Extracellular histones identified in crocodile blood inhibit in-vitro HIV-1 infection

AIDS

Volumn 30, Issue 13, 2016, Pages 2043-2052

  Kozlowski, Hannah N ^a,b   Lai, Eric T L ^b   Havugimana, Pierre C ^a   White, Carl ^a   Emili, Andrew ^a   Sakac, Darinka ^b   Binnington, Beth ^b   Neschadim, Anton ^b   Mccarthy, Stephen D S ^a,b   Branch, Donald R ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CANADIAN BLOOD SERVICES   (Canada)

Author keywords

Crocodylus porosus; extracellular histones; histones; HIV 1 inhibition; innate immunity; neutrophil extracellular traps; saltwater crocodile

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; COMPLEMENTARY DNA; LUCIFERASE; RECOMBINANT HISTONE H1; RECOMBINANT HISTONE H2A; RECOMBINANT HISTONE H2B; RECOMBINANT HISTONE H3; RECOMBINANT HISTONE H4; RECOMBINANT PROTEIN; SALT WATER; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA; GAG PROTEIN; HISTONE;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CROCODILE; CROCODYLUS POROSUS; DNA TRANSCRIPTION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PURIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN IIIB); HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN JR FL); HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IC50; JURKAT CELL LINE; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; VIRUS INHIBITION; ANIMAL; CROCODILIAN; DRUG EFFECTS; GENETIC TRANSCRIPTION; GROWTH, DEVELOPMENT AND AGING; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM;

ALLIGATORS AND CROCODILES; ANIMALS; ANTI-HIV AGENTS; CHROMATOGRAPHY, LIQUID; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTONES; HIV CORE PROTEIN P24; HIV-1; HUMANS; JURKAT CELLS; LUCIFERASES; MASS SPECTROMETRY; RNA, VIRAL; TRANSCRIPTION, GENETIC;

EID: 84969168226     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000001159     Document Type: Article

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