Female orgasm dysfunction

Handbook of Sexual Dysfunction

Volumn , Issue , 2005, Pages 193-214

  Meston, Cindy M ^a   Levin, Roy J ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84967637928     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (95)

1. Kinsey AC, Pomeroy WD, Martin CE, Gebhard PH. Sexual Behaviour in the Human Female. Philadelphia: WB Saunders Company, 1953:628.
2. Masters WH, Johnson V. Human Sexual Response. Boston: Little, Brown & Co, 1966.
3. Levin RJ. Measuring the menopause genital changes: a critical account of laboratory procedures past and for the future. Menopause Rev 1999; 1V:49–57.
4. Henson DE, Rubin HB, Henson C, Williams JR. Temperature changes of the labia minora as an objective measure of female eroticism. J Behav Ther Exp Psychiatry 1977; 8:401–410.
5. Henson DE, Rubin HB, Henson C. Labial and vaginal blood volume responses to visual and tactile stimuli. Arch Sex Behav 1982; 11:23–31.
6. Bohlen GJ, Held JP, Sanderson MO. Response of the circumvaginal musculature during masturbation. In: Graber B, ed. Circumvaginal Musculature and Sexual Function. Basel: Kager, 1982:43–60.
7. Carmichael MS, Warburton VL, Dixen J, Davidson JM. Relationship among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav 1994; 23:59–79.
8. Levin RJ, Wagner G, Ottesen B. Simultaneous monitoring of human vaginal haemo-dynamics by three independent methods during sexual arousal. In: Hoch Z, Lief HI, eds. Sexology. Amsterdam: Elsevier Publishing Co, 1981:114–120.
9. Bohlen G, Held JP, Sanderson MO, Ahlgren A. The female orgasm: pelvic contractions. Arch Sex Behav 1982; 11:367–386.
10. Davidson JM. The psychobiology of sexual experience. In: Davidson JM, Davidson RJ, eds. The Psychobiology of Consciousness. New York: Plenum Press, 1980:271–332.
11. Ladas AK, Whipple B, Perry JD. The G-spot and Other Recent Discoveries About Human Sexuality. New York: Holt, Rinehart & Winston, 1982.
12. Hines TM. The G-spot: a modern gynecologic myth. Am J Obstet Gynecol 2001; 185:359–362.
13. Geer JH, Quartararo J. Vaginal blood volume responses during masturbation. Arch Sex Behav 1976; 5:403–413.
14. Kruger THC, Haake P, Hartman U, Schedlowski M, Exton MS. Orgasm-induced prolactin secretion: Feedback control of sexual drive? Neurosci Biobehav Rev 2002; 26:31–44.
15. Levin RJ. Sexual desire and the deconstruction and reconstruction of the human female sexual response model of Masters & Johnson. In: Everaerd W, Laan E, Both S, eds. Sexual Appetite, Desire and Motivation: Energetics of the Sexual System. Amsterdam: Royal Netherlands Academy of Arts and Sciences, 2001:63–93.
16. Whipple B, Ogden G, Komisaruk BR. Physiological correlates of imagery-induced orgasm in women. Arch Sex Behav 1992; 21:121–133.
17. Levin RJ. The mechanisms of human female sexual arousal. Annu Rev Sex Res 1992; 3:1–48.
18. Fisher C, Cohen HD, Schiavi RC, Davis D, Furman B, Ward K, Edwards A, Cunningham J. Patterns of female sexual arousal during sleep and waking: vaginal thermo-conductance studies. Arch Sex Behav 1983; 12:97–122.
19. Wells BL. Nocturnal orgasms: Females’ perception of a “normal” sexual experience. J Sex Res 1983; 22:412–437.
20. Polatin P, Douglas DE. Spontaneous orgasm in a case of schizophrenia. Psychoanal Rev 1953; 40:17–26.
21. Whipple B, Komisaruk BR. Brain (PET) responses to vaginal-cervical self-stimulation in women with complete spinal cord injury: preliminary findings. J Sex Marital Ther 2002; 28:79–86.
22. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 1997; 154:926–933.
23. Morris JS, Frith CD, Perrett DI, Rowland D, Young AW, Calder AJ, Dolan RJ. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 1996; 383:812–815.
24. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998; 8:411–418.
25. Fisher S. The Female Orgasm. New York: Basic Books, 1973.
26. Sherfey MJ. The Nature and Evolution of Female Sexuality. New York: Vintage Books, Random House, 1972:121.
27. Vance EB, Wagner NN. Written descriptions of orgasm: a study of sex differences. Arch Sex Behav 1976; 5:87–98.
28. Laqueur T. Making Sex: Body and Gender from the Greeks to Freud. Cambridge, MA: Harvard University Press, 1990.
29. Levin RJ. The physiology of sexual arousal in the human female: a recreational and procreational synthesis. Arch Sex Behav 2002; 31:405–411.
30. Baker RR, Bellis MA. Human sperm competition: ejaculate manipulation by females and a function for the female orgasm. Anim Behav 1993; 6:887–909.
31. Baker RR, Bellis MA. Human Sperm Competition: Copulation, Masturbation and Infidelity. London: Chapman & Hall, 1995.
32. Reyes A, Para A, Chavarria ME, Goicoechea B, Rosado A. Effect of prolactin on the calcium binding and/or transport of ejaculated and epididymal human spermatozoa. Fertil Steril 1979; 31:669–672.
33. Levin RJ. Do women gain anything from coitus apart from pregnancy? Changes in the human female genital tract activated by coitus. J Sex Marital Ther 2003; 29(suppl):59–69.
34. Feiger A, Kiev A, Shrivastava RK, Wisselink PG, Wilcox CS. Nefazodone versus sertraline in outpatients with major depression: focus on efficacy, tolerability, and effects on sexual function and satisfaction. J Clin Psychiatry 1996; 57(suppl 2):53–62.
35. Alcantara AG. A possible dopaminergic mechanism in the serotonergic antidepressant-induced sexual dysfunctions. J Sex Marital Ther 1999; 25:125–129.
36. Montejo-Gonzalez AL, Llorca G, Izquierdo JA, Ledesma A, Bousono M, Calcedo A, Carrasco JL, Ciudad J, Daniel E, De la Gandara J, Derecho J, Franco M, Gomez MJ, Macias JA, Martin T, Perez V, Sanchez JM, Sanchez S, Vicens E. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23:176–194.
37. Bobes J, Gonzalez MP, Bascaran MT, Clayton A, Garcia M, Rico-Villade Moros F, Banus S. Evaluating changes in sexual functioning in depressed patients: sensitivity to change of the CSFQ. J Sex Marital Ther 2002; 28:93–103.
38. Rosen RC, Lane RM, Menza M. Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 1999; 19:67–85.
39. Labbate LA, Grimes J, Hines A, Oleshansky MA, Arana GW. Sexual dysfunction induced by serotonin reuptake antidepressants. J Sex Marital Ther 1998; 24:3–12.
40. Michelson D, Schmidt M, Lee J, Tepner R. Changes in sexual function during acute and six-month fluoxetine therapy: a prospective assessment. J Sex Marital Ther 2001; 27:289–302.
41. Meston CM, Gorzalka BB. Psychoactive drugs and human sexual behavior: the role of serotonergic activity. J Psychoactive Drugs 1992; 24:1–42.
42. Duncan S, Blacklaw J, Beastall GH, Brodie MJ. Sexual function in women with epilepsy. Epilepsia 1997; 38:1074–1081.
43. Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. Int J Obstet Gynaecol 2001; 108:623–628.
44. Kaplan SA, Reis RB, Kohn IJ, Ikeguchi EF, Laor E, Te AE, Martins AC. Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction. Urology 1999; 53:481–486.
45. Berman JR, Berman LA, Lin H, Flaherty E, Lahey N, Goldstein I, Cantey-Kiser J. Effect of sildenafil on subjective and physiologic parameters of the female sexual response in women with sexual arousal disorder. J Sex Marital Ther 2001; 27: 411–420.
46. Ashton AK. Sildenafil treatment of paroxetine-induced anorgasmia in a woman [Letter]. Am J Psychiatry 1999; 156:800.
47. Nurnberg HG, Lauriello J, Hensley PL, Parker LM, Keith SJ. Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients. J Clin Psychiatry 1999; 60:33–35.
48. Rosenberg KP. Sildenafil citrate for SSRI-induced sexual side effects [Letter]. Am J Psychiatry 1999; 156:157.
49. Shen WW, Urosevich Z, Clayton DO. Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. J Reprod Med 1999; 44:535–542.
50. Bulpitt CJ, Beevers DG, Butler A, Coles EC, Hunt D, Munro-Faure AD, Newson RB, O’Riodan PW, Petrie JC, Rajagopalan B. The effects of anti-hypertensive drugs on sexual function in men and women: a report from the DHSS Hypertension Care Computing Project (DHCCP). J Hum Hypertens 1989; 3:53–56.
51. Grimm RH, Grandits GA, Prineas RJ, McDonald RH, Lewis CE, Flack JM, Yunis C, Svendsen K, Liebson PR, Elmer PJ. Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997; 29:8–14.
52. Wagner G, Levin RJ. Effect of atropine and methylatropine on human vaginal blood flow, sexual arousal and climax. Acta Pharmacol Toxicol 1980; 46:321–325.
53. Eicher W, Muck AO. Treatment of estrogen deficiency-induced sex disorders. Gynakologisch-Geburtshilfliche Rundschau 1996; 36:83–89.
54. Nathorst-Boos J, von Schoultz B, Carlstrom K. Elective ovarian removal and estrogen replacement therapy: effects on sexual life, psychological well-being and androgen status. J Psychosom Obstet Gynecol 1993; 14:283–293.
55. Kokcu A, Cetinkaya MB, Yanik F, Alper T, Malatyalioglu E. The comparison of effects of tibolone and conjugated estrogen–medroxyprogesterone acetate therapy on sexual performance in postmenopausal women. Maturitas 2000; 36:75–80.
56. Wu MH, Pan HA, Wang ST, Hsu CC, Chang FM, Huang KE. Quality of life and sexuality changes in postmenopausal women receiving tibolone therapy. Climacteric 2001; 4:314–319.
57. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987; 49:397–409.
58. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343:682–688.
59. Munarriz R, Talakoub L, Flaherty E, Gioia M, Hoag L, Kim NN, Traish A, Goldstein I, Guay A, Spark R. Androgen replacement therapy with dehydroepiandrosterone for androgen insufficiency and female sexual dysfunction: androgen and questionnaire results. J Sex Marital Ther 2002; 28(suppl 1):165–173.
60. Laumann EO, Gagnon JH, Michael RT, Michaels S. The Social Organization of Sexuality: Sexual Practices in the United States. Chicago: University of Chicago Press, 1994.
61. Sholty MJ, Ephross PH, Plaut SM, Fischman SH, Charnas JF, Cody CA. Female orgasmic experience: a subjective study. Arch Sex Behav 1984; 13:155–164.
62. Bartoi MG, Kinder BN. Effects of child and adult sexual abuse on adult sexuality. J Sex Marital Ther 1998; 24:75–90.
63. Feinauer LL. Sexual dysfunction in women sexually abused as children. Contemp Fam Ther 1989; 11:299–309.
64. Meston CM, Heiman JR, Trapnell PD. The relation between early abuse and adult sexuality. J Sex Res 1999; 36:385–395.
65. Mah K, Binik YM. The nature of human orgasm: a critical review of major trends. Clin Psychol Rev 2001; 21:823–856.
66. Rosen RC, Taylor JF, Leiblum S, Bachman GA. Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 1993; 19:171–188.
67. Read S, King M, Watson J. Sexual dysfunction in primary medical care: prevalence, characteristics and detection by the general practitioner. J Public Health Med 1997; 19:387–391.
68. American Psychiatric Association. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text revision. Washington, DC: American Psychiatric Association, 1994.
69. Heiman JR. Orgasmic disorders in women. In: Leiblum SR, Rosen RC, eds. Principles and Practice of Sex Therapy. 3rd ed. New York: Guilford Press, 2000.
70. Barlow DH. Causes of sexual dysfunction: the role of anxiety and cognitive interference. J Consult Clin Psychol 1986; 54:140–148.
71. LoPiccolo J, Lobitz WC. The role of masturbation in the treatment of orgasmic dysfunction. Arch Sex Behav 1972; 2:163–171.
72. Annon JS. The therapeutic use of masturbation in the treatment of sexual disorders. In: Rubin RD, Brady JP, Henderson JD, eds. Advances in Behavior Therapy. Vol. 4. New York: Academic Press, 1973.
73. Heiman JR, LoPiccolo L, LoPiccolo J. Becoming Orgasmic: A Sexual Growth Program for Women. Englewood Cliffs, NJ: Prentice-Hall, 1976.
74. Heinrich AG. The Effect of Group and Self-Directed Behavioral –Educational Treatment of Primary Orgasmic Dysfunction in Females Treated Without their Partners. Ph.D. dissertation, University of Colorado, Boulder, CO, 1976.
75. McMullen S, Rosen RC. Self-administered masturbation training in the treatment of primary orgasmic dysfunction. J Consult Clin Psychol 1979; 47:912–918.
76. Fichen CS, Libman E, Brender W. Methodological issues in the study of sex therapy: effective components in the treatment of secondary orgasmic dysfunction. J Sex Marital Ther 1983; 9:191–202.
77. Hurlbert DF, Apt C. Coital alignment technique and directed masturbation: a comparative study on female orgasm. J Sex Marital Ther 1995; 21:21–29.
78. Masters WH, Johnson VE. Human Sexual Inadequacy. London: Churchill, 1970.
79. Meston CM, Gorzalka BB. The effects of sympathetic activation following acute exercise on physiological and subjective sexual arousal in women. Behav Res Ther 1995; 33:651–664.
80. Meston CM, Gorzalka BB. The differential effects of sympathetic activation on sexual arousal in sexually functional and dysfunctional women. J Abnorm Psychol 1996a; 105:582–591.
81. Meston CM, Gorzalka BB. The effects of immediate, delayed, and residual sympathetic activation on physiological and subjective sexual arousal in women. Behav Res Ther 1996b; 34:143–148.
82. Wolpe J. Psychotherapy by Reciprocal Inhibition. Stanford: Stanford University Press, 1958.
83. Brady JP. Brevital-relaxation treatment of frigidity. Behav Res Ther 1966; 4:71–77.
84. Kraft T, Al-Issa I. Behavior therapy and the treatment of frigidity. Am J Psychol 1967; 21:116–120.
85. Jankovich R, Miller PR. Response of women with primary orgasmic dysfunction to audiovisual education. J Sex Marital Ther 1978; 4:16–19.
86. Kilmann PR, Mills KH, Caid C, Davidson E, Bella B, Milan R, Drose G, Boland J, Follingstad D, Montgomery B, Wanlass R. Treatment of secondary orgasmic dysfunction: an outcome study. Arch Sex Behav 1986; 15:211–229.
87. Everaerd W, Dekker J. Treatment of secondary orgasmic dysfunction: a comparison of systematic desensitization and sex therapy. Behav Res Ther 1982; 20:269–274.
88. Kegel AH. Sexual functions of the pubococcygeus muscle. West J Surg Obstet Gynecol 1952; 60:521–524.
89. Modell JG, May RS, Katholi CR. Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: a pilot study. J Sex Marital Ther 2000; 26:231–240.
90. Ito TY, Trant AS, Polan ML. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther 2001; 27:541–549.
91. Michelson D, Bancroft J, Targum S, Kim Y, Tepner R. Female sexual dysfunction associated with antidepressant administration: a randomized, placebo-controlled study of pharmacologic intervention. Am J Psychiatry 2000; 157:239–243.
92. Landen M, Eriksson E, Agren H, Fahlen T. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol 1999; 19:268–271.
93. Michelson D, Kociban K, Tamura R, Morrison MF. Mirtazapine, yohimbine, or olanzapine augmentation therapy for serotonin reuptake-associated female sexual dysfunction: a randomized, placebo controlled trial. J Psychiatr Res 2002; 36:147–152.
94. Kang B, Lee S, Kim M, Cho M. A placebo-controlled, double-blind trial of ginkgo biloba for antidepressant-induced sexual dysfunction. Hum Psychopharmacol 2002; 17:279–284.
95. Meston CM. A randomized, placebo-controlled, crossover study of ephedrine for SSRI-induced female sexual dysfunction. J Sex Marital Ther 2004; 30:57–68.