Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

Journal of Medicinal Chemistry

Volumn 59, Issue 8, 2016, Pages 3650-3660

  Takemoto, Yasushi ^a   Ito, Akihiro ^a,b   Niwa, Hideaki ^a   Okamura, Mutsumi ^c   Fujiwara, Takashi ^d   Hirano, Tomoya ^d   Handa, Noriko ^a   Umehara, Takashi ^a   Sonoda, Takeshi ^b   Ogawa, Kenji ^a   Tariq, Mohammad ^a,e   Nishino, Norikazu ^f   Dan, Shingo ^c   Kagechika, Hiroyuki ^d   Yamori, Takao ^c   Yokoyama, Shigeyuki ^a   Yoshida, Minoru ^a,b,e,g  

^a RIKEN   (Japan)

^b Elements Chemistry Laboratory   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e SAITAMA UNIVERSITY   (Japan)

^f KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^g JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROHEPTADINE; ESTROGEN RECEPTOR ALPHA; HISTONE LYSINE METHYLTRANSFERASE; ENZYME INHIBITOR; ESTROGEN;

ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; FEMALE; HYDROGEN BOND; MCF 7 CELL LINE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC TRANSCRIPTION; HUMAN; MCF-7 CELL LINE; PHYSIOLOGY;

CRYSTALLOGRAPHY, X-RAY; CYPROHEPTADINE; ENZYME INHIBITORS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; TRANSCRIPTION, GENETIC;

EID: 84966929779     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01732     Document Type: Article

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