Pyrene did not induce gene mutation in red blood cell Pig-a assay and PIGRET assay in rats

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 811, Issue , 2016, Pages 49-53

  Yoshida, Ikuma ^a   Matsumoto, Akemi ^a   Sakai, Yumi ^a   Harada, Yumiko ^a   Hashizume, Tsuneo ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Gene mutation; Pig a gene; Pyrene; Red blood cells; Reticulocytes

Indexed keywords

CD59 ANTIGEN; ETHYLNITROSOUREA; PYRENE; MEMBRANE PROTEIN; MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN; PYRENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CONTROLLED STUDY; ERYTHROCYTE; GENE; GENE MUTATION; GENOTOXICITY; IN VIVO STUDY; MALE; MORTALITY; MUTAGENICITY; NONHUMAN; PIG A GENE; PRIORITY JOURNAL; RAT; RETICULOCYTE; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; MUTAGEN TESTING; MUTATION; PROCEDURES; VALIDATION STUDY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; MEMBRANE PROTEINS; MUTAGENICITY TESTS; MUTAGENS; MUTATION; PYRENES; RATS; RETICULOCYTES;

EID: 84966457724     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2016.04.007     Document Type: Article

References (24)

1. [1] Kimoto, T., Introduction to a special issue on the Pig-a gene mutation assay. Genes Environ. 36 (2014), 167–168.
2. [2] Miura, D., The in vivo Pig-a gene mutation assay. Genes Environ. 36 (2014), 169–173.
3. [3] Gollapudi, B.B., Lynch, A.M., Heflich, R.H., Dertinger, S.D., Dobrovolsky, V.N., Froetschl, R., et al. The in vivo Pig-a assay: a report of the international workshop on genotoxicity testing (IWGT) workgroup. Mutat. Res. 783 (2015), 23–25.
4. [4] Kimoto, T., Chikura, S., Suzuki, K., Kobayashi, X.M., Itano, Y., Horibata, K., et al. Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ. Mol. Mutagen. 52 (2011), 774–783.
5. [5] Somerharju, P., Pyrene-labeled lipids as tools in membrane biophysics and cell biology. Chem. Phys. Lipids 116 (2002), 57–74.
6. [6] Bains, G., Patel, A.B., Narayanaswami, V., Pyrene: a probe to study protein conformation and conformational changes. Molecules 16 (2011), 7909–7935.
7. [7] Bos, R.P., Theuws, J.L.G., Jongeneelen, F.J., Th Henderson, P., Mutagenicity of bi-, tri- and tetra-cyclic aromatic hydrocarbons in the taped-plate assay and in the conventional salmonella mutagenicity assay. Mutat. Res. 204 (1988), 203–206.
8. [8] O'Donovan, M.R., The comparative responses of salmonella typhimurium TA1537 and TA97a to a range of reference mutagens and novel compounds. Mutagenesis 5 (1990), 267–274.
9. [9] Mamber, S.W., Bryson, V., Katz, S.E., The escherichia coli WP2/WP 100 rec assay for detection of potential chemical carcinogens. Mutat. Res. 119 (1983), 135–144.
10. [10] Matijašević, Z., Zeiger, E., Mutagenicity of pyrene in salmonella. Mutat. Res. 142 (1985), 149–152.
11. [11] Nagao, M., Sugimura, T., Mutagenesis: microbial systems. Gelboin, H.V., TS'O, P.O.P., (eds.) Polycyclic Hydrocarbons and Cancer, vol. 2, 1978, Academic Press Inc, New York, 99–122 Molecular and Cell Biology.
12. 1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies. Mutagenesis 25 (2010), 33–40.
13. [13] Abe, S., Sasaki, M., Studies on chromosomal aberrations and sister chromatid exchanges induced by chemicals. Proc. Jpn. Acad. 53 (1977), 46–49.
14. [14] Latt, S.A., Allen, J., Bloom, S.E., Carrano, A., Falke, E., Kram, D., Wolff, S., et al. Sister-chromatid exchanges: a report of the GENE-TOX program. Mutat. Res. 87 (1981), 17–62.
15. [15] Ashby, J., Shelby, M.D., de Serres, F.J., The IPCS in vivo collaborative study: overview and conclusions. Ashby, J., et, al., (eds.) Evaluation of Short-Term Tests for Carcinogens, vol 1, 1988, Cambridge University Press, Cambridge, 6–27.
16. [16] Torous, D.K., Phonethepswath, S., Avlasevich, S.L., Mereness, J., Bryce, S.M., Bemis, J.C., et al. In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs. Environ. Mol. Mutagen. 53 (2012), 420–428.
17. [17] Pyrene, I.A.R.C., Polynuclear aromatic compounds, part 1, chemical, environmental and experimental data. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol 32, 1983, International Agency for Research on Cancer, Lyon.
18. [18] Itoh, S., Nagata, M., Hattori, C., Takasaki, W., In vivo mutagenicity of ethyl methanesulfonate detected by Pig-a and PIGRET assays. Genes Environ. 36 (2014), 174–178.
19. [19] Sanada, H., Okamoto, M., Ohsumi, T., Nakamura, T., Evaluation for a mutagenicity of 4,4'-methylenedianiline on hematopoietic cells by a Pig-a gene mutation assay in rats. Genes Environ. 36 (2014), 179–185.
20. [20] Muto, S., Yamada, K., Kato, T., Iwase, Y., Uno, Y., Pig-a gene mutation and micronucleus induction in rat peripheral blood by methyl methanesulfonate. Genes Environ. 36 (2014), 186–190.
21. [21] Horibata, K., Ukai, A., Honma, M., Evaluation of rats’ In vivo genotoxicity induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt assays. Genes Environ. 36 (2014), 199–202.
22. [22] Kimoto, T., Horibata, K., Chikura, S., Hashimoto, K., Itoh, S., Sanada, H., et al. Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat. Res. 755 (2013), 126–134.
23. [23] Kimoto, T., et al. The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: summary of the MMS/JEMS-collaborative study across 16 laboratoriesusing 24 chemicals. Mutat. Res. 811 (2016), 3–15.
24. [24] Labash, C., Avlasevich, S.L., Carlson, K., Berg, A., Torous, D.K., Bryce, S.M., Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate. Environ. Mol. Mutagen 57 (2016), 28–40.