Outcomes of Clostridium difficile Infection in Hospitalized Leukemia Patients: A Nationwide Analysis

Infection Control and Hospital Epidemiology

Volumn 36, Issue 7, 2015, Pages 794-801

  Luo, Ruihong ^a   Greenberg, Alan ^b   Stone, Christian D ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b University Medical Center of Southern Nevada   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER MORTALITY; CANCER PATIENT; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; FEMALE; HOSPITAL ADMISSION; HOSPITAL CHARGE; HOSPITAL PATIENT; HUMAN; INCIDENCE; INFECTION RISK; KIDNEY FAILURE; LENGTH OF STAY; LEUKEMIA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUTROPENIA; OUTCOME ASSESSMENT; SEPSIS; STEM CELL TRANSPLANTATION; TEACHING HOSPITAL; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADVERSE EFFECTS; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; ECONOMICS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HOSPITALIZATION; MICROBIOLOGY; MORTALITY; PEPTOCLOSTRIDIUM DIFFICILE; RENAL INSUFFICIENCY; RETROSPECTIVE STUDY; RISK FACTOR; SEX DIFFERENCE; STATISTICS AND NUMERICAL DATA; UNITED STATES; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BONE MARROW TRANSPLANTATION; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; HOSPITAL CHARGES; HOSPITALIZATION; HOSPITALS, TEACHING; HUMANS; INCIDENCE; LENGTH OF STAY; LEUKEMIA; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; NEUTROPENIA; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RENAL INSUFFICIENCY; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SEX FACTORS; UNITED STATES;

EID: 84965091691     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1017/ice.2015.54     Document Type: Article

References (34)

1. Kelly CP, LaMont JT. Clostridium difficile-more difficult than ever. N Engl J Med 2008;359:1932-1940.
2. Kyne L, Hamer MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002;34:346-353.
3. Bignard GE. Risk factors for Clostridium difficile infection. J Hosp Infect 1998;40:1-15.
4. Schalk E, Bohr UR, Konig B, Scheinpflug K, Mohren M. Clostridium difficile associated diarrhea, a frequent complication in patients with acute myeloid leukemia. Ann Hematol 2010;89:9-14.
5. Cartoni C, Dragoni F, Micozzi A, et al. Neutropenic enterocolitis in patients with acute leukemia: prognostic significance of bowel wall thickening detected by ultrasonography. J Clin Oncol 2001; 19:756-761.
6. Ballett JG, Gerding DN. Clinical recognition and diagnosis of Clostridium difficile infection. Clin Infect Dis 2008;46:S12-S18.
7. Anand A, Glatt AE. Clostridium difficile infection associated with antineoplastic chemotherapy: a review. Clin Infect Dis 1993;17: 109-113.
8. Agency for Healthcare Research and Quality, Rockville, MD. Nationwide Inpatient Sample (NIS)-HCUP Coding Practices. http://www.hcup-us.ahrq.gov/db/coding.jsp. Published 2008. Accessed January 29, 2015.
9. Spadao F, Gerhardt J, Guimaraes T, et al. Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: Risk factors for severe forms and death. Rev Inst Med Trop Sao Paulo 2014;56:325-331.
10. Alonso CD, Treadway SB, Hanna DB, et al. Epidemiology and outcomes of Clostridium difficile infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 2012;54:1053-1063.
11. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353:2442-2449.
12. Cohen SH, Gerding DN, Johnson S, et al. Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431-455.
13. Dubberke ER, Reske KA, Yan Y, Olsen MA, McDonald LC, Fraser VJ. Clostridium difficile-associated disease in a setting of endemicity: identification of novel risk factors. Clin Infect Dis 2007;45:1543-1549.
14. Gafter-Gvili A, Fraser A, Paul M, Leibovici L. Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients. Ann Intern Med 2005;142:979-995.
15. Bucaneve G, Micozzi A, Menichetti F, et al. Grouppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Infection Program. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005;353:977-987.
16. Cullen M, Steven N, Billingham L, et al. Simple Investigation in Neutropenic Individuals of the Frequency of Infection after Chemotherapy Antibiotic in a Number of Tumours (SIGNIFICANT) Trial Group. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med 2005;353:988-998.
17. Pepin J, Saheb N, Coulombe MA, et al. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis 2005;41:1254-1260.
18. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353:2433-2441.
19. Dettenkofer M, Ebner W, Bertz H, et al. Surveillance of nosocomial infections in adult recipients of allogeneic and autologous bone marrow and peripheral blood stem-cell transplantation. Bone Marrow Transpl 2003;31:795-801.
20. Pant C, Anderson MP, O'Connor JA, Marshall CM, Deshpande A, Sferra TJ. Association of Clostridium difficile infection with outcomes of hospitalized solid organ transplant recipients: results from the 2009 Nationwide Inpatient Sample database. Transpl Infect Dis 2012;14:540-547.
21. Ali M, Anathakrishnan AN, Ahmad S, Kumar N, Kumar G, Saeian K. Clostridium difficile infection in hospitalized liver transplant patients: a nationwide analysis. Liver Transpl 2012;18:972-978.
22. Nguyen GC, Kaplan GG, Harris ML, Brant SR. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol 2008;103:1443-1450.
23. Miller M, Gravel D, Mulvey M, et al. Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis 2010;50:194-201.
24. He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet 2013;45:109-113.
25. Apostolopoulou E, Raftopoulos V, Terzis K, Elefsiniotis I. Infection probability score: a predictor of Clostridium difficile-associated disease onset in patients with haematological malignancy. Eur J Oncol Nurs 2011;15:404-409.
26. Rodemann JF, Dubberke ER, Reske KA, Seo Da H, Stone CD. Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol 2007;5:339-344.
27. Bajaj JS, Ananthakrishnan AN, Hafeezullah M, et al. Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective. Am J Gastroenterol 2010;105:106-113.
28. Micek ST, Schramm G, Morrow L, et al. Clostridium difficile infection: a multicenter study of epidemiology and outcomes in mechanically ventilated patients. Crit CareMed 2013;41:1968-1975.
29. Mitchell BG, Gardner A, Barnett AG, Hiller JE, Graves N. The prolongation of length of stay because of Clostridium difficile infection. Am J Infect Control 2014;42:164-167.
30. Leung S, Metzger BS, Currie BP. Incidence of Clostridium difficile infection in patients with acute leukemia and lymphoma after allogeneic hematopoietic stem cell transplantation. Infect Control Hosp Epidemiol 2010;31:313-315.
31. McKinnell JA, Miller LG, Eells SJ, Cui E, Huang SS. A systematic literature review and meta-analysis of factors associated with methicillin-resistant Staphylococcus aureus colonization at time of hospital or intensive care unit admission. Infect Control Hosp Epidemiol 2013;34:1077-1086.
32. Pant C, Sferra TJ, Deshpande A, Minocha A. Clinical approach to severe Clostridium difficile infection: update for the hospital practitioner. Eur J Intern Med 2011;22:561-568.
33. Scheurer DB, Hicks LS, Cook EF, Schnipper JL. Accuracy of ICD-9 coding for Clostridium difficile infections: a retrospective cohort. Epidemiol Infect 2007;135:1010-1013.
34. Dubberke ER, Reske KA, McDonald LC, Fraser VJ. ICD-9 codes and surveillance for Clostridium difficile-associated disease. Emerg Infect Dis 2006;12:1576-1579.