Exogenous dopamine reduces GABA receptor availability in the human brain

Brain and Behavior

Volumn 6, Issue 7, 2016, Pages

  Lou, Hans C ^a   Rosenstand, Astrid ^b   Brooks, David J ^a   Bender, Dirk ^a   Jakobsen, Steen ^a   Blicher, Jakob U ^a   Hansen, Kim V ^a   Møller, Arne ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Dopamine; GABA; insula; medial prefrontal anterior cingulate; self awareness

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; CARBIDOPA PLUS LEVODOPA; CARBON 11; DOPAMINE; PLACEBO; AZIDE; BENZODIAZEPINE DERIVATIVE; CARBON; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; LIGAND;

ADULT; ANTERIOR CINGULATE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; INSULA; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; BRAIN; CINGULATE GYRUS; DIAGNOSTIC IMAGING; DRUG EFFECTS; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; AZIDES; BENZODIAZEPINES; BRAIN; CARBON RADIOISOTOPES; DOPAMINE AGENTS; GYRUS CINGULI; HUMANS; LEVODOPA; LIGANDS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GABA; YOUNG ADULT;

EID: 84965074794     PISSN: None     EISSN: 21623279     Source Type: Journal    
DOI: 10.1002/brb3.484     Document Type: Article

References (25)

1. Assaf, M., K. Jagannathan, V. D. Calhoun, L. Miller, M. C. Stevens, R. Sahl, et al. 2010. Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage 53:247–256.
2. Castellanos, F. X., D. S. Margulies, C. Kelly, L. Q. Uddin, M. Ghaffari, A. Kirsch Shaw, et al. 2008. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biol. Psychiatry 63:332–337.
3. Collins, D. J., A. P. Zijdenbos, V. Kollokian, J. G. Sled, N. J. Kabani, C. J. Holmes, and A. C. Evans. 1998. Design and construction of a realistic digital brain phantom. IEEE Trans. Med. Imaging 17:463–468.
4. Gallinat, J., G. Winterer, C. S. Herrmann, and D. Senkowski. 2004. Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clin. Neurophysiol. 115:1863–1874.
5. 11C]Ro-15-4513, a ligand for visualization of benzodiazepine receptor binding: preparation, autoradiography, and positron emission tomography. Psychopharmacology 108:16–22.
6. Ham, T. E., V. Bonnelle, P. Hellyer, S. Jilka, I. H. Robertson, R. Leech, and D.J. Sharp. 2014. The neural basis of impaired self-awareness after traumatic brain injury. Brain 137:586–597.
7. Hoerbelt, P., T. A. Lindsley, and M. W. Fleck. 2015. Dopamine directly modulates GABAA receptors. J. Neurosci. 35:3525–3536.
8. Joensson, M., K. R. Thomsen, L. M. Andersen, J. Gross, K. Mouridsen, K. Sandberg, et al. 2015. Making sense: dopamine activates conscious self-monitoring through medial prefrontal cortex. Hum. Brain Mapp. 36:1866–1877.
9. Keenan, J. P., A. Nelson, M. O'Connor, and A. Pascual Leone. 2001. Self-recognition and the right hemisphere. Nature 409:305.
10. Lew, S. E., and K. Y. Tseng. 2014. Dopamine modulation of GABAergic function enables network stability and input selectivity for sustaining working memory in a computational model of the prefrontal cortex. Neuropsychopharmacology 39:3067–3076.
11. Lingford-Hughes, A., S. P. Hume, A. Feeney, E. Hirani, S. Osman, V. J. Cunningham, et al. 2002. Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography. J. Cereb. Blood Flow Metab. 22:878–889.
12. Liu, Y., C. Yu, X. Zhang, J. Liu, Y. Duan, A. F. Alexander-Bloch, et al. 2014. Impaired long distance functional connectivity and weighted network architecture in Alzheimer's disease. Cereb. Cortex 24:1422–1435.
13. Lou, H. C., B. Luber, M. Crupain, J. P. Keenan, M. Nowak, T. W. Kjaer, et al. 2004. Parietal cortex and representation of the mental Self. Proc. Natl Acad. Sci. USA 101:6827–6832.
14. Lou, H. C., J. C. Skewes, K. R. Thomsen, M. Overgaard, H. C. Lau, K. Mouridsen, and A. Roepstorff. 2011. Dopaminergic stimulation enhances confidence and accuracy in seeing rapidly presented words. J. Vis. 11:1–6.
15. Luber, B., H. C. Lou, J. P. Keenan, and S. H. Lisanby. 2012. Self-enhancement processing in the default network: a single-pulse TMS study. Exp. Brain Res. 223:177–187.
16. Ransom, C. B., W. Tao, Y. Wu, W. J. Spain, and G. B. Richerson. 2013. Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons. J. Neurophysiol. 109:803–812.
17. Rømer Thomsen, K., M. Joensson, H. C. Lou, A. Møller, J. Gross, M. L. Kringelbach, and J.P. Changeux. 2013. Altered paralimbic interaction in behavioral addiction. Proc. Natl Acad. Sci. USA 110:4744–4749.
18. Romo-Parra, H., J. Aceves, and R. Gutières. 2005. Tonic modulation inhibition by dopamine D4 receptors in rat hippocampus. Hippocampus 15:254–259.
19. Semyano, A., M. C. Walker, D. M. Kullmann, and R. A. Silver. 2004. Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci. 27:262–269.
20. Sesack, S. R., D. B. Carr, N. Omelchenko, and A. Pinto. 2003. Anatomical substrates for glutamate-dopamine interactions. Ann. N. Y. Acad. Sci. 1003:36–52.
21. Sohal, V. S., F. Zhang, O. Yizhar, and K. Deisseroth. 2009. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459:698–702.
22. Stokes, P. R., J. F. Myers, N. J. Kalk, B. J. Watson, D. Erritzoe, S. J. Wilson, et al. 2014. Acute increases in synaptic GABA detectable in the living human brain: a [11C]Ro15-4513 study. NeuroImage 99:158–165.
23. Tomasi, D., G. J. Wang, and N. D. Volkow. 2013. Energetic cost of brain functional connectivity. Proc. Natl Acad. Sci. USA 1010:13642–13647.
24. Voss, U., R. Holzmann, A. Hobson, W. Paulus, J. Koppehele-Gossel, A. Klimke, and M. Nitsche. 2014. Induction of self awareness in dreams through frontal low current stimulation of gamma activity. Nat. Neurosci. 17:810–812.
25. Wu, Y., and R. E. Carson. 2002. Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging. J. Cereb. Blood Flow Metab. 22:1440–1452.