메뉴 건너뛰기




Volumn 9, Issue , 2016, Pages 2945-2953

Idelalisib for the treatment of indolent non-hodgkin lymphoma: A review of its clinical potential

Author keywords

B cell receptor; Elderly; Follicular lymphoma; Kinase inhibitor; Phosphatidylinositol 3 kinase; Targeted therapy

Indexed keywords

BENDAMUSTINE; BRUTON TYROSINE KINASE INHIBITOR; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; FLUDARABINE; GS 4059; IDELALISIB; LENALIDOMIDE; MITOXANTRONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PREDNISONE; RITUXIMAB; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 84969567683     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S102573     Document Type: Review
Times cited : (26)

References (52)
  • 3
    • 84896693794 scopus 로고    scopus 로고
    • PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma
    • Gopal AK, Kahl BS, de Vos S, et al. PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med. 2014;370(11):1008-1018.
    • (2014) N Engl J Med , vol.370 , Issue.11 , pp. 1008-1018
    • Gopal, A.K.1    Kahl, B.S.2    De Vos, S.3
  • 5
    • 84868201843 scopus 로고    scopus 로고
    • Management of indolent lymphoma: Where are we now and where are we going
    • Lunning MA, Vose JM. Management of indolent lymphoma: where are we now and where are we going. Blood Rev. 2012;26(6):279-288.
    • (2012) Blood Rev , vol.26 , Issue.6 , pp. 279-288
    • Lunning, M.A.1    Vose, J.M.2
  • 6
    • 0022963642 scopus 로고
    • Relationship of classification to biologic behavior of non-Hodgkin’s lymphomas
    • Jaffe ES. Relationship of classification to biologic behavior of non-Hodgkin’s lymphomas. Semin Oncol. 1986;13(4 suppl 5):3-9.
    • (1986) Semin Oncol , vol.13 , Issue.4 , pp. 3-9
    • Jaffe, E.S.1
  • 8
    • 0027376013 scopus 로고
    • Natural history of and therapy for the indolent non-Hodgkin’s lymphomas
    • Horning SJ. Natural history of and therapy for the indolent non-Hodgkin’s lymphomas. Semin Oncol. 1993;20(5 suppl 5):75-88.
    • (1993) Semin Oncol , vol.20 , Issue.5 , pp. 75-88
    • Horning, S.J.1
  • 9
    • 84884769047 scopus 로고    scopus 로고
    • Lymphoma occurring in patients over 90 years of age: Characteristics, outcomes, and prognostic factors. A retrospective analysis of 234 cases from the LYSA
    • Trebouet A, Marchand T, Lemal R, et al. Lymphoma occurring in patients over 90 years of age: characteristics, outcomes, and prognostic factors. A retrospective analysis of 234 cases from the LYSA. Ann Oncol. 2013;24(10):2612-2618.
    • (2013) Ann Oncol , vol.24 , Issue.10 , pp. 2612-2618
    • Trebouet, A.1    Marchand, T.2    Lemal, R.3
  • 10
    • 4444326818 scopus 로고    scopus 로고
    • Follicular lymphoma international prognostic index
    • Solal-Celigny P, Roy P, Colombat P, et al. Follicular lymphoma international prognostic index. Blood. 2004;104(5):1258-1265.
    • (2004) Blood , vol.104 , Issue.5 , pp. 1258-1265
    • Solal-Celigny, P.1    Roy, P.2    Colombat, P.3
  • 11
    • 84940546789 scopus 로고    scopus 로고
    • Early relapse of follicular lymphoma after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone defines patients at high risk for death: An analysis from the National LymphoCare Study
    • Casulo C, Byrtek M, Dawson KL, et al. Early relapse of follicular lymphoma after rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone defines patients at high risk for death: an analysis from the National LymphoCare Study. J Clin Oncol. 2015;33(23):2516-2522.
    • (2015) J Clin Oncol , vol.33 , Issue.23 , pp. 2516-2522
    • Casulo, C.1    Byrtek, M.2    Dawson, K.L.3
  • 12
    • 84940584440 scopus 로고    scopus 로고
    • Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: A retrospective analysis of a prospective clinical trial and validation in a population-based registry
    • Pastore A, Jurinovic V, Kridel R, et al. Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry. Lancet Oncol. 2015;16(9):1111-1122.
    • (2015) Lancet Oncol , vol.16 , Issue.9 , pp. 1111-1122
    • Pastore, A.1    Jurinovic, V.2    Kridel, R.3
  • 13
    • 81955165195 scopus 로고    scopus 로고
    • Incidence of haematological malignancy by sub-type: A report from the Haematological Malignancy Research Network
    • Smith A, Howell D, Patmore R, Jack A, Roman E. Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network. Br J Cancer. 2011;105(11):1684-1692.
    • (2011) Br J Cancer , vol.105 , Issue.11 , pp. 1684-1692
    • Smith, A.1    Howell, D.2    Patmore, R.3    Jack, A.4    Roman, E.5
  • 14
    • 84155180784 scopus 로고    scopus 로고
    • Analysis of very elderly ($80 years) non-Hodgkin lymphoma: Impact of functional status and co-morbidities on outcome
    • Nabhan C, Smith SM, Helenowski I, et al. Analysis of very elderly ($80 years) non-Hodgkin lymphoma: impact of functional status and co-morbidities on outcome. Br J Haematol. 2012;156(2):196-204.
    • (2012) Br J Haematol , vol.156 , Issue.2 , pp. 196-204
    • Nabhan, C.1    Smith, S.M.2    Helenowski, I.3
  • 15
    • 84966416069 scopus 로고    scopus 로고
    • webpage on the Internet, version 1.2015, Accessed October 6, 2015
    • National Comprehensive Cancer Network [webpage on the Internet]. NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin’s Lymphomas (version 1.2015); 2015. Available from: http://www.nccn.org/professionals/physician_gls/f_guidelines.asp#site. Accessed October 6, 2015.
    • (2015) NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin’s Lymphomas
  • 16
    • 0036175938 scopus 로고    scopus 로고
    • Rituximab as first-line and maintenance therapy for patients with indolent non-Hodgkin’s lymphoma: Interim follow-up of a multicenter phase II trial
    • Hainsworth JD. Rituximab as first-line and maintenance therapy for patients with indolent non-Hodgkin’s lymphoma: interim follow-up of a multicenter phase II trial. Semin Oncol. 2002;29(1 suppl 2):25-29.
    • (2002) Semin Oncol , vol.29 , Issue.1 , pp. 25-29
    • Hainsworth, J.D.1
  • 17
    • 34249704600 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: A systematic review and meta-analysis
    • Schulz H, Bohlius JF, Trelle S, et al. Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysis. J Natl Cancer Inst. 2007;99(9):706-714.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.9 , pp. 706-714
    • Schulz, H.1    Bohlius, J.F.2    Trelle, S.3
  • 18
    • 28544435078 scopus 로고    scopus 로고
    • Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
    • Hiddemann W, Kneba M, Dreyling M, et al. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood. 2005;106(12):3725-3732.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3725-3732
    • Hiddemann, W.1    Kneba, M.2    Dreyling, M.3
  • 19
    • 13244288836 scopus 로고    scopus 로고
    • Prolonged clinical and molecular remission in patients with low-grade or follicular non-Hodgkin’s lymphoma treated with rituximab plus CHOP chemotherapy: 9-year follow-up
    • Czuczman MS, Weaver R, Alkuzweny B, Berlfein J, Grillo-Lopez AJ. Prolonged clinical and molecular remission in patients with low-grade or follicular non-Hodgkin’s lymphoma treated with rituximab plus CHOP chemotherapy: 9-year follow-up. J Clin Oncol. 2004;22(23):4711-4716.
    • (2004) J Clin Oncol , vol.22 , Issue.23 , pp. 4711-4716
    • Czuczman, M.S.1    Weaver, R.2    Alkuzweny, B.3    Berlfein, J.4    Grillo-Lopez, A.J.5
  • 20
    • 13244270361 scopus 로고    scopus 로고
    • CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma
    • Marcus R, Imrie K, Belch A, et al. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood. 2005;105(4):1417-1423.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1417-1423
    • Marcus, R.1    Imrie, K.2    Belch, A.3
  • 21
    • 53749085410 scopus 로고    scopus 로고
    • Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma
    • Marcus R, Imrie K, Solal-Celigny P, et al. Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol. 2008;26(28):4579-4586.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4579-4586
    • Marcus, R.1    Imrie, K.2    Solal-Celigny, P.3
  • 22
    • 84875840492 scopus 로고    scopus 로고
    • Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: An open-label, multicentre, randomised, phase 3 non-inferiority trial
    • Rummel MJ, Niederle N, Maschmeyer G, et al. Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013;381(9873):1203-1210.
    • (2013) Lancet , vol.381 , Issue.9873 , pp. 1203-1210
    • Rummel, M.J.1    Niederle, N.2    Maschmeyer, G.3
  • 23
    • 84975231440 scopus 로고    scopus 로고
    • webpage on the Internet, Accessed March 31, 2015
    • American Cancer Society [webpage on the Internet]. Cancer Facts & Figures 2015. Available from: http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf. Accessed March 31, 2015.
    • Cancer Facts & Figures 2015
  • 24
    • 84920589992 scopus 로고    scopus 로고
    • Transformed follicular non-Hodgkin lymphoma
    • Casulo C, Burack WR, Friedberg JW. Transformed follicular non-Hodgkin lymphoma. Blood. 2015;125(1):40-47.
    • (2015) Blood , vol.125 , Issue.1 , pp. 40-47
    • Casulo, C.1    Burack, W.R.2    Friedberg, J.W.3
  • 25
    • 84873397196 scopus 로고    scopus 로고
    • Phase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016
    • Press OW, Unger JM, Rimsza LM, et al. Phase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016. J Clin Oncol. 2013;31(3):314-320.
    • (2013) J Clin Oncol , vol.31 , Issue.3 , pp. 314-320
    • Press, O.W.1    Unger, J.M.2    Rimsza, L.M.3
  • 26
    • 84884585831 scopus 로고    scopus 로고
    • Treatment challenges in the management of relapsed or refractory non-Hodgkin’s lymphoma-novel and emerging therapies
    • Chao MP. Treatment challenges in the management of relapsed or refractory non-Hodgkin’s lymphoma-novel and emerging therapies. Cancer Manage Res. 2013;5:251-269.
    • (2013) Cancer Manage Res , vol.5 , pp. 251-269
    • Chao, M.P.1
  • 27
    • 84931576917 scopus 로고    scopus 로고
    • Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States
    • Nabhan C, Byrtek M, Rai A, et al. Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States. Br J Haematol. 2015;170(1):85-95.
    • (2015) Br J Haematol , vol.170 , Issue.1 , pp. 85-95
    • Nabhan, C.1    Byrtek, M.2    Rai, A.3
  • 28
    • 84904053333 scopus 로고    scopus 로고
    • How we manage follicular lymphoma
    • Hiddemann W, Cheson BD. How we manage follicular lymphoma. Leukemia. 2014;28(7):1388-1395.
    • (2014) Leukemia , vol.28 , Issue.7 , pp. 1388-1395
    • Hiddemann, W.1    Cheson, B.D.2
  • 29
    • 0030611198 scopus 로고    scopus 로고
    • P110delta, a novel phosphoinositide 3-kinase in leukocytes
    • Vanhaesebroeck B, Welham MJ, Kotani K, et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A. 1997;94(9):4330-4335.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.9 , pp. 4330-4335
    • Vanhaesebroeck, B.1    Welham, M.J.2    Kotani, K.3
  • 31
    • 84874196138 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: Activation mechanisms, regulation and impact on cellular functions
    • Pauls SD, Lafarge ST, Landego I, Zhang T, Marshall AJ. The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol. 2012;3:224.
    • (2012) Front Immunol , vol.3 , pp. 224
    • Pauls, S.D.1    Lafarge, S.T.2    Landego, I.3    Zhang, T.4    Marshall, A.J.5
  • 32
    • 84969534866 scopus 로고    scopus 로고
    • Idelalisib: The first-in-class phosphatidylinositol 3-kinase inhibitor for relapsed CLL, SLL, and indolent NHL
    • Forcello N, Saraiya N. Idelalisib: the first-in-class phosphatidylinositol 3-kinase inhibitor for relapsed CLL, SLL, and indolent NHL. J Adv Pract Oncol. 2014;5:455-459.
    • (2014) J Adv Pract Oncol , vol.5 , pp. 455-459
    • Forcello, N.1    Saraiya, N.2
  • 33
    • 84925815654 scopus 로고    scopus 로고
    • Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta
    • Somoza JR, Koditek D, Villasenor AG, et al. Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase delta. J Biol Chem. 2015;290(13):8439-8446.
    • (2015) J Biol Chem , vol.290 , Issue.13 , pp. 8439-8446
    • Somoza, J.R.1    Koditek, D.2    Villasenor, A.G.3
  • 34
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117(2):591-594.
    • (2011) Blood , vol.117 , Issue.2 , pp. 591-594
    • Lannutti, B.J.1    Meadows, S.A.2    Herman, S.E.3
  • 36
    • 77952118055 scopus 로고    scopus 로고
    • Accessed October 6, 2015
    • European Medicines Agency [webpage on the Internet]. Idelalisib. Summary of Product Characteristics; 2014. Available from: https://www.medicines.org.uk/emc/medicine/29202. Accessed October 6, 2015.
    • (2014) Idelalisib. Summary of Product Characteristics
  • 37
    • 84901703641 scopus 로고    scopus 로고
    • Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma
    • Flinn IW, Kahl BS, Leonard JP, et al. Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-delta, as therapy for previously treated indolent non-Hodgkin lymphoma. Blood. 2014;123(22): 3406-3413.
    • (2014) Blood , vol.123 , Issue.22 , pp. 3406-3413
    • Flinn, I.W.1    Kahl, B.S.2    Leonard, J.P.3
  • 38
    • 84944960448 scopus 로고    scopus 로고
    • Durable responses following treatment with the PI3K-delta inhibitor idelalisib in combination with rituximab, bendamustine, or both, in recurrent indolent non-Hodgkin lymphoma: Phase I/II results
    • abstract3063
    • de Vos S, Wagner-Johnston ND, Coutre SE, et al. Durable responses following treatment with the PI3K-delta inhibitor idelalisib in combination with rituximab, bendamustine, or both, in recurrent indolent non-Hodgkin lymphoma: phase I/II results. Blood. 2014;124(21): abstract3063.
    • (2014) Blood , vol.124 , Issue.21
    • De Vos, S.1    Wagner-Johnston, N.D.2    Coutre, S.E.3
  • 39
    • 84910671189 scopus 로고    scopus 로고
    • Patient-reported outcomes data from a phase 2 study of idelalisib in patients with refractory indolent B-cell non-Hodgkin lymphoma (INHL)
    • Wagner-Johnston ND, Gopal AK, Kahl BS, et al. Patient-reported outcomes data from a phase 2 study of idelalisib in patients with refractory indolent B-cell non-Hodgkin lymphoma (iNHL). J Clin Oncol. 2014;32:e19554.
    • (2014) J Clin Oncol , vol.32
    • Wagner-Johnston, N.D.1    Gopal, A.K.2    Kahl, B.S.3
  • 40
    • 85043646584 scopus 로고    scopus 로고
    • A decision-analytic model of idelalisib in relapsed or refractory patients with indolent non-Hodgkin lymphoma
    • Smith N, Xenakis A, Beckerman R, Chhatwal J, Gregory SA, Briggs A. A decision-analytic model of idelalisib in relapsed or refractory patients with indolent non-Hodgkin lymphoma. J Clin Oncol. 2014;32:e17655.
    • (2014) J Clin Oncol , vol.32
    • Smith, N.1    Xenakis, A.2    Beckerman, R.3    Chhatwal, J.4    Gregory, S.A.5    Briggs, A.6
  • 41
    • 84969535474 scopus 로고    scopus 로고
    • Idelalisib efficacy and safety in follicular lymphoma patients from a phase 2 study
    • Paper presented at, May 28-June 3, Chicago, IL
    • Salles G, Schuster S, de Vos S, et al. Idelalisib efficacy and safety in follicular lymphoma patients from a phase 2 study. Paper presented at: 2015 American Society of Clinical Oncology Annual Meeting; May 28-June 3, 2015; Chicago, IL.
    • (2015) 2015 American Society of Clinical Oncology Annual Meeting
    • Salles, G.1    Schuster, S.2    De Vos, S.3
  • 42
    • 84969556918 scopus 로고    scopus 로고
    • Outcomes of anticoagulant or antiplatelet use in patients with chronic lymphocytic leukemia or indolent non-hodgkin lymphoma in idelalisib trials
    • Paper presented at, May 29-June 2, Chicago, IL
    • Barrientos J, Ghia P, Pagel J, et al. Outcomes of anticoagulant or antiplatelet use in patients with chronic lymphocytic leukemia or indolent non-hodgkin lymphoma in idelalisib trials. Paper presented at: ASCO Annual Meeting; May 29-June 2, 2015; Chicago, IL.
    • (2015) ASCO Annual Meeting
    • Barrientos, J.1    Ghia, P.2    Pagel, J.3
  • 43
    • 84941200862 scopus 로고    scopus 로고
    • Management of adverse events associated with idelalisib treatment-expert panel opinion
    • Coutre SE, Barrientos JC, Brown JR, et al. Management of adverse events associated with idelalisib treatment-expert panel opinion. Leuk Lymphoma. 2015;56:1-20.
    • (2015) Leuk Lymphoma , vol.56 , pp. 1-20
    • Coutre, S.E.1    Barrientos, J.C.2    Brown, J.R.3
  • 44
    • 84975186755 scopus 로고    scopus 로고
    • Idelalisib given front-line for the treatment of chronic lymphocytic leukemia results in frequent and severe immune-mediated toxicities
    • Lampson BL, Matos T, Kim HT, et al. Idelalisib given front-line for the treatment of chronic lymphocytic leukemia results in frequent and severe immune-mediated toxicities. Blood. 2015;126(23):497.
    • (2015) Blood , vol.126 , Issue.23 , pp. 497
    • Lampson, B.L.1    Matos, T.2    Kim, H.T.3
  • 45
    • 84951268355 scopus 로고    scopus 로고
    • A phase 2 study of idelalisib plus rituximab in treatment-naive older patients with chronic lymphocytic leukemia
    • O’Brien SM, Lamanna N, Kipps TJ, et al. A phase 2 study of idelalisib plus rituximab in treatment-naive older patients with chronic lymphocytic leukemia. Blood. 2015;126(25):2686-2694.
    • (2015) Blood , vol.126 , Issue.25 , pp. 2686-2694
    • O’Brien, S.M.1    Lamanna, N.2    Kipps, T.J.3
  • 47
    • 84927776088 scopus 로고    scopus 로고
    • A phase 1 evaluation of duvelisib (IPI-145), a PI3K-δ,γ inhibitor, in patients with relapsed/refractory iNHL
    • abstr802
    • Flinn I, Oki Y, Patel M, et al. A phase 1 evaluation of duvelisib (IPI-145), a PI3K-δ,γ inhibitor, in patients with relapsed/refractory iNHL. Blood. 2014;124(21):abstr802.
    • (2014) Blood , vol.124 , Issue.21
    • Flinn, I.1    Oki, Y.2    Patel, M.3
  • 48
    • 84969548434 scopus 로고    scopus 로고
    • Phase 2A study of copanlisib, a novel PI3K inhibitor, in patients with indolent lymphoma
    • abstract1701
    • Dreyling M, Cunningham D, Bouabdallah K, et al. Phase 2A study of copanlisib, a novel PI3K inhibitor, in patients with indolent lymphoma. Blood. 2014;124(21):abstract1701.
    • (2014) Blood , vol.124 , Issue.21
    • Dreyling, M.1    Cunningham, D.2    Bouabdallah, K.3
  • 49
    • 84927516499 scopus 로고    scopus 로고
    • Phase 2 trial of GS-9973, a selective syk inhibitor, and idelalisib (Idela) in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL)
    • abstract7059
    • Barr PM, Saylors GB, Forbes Spurgeon SE, et al. Phase 2 trial of GS-9973, a selective syk inhibitor, and idelalisib (idela) in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). J Clin Oncol. 2014;32(5s):abstract7059.
    • (2014) J Clin Oncol , vol.32 , Issue.5s
    • Barr, P.M.1    Saylors, G.B.2    Forbes Spurgeon, S.E.3
  • 50
    • 84927730010 scopus 로고    scopus 로고
    • Unexpected and serious toxicity observed with combined idelalisib, lenalidomide and rituximab in relapsed/refractory B cell lymphomas: Alliance A051201 and A051202
    • Smith SM, Pitcher B, Jung S-H, et al. Unexpected and serious toxicity observed with combined idelalisib, lenalidomide and rituximab in relapsed/refractory B cell lymphomas: Alliance A051201 and A051202. Blood. 2014;124(21):3091.
    • (2014) Blood , vol.124 , Issue.21 , pp. 3091
    • Smith, S.M.1    Pitcher, B.2    Jung, S.-H.3
  • 51
    • 84944960444 scopus 로고    scopus 로고
    • Lenalidomide, idelalisib, and rituximab are unacceptably toxic in patients with relapsed/refractory indolent lymphoma
    • Cheah CY, Nastoupil LJ, Neelapu SS, Forbes SG, Oki Y, Fowler NH. Lenalidomide, idelalisib, and rituximab are unacceptably toxic in patients with relapsed/refractory indolent lymphoma. Blood. 2015;125(21):3357-3359.
    • (2015) Blood , vol.125 , Issue.21 , pp. 3357-3359
    • Cheah, C.Y.1    Nastoupil, L.J.2    Neelapu, S.S.3    Forbes, S.G.4    Oki, Y.5    Fowler, N.H.6
  • 52
    • 84964410584 scopus 로고    scopus 로고
    • Idelalisib plus bendamustine and rituximab (BR) is superior to BR alone in patients with relapsed/refractory chronic lymphocytic leukemia: Results of a phase 3 randomized double-blind placebo-controlled study
    • abstract LBA-5
    • Zelenetz AD, Robak T, Coiffier B, et al. Idelalisib plus bendamustine and rituximab (BR) is superior to BR alone in patients with relapsed/refractory chronic lymphocytic leukemia: results of a phase 3 randomized double-blind placebo-controlled study. Blood. 2015;126(23):abstract LBA-5.
    • (2015) Blood , vol.126 , Issue.23
    • Zelenetz, A.D.1    Robak, T.2    Coiffier, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.