Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: A cross-sectional study

Journal of Translational Medicine

Volumn 14, Issue 1, 2016, Pages

  Wyller, Vegard Bruun ^a,b   Vitelli, Valieria ^c   Sulheim, Dag ^d,e   Fagermoen, Even ^a,d   Winger, Anette ^f   Godang, Kristin ^g   Bollerslev, Jens ^g  

^a UNIVERSITY OF OSLO   (Norway)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e Lillehammer Co Hosp Lillehammer S   (Norway)

^f OSLO METROPOLITAN UNIVERSITY   (Norway)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Adolescence; Chronic fatigue syndrome; Network analyses

Indexed keywords

ADRENALIN; CORTICOTROPIN; CREATININE; HYDROCORTISONE; NORADRENALIN; THYROTROPIN; THYROXINE; BIOLOGICAL MARKER; HORMONE;

ACCELEROMETER; ADOLESCENT; ADOLESCENT HEALTH; ADRENAL MEDULLA; ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE DURATION; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; MENARCHE; MENSTRUAL CYCLE; NEUROENDOCRINE SYSTEM; NORADRENALIN BLOOD LEVEL; PHYSICAL ACTIVITY; QUESTIONNAIRE; SYMPTOMATOLOGY; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; BLOOD; CASE CONTROL STUDY; CHILD; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MULTIVARIATE ANALYSIS; NEUROSECRETION; PATHOLOGY; STATISTICAL MODEL;

ADOLESCENT; BIOMARKERS; CASE-CONTROL STUDIES; CHILD; CROSS-SECTIONAL STUDIES; FATIGUE SYNDROME, CHRONIC; FEMALE; HORMONES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LINEAR MODELS; MALE; MULTIVARIATE ANALYSIS; NEUROSECRETORY SYSTEMS; PITUITARY-ADRENAL SYSTEM;

EID: 84965082812     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-0873-1     Document Type: Article

References (48)

1. Institute of Medicine. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Washington, DC: The National Academies Press; 2015.
2. Kennedy G, Underwood C, Belch JJ. Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood. Pediatrics. 2010;125:e1324-30.
3. Winger A, Kvarstein G, Wyller VB, Ekstedt M, Sulheim D, Fagermoen E, Smastuen MC, Helseth S. Health related quality of life in adolescents with chronic fatigue syndrome: a cross-sectional study. Health Qual Life Outcomes. 2015;96:13.
4. Missen A, Hollinqworth W, Eaton N, Crawley E. The financial and psychological impacts on mothers of children with chronic fatigue syndrome (CFS/ME). Child Care Health Dev. 2012;38:505-12.
5. Nijhof SL, Maijer K, Bleijenberg G, Uiterwaal CS, Kimpen JL, van der Putte EM. Adolscent chronic fatigue syndrome: prevalence, incidence, and morbidity. Pediatrics. 2011;127:e1169-75.
6. Crawley EM, Emond AM, Sterne JA. Unidentified chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics. BMJ Open. 2011;1:e000252.
7. Papadopoulos AS, Cleare AJ. Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat Rev Endocrinol. 2011;8:22-32.
8. Segal TY, Hindmarsh PC, Viner RM. Disturbed adrenal function in adolescents with chronic fatigue syndrome. J Pediatr Endocrinol Metab. 2005;18:295-301.
9. Nijhof SL, Rutten JM, Uiterwaal CS, Bleijenberg G, Kimpen JL, Putte EM. The role of hypocortisolism in chronic fatigue syndrome. Psychoneuroendocrinology. 2014;42:199-206.
10. Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB. Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized controlled trial. JAMA Pediatr. 2014;168:351-60.
11. Hall DL, Lattei EG, Antoni MH, Fletcher MA, Czaja S, Perdomo D, Klimas NG. Stress management skills, cortisol awakening response, and post-exertional malaise in chronic fatigue syndrome. Psychoneuroendocrinology. 2014;49:26-31.
12. Wyller VB, Due R, Saul JP, Amlie JP, Thaulow E. Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls. Am J Cardiol. 2007;99:997-1001.
13. Wyller VB, Godang K, Mørkrid L, Saul JP, Thaulow E, Walløe L. Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms. Pediatrics. 2007;120:e129-37.
14. Wyller VB, Barbieri R, Saul JP. Blood pressure variability and closed- loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. Eur J Appl Physiol. 2011;111:497-507.
15. Sulheim D, Hurum H, Helland IB, Thaulow E, Wyller VB. Adolescent chronic fatigue syndrome; a follow-up study displays concurrent improvement of circulatory abnormalities and clinical symptoms. Biopsychosoc Med. 2012;6:10.
16. Moorkens G, Berwaerts J, Wynants H, Abs R. Characterisation of pituitary function with emphasis on GH secretion in the chronic fatigue syndrome. Clin Endocrinol. 2000;53:99-106.
17. Wyller VB, Malterud K, Eriksen HR. Can sustained arousal explain chronic fatigue syndrome? Behav Brain Funct. 2009;5:10.
18. Malloney EM, Boneva R, Nater UM, Reeves WC. Chronic fatigue syndrome and high allostatic load: results from a population-based case-control study in Georgia. Psychosom Med. 2009;71:549-56.
19. Fuite J, Vernon SD, Broderick G. Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis. Genomics. 2008;92:393-9.
20. Royal College of Paediatrics and Child Health. Evidence based guidelines for the management of CFS/ME (chronic fatigue syndrome/myalgic encephalopathy) in children and young adults. London: Royal College of Paediatrics and Child Health; 2004.
21. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Int Med. 1994;121:953-9.
22. Carruthers BM, Jain AK, De Meirleir KL, Peterson DL, Klimas NG, Lerner AM, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols. J Chron Fatigue Syndr. 2003;11:7-11.
23. Brurberg KG, Fønhus MS, Larun L, Flottorp S, Malterud K. Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review. BMJ Open. 2014;4:e003973.
24. Nisenbaum R, Reyes M, Unger ER, Reeves WC. Factor analyses of symptoms among subjects with unexplained chronic fatigue: what can we learn about chronic fatigue syndrome? J Psychosom Res. 2004;56:171-8.
25. Sullivan PF, Pedersen NL, Jacks A, Evengård B. Chronic fatigue in a population sample: definitions and heterogeneity. Psychol Med. 2005;35:1337-48.
26. Asprusten TT, Fagermoen E, Sulheim D, Skovlund E, Sørensen Ø, Mollnes TE, Wyller VB. Study finding challenge the content validity of the Canadian consensus criteria for adolescent chronic fatigue syndrome. Acta Pediatr. 2015;104:498-503.
27. Wagner D, Nisenbaum R, Heim C, Jones JF, Unger ER, Reeves WC. Psychometric properties of the CDC symptom inventory for assessment of Chronic Fatigue Syndrome. Popul Health Metr. 2005;3:8.
28. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, Wallace EP. Development of a fatigue scale. J Psychosom Res. 1993;37:147-53.
29. Godfrey E, Cleare A, Coddington A, Roberts A, Weinman J, Chalder T. Chronic fatigue syndrome in adolescents: do parental expectations of their child's intellectual ability match the child's ability? J Psychosom Res. 2009;67:165-8.
30. Daviss WB, Birmaher B, Melhem NA, Axelson DA, Michaels SM, Brent DA. Criterion validity of the mood and feelings questionnaire for depressive episodes in clinic and non-clinic subjects. J Child Psychol Psychiatry. 2006;47:927-34.
31. Wood A, Kroll L, Moore A, Harrington R. Properties of the mood and feelings questionnaire in adolescent psychiatric outpatients: a research note. J Child Psychol Psychiatry. 1995;36:327-34.
32. Meeus M, van Eupen I, van Baarle E, De Boeck V, Luyckx A, Kos D, Nijs J. Symptom fluctuations and daily physical activity in patients with chronic fatigue syndrome: a case-control study. Arch Phys Med Rehabil. 2011;92:1820-6.
33. Evering RM, Tönis TM, Vollenbroek-Hutten MM. Deviations in daily physical activity patterns in patients with the chronic fatigue syndrome: a case control study. J Psychosom Res. 2011;71:129-35.
34. Grant PM, Ryan CG, Tigbe WW, Granat MH. The validation of a novel activity monitor in the measurement of posture and motion during everyday activities. Br J Sports Med. 2006;40:992-7.
35. Ryan CG, Grant PM, Tigbe WW, Granat MH. The validity and reliability of a novel activity monitor as a measure of walking. Br J Sports Med. 2006;40:779-84.
36. Tsunoda M. Recent advances in methods for the analysis of catecholamines and their metabolites. Anal Bioanal Chem. 2006;386:506-14.
37. Hjemdahl P. Catecholamine measurements by high-performance liquid chromatography. Am J Physiol. 1984;247:E13-20.
38. Gatti R, Antonelli A, Prearo M, Spinella P, Cappellini E, DePalo EF. Cortisol assays and diagnostic laboratory procedures in human biological fluids. Clin Biochem. 2009;42:1205-17.
39. Rubin D. Multiple imputation for nonresponse in surveys. New York: Wiley; 1987.
40. R Development Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2008.
41. Margolin A, Nemenman I, Basso K, Wiggins C, Stolovitsky G, Favera RD, Califano A. Aracne: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics. 2004;7(Suppl 1):S7.
42. Margolin A, Wang K, Lim W, Kustagi M, Nemanman I, Califano A. Reverse engineering cellular networks. Nat Protoc. 2006;2006(1):663-72.
43. Scutari M. Learning bayesian networks with the bnlearn r package. J Stat Softw. 2010;35:1-22.
44. Csardi G, Nepusz T. The igraph software package for complex network research. InterJ Complex Syst. 2006;1695:1-9.
45. Wyller VB, Sørensen Ø, Sulheim D, Fagermoen E, Ueland T, Mollnes TE. Plasma cytokine expression in adolescent chronic fatigue syndrome. Brain Behav Immun. 2015;46:80-6.
46. Papadimitriou A, Priftis KN. Regulation of the hypothalamic-pituitary-adrenal axis. NeuroImmunoModulation. 2009;16:265-71.
47. Vangeel E, Van den Eede F, Hompes T, Izzi B, Del Favero J, Moorkens G, Lambrechts D, Freson K, Claes S. Chronic fatigue syndrome and DNA hypomethylation of the glucocorticoid receptor gene promotor 1F region: association with HPA axis hypofunction and childhood trauma. Psychosom Med. 2015;77:853-62.
48. Pervanidou P, Chrosous GP. Neuroendocrinology of post-traumatic stress disorder. Prog Brain Res. 2010;182:149-60.