Association of Clostridium difficile infection with outcomes of hospitalized solid organ transplant recipients: Results from the 2009 Nationwide Inpatient Sample database

Transplant Infectious Disease

Volumn 14, Issue 5, 2012, Pages 540-547

  Pant, C ^a   Anderson, M P ^b   O'Connor, J A ^a   Marshall, C M ^a   Deshpande, A ^c   Sferra, T J ^d  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Clostridium difficile; Mortality; Nationwide Inpatient Sample database; Outcomes; Solid organ transplantation

Indexed keywords

ADULT; AGED; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COLON RESECTION; DIARRHEA; DISEASE COURSE; FEMALE; GRAFT DYSFUNCTION; GRAFT RECIPIENT; HEALTH CARE COST; HOSPITAL PATIENT; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DATABASES, FACTUAL; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; ODDS RATIO; ORGAN TRANSPLANTATION; REGRESSION ANALYSIS; UNITED STATES; YOUNG ADULT;

EID: 84867640865     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2012.00761.x     Document Type: Article

References (25)

1. Pescovitz MD, Navarro MT. Immunosuppressive therapy and post-transplantation diarrhea. Clin Transplant 2001; 15 (Suppl 4): 23-28.
2. Bunnapradist S, Neri L, Wong W, et al. Incidence and risk factors for diarrhea following kidney transplantation and association with graft loss and mortality. Am J Kidney Dis 2008; 51 (3): 478-486.
3. Ginsburg PM, Thuluvath PJ. Diarrhea in liver transplant recipients: etiology and management. Liver Transpl 2005; 11 (8): 881-890.
4. Guerrant RL, Hughes JM, Lima NL, Crane J. Diarrhea in developed and developing countries: magnitude, special settings, and etiologies. Rev Infect Dis 1990; 12 (Suppl 1): S41-S50.
5. McFarland LV. Epidemiology of infectious and iatrogenic nosocomial diarrhea in a cohort of general medicine patients. Am J Infect Control 1995; 23 (5): 295-305.
6. Riddle DJ, Dubberke ER. Clostridium difficile infection in solid organ transplant recipients. Curr Opin Organ Transplant 2008; 13 (6): 592-600.
7. Niemczyk M, Leszczyniski P, Wyzgal J, Paczek L, Krawczyk M, Luczak M. Infections caused by Clostridium difficile in kidney or liver graft recipients. Ann Transplant 2005; 10 (2): 70-74.
8. Munoz P, Giannella M, Alcala L, et al. Clostridium difficile-associated diarrhea in heart transplant recipients: is hypogammaglobulinemia the answer? J Heart Lung Transplant 2007; 26 (9): 907-914.
9. West M, Pirenne J, Chavers B, et al. Clostridium difficile colitis after kidney and kidney-pancreas transplantation. Clin Transplant 1999; 13 (4): 318-323.
10. Ananthakrishnan AN. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol 2011; 8 (1): 17-26.
11. Albright JB, Bonatti H, Mendez J, et al. Early and late onset Clostridium difficile-associated colitis following liver transplantation. Transpl Int 2007; 20 (10): 856-866.
12. Dallal RM, Harbrecht BG, Boujoukas AJ, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002; 235 (3): 363-372.
13. Gellad ZF, Alexander BD, Liu JK, et al. Severity of Clostridium difficile-associated diarrhea in solid organ transplant patients. Transpl Infect Dis 2007; 9 (4): 276-280.
14. Perkins RM, Bucaloiu ID, Kirchner HL, Ashouian N, Hartle JE, Yahya T. GFR decline and mortality risk among patients with chronic kidney disease. Clin J Am Soc Nephrol 2011; 6 (8): 1879-1886.
15. Herring AA, Woolhandler S, Himmelstein DU. Insurance status of U.S. organ donors and transplant recipients: the uninsured give, but rarely receive. Int J Health Serv 2008; 38 (4): 641-652.
16. Dubberke ER, Reske KA, McDonald LC, Fraser VJ. ICD-9 codes and surveillance for Clostridium difficile-associated disease. Emerg Infect Dis 2006; 12 (10): 1576-1579.
17. Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med 1998; 338 (24): 1741-1751.
18. Quan H, Sundararajan V, Halfon P, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 2005; 43 (11): 1130-1139.
19. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45 (6): 613-619.
20. Bajaj JS, Ananthakrishnan AN, Hafeezullah M, et al. Clostridium difficile is associated with poor outcomes in patients with cirrhosis: a national and tertiary center perspective. Am J Gastroenterol 2010; 105 (1): 106-113.
21. Ovbiagele B. Chronic kidney disease and risk of death during hospitalization for stroke. J Neurol Sci 2011; 301 (1-2): 46-50.
22. Pant C, Deshpande A, Anderson MP, Sferra TJ. Clostridium difficile infection is associated with poor outcomes in end-stage renal disease. J Investig Med 2012; 60 (2): 529-532.
23. Mermel LA, Maki DG. Bacterial pneumonia in solid organ transplantation. Semin Respir Infect 1990; 5 (1): 10-29.
24. Linares L, Sanclemente G, Cervera C, et al. Influence of cytomegalovirus disease in outcome of solid organ transplant patients. Transplant Proc 2011; 43 (6): 2145-2148.
25. Volk ML, Hernandez JC, Lok AS, Marrero JA. Modified Charlson comorbidity index for predicting survival after liver transplantation. Liver Transpl 2007; 13 (11): 1515-1520.