Myocardial T1 maps reflect histological findings in acute and chronic stages of myocarditis in a rat model

Journal of Cardiovascular Magnetic Resonance

Volumn 18, Issue 1, 2016, Pages

  Jeuthe, Sarah ^a   Wassilew, Katharina ^a   Oh Ici, Darach ^a   Da Silva, Tiago Ferreira ^a   Münch, Frédéric ^a   Berger, Felix ^a   Kuehne, Titus ^a   Pieske, Burkert ^a   Messroghli, Daniel R ^a  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Autoimmune myocarditis; Cardiovascular magnetic resonance; Dilated cardiomyopathy; Lewis rat; T1 mapping

Indexed keywords

CD68 ANTIGEN; GADOBUTROL; CD68 PROTEIN, RAT; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC IMAGING; CARDIAC MAPPING SYSTEM; CARDIAC T1 MAPPING; CONTRAST ENHANCEMENT; DISEASE SEVERITY; ELECTROCARDIOGRAM; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MALE; MEASUREMENT ACCURACY; MORBIDITY; MYOCARDITIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RAT; ACUTE DISEASE; ANIMAL; AUTOIMMUNE DISEASE; CARDIAC MUSCLE; CHEMICALLY INDUCED; CHRONIC DISEASE; CONGESTIVE CARDIOMYOPATHY; DISEASE MODEL; IMMUNOLOGY; LEWIS RAT; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; TIME FACTOR;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AUTOIMMUNE DISEASES; CARDIOMYOPATHY, DILATED; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MYOCARDITIS; MYOCARDIUM; MYOSINS; PREDICTIVE VALUE OF TESTS; RATS, INBRED LEW; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 84966341162     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/s12968-016-0241-6     Document Type: Article

References (40)

1. Cooper LT. Myocarditis. N Engl J Med. 2009;360:1526-38.
2. Moon H, Park HE, Kang J, Lee H, Cheong C, Lim YT, Ihm S-H, Seung K-B, Jaffer FA, Narula J, et al. Noninvasive assessment of myocardial inflammation by cardiovascular magnetic resonance in a rat model of experimental autoimmune myocarditis. Circulation. 2012;125:2603-12.
3. Skouri HN, Dec GW, Friedrich MG, Cooper LT. Noninvasive imaging in myocarditis. J Am Coll Cardiol. 2006;48:2085-93.
4. Felker GM, Jaeger CJ, Klodas E, Thiemann DR, Hare JM, Hruban RH, Kasper EK, and Baughman KL. Myocarditis and long-term survival in peripartum cardiomyopathy. Am Heart J. 2000;140:785-91.
5. Maisch B, Richter A, Sandmöller A, Portig I, Pankuweit S, BMBF-Heart Failure Network. Inflammatory dilated cardiomyopathy (DCMI). Herz. 2005;30:535-44.
6. Kromen W, Korkusuz H, Korkusuz Y, Esters P, Bauer RW, Huebner F, Lindemayr S, and Vogl TJ. Correlation of left ventricular wall thickness, heart mass, serological parameters and late gadolinium enhancement in cardiovascular magnetic resonance imaging of myocardial inflammation in an experimental animal model of autoimmune myocarditis. Int J Cardiovasc Imaging. 2012;28:1983-97.
7. Yelgec NS, Dymarkowski S, Ganame J, Bogaert J. Value of MRI in patients with a clinical suspicion of acute myocarditis. Eur Radiol. 2007;17:2211-7.
8. Billingham ME. Acute myocarditis: is sampling error a contraindication for diagnostic biopsies? J Am Coll Cardiol. 1989;14:921-2.
9. Lie JT. Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease. Ann Intern Med. 1988;109:525-8.
10. Yilmaz A, Kindermann I, Kindermann M, Mahfoud F, Ukena C, Athanasiadis A, Hill S, Mahrholdt H, Voehringer M, Schieber M, et al. Comparative evaluation of left and right ventricular endomyocardial biopsy: differences in complication rate and diagnostic performance. Circulation. 2010;122:900-9.
11. Laissy J-P, Hyafil F, Feldman LJ, Juliard J-M, Schouman-Claeys E, Steg PG, and Faraggi, M. Differentiating acute myocardial infarction from myocarditis: diagnostic value of early- and delayed-perfusion cardiac MR imaging. Radiology. 2005;237:75-82.
12. Deckers JW, Hare JM, Baughman KL. Complications of transvenous right ventricular endomyocardial biopsy in adult patients with cardiomyopathy: a seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral center. J Am Coll Cardiol. 1992;19:43-7.
13. Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, Hoffmann W, Morguet A, Witzenbichler B, Tschöpe C, Schultheiss H-P, et al. Complication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year period. Circulation. 2008;118:1722-8.
14. Codreanu A, Djaballah W, Angioi M, Ethevenot G, Moulin F, Felblinger J, Sadoul N, Karcher G, Aliot E, and Marie PY. Detection of myocarditis by contrast-enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis. J Magn Reson Imaging. 2007;25:957-64.
15. Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT, White JA, Abdel-Aty H, Gutberlet M, Prasad S, et al. Cardiovascular magnetic resonance in myocarditis: A JACC white paper. J Am Coll Cardiol. 2009;53:1475-87.
16. Marcu CB, Beek AM, van Rossum AC. Clinical applications of cardiovascular magnetic resonance imaging. CMAJ. 2006;175:911-7.
17. Sechtem U, Mahrholdt H, Vogelsberg H. Cardiac magnetic resonance in myocardial disease. Heart Br Card Soc. 2007;93:1520-7.
18. Mahrholdt H, Wagner A, Deluigi CC, Kispert E, Hager S, Meinhardt G, Vogelsberg H, Fritz P, Dippon J, Bock C-T, et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation. 2006;114:1581-90.
19. Abdel-Aty H, Boyé P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, Bock P, Dietz R, Friedrich MG, and Schulz-Menger J. Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol. 2005;45:1815-22.
20. Flett AS, Hayward MP, Ashworth MT, Hansen MS, Taylor AM, Elliott PM, McGregor C, and Moon JC. Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation. 2010;122:138-44.
21. Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, Kaye DM, and Taylor AJ. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol. 2008;52:1574-80.
22. Messroghli DR, Nordmeyer S, Dietrich T, Dirsch O, Kaschina E, Savvatis K, O h-Ici D., Klein C, Berger F, and Kuehne T. Assessment of diffuse myocardial fibrosis in rats using small-animal Look-Locker inversion recovery T1 mapping. Circ Cardiovasc Imaging. 2011;4:636-40.
23. Mewton N, Liu CY, Croisille P, Bluemke D, Lima JAC. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol. 2011;57:891-903.
24. Kodama M, Tachikawa H, Kashimura T, Hayashi M, Yoshida T, Hanawa H, Aizawa Y, Nakazawa M, and Watanabe K. Effects of humoral factors on left ventricular remodeling under chronic heart failure. Nihon Yakurigaku Zasshi Folia Pharmacol Jpn. 2004;123:63-70.
25. Korkusuz H, Esters P, Naguib N, Nour Eldin N-E, Lindemayr S, Huebner F, Koujan A, Bug R, Ackermann H, and Vogl TJ. Acute myocarditis in a rat model: Late Gadolinium Enhancement with histopathological correlation. Eur Radiol. 2009;19:2672-8.
26. Korkusuz H, Esters P, Huebner F, Bug R, Ackermann H, Vogl TJ. Accuracy of cardiovascular magnetic resonance in myocarditis: comparison of MR and histological findings in an animal model. J Cardiovasc Magn Reson. 2010;12:49.
27. Godsel LM, Leon JS, Wang K, Fornek JL, Molteni A, Engman DM. Captopril prevents experimental autoimmune myocarditis. J Immunol Baltim Md 1950. 2003;171:346-52.
28. Kodama M, Matsumoto Y, Fujiwara M, Masani F, Izumi T, Shibata A. A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction. Clin Immunol Immunopathol. 1990;57:250-62.
29. Kodama M, Matsumoto Y, Fujiwara M, Zhang SS, Hanawa H, Itoh E, Tsuda T, Izumi T, Shibata A. Characteristics of giant cells and factors related to the formation of giant cells in myocarditis. Circ Res. 1991;69:1042-50.
30. Schmerler P, Jeuthe S, O h-Ici D, Wassilew K, Lauer D, Kaschina E, Kintscher, U, Müller, S, Muench F, Kuehne T, et al. Mortality and morbidity in different immunization protocols for experimental autoimmune myocarditis in rats. Acta Physiol Oxf Engl. 2014;210:889-98.
31. Messroghli DR, Nordmeyer S, Buehrer M, Kozerke S, Dietrich T, Kaschina E, Becher PM, Hucko T, Berger F, Klein C, Kuehne T. Small animal Look-Locker inversion recovery (SALLI) for simultaneous generation of cardiac T1 maps and cine and inversion recovery-prepared images at high heart rates: initial experience. Radiology. 2011;261(1):258-65.
32. Bleuel H, Deschl U, Bertsch T, Bölz G, Rebel W. Diagnostic efficiency of troponin T measurements in rats with experimental myocardial cell damage. Exp Toxicol Pathol. 1995;47:121-7.
33. Arteaga E, de Araújo AQ, Bernstein M, Ramires FJA, Ianni BM, Fernandes F, Mady C. Prognostic value of the collagen volume fraction in hypertrophic cardiomyopathy. Arq Bras Cardiol. 2009;92:210-4. 216-220.
34. Ferreira VM, Piechnik SK, Dall'Armellina E, Karamitsos TD, Francis JM, Ntusi N, Holloway, C, Choudhury RP, Kardos A, Robson MD, et al. T(1) mapping for the diagnosis of acute myocarditis using CMR: comparison to T2-weighted and late gadolinium enhanced imaging. JACC Cardiovasc Imaging. 2013;6:1048-58.
35. Ferreira VM, Piechnik SK, Dall'Armellina E, Karamitsos TD, Francis JM, Ntusi N Holloway C, Choudhury RP, Kardos A, Robson MD, et al. Native T1-mapping detects the location, extent and patterns of acute myocarditis without the need for gadolinium contrast agents. J Cardiovasc Magn Reson. 2014;16:36.
36. Greulich S, Ferreira VM, Dall'Armellina E, Mahrholdt H. Myocardial Inflammation-Are We There Yet? Curr Cardiovasc Imaging Rep. 2015;8:6.
37. Hinojar R, Foote L, Arroyo Ucar E, Jackson T, Jabbour A, Yu C-Y, McCrohon J, Higgins DM, Carr-White G, Mayr M, et al. Native T1 in discrimination of acute and convalescent stages in patients with clinical diagnosis of myocarditis: a proposed diagnostic algorithm using CMR. JACC Cardiovasc Imaging. 2015;8:37-46.
38. Sibley CT, Noureldin RA, Gai N, Nacif MS, Liu S, Turkbey EB, Mudd JO, van der Geest RJ, Lima JAC, Halushka MK, et al. T1 Mapping in cardiomyopathy at cardiac MR: comparison with endomyocardial biopsy. Radiology. 2012;265:724-32.
39. Frustaci A, Chimenti C. Immunosuppressive therapy in virus-negative inflammatory cardiomyopathy. Herz. 2012;37:854-8.
40. Kühl U, Schultheiss H-P. Viral myocarditis. Swiss Med Wkly. 2014;144:w14010.