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G.E.Stein, E.M.Wells. The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid. Curr Med Res Opin. 2010;26:571–588.
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Y.Tsuji, Y.Hiraki, K.Matsumoto, et al. Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction. J Infect Chemother. 2011;17:70–75.• This article is considerably important as it was one of the first studies that associated a higher frequency of toxicity with higher linezolid concentrations.
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This article is considerably important as it demonstrated the reduction of toxicity while retaining efficacy by means of therapeutic drug monitoring
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F.Pea, P.Viale, P.Cojutti, et al. Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients. J Antimicrob Chemoth. 2012;67:2034–2042.•• This article is considerably important as it demonstrated the reduction of toxicity while retaining efficacy by means of therapeutic drug monitoring.
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K.Matsumoto, A.Takeshita, K.Ikawa, et al. Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction. Int J Antimicrob Ag. 2010;36:179–181.•• This article is considerably important as it was one of the first studies that associated a higher frequency of toxicity with higher linezolid concentrations.
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K.Matsumoto, A.Shigemi, A.Takeshita, et al. Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients. Int J Antimicrob Ag. 2014;44:242–247.• This is an interesting study as it developed a nomogram suggesting different initial daily doses depending on the creatinine clearance.
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