The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2

Journal of Experimental Medicine

Volumn 213, Issue 5, 2016, Pages 687-696

  Zook, Erin C ^a   Ramirez, Kevin ^a   Guo, Xiaohuan ^a   van der Voort, Grant ^a   Sigvardsson, Mikael ^b   Svensson, Eric C ^a   Fu, Yang Xin ^a   Kee, Barbara L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITOR OF DIFFERENTIATION 2; INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 5; MESSENGER RNA; TRANSCRIPTION FACTOR ETS 1; CYTOKINE; ETS1 PROTEIN, MOUSE; IDB2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL CULTURE; CELL EXPANSION; CELL LOSS; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE DELETION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; LYMPHOID CELL; LYMPHOID PROGENITOR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION; ANIMAL; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LYMPHOCYTE;

ANIMALS; CYTOKINES; IMMUNITY, INNATE; INHIBITOR OF DIFFERENTIATION PROTEIN 2; LYMPHOCYTES; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEIN C-ETS-1;

EID: 84969135479     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150851     Document Type: Article

References (28)

1. Barton, K., N. Muthusamy, C. Fischer, C.N. Ting, T.L. Walunas, L.L. Lanier, and J.M. Leiden. 1998. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity. 9:555-563. http://dx.doi.org/10.1016/S1074-7613(00)80638-X
2. Bories, J.C., D.M. Willerford, D. Grévin, L. Davidson, A. Camus, P. Martin, D. Stéhelin, and F.W. Alt. 1995. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 protooncogene. Nature. 377:635-638. http://dx.doi.org/10.1038/377635a0
3. Califano, D., J.J. Cho, M.N. Uddin, K.J. Lorentsen, Q. Yang, A. Bhandoola, H. Li, and D. Avram. 2015. Transcription factor Bcl11b controls identity and function of mature type 2 innate lymphoid cells. Immunity. 43:354-368. http://dx.doi.org/10.1016/j.immuni.2015.07.005
4. Dias, S., R. Månsson, S. Gurbuxani, M. Sigvardsson, and B.L. Kee. 2008. E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity. 29:217-227. http://dx.doi.org/10.1016/j.immuni.2008.05.015
5. Diefenbach, A., M. Colonna, and S. Koyasu. 2014. Development, differentiation, and diversity of innate lymphoid cells. Immunity. 41:354-365. http://dx.doi.org/10.1016/j.immuni.2014.09.005
6. Gao, Z., G.H. Kim, A.C. Mackinnon, A.E. Flagg, B. Bassett, J.U. Earley, and E.C. Svensson. 2010. Ets1 is required for proper migration and differentiation of the cardiac neural crest. Development. 137:1543-1551. http://dx.doi.org/10.1242/dev.047696
7. Garrett-Sinha, L.A. 2013. Review of Ets1 structure, function, and roles in immunity. Cell. Mol. Life Sci. 70:3375-3390. http://dx.doi.org/10.1007/s00018-012-1243-7
8. Gasteiger, G., X. Fan, S. Dikiy, S.Y. Lee, and A.Y. Rudensky. 2015. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 350:981-985. http://dx.doi.org/10.1126/science.aac9593
9. hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells. Nat. Immunol. 16:161-169. http://dx.doi.org/10.1038/ni.3078
10. Kim, T.J., V. Upadhyay, V. Kumar, K.M. Lee, and Y.X. Fu. 2014. Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment. J. Exp. Med. 211:1421-1431. http://dx.doi.org/10.1084/jem.20131501
11. Klose, C.S., M. Flach, L. Möhle, L. Rogell, T. Hoyler, K. Ebert, C. Fabiunke, D. Pfeifer, V. Sexl, D. Fonseca-Pereira, et al. 2014. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 157:340-356. http://dx.doi.org/10.1016/j.cell.2014.03.030
12. McKenzie, A.N., H. Spits, and G. Eberl. 2014. Innate lymphoid cells in inflammation and immunity. Immunity. 41:366-374. http://dx.doi.org/10.1016/j.immuni.2014.09.006
13. + lymphoid cells. Nature. 463:540-544. http://dx.doi.org/10.1038/nature08636
14. Neill, D.R., S.H. Wong, A. Bellosi, R.J. Flynn, M. Daly, T.K. Langford, C. Bucks, C.M. Kane, P.G. Fallon, R. Pannell, et al. 2010. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 464:1367-1370. http://dx.doi.org/10.1038/nature08900
15. Pereira de Sousa, A., C. Berthault, A. Granato, S. Dias, C. Ramond, B.L. Kee, A. Cumano, and P. Vieira. 2012. Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors. J. Immunol. 189:3822-3830. http://dx.doi.org/10.4049/jimmunol.1103723
16. Ramirez, K., K.J. Chandler, C. Spaulding, S. Zandi, M. Sigvardsson, B.J. Graves, and B.L. Kee. 2012. Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1. Immunity. 36:921-932. http://dx.doi.org/10.1016/j.immuni.2012.04.006
17. + cell subsets from Id2-dependent precursors. J. Exp. Med. 207:273-280. http://dx.doi.org/10.1084/jem.20092029
18. Schlenner, S.M., V. Madan, K. Busch, A. Tietz, C. Läufle, C. Costa, C. Blum, H.J. Fehling, and H.R. Rodewald. 2010. Fate mapping reveals separate origins of T cells and myeloid lineages in the thymus. Immunity. 32:426-436. http://dx.doi.org/10.1016/j.immuni.2010.03.005
19. Shui, J.W., A. Larange, G. Kim, J.L. Vela, S. Zahner, H. Cheroutre, and M. Kronenberg. 2012. HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria. Nature. 488:222-225. http://dx.doi.org/10.1038/nature11242
20. Spooner, C.J., J. Lesch, D. Yan, A.A. Khan, A. Abbas, V. Ramirez-Carrozzi, M. Zhou, R. Soriano, J. Eastham-Anderson, L. Diehl, et al. 2013. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nat. Immunol. 14:1229-1236. http://dx.doi.org/10.1038/ni.2743
21. Tu, T.C., N.K. Brown, T.J. Kim, J. Wroblewska, X. Yang, X. Guo, S.H. Lee, V. Kumar, K.M. Lee, and Y.X. Fu. 2015. CD160 is essential for NK-mediated IFN-γ production. J. Exp. Med. 212:415-429. http://dx.doi.org/10.1084/jem.20131601
22. Turner, J.E., P.J. Morrison, C. Wilhelm, M. Wilson, H. Ahlfors, J.C. Renauld, U. Panzer, H. Helmby, and B. Stockinger. 2013. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J. Exp. Med. 210:2951-2965. http://dx.doi.org/10.1084/jem.20130071
23. Verykokakis, M., E.C. Zook, and B.L. Kee. 2014. ID'ing innate and innate-like lymphoid cells. Immunol. Rev. 261:177-197. http://dx.doi.org/10.1111/imr.12203
24. Walker, J.A., C.J. Oliphant, A. Englezakis, Y. Yu, S. Clare, H.R. Rodewald, G. Belz, P. Liu, P.G. Fallon, and A.N. McKenzie. 2015. Bcl11b is essential for group 2 innate lymphoid cell development. J. Exp. Med. 212:875-882. http://dx.doi.org/10.1084/jem.20142224
25. Wong, S.H., J.A. Walker, H.E. Jolin, L.F. Drynan, E. Hams, A. Camelo, J.L. Barlow, D.R. Neill, V. Panova, U. Koch, et al. 2012. Transcription factor RORα is critical for nuocyte development. Nat. Immunol. 13:229-236. http://dx.doi.org/10.1038/ni.2208
26. Yagi, R., C. Zhong, D.L. Northrup, F. Yu, N. Bouladoux, S. Spencer, G. Hu, L. Barron, S. Sharma, T. Nakayama, et al. 2014. The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells. Immunity. 40:378-388. http://dx.doi.org/10.1016/j.immuni.2014.01.012
27. Yang, Q., F. Li, C. Harly, S. Xing, L. Ye, X. Xia, H. Wang, X. Wang, S. Yu, X. Zhou, et al. 2015. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat. Immunol. 16:1044-1050. http://dx.doi.org/10.1038/ni.3248
28. Yu, Y., C. Wang, S. Clare, J. Wang, S.C. Lee, C. Brandt, S. Burke, L. Lu, D. He, N.A. Jenkins, et al. 2015. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J. Exp. Med. 212:865-874. http://dx.doi.org/10.1084/jem.20142318