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Volumn 61, Issue , 2016, Pages 111-121

Role of the novel generation of androgen receptor pathway targeted agents in the management of castration-resistant prostate cancer: A literature based meta-analysis of randomized trials

Author keywords

Abiraterone acetate; Enzalutamide; Orteronel; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; PROSTATE SPECIFIC ANTIGEN; ANDROGEN RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT;

EID: 84965149689     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2016.04.002     Document Type: Review
Times cited : (48)

References (40)
  • 1
    • 84860476716 scopus 로고    scopus 로고
    • Changes in incidence, survival and mortality of prostate cancer in Europe and the United States in the PSA era: Additional diagnoses and avoided deaths
    • May
    • C. Neppl-Huber, M. Zappa, J.W. Coebergh, E. Rapiti, J. Rachtan, B. Holleczek, et al. EUNICE Survival Working Group Changes in incidence, survival and mortality of prostate cancer in Europe and the United States in the PSA era: additional diagnoses and avoided deaths Ann Oncol 23 5 2012 May 1325 1334
    • (2012) Ann Oncol , vol.23 , Issue.5 , pp. 1325-1334
    • Neppl-Huber, C.1    Zappa, M.2    Coebergh, J.W.3    Rapiti, E.4    Rachtan, J.5    Holleczek, B.6
  • 2
    • 84905089818 scopus 로고    scopus 로고
    • Metastatic castration-resistant prostate cancer (CRPC): Preclinical and clinical evidence for the sequential use of novel therapeutics
    • Sep
    • D. Mukherji, A. Omlin, C. Pezaro, A. Shamseddine, and J. de Bono Metastatic castration-resistant prostate cancer (CRPC): preclinical and clinical evidence for the sequential use of novel therapeutics Cancer Metastasis Rev 33 2-3 2014 Sep 555 566
    • (2014) Cancer Metastasis Rev , vol.33 , Issue.2-3 , pp. 555-566
    • Mukherji, D.1    Omlin, A.2    Pezaro, C.3    Shamseddine, A.4    De Bono, J.5
  • 4
    • 84866770294 scopus 로고    scopus 로고
    • AFFIRM investigators increased survival with enzalutamide in prostate cancer after chemotherapy
    • H.I. Scher, K. Fizazi, F. Saad, M.E. Taplin, C.N. Sternberg, K. Miller, and et al. AFFIRM investigators increased survival with enzalutamide in prostate cancer after chemotherapy N Engl J Med 367 2012 1187 1197
    • (2012) N Engl J Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3    Taplin, M.E.4    Sternberg, C.N.5    Miller, K.6
  • 5
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • C.J. Ryan, M.R. Smith, J.S. de Bono, and et al. Abiraterone in metastatic prostate cancer without previous chemotherapy N Engl J Med 368 2013 138 148
    • (2013) N Engl J Med , vol.368 , pp. 138-148
    • Ryan, C.J.1    Smith, M.R.2    De Bono, J.S.3
  • 7
    • 84925006635 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5
    • Mar 1
    • K. Fizazi, R. Jones, S. Oudard, E. Efstathiou, F. Saad, R. de Wit, and et al. Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5 J Clin Oncol 33 7 2015 Mar 1 723 731
    • (2015) J Clin Oncol , vol.33 , Issue.7 , pp. 723-731
    • Fizazi, K.1    Jones, R.2    Oudard, S.3    Efstathiou, E.4    Saad, F.5    De Wit, R.6
  • 8
    • 84925016549 scopus 로고    scopus 로고
    • Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): A double-blind, multicentre, phase 3, randomised, placebo-controlled trial
    • Mar
    • F. Saad, K. Fizazi, V. Jinga, E. Efstathiou, P.C. Fong, L.L. Hart, et al. ELM-PC 4 investigators Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial Lancet Oncol 16 3 2015 Mar 338 348
    • (2015) Lancet Oncol , vol.16 , Issue.3 , pp. 338-348
    • Saad, F.1    Fizazi, K.2    Jinga, V.3    Efstathiou, E.4    Fong, P.C.5    Hart, L.L.6
  • 9
    • 84894543538 scopus 로고    scopus 로고
    • Beyond abiraterone: New hormonal therapies for metastatic castration-resistant prostate cancer
    • Feb
    • Á. Pinto Beyond abiraterone: new hormonal therapies for metastatic castration-resistant prostate cancer Cancer Biol Ther 15 2 2014 Feb 149 155
    • (2014) Cancer Biol Ther , vol.15 , Issue.2 , pp. 149-155
    • Pinto, Á.1
  • 10
    • 70349395222 scopus 로고    scopus 로고
    • Anti-androgens and androgen-depleting therapies in prostate cancer: New agents for an established target
    • Y. Chen, N.J. Clegg, and H.I. Scher Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target Lancet Oncol 10 2009 981 991
    • (2009) Lancet Oncol , vol.10 , pp. 981-991
    • Chen, Y.1    Clegg, N.J.2    Scher, H.I.3
  • 11
    • 79959233647 scopus 로고    scopus 로고
    • Targeting continued androgen receptor signaling in prostate cancer
    • PMID:21680543
    • C. Massard, and K. Fizazi Targeting continued androgen receptor signaling in prostate cancer Clin Cancer Res 17 2011 3876 3883 PMID:21680543
    • (2011) Clin Cancer Res , vol.17 , pp. 3876-3883
    • Massard, C.1    Fizazi, K.2
  • 12
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
    • D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement PLoS Med 6 2009 e1000097
    • (2009) PLoS Med , vol.6 , pp. e1000097
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 15
    • 41049093347 scopus 로고
    • The combination of estimates from different experiments
    • W.G. Cochran The combination of estimates from different experiments Biometrics 10 1954 101 129
    • (1954) Biometrics , vol.10 , pp. 101-129
    • Cochran, W.G.1
  • 17
    • 84959368921 scopus 로고    scopus 로고
    • Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): A randomised, double-blind, phase 2 study
    • Jan 13 pii: S1470-2045(15) 00518-5
    • N.D. Shore, S. Chowdhury, A. Villers, L. Klotz, D.R. Siemens, Phung, and et al. Efficacy and safety of enzalutamide versus bicalutamide for patients with metastatic prostate cancer (TERRAIN): a randomised, double-blind, phase 2 study Lancet Oncol 2016 Jan 13 pii: S1470-2045(15) 00518-5
    • (2016) Lancet Oncol
    • Shore, N.D.1    Chowdhury, S.2    Villers, A.3    Klotz, L.4    Siemens, D.R.5    Phung6
  • 19
    • 84866948935 scopus 로고    scopus 로고
    • Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: Final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
    • Oct Erratum in: Lancet Oncol. 2012 Nov;13(11):e464. Lancet Oncol. 2014 Aug;15(9):e365
    • K. Fizazi, H.I. Scher, A. Molina, C.J. Logothetis, K.N. Chi, R.J. Jones, et al. COU-AA-301 Investigators Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study Lancet Oncol 13 10 2012 Oct 983 992 Erratum in: Lancet Oncol. 2012 Nov;13(11):e464. Lancet Oncol. 2014 Aug;15(9):e365
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 983-992
    • Fizazi, K.1    Scher, H.I.2    Molina, A.3    Logothetis, C.J.4    Chi, K.N.5    Jones, R.J.6
  • 20
    • 84921846878 scopus 로고    scopus 로고
    • Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study
    • Feb
    • C.J. Ryan, M.R. Smith, K. Fizazi, F. Saad, P.F. Mulders, C.N. Sternberg, et al. COU-AA-302 Investigators Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study Lancet Oncol 16 2 2015 Feb 152 160
    • (2015) Lancet Oncol , vol.16 , Issue.2 , pp. 152-160
    • Ryan, C.J.1    Smith, M.R.2    Fizazi, K.3    Saad, F.4    Mulders, P.F.5    Sternberg, C.N.6
  • 21
    • 84870243969 scopus 로고    scopus 로고
    • Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: Exploratory analysis of data from the COU-AA-301 randomised trial
    • Dec
    • C.J. Logothetis, E. Basch, A. Molina, K. Fizazi, S.A. North, K.N. Chi, and et al. Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial Lancet Oncol 13 12 2012 Dec 1210 1217
    • (2012) Lancet Oncol , vol.13 , Issue.12 , pp. 1210-1217
    • Logothetis, C.J.1    Basch, E.2    Molina, A.3    Fizazi, K.4    North, S.A.5    Chi, K.N.6
  • 22
    • 84907585184 scopus 로고    scopus 로고
    • Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302)
    • Nov
    • D.E. Rathkopf, M.R. Smith, J.S. de Bono, C.J. Logothetis, N.D. Shore, P. de Souza, and et al. Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302) Eur Urol 66 5 2014 Nov 815 825
    • (2014) Eur Urol , vol.66 , Issue.5 , pp. 815-825
    • Rathkopf, D.E.1    Smith, M.R.2    De Bono, J.S.3    Logothetis, C.J.4    Shore, N.D.5    De Souza, P.6
  • 23
    • 84933674851 scopus 로고    scopus 로고
    • Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): Results from a randomised, phase 3 trial
    • May
    • Y. Loriot, K. Miller, C.N. Sternberg, K. Fizazi, J.S. De Bono, S. Chowdhury, and et al. Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): results from a randomised, phase 3 trial Lancet Oncol 16 5 2015 May 509 521
    • (2015) Lancet Oncol , vol.16 , Issue.5 , pp. 509-521
    • Loriot, Y.1    Miller, K.2    Sternberg, C.N.3    Fizazi, K.4    De Bono, J.S.5    Chowdhury, S.6
  • 24
    • 84957698351 scopus 로고    scopus 로고
    • Enzalutamide (ENZA) in men with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC): Final analysis of the phase 3 PREVAIL study
    • abstr 5036
    • T.M. Beer, A.J. Armstrong, C.N. Sternberg, C.S. Higano, D.E. Rathkopf, Y. Loriot, and et al. Enzalutamide (ENZA) in men with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC): final analysis of the phase 3 PREVAIL study J Clin Oncol 33 2015 (suppl; abstr 5036)
    • (2015) J Clin Oncol , vol.33
    • Beer, T.M.1    Armstrong, A.J.2    Sternberg, C.N.3    Higano, C.S.4    Rathkopf, D.E.5    Loriot, Y.6
  • 25
    • 84924778567 scopus 로고    scopus 로고
    • Corticosteroids in the management of prostate cancer: A critical review
    • Feb
    • C. Ndibe, C.G. Wang, and G. Sonpavde Corticosteroids in the management of prostate cancer: a critical review Curr Treat Options Oncol 16 2 2015 Feb 6
    • (2015) Curr Treat Options Oncol , vol.16 , Issue.2 , pp. 6
    • Ndibe, C.1    Wang, C.G.2    Sonpavde, G.3
  • 27
    • 27644452640 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    • M.A. Titus, M.J. Schell, F.B. Lih, and et al. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer Clin Cancer Res 11 2005 4653 4657
    • (2005) Clin Cancer Res , vol.11 , pp. 4653-4657
    • Titus, M.A.1    Schell, M.J.2    Lih, F.B.3
  • 28
    • 54849435425 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    • P.R. Dillard, M.F. Lin, and S.A. Khan Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol Mol Cell Endocrinol 295 2008 115 120
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 115-120
    • Dillard, P.R.1    Lin, M.F.2    Khan, S.A.3
  • 29
    • 0042978480 scopus 로고    scopus 로고
    • Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer
    • J. Edwards, N.S. Krishna, K.M. Grigor, and et al. Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer Br J Cancer 89 2003 552 556
    • (2003) Br J Cancer , vol.89 , pp. 552-556
    • Edwards, J.1    Krishna, N.S.2    Grigor, K.M.3
  • 30
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 31
    • 84938199873 scopus 로고    scopus 로고
    • The third line of treatment for metastatic prostate cancer patients: Option or strategy?
    • May 21 pii: S1040-8428(15) 00087-6
    • G. Roviello, R. Petrioli, L. Laera, and E. Francini The third line of treatment for metastatic prostate cancer patients: option or strategy? Crit Rev Oncol Hematol 2015 May 21 pii: S1040-8428(15) 00087-6
    • (2015) Crit Rev Oncol Hematol
    • Roviello, G.1    Petrioli, R.2    Laera, L.3    Francini, E.4
  • 32
    • 84907516347 scopus 로고    scopus 로고
    • No clear evidence of a clinical benefit of a sequential therapy regimen with abiraterone acetate and enzalutamide
    • Aug 19
    • E. Francini, R. Petrioli, and G. Roviello No clear evidence of a clinical benefit of a sequential therapy regimen with abiraterone acetate and enzalutamide Expert Rev Anticancer Ther 2014 Aug 19 1 6
    • (2014) Expert Rev Anticancer Ther , pp. 1-6
    • Francini, E.1    Petrioli, R.2    Roviello, G.3
  • 33
    • 84922392398 scopus 로고    scopus 로고
    • How to optimize the sequential use of novel therapeutics in metastatic prostate cancer patients? Response should be found in prostate cancer tissue
    • May 30
    • E. Francini, and G. Roviello How to optimize the sequential use of novel therapeutics in metastatic prostate cancer patients? Response should be found in prostate cancer tissue Tumour Biol 2014 May 30
    • (2014) Tumour Biol
    • Francini, E.1    Roviello, G.2
  • 34
    • 84939574968 scopus 로고    scopus 로고
    • Role of chemotherapy in the treatment of metastatic castration-resistant prostate cancer patients who have progressed after abiraterone acetate
    • Jun 17
    • R. Petrioli, E. Francini, L. Laera, A.I. Fiaschi, R. Ponchietti, and G. Roviello Role of chemotherapy in the treatment of metastatic castration-resistant prostate cancer patients who have progressed after abiraterone acetate Cancer Chemother Pharmacol 2015 Jun 17
    • (2015) Cancer Chemother Pharmacol
    • Petrioli, R.1    Francini, E.2    Laera, L.3    Fiaschi, A.I.4    Ponchietti, R.5    Roviello, G.6
  • 35
    • 84905911748 scopus 로고    scopus 로고
    • Activity of cabazitaxel in castration-resistant prostate cancer progressing after docetaxel and next-generation endocrine agents
    • C.J. Pezaro, A.G. Omlin, A. Altavilla, and et al. Activity of cabazitaxel in castration-resistant prostate cancer progressing after docetaxel and next-generation endocrine agents Eur Urol 66 2014 459 465
    • (2014) Eur Urol , vol.66 , pp. 459-465
    • Pezaro, C.J.1    Omlin, A.G.2    Altavilla, A.3
  • 36
    • 84945125657 scopus 로고    scopus 로고
    • Is there still a place for docetaxel rechallenge in prostate cancer?
    • R. Petrioli, E. Francini, and G. Roviello Is there still a place for docetaxel rechallenge in prostate cancer? World J Clin Oncol 6 5 2015 99 103
    • (2015) World J Clin Oncol , vol.6 , Issue.5 , pp. 99-103
    • Petrioli, R.1    Francini, E.2    Roviello, G.3
  • 37
    • 84908125722 scopus 로고    scopus 로고
    • Abiraterone acetate for patients with metastatic castration-resistant prostate cancer progressing after chemotherapy: Final analysis of a multicentre, open-label, early-access protocol trial
    • Oct Erratum in: Lancet Oncol. 2014 Nov;15(12):e528
    • C.N. Sternberg, D. Castellano, G. Daugaard, L. Géczi, S.J. Hotte, P.N. Mainwaring, et al. Abiraterone Global EAP Investigators Abiraterone acetate for patients with metastatic castration-resistant prostate cancer progressing after chemotherapy: final analysis of a multicentre, open-label, early-access protocol trial Lancet Oncol 15 11 2014 Oct 1263 1268 Erratum in: Lancet Oncol. 2014 Nov;15(12):e528
    • (2014) Lancet Oncol , vol.15 , Issue.11 , pp. 1263-1268
    • Sternberg, C.N.1    Castellano, D.2    Daugaard, G.3    Géczi, L.4    Hotte, S.J.5    Mainwaring, P.N.6
  • 38
    • 84927748742 scopus 로고    scopus 로고
    • Safety and clinical outcomes of patients treated with abiraterone acetate after docetaxel: Results of the Italian Named Patient Programme
    • May
    • O. Caffo, U. De Giorgi, L. Fratino, G. Lo Re, U. Basso, A. D'Angelo, and et al. Safety and clinical outcomes of patients treated with abiraterone acetate after docetaxel: results of the Italian Named Patient Programme BJU Int 115 5 2015 May 764 771
    • (2015) BJU Int , vol.115 , Issue.5 , pp. 764-771
    • Caffo, O.1    De Giorgi, U.2    Fratino, L.3    Lo Re, G.4    Basso, U.5    D'Angelo, A.6
  • 39
    • 84927912624 scopus 로고    scopus 로고
    • Safety of enzalutamide in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Expanded access in North America
    • Jun
    • A.M. Joshua, N.D. Shore, F. Saad, K.N. Chi, C.A. Olsson, U. Emmenegger, et al. Enzalutamide Expanded Access Study Investigators Safety of enzalutamide in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: expanded access in North America Prostate 75 8 2015 Jun 836 844
    • (2015) Prostate , vol.75 , Issue.8 , pp. 836-844
    • Joshua, A.M.1    Shore, N.D.2    Saad, F.3    Chi, K.N.4    Olsson, C.A.5    Emmenegger, U.6
  • 40
    • 84939572850 scopus 로고    scopus 로고
    • The incidence and relative risk of cardiovascular toxicity in patients treated with new hormonal agents for castration-resistant prostate cancer
    • Jul 10 pii: S0959-8049(15) 00621-8
    • R. Iacovelli, E. Verri, M. Cossu Rocca, G. Aurilio, D. Cullurà, O. De Cobelli, and et al. The incidence and relative risk of cardiovascular toxicity in patients treated with new hormonal agents for castration-resistant prostate cancer Eur J Cancer 2015 Jul 10 pii: S0959-8049(15) 00621-8
    • (2015) Eur J Cancer
    • Iacovelli, R.1    Verri, E.2    Cossu Rocca, M.3    Aurilio, G.4    Cullurà, D.5    De Cobelli, O.6


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