Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma

Clinical and Experimental Allergy

Volumn 46, Issue 9, 2016, Pages 1152-1161

  Nakamura, Y ^a   Suzuki, R ^a   Mizuno, T ^a   Abe, K ^a   Chiba, S ^a   Horii, Y ^a   Tsuboi, J ^a   Ito, S ^a   Obara, W ^a   Tanita, T ^a   Kanno, H ^b   Yamauchi, K ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

airway remodelling; asthma; bronchial biopsy; genetic variation; IL13; single nucleotide polymorphisms; STAT4

Indexed keywords

CORTICOSTEROID; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYALURONIC ACID; IMMUNOGLOBULIN E; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 23; INTERLEUKIN 24; INTERLEUKIN 4; INTERLEUKIN 5; MONOCYTE CHEMOTACTIC PROTEIN 2; STAT4 PROTEIN; ANTIASTHMATIC AGENT; BIOLOGICAL MARKER; CYTOKINE;

ADULT; AIRWAY REMODELING; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE COURSE; DRUG EFFECT; DRUG MEGADOSE; EOSINOPHIL COUNT; FEMALE; FIBEROPTIC BRONCHOSCOPY; FORCED EXPIRATORY VOLUME; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; LONG TERM CARE; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SPECIMEN HANDLING; TRACHEOBRONCHIAL TOILET; ALLELE; BRONCHOALVEOLAR LAVAGE FLUID; DRUG EFFECTS; EOSINOPHIL; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; LUNG FUNCTION TEST; METABOLISM; MIDDLE AGED; PATHOLOGY; RESPIRATORY MUCOSA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; AIRWAY REMODELING; ALLELES; ANTI-ASTHMATIC AGENTS; ASTHMA; BIOMARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; EOSINOPHILS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-13; LEUKOCYTE COUNT; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUCOSA; STAT4 TRANSCRIPTION FACTOR;

EID: 84965123548     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12710     Document Type: Article

References (41)

1. Global Initiative for asthma, Global Strategy for Asthma Management and Prevention 2014. http://www.ginasthma.org/documents/4 (Last accessed 10 May 2014)
2. Kay AB. Asthma and inflammation. J Allergy Clin Immunol 1991; 87:893–910.
3. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012; 18:716–25.
4. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest 2003; 111:291–7.
5. Battle NC, Choudhry S, Tsai HJ et al. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma. Am J Respir Crit Care Med 2007; 175:881–7.
6. Park HW, Lee JE, Kim SH et al. Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: a cross-sectional population-based study in Korea. Respir Med 2009; 103:284–8.
7. Nagashima H, Nakamura Y, Kanno H et al. Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma. Allergy Int 2011; 60:291–8.
8. Utsumi Y, Sasaki N, Nagashima H et al. Association of IL-13 gene polymorphisms with airway hyperresponsiveness in a Japanese adult asthmatic population. Res Invest 2013; 51:147–52.
9. Beghé B, Hall IP, Parker SG et al. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 2010; 65:474–81.
10. Sumino K, Tucker J, Shahab M et al. Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life. J Allergy Clin Immunol 2012; 129:1267–73.
11. Mallia P, Johnston SL. How viral infections cause exacerbation of airway diseases. Chest 2006; 130:1203–10.
12. Bosco A, Ehteshami S, Stern DA, Martinez FD. Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction. Mucosal Immunol 2010; 3:399–409.
13. Li X, Hawkins GA, Ampleford EJ et al. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol 2013; 132:313–20.
14. Thierfelder WE, van Deursen JM, Yamamoto K et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382:171–4.
15. Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996; 382:174–7.
16. Gern JE, Brooks GD, Meyer P et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol 2006; 117:72–8.
17. Copenhaver CC, Gern JE, Li Z et al. Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life. Am J Respir Crit Care Med 2004; 170:175–80.
18. Gern JE, Vrtis R, Grindle KA, Swenson C, Busse WW. Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med 2000; 162:2226–31.
19. Li Y, Wu B, Xiong H, Zhu C, Zhang L. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. Respir Med 2007; 101:1977–81.
20. Park BL, Cheong HS, Kim LH et al. Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma. J Hum Genet 2005; 50:133–8.
21. Pykäläinen M, Kinos R, Valkonen S et al. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol 2005; 115:80–7.
22. Loisel DA, Du G, Ahluwalia TS et al. Genetic associations with viral respiratory illnesses and asthma control in children. Clin Exp Allergy 2016; 46:112–24.
23. Meuronen A, Karisola P, Leino M et al. Attenuated expression of tenascin-C in ovalbumin-challenged STAT4-/- mice. Respir Res 2011; 12:2.
24. Raman K, Kaplan MH, Hogaboam CM, Berlin A, Lukacs NW. STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines. J Immunol 2003; 170:3859–65.
25. Syrbe U, Hoffmann U, Schlawe K, Liesenfeld O, Erb K, Hamann A. Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice. J Immunol 2006; 177:7673–9.
26. Takishima T, Hida W, Sasaki H, Suzuki S, Sasaki T. Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application. Chest 1981; 80:600–6.
27. Nakamura Y, Hoshino M, Sim JJ, Ishii K, Hosaka K, Sakamoto T. Effect of leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma. Thorax 1998; 53:835–41.
28. Drasen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000; 56:1054–70.
29. Szefler SJ, Martin RJ, King TS et al. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002; 109:410–8.
30. Armaly MF. The heritable nature of dexamethasone-induced ocular hypertension. Arch Ophthalmol 1966; 75:32–5.
31. Schwartz JT, Reuling FH, Feinleib M, Garrison RJ, Collie DJ. Twin heritability study of the effect of corticosteroids on intraocular pressure. J Med Genet 1972; 9:137–43.
32. Hoshino M, Nakamura Y, Sim JJ et al. Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF)-I expression in bronchial asthma. Clin Exp Allergy 1998; 28:568–77.
33. Hoshino M, Takahashi M, Takai Y, Sim J. Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol 1999; 104:356–63.
34. Laitinen A, Altraja A, Kämpe M et al. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med 1997; 156:951–8.
35. Sont JK, Willems LN, Bel EH et al. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999; 159:1043–51.
36. Chetta A, Zanini A, Foresi A et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med 2003; 167:751–7.
37. Boulet LP, Turcotte H, Laviolette M et al. Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids. Am J Respir Crit Care Med 2000; 162:1308–13.
38. Baraket M, Oliver BG, Burgess JK, Lim S, King GG, Black JL. Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study. Respir Res 2012; 13:11.
39. Kim YS, Choi SJ, Choi JP et al. IL-12-Stat4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model. Exp Mol Med 2010; 42:533–46.
40. Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 1995; 11:2477–86.
41. Bochkov YA, Hanson KM, Keles S, Brockman-Shneider RA, Jarjour NN, Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol 2010; 3:69–80.