Efficient and Controlled Generation of 2D and 3D Bile Duct Tissue from Human Pluripotent Stem Cell-Derived Spheroids

Stem Cell Reviews and Reports

Volumn 12, Issue 4, 2016, Pages 500-508

  Tian, Lipeng ^a   Deshmukh, Abhijeet ^a   Ye, Zhaohui ^b   Jang, Yoon Young ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3D tissue engineering; Ductal differentiation; Genome editing; Induced pluripotent stem cells; Liver progenitor; Spheroids

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; EPITHELIAL CELL ADHESION MOLECULE; MATRIGEL; RHODAMINE 123; RNA; TRANSCRIPTION FACTOR SOX17; VERAPAMIL; COLLAGEN; DRUG COMBINATION; EPIDERMAL GROWTH FACTOR; LAMININ; PROTEOGLYCAN; SCATTER FACTOR;

ARTICLE; BILE DUCT; CELL CULTURE; CELL DIFFERENTIATION; CELLULAR PARAMETERS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CELL; MICROSCOPY; MULTIDRUG RESISTANCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPHEROID CELL; THREE DIMENSIONAL CONDITION; TWO DIMENSIONAL CONDITION; CELL CULTURE TECHNIQUE; CELL LINE; CYTOLOGY; DRUG COMBINATION; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETICS; INDUCED PLURIPOTENT STEM CELL; LIVER; METABOLISM; MULTICELLULAR SPHEROID; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME FACTOR; TISSUE ENGINEERING;

BILE DUCTS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; COLLAGEN; DRUG COMBINATIONS; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELL ADHESION MOLECULE; GENE EXPRESSION; HEPATOCYTE GROWTH FACTOR; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LAMININ; LIVER; MICROSCOPY, FLUORESCENCE; PROTEOGLYCANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPHEROIDS, CELLULAR; TIME FACTORS; TISSUE ENGINEERING;

EID: 84965031075     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-016-9657-5     Document Type: Article

References (24)

1. Tietz, P. S., & Larusso, N. F. (2006). Cholangiocyte biology. Current Opinion in Gastroenterology, 22(3), 279–287. doi:10.1097/01.mog.0000218965.78558.bc.
2. Strazzabosco, M., & Fabris, L. (2012). Development of the bile ducts: essentials for the clinical hepatologist. Journal of Hepatology, 56(5), 1159–1170. doi:10.1016/j.jhep.2011.09.022.
3. Gouw, A. S., Clouston, A. D., & Theise, N. D. (2011). Ductular reactions in human liver: diversity at the interface. Hepatology, 54(5), 1853–1863. doi:10.1002/hep.24613.
4. Okabe, M., Tsukahara, Y., Tanaka, M., Suzuki, K., Saito, S., Kamiya, Y., Tsujimura, T., Nakamura, K., & Miyajima, A. (2009). Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development, 136(11), 1951–1960. doi:10.1242/dev.031369.
5. Tanimizu, N., & Mitaka, T. (2014). Re-evaluation of liver stem/progenitor cells. Organogenesis, 10(2), 208–215. doi:10.4161/org.27591.
6. Lee, S. J., Park, J. B., Kim, K. H., Lee, W. R., Kim, J. Y., An, H. J., & Park, K. K. (2014). Immunohistochemical study for the origin of ductular reaction in chronic liver disease. International Journal of Clinical and Experimental Pathology, 7(7), 4076–4085.
7. Lazaridis, K. N., & LaRusso, N. F. (2015). The Cholangiopathies. Mayo Clinic Proceedings, 90(6), 791–800. doi:10.1016/j.mayocp.2015.03.017.
8. Takayama, K., Inamura, M., Kawabata, K., Katayama, K., Higuchi, M., Tashiro, K., Nonaka, A., Sakurai, F., Hayakawa, T., Furue, M. K., & Mizuguchi, H. (2012). Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4alpha transduction. Molecular Therapy, 20(1), 127–137. doi:10.1038/mt.2011.234.
9. Ma, X., Duan, Y., Tschudy-Seney, B., Roll, G., Behbahan, I. S., Ahuja, T. P., Tolstikov, V., Wang, C., McGee, J., Khoobyari, S., Nolta, J. A., Willenbring, H., & Zern, M. A. (2013). Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Translational Medicine, 2(6), 409–419. doi:10.5966/sctm.2012-0160.
10. Choi, S. M., Kim, Y., Liu, H., Chaudhari, P., Ye, Z., & Jang, Y. Y. (2011). Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells. Cell Cycle, 10(15), 2423–2427.
11. Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S. J., Kemperman, H., de Jonge, J., Ijzermans, J. N., Nieuwenhuis, E. E., Hoekstra, R., Strom, S., Vries, R. R., van der Laan, L. J., Cuppen, E., & Clevers, H. (2015). Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell, 160(1–2), 299–312. doi:10.1016/j.cell.2014.11.050.
12. Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M., & Clevers, H. (2013). In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature, 494(7436), 247–250. doi:10.1038/nature11826.
13. Krause, P., Unthan-Fechner, K., Probst, I., & Koenig, S. (2014). Cultured hepatocytes adopt progenitor characteristics and display bipotent capacity to repopulate the liver. Cell Transplantation, 23(7), 805–817. doi:10.3727/096368913X664856.
14. Ogawa, M., Ogawa, S., Bear, C. E., Ahmadi, S., Chin, S., Li, B., Grompe, M., Keller, G., Kamath, B. M., & Ghanekar, A. (2015). Directed differentiation of cholangiocytes from human pluripotent stem cells. Nature Biotechnology, 33(8), 853–861. doi:10.1038/nbt.3294.
15. Dianat, N., Dubois-Pot-Schneider, H., Steichen, C., Desterke, C., Leclerc, P., Raveux, A., Combettes, L., Weber, A., Corlu, A., & Dubart-Kupperschmitt, A. (2014). Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells. Hepatology, 60(2), 700–714. doi:10.1002/hep.27165.
16. Sampaziotis, F., Cardoso de Brito, M., Madrigal, P., Bertero, A., Saeb-Parsy, K., Soares, F. A., Schrumpf, E., Melum, E., Karlsen, T. H., Bradley, J. A., Gelson, W. T., Davies, S., Baker, A., Kaser, A., Alexander, G. J., Hannan, N. R., & Vallier, L. (2015). Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33(8), 845–852. doi:10.1038/nbt.3275.
17. Choi, S. M., Liu, H., Chaudhari, P., Kim, Y., Cheng, L., Feng, J., Sharkis, S., Ye, Z., & Jang, Y. Y. (2011). Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells. Blood, 118(7), 1801–1805. doi:10.1182/blood-2011-03-340620.
18. Liu, H., Kim, Y., Sharkis, S., Marchionni, L., & Jang, Y. Y. (2011). In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins. Science Translational Medicine, 3(82), 82ra39. doi:10.1126/scitranslmed.3002376.
19. Liu, H., Ye, Z., Kim, Y., Sharkis, S., & Jang, Y. Y. (2010). Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology, 51(5), 1810–1819. doi:10.1002/hep.23626.
20. Tian, L., Prasad, N., & Jang, Y. Y. (2014). In vitro modeling of alcohol-induced liver injury using human-induced pluripotent stem cells. Methods in Molecular Biology. doi:10.1007/7651_2014_168.
21. Choi, S. M., Kim, Y., Shim, J. S., Park, J. T., Wang, R. H., Leach, S. D., Liu, J. O., Deng, C., Ye, Z., & Jang, Y. Y. (2013). Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology, 57(6), 2458–2468. doi:10.1002/hep.26237.
22. Chun, Y. S., Chaudhari, P., & Jang, Y. Y. (2010). Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease. International Journal of Biological Sciences, 6(7), 796–805.
23. Tanimizu, N., Miyajima, A., & Mostov, K. E. (2007). Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Molecular Biology of the Cell, 18(4), 1472–1479. doi:10.1091/mbc.E06-09-0848.
24. Ueno, Y., Alpini, G., Yahagi, K., Kanno, N., Moritoki, Y., Fukushima, K., Glaser, S., LeSage, G., & Shimosegawa, T. (2003). Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice. Liver International, 23(6), 449–459.