Correlation between serum linezolid concentration and the development of thrombocytopenia

Scandinavian Journal of Infectious Diseases

Volumn 44, Issue 1, 2012, Pages 60-64

  Hiraki, Yoichi ^a   Tsuji, Yasuhiro ^b   Hiraike, Mikako ^a   Misumi, Nobuhiro ^a   Matsumoto, Kana ^c   Morita, Kunihiko ^c   Kamimura, Hidetoshi ^d   Karube, Yoshiharu ^d  

^a NATIONAL HOSPITAL ORGANIZATION KUMAMOTO MEDICAL CENTER   (Japan)

^b SASEBO CHUO HOSPITAL   (Japan)

^c DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^d FUKUOKA UNIVERSITY   (Japan)

Author keywords

Doseresponse curve; Linezolid; Logit analysis; Renal dysfunction; Thrombocytopenia

Indexed keywords

LINEZOLID;

AGED; ARTICLE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HUMAN; KIDNEY DYSFUNCTION; MALE; PNEUMONIA; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ACETAMIDES; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; OXAZOLIDINONES; PLATELET COUNT; PNEUMONIA; PROSPECTIVE STUDIES; THROMBOCYTOPENIA;

EID: 84555220559     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2011.608712     Document Type: Article

References (15)

1. 1] Zurenko GE, Gibson JK, Shinabarger DL, Aristoff PA, Ford CW, Tarpley WG. Oxazolidinones: a new class of antibacterials. Curr Opin Pharmacol 2001;1:470-6. (Pubitemid 33593835)
2. Mascini EM, Troelstra A, Beitsma M, Blok HE, Jalink KP, Hopmans TE, et al. Genotyping and preemptive isolation to control an outbreak of vancomycin-resistant Enterococcus faecium. Clin Infect Dis 2006;42:739-46. (Pubitemid 43363925)
3. Chang S, Sievert DM, Hageman JC, Boulton ML, Tenover FC, Downes FP, et al. Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene. N Engl J Med 2003;348:1342-7. (Pubitemid 36384101)
4. Pfi zer. ZYVOX (linezolid) label information. Pfi zer; 2008. Retrieved 20 June 2008.
5. Pfi zer Co. New phase 4 study shows higher rates of clinical and microbiological success for yvox versus vancomycin in MRSA nosocomial pneumonia. The 48 th Annual Meeting of the Infectious Diseases Society of America, Vancouver, Canada, October 21-24, 2010.
6. Wu VC, Wang YT, Wang CY, Tsai IJ, Wu KD, Hwang JJ, et al. High frequency of linezolid-associated thrombocytopenia and anemia among patients with end-stage renal disease. Clin Infect Dis 2006;42:66-72.
7. Minson Q, Gentry CA. Analysis of linezolid-associated hematologic toxicities in a large veterans affairs medical center. Pharmacotherapy 2010;30:895-903.
8. Gerson SL, Kaplan SL, Bruss JB, Le V, Arellano FM, Hafkin B, et al. Hematologic effects of linezolid: summary of clinical experience. Antimicrob Agents Chemother 2002;46: 2723-6. (Pubitemid 34793498)
9. Tsuji Y, Hiraki Y, Matsumoto K, Mizoguchi A, Kobayashi T, Sadoh S, et al. Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction. J Infect Chemother 2010;17: 70-5.
10. Majcher-Peszynska J, Haase G, Sass M, Mundkowski R, Pietsch A, Klammt S, et al. Pharmacokinetics and penetration of linezolid into infl amed soft tissue in diabetic foot infections. Eur J Clin Pharmacol 2008;64:1093-100.
11. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
12. Ihaka R, Gentleman R. R: A language for data analysis and graphics. J Comput Graph Stat 1996;5:299-314.
13. Sauerbrei W, Schumacher M. A bootstrap resampling procedure for model building: application to the Cox regression model. Stat Med 1992;11:2093-109. (Pubitemid 23066842)
14. Lin YH, Wu VC, Tsai IJ, Ho YL, Hwang JJ, Tsau YK, et al. High frequency of linezolid-associated thrombocytopenia among patients with renal insuffi ciency. Int J Antimicrob Agents 2006;28:345-51.
15. Matsumoto K, Takeshita A, Ikawa K, Shigemi A, Yaji K, Shimodozono Y, et al. Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction. Int J Antimicrob Agents 2010;36: 179-81.