Growth properties and vaccine efficacy of recombinant pseudorabies virus defective in glycoprotein E and thymidine kinase genes

Journal of Biotechnology

Volumn 229, Issue , 2016, Pages 58-64

  Wu, Ching Ying ^a   Liao, Chih Ming ^b   Chi, Jiun Ni ^a   Chien, Maw Sheng ^a   Huang, Chienjin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b Bayer Taiwan Co Ltd   (Taiwan)

Author keywords

Live attenuated virus; Marker vaccine; Pseudorabies virus; Recombinant virus

Indexed keywords

ENZYMES; GENES; GLYCOPROTEINS; IMMUNIZATION; MAMMALS; VACCINES;

ERADICATION PROGRAMS; GROWTH PROPERTIES; HOMOLOGOUS RECOMBINATION; IMMUNE RESPONSE; IMMUNOGENICITY; THYMIDINE KINASE; VACCINE EFFICACIES; VIRUS REPLICATION;

VIRUSES;

GLYCOPROTEIN E; MARKER VACCINE; NEUTRALIZING ANTIBODY; PSEUDORABIES VACCINE; THYMIDINE KINASE; DNA VACCINE; GLYCOPROTEIN E, SUID HERPESVIRUS 1; LIVE VACCINE; RECOMBINANT DNA; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; FEMALE; GENE DELETION; HOMOLOGOUS RECOMBINATION; IMMUNOFLUORESCENCE; IMMUNOGENICITY; LD50; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDORABIES VIRUS; SINGLE DRUG DOSE; VACCINATION; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; GENETICS; IMMUNOLOGY; METABOLISM; PIG; PSEUDORABIES; VIROLOGY;

ANIMALS; ANTIBODIES, VIRAL; DNA, RECOMBINANT; FEMALE; HERPESVIRUS 1, SUID; MICE; MICE, INBRED BALB C; PSEUDORABIES; SWINE; THYMIDINE KINASE; VACCINES, ATTENUATED; VACCINES, DNA; VIRAL ENVELOPE PROTEINS;

EID: 84969670156     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.05.009     Document Type: Article

References (22)

1. An T.Q., Peng J.M., Tian Z.J., Zhao H.Y., Li N., Liu Y.M., Chen J.Z., Leng C.L., Sun Y., Chang D., Tong G.Z. Pseudorabies virus variant in Bartha-K61-vaccinated pigs, China, 2012. Emerg. Infect. Dis. 2013, 19:1749-1755.
2. Bouma A. Determination of the effectiveness of Pseudorabies marker vaccines in experiments and field trials. Biologicals 2005, 33:241-245.
3. Casal J., Planasdemunt L., Varo J.A., Martin M. The use of different vaccination schedules for sows to protect piglets against Aujeszky's disease. J. Vet. Med. B 2004, 51:8-11.
4. Ch'ng T.H., Enquist L.W. An in vitro system to study trans-neuronal spread of pseudorabies virus infection. Vet. Microbiol. 2006, 113:193-197.
5. Enquist L.W., Husak P.J., Banfield B.W., Smith G.A. Infection and spread of alphaherpesviruses in the nervous system. Adv. Virus Res. 1998, 51:237-347.
6. Ferrari M., Gualandi G.L., Corradi A., Monaci C., Romanelli M.G., Tosi G., Cantoni A.M. Experimental infection of pigs with a thymidine kinase negative strain of pseudorabies virus. Comp. Immunol. Microb. 1998, 21:291-303.
7. Huang C., Hung J.J., Wu C.Y., Chien M.S. Multiplex PCR for rapid detection of pseudorabies virus, porcine parvovirus and porcine circoviruses. Vet. Microbiol. 2004, 101:209-214.
8. Klupp B.G., Hengartner C.J., Mettenleiter T.C., Enquist L.W. Complete, annotated sequence of the pseudorabies virus genome. J. Virol. 2003, 78:424-440.
9. Kramer T., Enquist L.W. Directional spread of alphaherpesviruses in the nervous system. Viruses 2013, 5:678-707.
10. Luo Y.Z., Li N., Cong X., Wang C.H., Du M., Li L., Zhao B.B., Yuan J., Liu D.D., Li S., Li Y.F., Sun Y., Qiu H.J. Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China. Vet. Microbiol. 2014, 174:107-115.
11. Mengeling W.L., Brockmeier S.L., Lager K.M., Vorwald A.C. The role of biotechnologically engineered vaccines and diagnostics in pseudorabies (Aujeszky's disease) eradication strategies. Vet. Microbiol. 1997, 55:49-60.
12. Mettenleiter T.C. Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis-state of the art, June 1999. Vet. Res. 2000, 31:99-115.
13. Pensaert M., Labarque G., Favoreel H., Nauwynck H. Aujeszky's disease vaccination and differentiation of vaccinated from infected pigs. Dev. Biol. 2004, 119:243-254.
14. Pomeranz L.E., Reynolds A.E., Hengartner C.J. Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine. Microbiol. Mol. Biol. Rev. 2005, 69:462-500.
15. Prieto J., Hernandez A.M.M., Tabares E. Loss of pseudorabies virus thymidine kinase-activity due to a single base mutation and amino-acid substitution. J. Gen. Virol. 1991, 72:1435-1439.
16. Reed L.J., Muench H. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 1938, 27:493-497.
17. Shibata I., Inaba Y., Akashi H. Avirulent Ts and thymidine kinase-deficient mutant of Aujeszkys disease virus. J. Vet. Med. Sci. 1991, 53:663-670.
18. van Oirschot J.T. Diva vaccines that reduce virus transmission. J. Biotechnol. 1999, 73:195-205.
19. Wang Y., Qiao S., Li X., Xie W., Guo J., Li Q., Liu X., Hou J., Xu Y., Wang L., Guo C. Molecular epidermiology of outbreak-associated pseudorabies virus (PRV) strains in central China. Virus Genes 2015, 10.1007/s11262-015-1190-0.
20. Wilson A.C., Mohr I. A cultured affair: HSV latency and reactivation in neurons. Trends Microbiol. 2012, 20:604-611.
21. Wu R., Bai C., Sun J., Chang S., Zhang X. Emergence of virulent pseudorabies virus infection in northern China. J. Vet. Sci. 2013, 14:363-365.
22. Yan L., He Q.G., Yu X.L., Bei W.C., Chen H.C. The co-administrating of recombinant porcine IL-2 could enhance protective immune responses to PRV inactivated vaccine in pigs. Vaccine 2005, 23:4436-4441.