Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: Risk factors for severe forms and death;Diarreia por Clostridium difficile em pacientes hematológicos e transplantados de células tronco hematopoiéticas: Fatores de risco da forma grave e morte

Revista do Instituto de Medicina Tropical de Sao Paulo

Volumn 56, Issue 4, 2014, Pages 325-331

  Spadão, Fernanda ^a   Gerhardt, Juliana ^a   Guimarães, Thais ^a   Dulley, Frederico ^a   de Almeida Junior, João Nóbrega ^a   Batista, Marjorie Vieira ^a   Shikanai Yasuda, Maria Aparecida ^a   Levin, Anna Sara ^a   Costa, Silvia Figueiredo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone marrow transplant; C. difficile; Hematology

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; CYCLOPHOSPHAMIDE; LINEZOLID; METRONIDAZOLE; VANCOMYCIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CLOSTRIDIUM DIFFICILE INFECTION; COLON RESECTION; DEATH; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; HYPOTENSION; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MICROBIAL COLONIZATION; MUCOSA INFLAMMATION; NEUTROPENIA; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; RISK FACTOR; SHOCK; TOXIC MEGACOLON;

ADOLESCENT; ADULT; AGED; BRAZIL; CHILD; CLOSTRIDIUM DIFFICILE; DIARRHEA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84905191636     PISSN: 00364665     EISSN: 16789946     Source Type: Journal    
DOI: 10.1590/S0036-46652014000400010     Document Type: Article

References (28)

1. Alonso CD, Treadway SB, Hanna DB, Huff CA, Neofytos D, Carroll KC, et al. Epidemiology and outcomes of Clostridium difficile infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 2012;54:1053-63.
2. Altclas J, Requejo A, Jaimovich G, Milovic V, Feldman L. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis. 2001;5:723.
3. Arango JI, Restrepo A, Schneider DL, Callander NS, Ochoa-Bayona JL, Restrepo MI, et al. Incidence of Clostridium difficile associated diarrhea before and after autologous peripheral blood stem cell transplantation for lymphoma and multiple myeloma. Bone Marrow Transplant. 2006;37:517-21.
4. Avery R, Pohlman B, Adal K, Bolwell B, Goldman M, Kalaycio M, et al. High prevalence of diarrhea but infrequency of documented Clostridium difficile in autologous peripheral blood progenitor cell transplant recipients. Bone Marrow Transplant. 2000;25:67-9.
5. Arvand M, Hauri AM, Zaiss NH, Witte W, Bettge-Weller G. Clostridium difficile ribotypes 001, 017 and 027 are associated with lethal C. difficile infection in Hesse, Germany. Euro Surveill. 2009;14(45):pii=19403.
6. Bacci S, Molback K, Kjeldsen MK, Olsen KEP. Binary toxin and death after Clostridium difficile infection. Emerging Infect Dis. 2011;17:976-82.
7. Baines SD, Noel AR, Huscroft GS, Todhunter SL, O'Connor R, Hobbs JK, et al. Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model. J Antimicrob Chemother. 2011;7:1537-46.
8. Balassiano IT, Miranda KR, Boente RF, Pauer H, Oliveira IC, Santos-Filho J, et al. Characterization of Clostridium difficile strains isolated from immunosuppressed inpatients in a hospital in Rio de Janeiro, Brazil. Anaerobe. 2009;15:61-4.
9. Balassiano IT, dos Santos-Filho J, Vital-Brazil JM, Nouér SA, Souza CR, Brazier JS, et al. Detection of cross-infection associated to a Brazilian PCR-ribotype of Clostridium difficile in a university hospital in Rio de Janeiro, Brazil. Antonie Van Leeuwenhoek. 2011;99:249-55.
10. Bilgrami S, Feingold JM, Dorsky D, Edwards RL, Bona RD, Khan AM, et al. Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999;23:1039-42.
11. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-55.
12. Chakrabarti S, Lees A, Jones SG, Milligan DW. Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality. Bone Marrow Transplant. 2000;26:871-6.
13. Chopra T, Chandrasekar P, Salimnia H, Heilbrun LK, Smith D, Alangaden GJ. Recent epidemiology of Clostridium difficile infection during hematopoietic stem cell transplantation. Clin Transplant. 2011;25:82-7.
14. Dettenkofer M, Wenzler-Röttele S, Babikir R, Bertz H, Ebner W, Meyer E, et al. Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project. Clin Infect Dis. 2005;40:926-31.
15. Dubberke ER, Sadhu J, Gatti R, Reske KA, DiPersio JF, Devine SM, et al. Severity of Clostridium difficile-associated disease (CDAD) in allogeneic stem cell transplant recipients: evaluation of a CDAD severity grading system. Infect Control Hosp Epidemiol. 2007;28:208-11.
16. Leung S, Metzger BS, Currie BP. Incidence of Clostridium difficile infection in patients with acute leukemia and lymphoma after allogeneic hematopoietic stem cell transplantation. Infect Control Hosp Epidemiol. 2010;31:313-5.
17. Mendes ET, Dulley F, Basso M, Batista MV, Coracin F, Guimarães T, et al. Healthcare-associated infection in hematopoietic stem cell transplantation patients: risk factors and impact on outcome. Int J Infect Dis. 2012;16:424-8.
18. Musgrave CR, Bookstaver PB, Sutton SS, Miller AD. Use of alternative or adjuvant pharmacologic treatment strategies in the prevention and treatment of Clostridium difficile infection. Int J Infect Dis. 2011;15:438-48.
19. Oka K, Osaki T, Hanawa T, Kurata S, Okazaki M, Manzoku T, et al. Molecular and microbiological characterization of Clostridium difficile isolates from single, relapse, and reinfection cases. J Clin Microbiol. 2012;3:915-21.
20. Ram R, Gafter-Gvili A, Raanani P, Yeshurun M, Shpilberg O, Dreyer J, et al. Surveillance of infectious complications in hemato-oncological patients. Isr Med Assoc J. 2009;3:133-7.
21. Schalk E, Bohr UR, Konig B, Scheinpflug K, Mohren M. Clostridium difficile-associated diarrhoea, a frequent complication in patients with acute myeloid leukaemia. Ann Hematol. 2010;89:9-14.
22. Tenover FC, Tickler IA, Persing DH. Antimicrobial-resistant strains of Clostridium difficile from North America. Antimicrob Agents Chemother. 2012;56:2929-32.
23. Tomblyn M, Gordon L, Singhal S, Tallman M, Williams S, Winter J, et al. Rarity of toxigenic Clostridium difficile infections after hematopoietic stem cell transplantation: implications for symptomatic management of diarrhea. Bone Marrow Transplant. 2002;30:517-9.
24. Valerio M, Pedromingo M, Muñoz P, Alcalá L, Marin M, Peláez T, et al. Potential protective role of linezolid against Clostridium difficile infection. Int J Antimicrob Agents. 2012;5:414-9.
25. Vehreschild MJ, Meissner AM, Cornely OA, Maschmeyer G, Neumann S, von Lilienfeld Toal M, et al. Clinically defined chemotherapy-associated bowel syndrome predicts severe complications and death in cancer patients. Haematologica. 2011;96:1855-60.
26. Venugopal AA, Riederer K, Patel SM, Szpunar S, Jahamy H, Valenti S, et al. Lack of association of outcomes with treatment duration and microbiologic susceptibility data in Clostridium difficile infections in a non-NAP1/BI/027 setting. Scand J Infect Dis. 2012;44:243-9.
27. Willems L, Porcher R, Lafaurie M, Casin I, Robin M, Xhaard A, et al. Clostridium difficile infection after allogeneic hematopoietic stem cell transplantation: incidence, risk factors, and outcome. Biol Blood Marrow Transplant. 2012;18:1295-301.
28. Zirakzadeh A, Gastineau DA, Mandrekar JN, Burke JP, Johnston PB, Patel R. Vancomycin-resistant enterococcal colonization appears associated with increased mortality among allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2008;41:385-92.