Methylprednisolone acetate-loaded hydroxyapatite nanoparticles as a potential drug delivery system for treatment of rheumatoid arthritis: In vitro and in vivo evaluations

European Journal of Pharmaceutical Sciences

Volumn 91, Issue , 2016, Pages 225-235

  Jafari, Samira ^a,b   Maleki Dizaji, Nasrin ^b   Barar, Jaleh ^a   Barzegar Jalali, Mohammad ^c   Rameshrad, Maryam ^b   Adibkia, Khosro ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytotoxicity; Histopathological evaluation; Hydroxyapatite; Methylprednisolone acetate; Nanoparticles; Rheumatoid arthritis

Indexed keywords

HYDROXYAPATITE NANOPARTICLE; METHYLPREDNISOLONE ACETATE; NANOPARTICLE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; HYDROXYAPATITE; METHYLPREDNISOLONE; POLYVINYL ALCOHOL;

3T3 CELL LINE; ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOTOXICITY; DESORPTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; DRUG RELEASE; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MTT ASSAY; NONHUMAN; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRECIPITATION; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SURFACE AREA; X RAY POWDER DIFFRACTION; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL ARTHRITIS; HUMAN; JOINT; MOUSE; NIH 3T3 CELL LINE; PATHOLOGY; TUMOR CELL LINE; WISTAR RAT;

ADSORPTION; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; DURAPATITE; HUMANS; JOINTS; MALE; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACETATE; MICE; NANOPARTICLES; NIH 3T3 CELLS; POLYVINYL ALCOHOL; RATS, WISTAR;

EID: 84969695713     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2016.05.014     Document Type: Article

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