Diabetes and risk of arterial stiffness: A mendelian randomization analysis

Diabetes

Volumn 65, Issue 6, 2016, Pages 1731-1740

  Xu, Min ^a   Huang, Ya ^a   Xie, Lan ^b   Peng, Kui ^a   Ding, Lin ^a   Lin, Lin ^a   Wang, Po ^a   Hao, Mingli ^a   Chen, Yuhong ^a   Sun, Yimin ^b,c   Qi, Lu ^d   Wang, Weiqing ^a   Ning, Guang ^a   Bi, Yufang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Tsinghua University   (China)

^c NATIONAL ENGINEERING RESEARCH CENTER FOR BEIJING BIOCHIP TECHNOLOGY   (China)

^d TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTERIAL STIFFNESS; ARTICLE; BRACHIAL ANKLE PULSE WAVE VELOCITY; DIABETIC PATIENT; EAST ASIAN; FEMALE; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIATION; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NON INVASIVE PROCEDURE; PRIORITY JOURNAL; PULSE WAVE; AGED; ANKLE BRACHIAL INDEX; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; ODDS RATIO; PATHOPHYSIOLOGY; RISK FACTOR; SECRETION (PROCESS);

INSULIN;

ADULT; AGED; ANKLE BRACHIAL INDEX; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; ODDS RATIO; PULSE WAVE ANALYSIS; RISK FACTORS; VASCULAR STIFFNESS;

EID: 84969784596     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1533     Document Type: Article

References (48)

1. Ogawa H, Nakayama M, Morimoto T, et al.; Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Investigators. Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial. JAMA 2008;300:2134-2141
2. Sarwar N, Gao P, Seshasai SR, et al.; Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375:2215-2222
3. Kochkina MS, Zateǐshchikov DA, Sidorenko BA. Measurement of arterial stiffness and its clinical value. Kardiologiia 2005;45:63-71 [in Russian]
4. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002;106: 2085-2090
5. Henry RM, Kostense PJ, Spijkerman AM, et al.; Hoorn Study. Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study. Circulation 2003;107:2089-2095
6. Salomaa V, Riley W, Kark JD, Nardo C, Folsom AR. Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995;91:1432-1443
7. Emoto M, Nishizawa Y, Kawagishi T, et al. Stiffness indexes beta of the common carotid and femoral arteries are associated with insulin resistance in NIDDM. Diabetes Care 1998;21:1178-1182
8. Ferreira MT, Leite NC, Cardoso CR, Salles GF. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro Type 2 Diabetes Cohort Study. Diabetes Care 2015;38:897-904
9. Patel A, MacMahon S, Chalmers J, et al.; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560-2572
10. Gerstein HC, Miller ME, Byington RP, et al.; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358:2545-2559
11. Duckworth W, Abraira C, Moritz T, et al.; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360:129-139
12. Scirica BM, Bhatt DL, Braunwald E, et al.; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369:1317-1326
13. Jansen H, Samani NJ, Schunkert H. Mendelian randomization studies in coronary artery disease. Eur Heart J 2014;35:1917-1924
14. Todd JN, Dahlström EH, Salem RM, et al.; FinnDiane Study Group. Genetic evidence for a causal role of obesity in diabetic kidney disease. Diabetes 2015; 64:4238-4246
15. Harrison SC, Holmes MV, Humphries SE. Mendelian randomisation, lipids, and cardiovascular disease. Lancet 2012;380:543-545
16. Ding EL, Song Y, Manson JE, et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009;361:1152-1163
17. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008;27:1133-1163
18. Lehmann ED. Clinical value of aortic pulse-wave velocity measurement. Lancet 1999;354:528-529
19. Yamashina A, Tomiyama H, Takeda K, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002;25:359-364
20. Yamashina A, Tomiyama H, Arai T, et al. Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens Res 2003;26:615-622
21. Palmer TM, Lawlor DA, Harbord RM, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res 2012; 21:223-242
22. Liu S, Song Y. Building genetic scores to predict risk of complex diseases in humans: is it possible? Diabetes 2010;59:2729-2731
23. Ning G; Reaction Study Group. Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. J Diabetes 2012;4:172-173
24. Bi Y, Lu J, Wang W, et al. Cohort profile: risk evaluation of cancers in Chinese diabetic individuals: a longitudinal (REACTION) study. J Diabetes 2014;6: 147-157
25. Hagströmer M, Oja P, Sjöström M. The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public Health Nutr 2006;9:755-762
26. Chen Y, Huang Y, Li X, et al. Association of arterial stiffness with HbA1c in 1,000 type 2 diabetic patients with or without hypertension. Endocrine 2009;36: 262-267
27. Bi Y, Wang W, Xu M, et al. Diabetes genetic risk score modifies effect of bisphenol a exposure on deterioration in glucose metabolism. J Clin Endocrinol Metab 2016;101:143-150
28. Cho YS, Lee JY, Park KS, Nho CW. Genetics of type 2 diabetes in East Asian populations. Curr Diab Rep 2012;12:686-696
29. Kato N. Insights into the genetic basis of type 2 diabetes. J Diabetes Investig 2013;4:233-244
30. Cho YS, Chen CH, Hu C, et al.; DIAGRAM Consortium; MuTHER Consortium. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 2012;44:67-72
31. Fall T, Hägg S, Mägi R, et al.; European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med 2013;10:e1001474
32. Rydén L, Standl E, Bartnik M, et al.; Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Eur Heart J 2007;28:88-136
33. Ravikumar R, Deepa R, Shanthirani C, Mohan V. Comparison of carotid intima-media thickness, arterial stiffness, and brachial artery flow mediated dilatation in diabetic and nondiabetic subjects (The Chennai Urban Population Study [CUPS-9]). Am J Cardiol 2002;90:702-707
34. Rema M, Mohan V, Deepa R, Ravikumar R; Chennai Urban Rural Epidemiology Study-2. Association of carotid intima-media thickness and arterial stiffness with diabetic retinopathy: the Chennai Urban Rural Epidemiology Study (CURES-2). Diabetes Care 2004;27:1962-1967
35. Cardoso CR, Ferreira MT, Leite NC, Barros PN, Conte PH, Salles GF. Microvascular degenerative complications are associated with increased aortic stiffness in type 2 diabetic patients. Atherosclerosis 2009;205:472-476
36. Ray KK, Seshasai SR, Wijesuriya S, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 2009;373:1765-1772
37. Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 2014;23(R1):R89-R98
38. Smith GD, Timpson N, Ebrahim S. Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med 2008;40:524-541
39. Rasmussen-Torvik LJ, Li M, Kao WH, et al. Association of a fasting glucose genetic risk score with subclinical atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes 2011;60:331-335
40. Benn M, Tybjaerg-Hansen A, McCarthy MI, Jensen GB, Grande P, Nordestgaard BG. Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study. J Am Coll Cardiol 2012;59:2356-2365
41. Ross S, Gerstein HC, Eikelboom J, Anand SS, Yusuf S, Paré G. Mendelian randomization analysis supports the causal role of dysglycaemia and diabetes in the risk of coronary artery disease. Eur Heart J 2015;36:1454-1462
42. Ahmad OS, Morris JA, Mujammami M, et al. A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease. Nat Commun 2015;6:7060
43. Sheehan NA, Didelez V, Burton PR, Tobin MD. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med 2008;5:e177
44. Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptorgamma-mediated effects in the vasculature. Circ Res 2008;102:283-294
45. Rodriguez S, Gaunt TR, Day IN. Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum Genet 2007;122:1-21
46. Bravard A, Vial G, Chauvin MA, et al. FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver. Cell Commun Signal 2014;12:4
47. Gjesing AP, Pedersen O. 'Omics'-driven discoveries in prevention and treatment of type 2 diabetes. Eur J Clin Invest 2012;42:579-588
48. Morris AP, Voight BF, Teslovich TM, et al.; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;44:981-990