Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients

European Neuropsychopharmacology

Volumn 26, Issue 8, 2016, Pages 1310-1319

  McCarthy, Michael J ^a,b   Wei, Heather ^a   Landgraf, Dominic ^b   Le Roux, Melissa J ^b   Welsh, David K ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bipolar disorder; Circadian rhythms; Kinase; Lithium; Phosphatase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 [4 (4 FLUOROPHENYL) 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] N (1 PHENYLETHYL) 2 PYRIDINAMINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LITHIUM CHLORIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR EGR 1; CIRCADIAN RHYTHM SIGNALING PROTEIN; CREB1 PROTEIN, HUMAN; DUAL SPECIFICITY PHOSPHATASE 6; DUSP6 PROTEIN, HUMAN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, HUMAN; ELK1 PROTEIN, HUMAN; LITHIUM; MAPK1 PROTEIN, HUMAN; PER2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; TRANQUILIZER; TRANSCRIPTION FACTOR ELK 1;

3T3 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIPOLAR DISORDER; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; MAPK SIGNALING; METABOLISM; NIH 3T3 CELL LINE; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; REPORTER GENE; RNA INTERFERENCE;

ANIMALS; ANTIMANIC AGENTS; BIPOLAR DISORDER; CELLS, CULTURED; CIRCADIAN RHYTHM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DUAL SPECIFICITY PHOSPHATASE 6; EARLY GROWTH RESPONSE PROTEIN 1; ETS-DOMAIN PROTEIN ELK-1; GENES, REPORTER; HUMANS; LITHIUM; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NIH 3T3 CELLS; PERIOD CIRCADIAN PROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA INTERFERENCE;

EID: 84969584452     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2016.05.003     Document Type: Article

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