Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation

Circulation Research

Volumn 119, Issue 2, 2016, Pages 222-236

  Wang, Yi Fu ^a,b   Hsu, Yu Juei ^c,d   Wu, Hsu Feng ^a   Lee, Guan Lin ^a,c   Yang, Ya Sung ^c,d   Wu, Jing Yiing ^a   Yet, Shaw Fang ^a,e,f   Wu, Kenneth K ^a,e,f,g   Kuo, Cheng Chin ^a,c,e,f  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g UNIVERSITY OF TEXAS   (United States)

Author keywords

5 methoxytryptophan; capillary permeability; inflammation; sepsis; shock

Indexed keywords

5 METHOXYTRYPTOPHAN; C REACTIVE PROTEIN; CHEMOKINE; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KYNURENINE; LIPOPOLYSACCHARIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; 5-METHOXYTRYPTOPHAN; ANTIINFLAMMATORY AGENT;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONDITIONED MEDIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENDOTOXEMIA; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIQUID CHROMATOGRAPHY; LUNG; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN; TRYPTOPHAN METABOLISM; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; C57BL MOUSE; METABOLISM; MIDDLE AGED; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANIMALS; ANTI-INFLAMMATORY AGENTS; ENDOTHELIUM, VASCULAR; ENDOTOXEMIA; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; TRYPTOPHAN;

EID: 84966697317     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.308559     Document Type: Article

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