Metabolite regulation of nuclear localization of carbohydrate-response element-binding protein (ChREBP): Role of amp as an allosteric inhibitor

Journal of Biological Chemistry

Volumn 291, Issue 20, 2016, Pages 10515-10527

  Sato, Shogo ^a   Jung, Hunmin ^a   Nakagawa, Tsutomu ^a   Pawlosky, Robert ^b   Takeshima, Tomomi ^a   Lee, Wan Ru ^a   Sakiyama, Haruhiko ^a   Laxman, Sunil ^a   Wynn, R Max ^a   Tu, Benjamin P ^a   MacMillan, John B ^a   De Brabander, Jef K ^a   Veech, Richard L ^b   Uyeda, Kosaku ^b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CRYSTAL STRUCTURE; CYTOLOGY; GLUCOSE; KETONES; PROTEINS; TRANSCRIPTION; UNSATURATED FATTY ACIDS;

14-3-3 PROTEINS; ALLOSTERIC ACTIVATION; ALLOSTERIC INHIBITOR; GLUCOSE LEVEL; GLUCOSE-RESPONSIVE; NUCLEAR LOCALIZATION; RESPONSE ELEMENTS; RIBONUCLEOTIDES;

METABOLITES;

2 OXOACID; ADENOSINE PHOSPHATE; CARBOHYDRATE; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; EXPORTIN 1; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KETONE BODY; PROTEIN 14 3 3; RIBONUCLEOTIDE; SATURATED FATTY ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CELL RECEPTOR; EXPORTIN 1 PROTEIN; KARYOPHERIN; MLXIPL PROTEIN, RAT;

ALLOSTERISM; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL NUCLEUS; CELL TRANSPORT; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KETOACIDOSIS; LIPID DIET; LIPOGENESIS; MALE; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; ADMINISTRATION AND DOSAGE; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; LIVER CELL; METABOLISM; SPRAGUE DAWLEY RAT; SUGAR INTAKE; X RAY CRYSTALLOGRAPHY;

14-3-3 PROTEINS; ADENOSINE MONOPHOSPHATE; ALLOSTERIC REGULATION; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL NUCLEUS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DIET, HIGH-FAT; DIETARY SUCROSE; HEPATOCYTES; KARYOPHERINS; KETONE BODIES; MALE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84969132762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.708982     Document Type: Article

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