Themicrovascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: A cardiovascular magnetic resonance study

European Heart Journal Cardiovascular Imaging

Volumn 15, Issue 12, 2014, Pages 1368-1376

  Larghat, Abdulghani M ^a,b   Swoboda, Peter P ^a   Biglands, John D ^c   Kearney, Mark T ^a   Greenwood, John P ^a   Plein, Sven ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF TRIPOLI   (Libyan Arab Jamahiriya)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Cardiovascular magnetic resonance; Diabetes; Myocardial perfusion reserve; Prediabetes; Strain; Tagging

Indexed keywords

ADENOSINE; GADOLINIUM PENTETATE MEGLUMINE;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR MAGNETIC RESONANCE; COMPARATIVE STUDY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORONARY ANGIOGRAPHY; DIABETES MELLITUS; DIASTOLE; FEMALE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE STRUCTURE; HEART LEFT VENTRICLE WALL; HEART MUSCLE BLOOD FLOW; HEART MUSCLE PERFUSION; HUMAN; IMAGING SOFTWARE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LAGRANGIAN CIRCUMFERENTIAL STRAIN; LEFT VENTRICULAR TORSION; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; PROSPECTIVE STUDY; WAIST HIP RATIO; WHOLE BODY MRI; AGED; HEART FAILURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; HEART FAILURE; HUMANS; INSULIN RESISTANCE; MAGNETIC RESONANCE IMAGING, CINE; MALE; MICROVESSELS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84965091102     PISSN: 20472404     EISSN: 20472412     Source Type: Journal    
DOI: 10.1093/ehjci/jeu142     Document Type: Article

References (40)

1. Bradley RF, Bryfogle JW. Survival of diabetic patients after myocardial infarction.AmJ Med 1956;20:207-16.
2. Pryor DB, Shaw L, McCants CB, Lee KL, Mark DB, Harrell FE Jr et al. Value of the history and physical in identifying patients at increased risk for coronary artery disease. Ann Intern Med 1993;118:81-90.
3. Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A. New type of cardio myopathy associated with diabetic glomerulosclerosis. Am J Cardiol 1972; 30:595-602.
4. Voulgari C, Tentolouris N, Dilaveris P, Tousoulis D, Katsilambros N, Stefanadis C. Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 2011;58: 1343-50.
5. Gottdiener JS, Arnold AM, AurigemmaGP, Polak JF, TracyRP, KitzmanDWet al. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol 2000;35:1628-37.
6. Voors AA, van der Horst IC. Diabetes: a driver for heart failure. Heart 2011;97: 774-80.
7. Cubbon RM, Adams B, Rajwani A, Mercer BN, Patel PA, Gherardi G et al. Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology. Diab Vasc Dis Res 2013;10:330-6.
8. FromAM, Leibson CL, Bursi F, RedfieldMM,Weston SA, Jacobsen SJ et al. Diabetes in heart failure: prevalence and impact on outcome in the population. Am J Med 2006; 119:591-9.
9. Falcao-Pires I, Leite-Moreira AF. Diabetic cardio myopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev 2012;17:325-44.
10. Boudina S, Abel ED. Diabetic cardio myopathy revisited. Circulation 2007;115: 3213-23.
11. Heckbert SR, PostW, Pearson GD, Arnett DK, Gomes AS, Jerosch-Herold M et al. Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis. J Am Coll Cardiol 2006;48:2285-92.
12. Fonseca CG, Dissanayake AM, Doughty RN, Whalley GA, Gamble GD, Cowan BR et al. Three-dimensional assessment of left ventricular systolic strain in patients with type 2 diabetes mellitus, diastolic dysfunction, and normal ejection fraction. Am J Cardiol 2004;94:1391-5.
13. From AM, Scott CG, Chen HH. The development of heart failure in patients with diabetes mellitus and pre-clinical diastolic dysfunction a population-based study. J Am Coll Cardiol 2010;55:300-5.
14. American Diabetes Association. Standards of medical care in diabetes-2013. Diabetes Care 2013;36(Suppl. 1):S11-66.
15. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-95.
16. Swoboda PP, Larghat A, Zaman A, Fairbairn TA, Motwani M, Greenwood JP et al. Reproducibility of myocardial strain and left ventricular twist measured using complementary spatial modulation of magnetization. J Magn Reson Imaging 2014;39:887-94.
17. Radjenovic A, Biglands JD, Larghat A, Ridgway JP, Ball SG, Greenwood JP et al. Estimates of systolic and diastolic myocardial blood flow by dynamic contrast-enhanced MRI. Magn Reson Med 2010;64:1696-703.
18. Pennell DJ. Ventricular volume and mass by CMR. J Cardiovasc Magn Reson 2002;4: 507-13.
19. Shah RV, Abbasi SA, Heydari B, Rickers C, Jacobs DR Jr,Wang L et al. Insulin resistance, subclinical left ventricular remodeling, and the obesity paradox: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2013;61:1698-706.
20. Gulati A, Ismail TF, Jabbour A, Ismail NA, Morarji K, Ali A et al. Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardio myopathy. Eur J Heart Fail 2013;15:660-70.
21. Larghat AM, Maredia N, Biglands J, Greenwood JP, Ball SG, Jerosch-Herold M et al. Reproducibility of first-pass cardiovascular magnetic resonance myocardial perfusion. J Magn Reson Imaging 2013;37:865-74.
22. Motwani M, Fairbairn TA, Larghat A, MatherAN, Biglands JD, RadjenovicAet al. Systolic versus diastolic acquisition in myocardial perfusion MR imaging. Radiology 2012; 262:816-23.
23. Jerosch-Herold M, Wilke N, Stillman A. Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. Med Phys 1998;25:73-84.
24. Young AA, Cowan BR. Evaluation of left ventricular torsion by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2012;14:49.
25. Velagaleti RS, Gona P, Chuang ML, Salton CJ, Fox CS, Blease SJ et al. Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study. Circ Cardiovasc Imaging 2010;3:257-63.
26. De Marco M, de Simone G, Roman MJ, Chinali M, Lee ET, Calhoun D et al. Cardiac geometry and function in diabetic or prediabetic adolescents and young adults: the Strong Heart Study. Diabetes Care 2011;34:2300-5.
27. Britton KA, Fox CS. Ectopic fat depots and cardiovascular disease. Circulation 2011; 124:e837-41.
28. Chung J, Abraszewski P, Yu X, LiuW, Krainik AJ, AshfordMet al. Paradoxical increase in ventricular torsion and systolic torsion rate in type I diabetic patients under tight glycemic control. J Am Coll Cardiol 2006;47:384-90.
29. From AM, Scott CG, Chen HH. Changes in diastolic dysfunction in diabetes mellitus over time. Am J Cardiol 2009;103:1463-6.
30. Giannetta E, Isidori AM, Galea N, Carbone I, Mandosi E, Vizza CD et al. Chronic inhibition of cGMP phosphodiesterase 5A improves diabetic cardio myopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging. Circulation 2012;125:2323-33.
31. Korosoglou G, Humpert PM, Ahrens J, Oikonomou D, Osman NF, GitsioudisGet al. Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve. J Magn Reson Imaging 2012;35:804-11.
32. Ahmed MI, Desai RV, Gaddam KK, Venkatesh BA, Agarwal S, Inusah S et al. Relation of torsion and myocardial strains to LV ejection fraction in hypertension. JACC Cardiovasc Imaging 2012;5:273-81.
33. Kawecka-Jaszcz K, Czarnecka D, Olszanecka A, Klecha A, Kwiecien-Sobstel A, Stolarz-Skrzypek K et al. Myocardial perfusion in hypertensive patients with normal coronary angiograms. J Hypertens 2008;26:1686-94.
34. Nakajima H, Onishi K, Kurita T, Ishida M, Nagata M, Kitagawa K et al. Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia. Hypertens Res 2010;33:1144-9.
35. Levy BI, Schiffrin EL, Mourad JJ, Agostini D, Vicaut E, Safar ME et al. Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus. Circulation 2008;118:968-76.
36. Prior JO, Quinones MJ, Hernandez-Pampaloni M, Facta AD, Schindler TH, Sayre JW et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation 2005;111:2291-8.
37. Rao AD, Shah RV, Garg R, Abbasi SA, Neilan TG, Perlstein TS et al. Aldosterone and myocardial extracellular matrix expansion in type 2 diabetes mellitus. Am J Cardiol 2013;112:73-8.
38. Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS et al. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J 2014;35:657-64.
39. van der Meer RW, Diamant M,Westenberg JJ, Doornbos J, Bax JJ, de Roos A et al. Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus. J Cardiovasc Magn Reson 2007;9:645-51.
40. Stacey RB, Bertoni AG, Eng J, Bluemke DA, Hundley WG, Herrington D. Modification of the effect of glycemic status on aortic distensibility by age in the multi-ethnic study of atherosclerosis. Hypertension 2010;55:26-32.