A simple and high-throughput analysis of amatoxins and phallotoxins in human plasma, serum and urine using UPLC-MS/MS combined with PRiME HLB μElution platform

Toxins

Volumn 8, Issue 5, 2016, Pages

  Zhang, Shuo ^a,b   Zhao, Yunfeng ^b   Li, Haijiao ^a   Zhou, Shuang ^b   Chen, Dawei ^b   Zhang, Yizhe ^a   Yao, Qunmei ^c   Sun, Chengye ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b BEIJING HOSPITAL   (China)

^c The People's Hospital of Chuxiong Yi Autonomous Prefecture   (China)

Author keywords

Amatoxin; Biological fluids; LC MS MS; Phallotoxin; Poisonous mushroom; PRiME HLB; Elution

Indexed keywords

ALPHA AMANITIN; AMANITIN; BETA AMANITIN; PHALLACIDIN; PHALLOIDIN; PHALLOTOXIN; CYCLOPEPTIDE;

AMANITA; ANALYTICAL PARAMETERS; ARTICLE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LINEARITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; NONHUMAN; SELECTIVITY; SPECIFICITY; STABILITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; BLOOD; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MUSHROOM POISONING; TANDEM MASS SPECTROMETRY; URINE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIMIT OF DETECTION; MUSHROOM POISONING; PEPTIDES, CYCLIC; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84965047611     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins8050128     Document Type: Article

References (38)

1. Chen, Z. H.; Zhang, P.; Zhang, Z. G. Investigation and analysis of 102 mushroom poisoning casesin Southern China from 1994 to 2012. Fungal Divers. 2014, 64, 123-131. [CrossRef]
2. Wang, R.; Gao, Y. J.; Ding, F.; Xie, R. H.; Wang, X. Y.; Li, Q. Epidemiological analysis on mushroom poisoning in China 2004-2011. Chin. J. Public Health 2014, 30, 158-161.
3. Wieland, T. The toxic peptides from Amanita mushrooms. Int. J. Peptideprotein Res. 1983, 22, 257-276. [CrossRef]
4. Luo, H.; Hallen-Adams, H. E.; Scott-Craig, J. S.; Walton, J. D. Ribosomal biosynthesis of α-amanitin in Galerina marginata. Fungal Genet. Biol. 2012, 49, 123-129. [CrossRef] [PubMed]
5. Mas, A. Mushrooms, amatoxins and the liver. J. Hepatol. 2005, 42, 166-169. [CrossRef] [PubMed]
6. Vargas, N.; Bernal, A.; Sarria, V.; Franco-Molano, A.; Restrepo, S. Amatoxin and phallotoxin composition in species of the genus Amanitain Colombia: A taxonomic perspective. Toxicon 2011, 58, 583-590. [CrossRef] [PubMed]
7. Sgambelluri, R. M.; Epis, S.; Sassera, D.; Luo, H.; Angelos, E. R.; Walton, J. D. Profiling of amatoxins and phallotoxins in the genus lepiota by liquid chromatography combined with UV absorbance and mass spectrometry. Toxins 2014, 6, 2336-2347. [CrossRef] [PubMed]
8. Enjalbert, F.; Rapior, S.; Nouguier-Soulé, J.; Guillon, S.; Amouroux, N.; Cabot, C. Treatment of amatoxin poisoning: 20-year retrospective analysis. J. Toxicol. 2002, 40, 715-757. [CrossRef]
9. Jaeger, A.; Jehl, F.; Flesch, F.; Sauder, P.; Kopferschmitt, J. Kinetics of amatoxins in human poisoning: Therapeutic implications. J. Clin. Toxicol. 1993, 31, 63-80. [CrossRef]
10. Rentsch, K. M. Laboratory diagnostics in acute poisoning: Critical overview. Clin. Chem. Lab. Med. 2010, 48, 1381-1387. [CrossRef] [PubMed]
11. Faulstich, H.; Zobeley, S.; Trischmann, H. A rapid radioimmunoassay, using a nylon support, for amatoxins from Amanita mushrooms. Toxicon 1982, 20, 913-924. [CrossRef]
12. Faulstich, H.; Trischmann, H.; Zobeley, S. A radioimmunoassay for amanitin. FEBS Lett. 1975, 56, 312-315. [CrossRef]
13. Homann, J.; Rawer, P.; Bleyl, H.; Matthes, K.; Heinrich, D. Early detection of amatoxins in human mushroom poisoning. Arch. Toxicol. 1986, 59, 190-191. [CrossRef] [PubMed]
14. Abuknesha, R. A.; Maragkou, A. A highly sensitive and specific enzyme immunoassay for detection of beta-amanitin in biological fluids. Anal. Bioanal. Chem. 1993, 379, 853-860.
15. Butera, R.; Locatelli, C.; Coccini, T.; Manzo, L. Diagnostic accuracy of urinary amanitin in suspected mushroom poisoning: A pilot study. J. Toxicol. Clin. Toxicol. 2004, 42, 901-912. [CrossRef] [PubMed]
16. Bruggemann, O.; Meder, M.; Freitag, R. Analysis of amatoxins α-amanitin and β-amanitin in toadstool extracts and body fluids by capillary zone electrophoresis with photodiode array detection. J. Chromatogr. A 1996, 744, 167-176. [CrossRef]
17. Robinson-Fuentes, V.; Jaimes-Sánchez, J.; García-Aguilar, L.; Gómez-Peralta, M.; Vázquez-Garciduenas, M.; Vázquez-Marrfo, G. Determination of α-and β-amanitin in clinical urine samples by Capillary Zone Electrophoresis. J. Pharm. Biomed. Anal. 2008, 47, 913-917. [CrossRef] [PubMed]
18. Rieck, W.; Platt, D. High-performance liquid chromatographic method for the determination of α-amanitin and phalloidin in human plasma using the column-switching technique and its application in suspected cases of poisoning by the green species of amanita mushroom (Amanita phalloides). J. Chromatogr. 1988, 425, 121-134. [PubMed]
19. Zhou, Z.; Cao, M.; Zhou, L.; Zuo, X.; Tang, Y. Determination of α-amanitin in human serum by solid-phase extraction coupled with HPLC-UV. LC GC N. Am. 2011, 29, 672-677.
20. Tagliaro, F.; Schiavon, G.; Bontempelli, G.; Carli, G.; Marigo, M. Improved high-performance liquid chromatographic determination with amperometric detection of α-amanitin in human plasma based on its voltammetric study. J. Chromatogr. 1991, 563, 299-311. [CrossRef]
21. Defendenti, C.; Bonacina, E.; Mauroni, M.; Gelosa, L. Validation of a high performance liquid chromatographic method for alpha amanitin determination in urine. Forensic Sci. Int. 1998, 92, 59-68. [CrossRef]
22. Garcia, J.; Costa, V. M.; Baptista, P.; Bastos, M. L.; Carvalho, F. Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV-diode array and electrochemical detection. J. Chromatogr. B 2015, 997, 85-95. [CrossRef] [PubMed]
23. Leite, M.; Freitas, A.; Azul, A. M.; Barbosa, J.; Costa, S.; Ramos, F. Development, optimization and application of an analytical methodology by ultra performance liquid chromatography-Tandem mass spectrometry for determination of amanitins in urine and liver samples. Anal. Chim. Acta 2013, 799, 77-87. [CrossRef] [PubMed]
24. Maurer, H. H.; Schmitt, C. J.; Weber, A. A.; Kraemer, T. Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins α-and β-amanitin in urine after immunoaffinity extraction. J. Chromatogr. B 2000, 748, 125-135. [CrossRef]
25. Chung, W.; Tso, S.; Sze, S. Separation of polar mushroom toxins by mixed-mode hydrophilic and ionic Interaction liquid chromatography-Electrospray ionization-mass spectrometry. J. Chromatogr. Sci. 2007, 45, 104-111. [CrossRef] [PubMed]
26. Tanahashi, M.; Kaneko, R.; Hirata, Y.; Hamajima, M.; Arinobu, T.; Ogawa, T.; Ishii, A. Simple analysis of α-amanitin and β-amanitin in human plasma by liquid chromatography-mass spectrometry. Forensic Toxicol. 2010, 28, 110-114. [CrossRef]
27. Nomura, M.; Suzuki, Y.; Kaneko, R.; Ogawa, T.; Hattori, H.; Seno, H.; Ishii, A. Simple and rapid analysis of amatoxins using UPLC-MS-MS. Forensic Toxicol. 2012, 30, 185-192. [CrossRef]
28. Helfer, A. G.; Meyer, M. R.; Michely, J. A.; Maurer, H. H. Direct analysis of the mushroom poisons α-and β-amanitin in human urine using a novel on-line turbulent flow chromatography modecoupled to liquid chromatography-high resolution-massspectrometry/mass spectrometry. J. Chromatogr. A 2014, 1325, 92-98. [CrossRef] [PubMed]
29. Tomkova, J.; Ondra, P.; Válka, I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci. Int. 2015, 251, 209-213. [CrossRef] [PubMed]
30. Gonmori, K.; Minakata, K.; Suzuki, M.; Yamagishi, I.; Nozawa, H.; Hasegawa, K.; Wurita, A.; Watanabe, K.; Suzuki, O. MALDI-TOF mass spectrometric analysis of α-amanitin, β-amanitin, and phalloidin in urine. Forensic Toxicol. 2012, 30, 179-184. [CrossRef]
31. Vetter, J. Toxins of Amanita phalloides. Toxicon 1997, 36, 13-24. [CrossRef]
32. Chambers, E.; Wagrowski-Diehl, D. M.; Lu, Z.; Mazzeo, J. R. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chromatogr. B 2007, 852, 22-34. [CrossRef] [PubMed]
33. Carmical, J.; Brown, S. The impact of phospholipids and phospholipid removal on bioanalytical method performance. Biomed. Chromatogr. 2016. [CrossRef] [PubMed]
34. Little, J. L.; Wempe, M. F.; Buchanan, C. M. Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma. J. Chromatogr. B 2006, 833, 219-230. [CrossRef] [PubMed]
35. Matuszewski, B. K.; Constanzer, M. L.; Chavez-Eng, C. M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 2003, 75, 3019-3030. [CrossRef] [PubMed]
36. Matuszewski, B. K. Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis. J. Chromatogr. B 2006, 830, 293-300. [CrossRef] [PubMed]
37. Guideline on bioanalytical method validation. European Medicines Agency. Available online: http: //www. ema. europa. eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686. pdf (accessed on 12 February 2016).
38. Deng, Q. W.; Li, T. H.; Xi, P. G.; Gan, L. X.; Xiao, Z. D.; Jiang, Z. D. Peptide toxin components of Amanita exitialis basidiocarps. Mycologia 2011, 103, 946-949. [CrossRef] [PubMed]