Prehospital administration of tranexamic acid in trauma patients

Critical Care

Volumn 20, Issue 1, 2016, Pages

  Wafaisade, Arasch ^a   Lefering, Rolf ^a   Bouillon, Bertil ^a   Böhmer, Andreas B ^a   Gäßler, Michael ^b   Ruppert, Matthias ^b  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b Institute for Research in Operative Medicine ^*  (Germany)

Author keywords

Bleeding; Coagulopathy; Tranexamic acid; Trauma

Indexed keywords

CATECHOLAMINE; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ARTICLE; BLUNT TRAUMA; CHEST TUBE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG USE; EMERGENCY CARE; ERYTHROCYTE COUNT; FEMALE; HUMAN; INJURY; INJURY SCALE; INTUBATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PLASMA; PRIORITY JOURNAL; SEPSIS; THROMBOEMBOLISM; TREATMENT OUTCOME; HOSPITAL MORTALITY; MIDDLE AGED; PROCEDURES; RESUSCITATION; WOUNDS AND INJURIES;

ADULT; ANTIFIBRINOLYTIC AGENTS; COHORT STUDIES; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; RESUSCITATION; TRANEXAMIC ACID; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 84968807197     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-016-1322-5     Document Type: Article

References (33)

1. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006;60(6 Suppl):S3-11.
2. Wafaisade A, Wutzler S, Lefering R, Tjardes T, Banerjee M, Paffrath T, et al. Drivers of acute coagulopathy after severe trauma: a multivariate analysis of 1987 patients. Emerg Med J. 2010;27:934-9.
3. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38:298-304.
4. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127-30.
5. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471-82.
6. Wafaisade A, Lefering R, Maegele M, Lendemans S, Flohé S, Hussmann B, et al. Coagulation management of bleeding trauma patients is changing in German trauma centers: an analysis from the trauma registry of the German Society for Trauma Surgery. J Trauma Acute Care Surg. 2012;72:936-42.
7. Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, et al. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014;77:811-7.
8. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376:23-32.
9. Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377:1096-101.e2.
10. Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care. 2013;17:R76.
11. Helm M, Haunstein B, Schlechtriemen T, Ruppert M, Lampl L, Gäßler M. EZ-IO(®) intraosseous device implementation in German Helicopter Emergency Medical Service. Resuscitation. 2015;88:43-7.
12. Weiss M, Bernoulli L, Zollinger A. The NACA scale: construct and predictive validity of the NACA scale for prehospital severity rating in trauma patients. Anaesthesist. 2001;50:150-4.
13. Scoring Study Committee of the German Society of Trauma Surgery. Trauma register of the German Society of Trauma Surgery [in German]. Unfallchirurg. 1994;97:230-7.
14. Baker SP, O'Neill B, Haddon W, Long WB. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187-96.
15. Gennarelli TA, Wodzin E. AIS 2005: a contemporary injury scale. Injury. 2006;37:1083-91.
16. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med. 1998;26:1793-800.
17. Bone RC. Let's agree on terminology: definitions of sepsis. Crit Care Med. 1991;19:973-6.
18. Wagner C, Dati F. Thromboplastinzeit. In: Thomas L, editor. Labor und Diagnose: Indikation und Bewertung von Laborbefunden für die medizinische Diagnostik. Frankfurt, Germany: TH-Books; 2000. p. 613-6.
19. Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, et al. Challenges to effective research in acute trauma resuscitation: consent and endpoints. Shock. 2011;35:107-13.
20. Jiménez JJ, Iribarren JL, Brouard M, Hernández D, Palmero S, Jiménez A, et al. Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dose-dependent, phase IV clinical trial. J Cardiothorac Surg. 2011;6:138.
21. Ker K, Prieto-Merino D, Roberts I. Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. Br J Surg. 2013;100:1271-9.
22. Casati V, Romano A, Novelli E, D'Angelo A. Tranexamic acid for trauma. Lancet. 2010;376:1049-50. author reply 1050-1.
23. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg. 2012;147:113-9.
24. Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE. Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. JAMA Surg. 2013;148:218-25.
25. Valle EJ, Allen CJ, Van Haren RM, Jouria JM, Li H, Livingstone AS, et al. Do all trauma patients benefit from tranexamic acid? J Trauma Acute Care Surg. 2014;76:1373-8.
26. Cole E, Davenport R, Willett K, Brohi K. Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg. 2015;261:390-4.
27. Ausset S, Glassberg E, Nadler R, Sunde G, Cap AP, Hoffmann C, et al. Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: a critical appraisal of the medical literature and available alternatives. J Trauma Acute Care Surg. 2015;78(6 Suppl 1):S70-5.
28. Paudyal P, Smith J, Robinson M, South A, Higginson I, Reuben A, et al. Tranexamic acid in major trauma: implementation and evaluation across South West England. Eur J Emerg Med. doi: 10.1097/MEJ.0000000000000323.
29. Lipsky AM, Abramovich A, Nadler R, Feinstein U, Shaked G, Kreiss Y, et al. Tranexamic acid in the prehospital setting: Israel Defense Forces' initial experience. Injury. 2014;45:66-70.
30. Benov A, Glassberg E, Nadler R, Gendler S, Erlich T, Bader T, et al. Role I trauma experience of the Israeli Defense Forces on the Syrian border. J Trauma Acute Care Surg. 2014;77(3 Suppl 2):S71-6.
31. Vu EN, Schlamp RS, Wand RT, Kleine-Deters GA, Vu MP, Tallon JM. Prehospital use of tranexamic acid for hemorrhagic shock in primary and secondary air medical evacuation. Air Med J. 2013;32:289-92.
32. Brown JB, Neal MD, Guyette FX, Peitzman AB, Billiar TR, Zuckerbraun BS, et al. Design of the Study of Tranexamic Acid during Air Medical Prehospital Transport (STAAMP) trial: addressing the knowledge gaps. Prehosp Emerg Care. 2015;19:79-86.
33. Mitra B, Mazur S, Cameron PA, Bernard S, Burns B, Smith A, et al. Tranexamic acid for trauma: filling the "GAP" in evidence. Emerg Med Australas. 2014;26:194-7.