-
1
-
-
84969503380
-
-
Accessed November 15, 2015
-
Lung Cancer. 2015. Available at: http://www.cancer.org/cancer/lungcancer/. Accessed November 15, 2015.
-
(2015)
Lung Cancer.
-
-
-
3
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28:3167-3175.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
4
-
-
84862903106
-
Safety and activity ofanti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity ofanti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366: 2455-2465.
-
(2012)
N Engl J Med.
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
5
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-2454.
-
(2012)
N Engl J Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
6
-
-
84887121328
-
Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (FORTIS-M trial)
-
Ramalingam S, Crawford J, Chang A, et al. Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (FORTIS-M trial). Ann Oncol. 2013;24:2875-2880.
-
(2013)
Ann Oncol.
, vol.24
, pp. 2875-2880
-
-
Ramalingam, S.1
Crawford, J.2
Chang, A.3
-
7
-
-
0026653868
-
Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer
-
Jansen RL, Slingerland R, Goey SH, et al. Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer. J Immunother. 1992;12:70-73.
-
(1992)
J Immunother.
, vol.12
, pp. 70-73
-
-
Jansen, R.L.1
Slingerland, R.2
Goey, S.H.3
-
9
-
-
84937636023
-
Addressing the unmet need in lung cancer: The potential of immuno-oncology
-
Scagliotti GV, Bironzo P, Vansteenkiste JF. Addressing the unmet need in lung cancer: the potential of immuno-oncology. Cancer Treat Rev. 2015; 41:465-475.
-
(2015)
Cancer Treat Rev.
, vol.41
, pp. 465-475
-
-
Scagliotti, G.V.1
Bironzo, P.2
Vansteenkiste, J.F.3
-
10
-
-
51349090152
-
Alteration of the immunological synapse in lung cancer: A microenvironmental approach
-
Derniame S, Vignaud JM, Faure GC, et al. Alteration of the immunological synapse in lung cancer: a microenvironmental approach. Clin Exp Immunol. 2008;154:48-55.
-
(2008)
Clin Exp Immunol.
, vol.154
, pp. 48-55
-
-
Derniame, S.1
Vignaud, J.M.2
Faure, G.C.3
-
11
-
-
0036569127
-
Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
-
Woo EY, Yeh H, Chu CS, et al. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol. 2002;168:4272-4276.
-
(2002)
J Immunol.
, vol.168
, pp. 4272-4276
-
-
Woo, E.Y.1
Yeh, H.2
Chu, C.S.3
-
12
-
-
84864954385
-
Lung cancer: A classic example of tumor escape and progression while providing opportunities for immunolog-ical intervention
-
Jadus MR, Natividad J, Mai A, et al. Lung cancer: a classic example of tumor escape and progression while providing opportunities for immunolog-ical intervention. Clin Dev Immunol. 2012;2012:160724.
-
(2012)
Clin Dev Immunol.
, vol.2012
, pp. 160724
-
-
Jadus, M.R.1
Natividad, J.2
Mai, A.3
-
13
-
-
52649163840
-
Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer
-
Al-Shibli KI, Donnem T, Al-Saad S, et al. Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer. Clin Cancer Res. 2008;14:5220-5227.
-
(2008)
Clin Cancer Res.
, vol.14
, pp. 5220-5227
-
-
Al-Shibli, K.I.1
Donnem, T.2
Al-Saad, S.3
-
14
-
-
52449102477
-
Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures
-
Dieu-Nosjean MC, Antoine M, Danel C, et al. Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol. 2008;26:4410-4417.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 4410-4417
-
-
Dieu-Nosjean, M.C.1
Antoine, M.2
Danel, C.3
-
15
-
-
77955093008
-
+ T cells expressing IL-10 are associated with a favourable prognosis in lung cancer
-
+ T cells expressing IL-10 are associated with a favourable prognosis in lung cancer. Lung Cancer. 2010;69:355-360.
-
(2010)
Lung Cancer.
, vol.69
, pp. 355-360
-
-
Miotto, D.1
Lo Cascio, N.2
Stendardo, M.3
-
16
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunother-apy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunother-apy. Nat Rev Cancer. 2012;12:252-264.
-
(2012)
Nat Rev Cancer.
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
17
-
-
84863783251
-
Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)
-
Erfani N, Mehrabadi SM, Ghayumi MA, et al. Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC). Lung Cancer. 2012;77:306-311.
-
(2012)
Lung Cancer.
, vol.77
, pp. 306-311
-
-
Erfani, N.1
Mehrabadi, S.M.2
Ghayumi, M.A.3
-
19
-
-
80052476869
-
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
-
Mu CY, Huang JA, Chen Y, et al. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol. 2011;28:682-688.
-
(2011)
Med Oncol.
, vol.28
, pp. 682-688
-
-
Mu, C.Y.1
Huang, J.A.2
Chen, Y.3
-
20
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30:2046-2054.
-
(2012)
J Clin Oncol.
, vol.30
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
-
21
-
-
85009840975
-
Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC)
-
[abstract 16LBA]
-
Besse B, Johnson M, Janne PA, et al. Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC). Eur J Cancer. 2015;55(suppl 3):S716-S718 [abstract 16LBA].
-
(2015)
Eur J Cancer.
, vol.55
, pp. S716-S718
-
-
Besse, B.1
Johnson, M.2
Janne, P.A.3
-
22
-
-
84969542128
-
Atezolizumab mono-therapy vs docetaxel in 2 L/3 L non-small cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR)
-
[abstract 14LBA]
-
Vansteenkiste J, Fehrenbacher L, Spira AI, et al. Atezolizumab mono-therapy vs docetaxel in 2 L/3 L non-small cell lung cancer: primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR). Eur J Cancer. 2015;55(suppl 3):S716-S718 [abstract 14LBA].
-
(2015)
Eur J Cancer.
, vol.55
, pp. S716-S718
-
-
Vansteenkiste, J.1
Fehrenbacher, L.2
Spira, A.I.3
-
23
-
-
84947444410
-
Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1-selected patients with non-small cell lung cancer (NSCLC)
-
abstract 8028
-
Spigel D, Chaft J, Gettinger S, et al. Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1-selected patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33 (suppl): abstract 8028.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Spigel, D.1
Chaft, J.2
Gettinger, S.3
-
24
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063):aphase 2, single-arm trial
-
Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063):aphase 2, single-arm trial. Lancet Oncol. 2015;16:257-265.
-
(2015)
Lancet Oncol.
, vol.16
, pp. 257-265
-
-
Rizvi, N.A.1
Mazieres, J.2
Planchard, D.3
-
25
-
-
76749084659
-
Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
abstract 8071
-
Zatloukal P, Heo DS, Park K, et al. Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27(suppl 15):abstract 8071.
-
(2009)
J Clin Oncol.
, vol.27
-
-
Zatloukal, P.1
Heo, D.S.2
Park, K.3
-
26
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15:7412-7420.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
-
27
-
-
84936749833
-
Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
-
Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33:2004-2012.
-
(2015)
J Clin Oncol.
, vol.33
, pp. 2004-2012
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
-
28
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372:2018-2028.
-
(2015)
N Engl J Med.
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
29
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014; 515:563-567.
-
(2014)
Nature.
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
30
-
-
84944734156
-
Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
-
abstract 8032
-
Rizvi N, Brahmer J, Ou S, et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33(suppl): abstract 8032.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Rizvi, N.1
Brahmer, J.2
Ou, S.3
-
31
-
-
84944751040
-
Avelumab (MSB0010718C), ananti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
-
abstract 8034
-
Gulley J, Spigel D, Kelly K, et al. Avelumab (MSB0010718C), ananti-PD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. J Clin Oncol. 2015;33(suppl): abstract 8034.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Gulley, J.1
Spigel, D.2
Kelly, K.3
-
32
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015; 373:123-135.
-
(2015)
N Engl J Med.
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
33
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373: 1627-1639.
-
(2015)
N Engl J Med.
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
34
-
-
84960187594
-
Pembrolizumab versus docetaxel for previously treated PD-L1-positive advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2015;S0140-673601281-01287.
-
(2015)
Lancet.
, vol.S0140
, pp. 673601281-673601287
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
37
-
-
84937635597
-
First-line monotherapy with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced non-small cell lung cancer (NSCLC): Safety, efficacy and correlation of outcomes with PD-L1 status
-
Rizvi N, Shepherd F, Antonia S, et al. First-line monotherapy with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced non-small cell lung cancer (NSCLC): safety, efficacy and correlation of outcomes with PD-L1 status. Int J Radiat Oncol. 2014;90:S31.
-
(2014)
Int J Radiat Oncol.
, vol.90
, pp. S31
-
-
Rizvi, N.1
Shepherd, F.2
Antonia, S.3
-
38
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
-
abstract 8113
-
Antonia S, Brahmer JR, Gettinger S, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;35(suppl): abstract 8113.
-
(2014)
J Clin Oncol.
, vol.35
-
-
Antonia, S.1
Brahmer, J.R.2
Gettinger, S.3
-
39
-
-
84937635835
-
Phase i study of anti-PD-1 antibody ONO-4538 (nivolumab) and chemotherapy in patients with advanced non-small-cell lung cancer
-
[abstract 1326P]
-
Kanda S, Goto K, Shiraishi H, et al. Phase I study of anti-PD-1 antibody ONO-4538 (nivolumab) and chemotherapy in patients with advanced non-small-cell lung cancer. Ann Oncol. 2014;25(suppl 4):iv426-iv470[abstract 1326P].
-
(2014)
Ann Oncol.
, vol.25
, pp. 4426-4470
-
-
Kanda, S.1
Goto, K.2
Shiraishi, H.3
-
40
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase i results
-
abstract 8023
-
Antonia S, Gettinger S, Chow L, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. J Clin Oncol. 2014;35(suppl): abstract 8023.
-
(2014)
J Clin Oncol.
, vol.35
-
-
Antonia, S.1
Gettinger, S.2
Chow, L.3
-
41
-
-
84946240266
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) maintenance as monotherapy or in combination with bevacizumab (BEV) for non-small cell lung cancer (NSCLC) previously treated with chemotherapy
-
Rizvi NA, Antonia SJ, Shepherd FA, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) maintenance as monotherapy or in combination with bevacizumab (BEV) for non-small cell lung cancer (NSCLC) previously treated with chemotherapy. Int J Radiat Oncol. 2014;90:S34.
-
(2014)
Int J Radiat Oncol.
, vol.90
, pp. S34
-
-
Rizvi, N.A.1
Antonia, S.J.2
Shepherd, F.A.3
-
42
-
-
84937632027
-
Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced non-small cell lung cancer (NSCLC)
-
Gettinger S, Chow LQ, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced non-small cell lung cancer (NSCLC). Int J Radiat Oncol. 2014;90:S34.
-
(2014)
Int J Radiat Oncol.
, vol.90
, pp. S34
-
-
Gettinger, S.1
Chow, L.Q.2
Borghaei, H.3
-
44
-
-
84947444749
-
Pembrolizumab (Pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohorts A and C
-
abstract 8031
-
Papadimitrakopoulou V, Patnaik A, Borghaei H, et al. Pembrolizumab (Pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohorts A and C. J Clin Oncol. 2015;33(suppl): abstract 8031.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Papadimitrakopoulou, V.1
Patnaik, A.2
Borghaei, H.3
-
45
-
-
84942138310
-
Phase 1 study of pembrolizumab (Pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
-
abstract 8011
-
Patnaik A, Socinski M, Gubens M, et al. Phase 1 study of pembrolizumab (Pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33(suppl): abstract 8011.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Patnaik, A.1
Socinski, M.2
Gubens, M.3
-
46
-
-
84969556749
-
-
FDA grants breakthrough therapy designation for Genentech's investi-gational cancer immunotherapy MPDL3280A (anti-PDL1) in non-small cell lung cancer Accessed November 1, 2015
-
FDA grants breakthrough therapy designation for Genentech's investi-gational cancer immunotherapy MPDL3280A (anti-PDL1) in non-small cell lung cancer. Available at: http://www.gene.com/media/press-releases/14583/2015-02-01/fda-grants-breakthrough-therapy-designat. Accessed November 1, 2015.
-
-
-
-
47
-
-
84969579184
-
Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): Update from a phase IA study. 2015 ASCO Annual Meeting
-
abstract 8029
-
Horn L, Spigel D, Gettinger S, et al. Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): update from a phase IA study. 2015 ASCO Annual Meeting. J Clin Oncol. 2015;33(suppl): abstract 8029.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Horn, L.1
Spigel, D.2
Gettinger, S.3
-
48
-
-
84942138309
-
Efficacy, safety and predictive biomarker results from a randomized phase II study comparing MPDL3280A vs docetaxel in 2 L/3 L NSCLC (POPLAR)
-
abstract 8010
-
Spira A, Park K, Mazieres J, et al. Efficacy, safety and predictive biomarker results from a randomized phase II study comparing MPDL3280A vs docetaxel in 2 L/3 L NSCLC (POPLAR). J Clin Oncol. 2015;33(suppl): abstract 8010.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Spira, A.1
Park, K.2
Mazieres, J.3
-
49
-
-
84944739668
-
Safety and efficacy of MPDL3280A (anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)
-
abstract 8030
-
Liu S, Powderly J, Camidge D, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33(suppl): abstract 8030.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Liu, S.1
Powderly, J.2
Camidge, D.3
-
50
-
-
84944728607
-
Safety and tolerability results from a phase i study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC)
-
abstract 3047
-
Creelan B, Chow L, Kim DW, et al. Safety and tolerability results from a phase I study of MEDI4736, a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib in patients (pts) with non-small-cell lung cancer (NSCLC). J Clin Oncol. 2015;33(suppl): abstract 3047.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Creelan, B.1
Chow, L.2
Kim, D.W.3
-
51
-
-
84938309673
-
Phase IB study of MEDI4736, aprogrammed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC
-
abstract 3014
-
Antonia S, Goldberg SB, Balmanoukian A, et al. Phase IB study of MEDI4736, aprogrammed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J Clin Oncol. 2015;33(suppl): abstract 3014.
-
(2015)
J Clin Oncol.
, vol.33
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.3
-
52
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-128.
-
(2015)
Science.
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
53
-
-
84937108473
-
Smoking history and response to nivolumab in patients with advanced NSCLCs
-
[abstract 1229PD]
-
Hellmann MD, Creelan BC, Woo K, et al. Smoking history and response to nivolumab in patients with advanced NSCLCs. Ann Oncol. 2014;25(suppl 4):iv429[abstract 1229PD].
-
(2014)
Ann Oncol.
, vol.25
, pp. iv429
-
-
Hellmann, M.D.1
Creelan, B.C.2
Woo, K.3
-
54
-
-
84922121587
-
An analysis of the relationship of clinical activity to baseline EGFR status, PD-L1 expression and prior treatment history in patients with non-small cell lung cancer (NSCLC) following PD-L1 blockade with MPDL3280A (anti-PDL1)
-
abstract M01801
-
Horn L, Herbst RS, Spigel D, et al. An analysis of the relationship of clinical activity to baseline EGFR status, PD-L1 expression and prior treatment history in patients with non-small cell lung cancer (NSCLC) following PD-L1 blockade with MPDL3280A (anti-PDL1). J Thorac Oncol. 2014; 8(suppl 2): abstract M01801.
-
(2014)
J Thorac Oncol.
, vol.8
-
-
Horn, L.1
Herbst, R.S.2
Spigel, D.3
-
55
-
-
84969710115
-
Managing immune checkpoint-blocking antibody side effects
-
M.A. Postow. Managing immune checkpoint-blocking antibody side effects. Am Soc Clin Oncol Educ Book, 35 (2015) 76-83.
-
(2015)
Am Soc Clin Oncol Educ Book
, vol.35
, pp. 76-83
-
-
Postow, M.A.1
-
56
-
-
84969570494
-
Antitumor activityofpembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC)
-
abstract LBA43
-
Garon EBGL, Rizvi N, et al. Antitumor activityofpembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC). Ann Oncol. 2014;25: abstract LBA43.
-
(2014)
Ann Oncol.
, vol.25
-
-
Ebgl, G.1
Rizvi, N.2
-
57
-
-
84937595375
-
Biomarkers associated with clinical activity of PD-L1 blockade in non-small cell lung cancer patients (NSCLC): Patients (pts) in a phase i study of MPDL3280A
-
[abstract 1322P])
-
Soria JC, Gettinger S, Gordon M, et al. Biomarkers associated with clinical activity of PD-L1 blockade in non-small cell lung cancer patients (NSCLC): patients (pts) in a phase I study of MPDL3280A. Ann Oncol. 2014; 25(suppl 4): iv426-70[abstract 1322P]).
-
(2014)
Ann Oncol.
, vol.25
, pp. 4426-4470
-
-
Soria, J.C.1
Gettinger, S.2
Gordon, M.3
-
58
-
-
84962366938
-
Differential expression of PD-L1 between primary and metastatic sites in clear-cell renal cell carcinoma
-
Callea M, Albiges L, Gupta M, et al. Differential expression of PD-L1 between primary and metastatic sites in clear-cell renal cell carcinoma. Cancer Immunol Res. 2015;3:1158-1164.
-
(2015)
Cancer Immunol Res.
, vol.3
, pp. 1158-1164
-
-
Callea, M.1
Albiges, L.2
Gupta, M.3
-
59
-
-
84977889148
-
Quantitative assessment of the heterogeneity of PD-L1 expression in non-small-cell lung cancer
-
McLaughlin J, Han G, Schalper KA, et al. Quantitative assessment of the heterogeneity of PD-L1 expression in non-small-cell lung cancer. JAMA Oncol. 2015:1-9.
-
(2015)
JAMA Oncol.
, pp. 1-9
-
-
McLaughlin, J.1
Han, G.2
Schalper, K.A.3
-
60
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
Weber JS, O'Day S, Urba W, et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26:5950-5956.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 5950-5956
-
-
Weber, J.S.1
O'Day, S.2
Urba, W.3
-
61
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92: 205-216.
-
(2000)
J Natl Cancer Inst.
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
62
-
-
84864052441
-
Management of immune-related adverse events and kinetics of response with ipilimumab
-
Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30:2691-2697.
-
(2012)
J Clin Oncol.
, vol.30
, pp. 2691-2697
-
-
Weber, J.S.1
Kahler, K.C.2
Hauschild, A.3
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