-95.
43. Borneman AR, Desany BA, Riches D, Affourtit JP, Forgan AH, Pretorius IS, Egholm M, Chambers PJ. Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet. 2011;7:e1001287.
44. Duboc P, von Stockar U. Systematic errors in data evaluation due to ethanol stripping and water vaporization. Biotechnol Bioeng. 1998;58:428-39.
45. Millard P, Letisse F, Sokol S, Portais J-C. IsoCor: correcting MS data in isotope labeling experiments. Bioinformatics. 2012;28:1294-6.
46. Teste M-A, Duquenne M, François JM, Parrou J-L. Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae. BMC Mol Biol. 2009;10:1-15.