Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 33, 2012, Pages 13231-13236

  Cheng, Huei Hsuan ^a   Kuo, Cheng Chin ^a   Yan, Jiann Long ^a   Chen, Hua Ling ^a   Lin, Wei Chung ^a   Wang, Kai Hsuan ^a,b   Tsai, Kelvin K C ^a   Guvén, Hayrettin ^c   Flaberg, Emilie ^c   Szekelyd, Laszlo ^c   Klein, George ^c   Wu, Kenneth K ^a,b,d  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Inflammation control; Tryptophan metabolism; Tumor suppression

Indexed keywords

5 METHOXYTRYPTOPHAN; ACETYLSEROTONIN METHYLTRANSFERASE; CYCLOOXYGENASE 2; TRYPTOPHAN DERIVATIVE; TRYPTOPHAN HYDROXYLASE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CATALYSIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; LUNG METASTASIS; MALE; METABOLITE; METABOLOMICS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SKIN FIBROBLAST; TUMOR XENOGRAFT;

ACETYLSEROTONIN O-METHYLTRANSFERASE; ANIMALS; BIOCATALYSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; FIBROBLASTS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MICE; NEOPLASM METASTASIS; SOLUBILITY; SUBCELLULAR FRACTIONS; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865190537     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209919109     Document Type: Article

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