Preoperative sildenafil administration in children undergoing cardiac surgery: A randomized controlled preconditioning study

European Journal of Cardio-thoracic Surgery

Volumn 49, Issue 5, 2016, Pages 1403-1410

  Walavalkara, Varsha ^a   Eversb, Egmond ^b   Pujara, Suresh ^a   Viralama, Kiran ^a   Maiyaa, Shreesha ^a   Frerichc, Stefan ^b   Johnd, Colin ^a   Raod, Shekhar ^a   Reddyd, Chinnaswamy ^a   Sproncke, Bart ^b   Prinzenb, Frits W ^b   Delhaasc, Tammo ^b   Vanagt, Ward Y ^b  

^a NARAYANA INSTITUTE OF CARDIAC SCIENCES   (India)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Cardiac surgery; Cardioprotection; Congenital heart disease; Preconditioning

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE MB; INTERLEUKIN 6; SILDENAFIL; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; AORTA CLAMPING; ARTICLE; ASSISTED VENTILATION; CARDIOPULMONARY BYPASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; ECHOCARDIOGRAPHY; ELECTIVE SURGERY; HEART MUSCLE ISCHEMIA; HEART SURGERY; HEART VENTRICLE SEPTUM DEFECT; HUMAN; INOTROPISM; LOW DRUG DOSE; MEAN ARTERIAL PRESSURE; OUTCOME ASSESSMENT; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROTEIN SECRETION; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; VENTILATION WEANING TIME; VENTRICULAR SEPTAL DEFECT CLOSURE; ADVERSE EFFECTS; BLOOD PRESSURE; DRUG EFFECTS; FEMALE; HEART; HEART DEFECTS, CONGENITAL; HEART INFARCTION PREVENTION; INFANT; MALE; MORTALITY; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROCEDURES; STATISTICS AND NUMERICAL DATA;

ADOLESCENT; BLOOD PRESSURE; CARDIAC SURGICAL PROCEDURES; CHILD; CHILD, PRESCHOOL; FEMALE; HEART; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; SILDENAFIL CITRATE;

EID: 84965174287     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezv353     Document Type: Article

References (25)

1. Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J et al. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 2006;47:2277-82.
2. Gessler P, Schmitt B, Pretre R, Latal B. Inflammatory response and neurodevelopmental outcome after open-heart surgery in children. Pediatr Cardiol 2009;30:301-5.
3. Jin Z, Duan W, Chen M, Yu S, Zhang H, Feng G et al. The myocardial protective effects of adenosine pretreatment in children undergoing cardiac surgery: a randomized controlled clinical trial. Eur J Cardiothorac Surg 2011;39:e90-6.
4. Luo W, Zhu M, Huang R, Zhang Y. A comparison of cardiac postconditioning and remote pre-conditioning in paediatric cardiac surgery. Cardiol Young 2011;21:266-70.
5. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischaemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74: 1124-36.
6. Hausenloy DJ, Yellon DM. The evolving story of 'conditioning' to protect against acute myocardial ischaemia-reperfusion injury. Heart 2007;93: 649-51.
7. Piriou V, Chiari P, Lhuillier F, Bastien O, Loufoua J, Raisky O et al. Pharmacological preconditioning: comparison of desflurane, sevoflurane, isoflurane and halothane in rabbit myocardium. Br J Anaesth 2002;89: 486-91.
8. Bremer YA, Salloum F, Ockaili R, Chou E, Moskowitz WB, Kukreja RC. Sildenafil citrate (viagra) induces cardioprotective effects after ischaemia/ reperfusion injury in infant rabbits. Pediatr Res 2005;57:22-7.
9. Das S, Maulik N, Das DK, Kadowitz PJ, Bivalacqua TJ. Cardioprotection with sildenafil, a selective inhibitor of cyclic 30,50-monophosphate-specific phosphodiesterase 5. Drugs Exp Clin Res 2002;28:213-9.
10. du Toit EF, Rossouw E, Salie R, Opie LH, Lochner A. Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model. Cardiovasc Drugs Ther 2005;19:23-31.
11. Kukreja RC, Salloum F, Das A, Ockaili R, Yin C, Bremer YA et al. Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications. Vascul Pharmacol 2005;42:219-32.
12. Ockaili R, Salloum F, Hawkins J, Kukreja RC. Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K (ATP) channels in rabbits. Am J Physiol Heart Circ Physiol 2002;283: H1263-9.
13. Salloum F, Yin C, Xi L, Kukreja RC. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ Res 2003;92:595-7.
14. Das A, Xi L, Kukreja RC. Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 2005;280:12944-55.
15. Karatza AA, Bush A, Magee AG. Safety and efficacy of sildenafil therapy in children with pulmonary hypertension. Int J Cardiol 2005;100: 267-73.
16. Botha P, Parry G, Dark JH, Macgowan GA. Acute haemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition. J Heart Lung Transplant 2009; 28:676-82.
17. Jones BO, Pepe S, Sheeran FL, Donath S, Hardy P, Shekerdemian L et al. Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial. J Thorac Cardiovasc Surg 2013;146:1334-40.
18. R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2015.
19. Pinheiro J, Bates D, DebRoy S, Sarkar D, R Core Team. nlme: Linear and Nonlinear Mixed Effects Models. 2015; R package version 3.1-120, http://CRAN.R-project.org/package=nlme (1 August 2015, date last accessed).
20. Gelman A, Hill J. Data Analysis Using Regression and Multilevel/Hierarchical Models. Cambridge, New York: Cambridge University Press, 2007.
21. Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J 2008;50:346-63.
22. Pepe S, Liaw NY, Hepponstall M, Sheeran FL, Yong MS, d'Udekem Y et al. Effect of remote ischemic preconditioning on phosphorylated protein signaling in children undergoing tetralogy of Fallot repair: a randomized controlled trial. J Am Heart Assoc 2013;2:e000095.
23. Lecour S, Botker HE, Condorelli G, Davidson SM, Garcia-Dorado D, Engel FB et al. ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovasc Res 2014;104:399-411.
24. Jones SP, Tang XL, Guo Y, Steenbergen C, Lefer DJ, Kukreja RC et al. The NHLBI-Sponsored Consortium for preclinicAl assESsment of cARdioprotective Therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs. Circ Res 2015;116:572-86.
25. Barst RJ, Beghetti M, Pulido T, Layton G, Konourina I, Zhang M et al. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. Circulation 2014;129:1914-23.