메뉴 건너뛰기




Volumn 9, Issue 3, 2016, Pages 621-633

Cervicovaginal microbiome dysbiosis is associated with proteome changes related to alterations of the cervicovaginal mucosal barrier

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALGRANULIN; CYTOKINE; HISTONE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; KERATIN; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; LACTATE DEHYDROGENASE B; LYSOZYME; MUCIN 5AC; MUCIN 5B; PROTEASOME; PROTEINASE; PSORIASIN; UBIQUITIN; UNCLASSIFIED DRUG; AUTACOID; PROTEOME;

EID: 84964992824     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2015.86     Document Type: Article
Times cited : (174)

References (56)
  • 1
    • 84922925221 scopus 로고    scopus 로고
    • The vaginal microbiota: What have we learned after a decade of molecular characterization?
    • van de Wijgert, J.H. et al. The vaginal microbiota: what have we learned after a decade of molecular characterization? PLoS One 9, e105998 (2014).
    • (2014) PLoS One , vol.9 , pp. e105998
    • Van De Wijgert, J.H.1
  • 3
    • 0020665888 scopus 로고
    • Nonspecific vaginitis-diagnostic criteria and microbial and epidemiologic associations
    • Amsel, R., Totten, P.A., Spiegel, C.A., Chen, K.C.S., Eschenbach, D. & Holmes, K.K. Nonspecific vaginitis-diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 74, 14-22 (1983).
    • (1983) Am. J. Med. , vol.74 , pp. 14-22
    • Amsel, R.1    Totten, P.A.2    Spiegel, C.A.3    Chen, K.C.S.4    Eschenbach, D.5    Holmes, K.K.6
  • 4
    • 0026088584 scopus 로고
    • Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation
    • Nugent, R.P., Krohn, M.A. & Hillier, S.L. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J. Clin. Microbiol. 29, 297-301 (1991).
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 297-301
    • Nugent, R.P.1    Krohn, M.A.2    Hillier, S.L.3
  • 5
    • 79952264089 scopus 로고    scopus 로고
    • Intravaginal practices, bacterial vaginosis, and HIV infection in women: Individual participant data meta-analysis
    • Low, N. et al. Intravaginal practices, bacterial vaginosis, and HIV infection in women: individual participant data meta-analysis. PLoS Med. 15, e1000416 (2011).
    • (2011) PLoS Med. , vol.15 , pp. e1000416
    • Low, N.1
  • 6
    • 84055193937 scopus 로고    scopus 로고
    • Vaginal microbiome and sexually transmitted infections: An epidemiologic perspective
    • Brotman, R.M. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J. Clin. Invest. 121, 4610-4617 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 4610-4617
    • Brotman, R.M.1
  • 7
    • 0034817210 scopus 로고    scopus 로고
    • Origins of vaginal acidity: High D/L lactate ratio is consistent with bacteria being the primary source
    • Boskey, E.R., Cone, R.A., Whaley, K.J. & Moench, T.R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 16, 1809-1813 (2001).
    • (2001) Hum. Reprod. , vol.16 , pp. 1809-1813
    • Boskey, E.R.1    Cone, R.A.2    Whaley, K.J.3    Moench, T.R.4
  • 8
    • 77953229628 scopus 로고    scopus 로고
    • In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women
    • Matu, M.N., Orinda, G.O., Njagi, E.N., Cohen, C.R. & Bukusi, E.A. In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women. Anaerobe 16, 210-215 (2010).
    • (2010) Anaerobe , vol.16 , pp. 210-215
    • Matu, M.N.1    Orinda, G.O.2    Njagi, E.N.3    Cohen, C.R.4    Bukusi, E.A.5
  • 9
    • 41849088447 scopus 로고    scopus 로고
    • The lower genital tract microbiota in relation to cytokine-, SLPI-and endotoxin levels: Application of checkerboard DNA-DNA hybridization (CDH)
    • Nikolaitchouk, N., Andersch, B., Falsen, E., Strömbeck, L. & Mattsby-Baltzer, I. The lower genital tract microbiota in relation to cytokine-, SLPI-and endotoxin levels: application of checkerboard DNA-DNA hybridization (CDH). APMIS 116, 263-277 (2008).
    • (2008) APMIS , vol.116 , pp. 263-277
    • Nikolaitchouk, N.1    Andersch, B.2    Falsen, E.3    Strömbeck, L.4    Mattsby-Baltzer, I.5
  • 10
    • 79551619576 scopus 로고    scopus 로고
    • Innate immunity in the human female reproductive tract: Endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections
    • Wira, C.R., Patel, M.V., Ghosh, M., Mukura, L. & Fahey, J.V. Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections. Am. J. Reprod. Immunol. 65, 196-211 (2011).
    • (2011) Am. J. Reprod. Immunol. , vol.65 , pp. 196-211
    • Wira, C.R.1    Patel, M.V.2    Ghosh, M.3    Mukura, L.4    Fahey, J.V.5
  • 11
    • 84900530093 scopus 로고    scopus 로고
    • Bacterial vaginosis and the cervicovaginal immune response
    • Mitchell, C. & Marrazzo, J. Bacterial vaginosis and the cervicovaginal immune response. Am. J. Reprod. Immunol. 71, 555-563 (2014).
    • (2014) Am. J. Reprod. Immunol. , vol.71 , pp. 555-563
    • Mitchell, C.1    Marrazzo, J.2
  • 12
    • 84929754743 scopus 로고    scopus 로고
    • Antimicrobial peptides in the female reproductive tract: A critical component of the mucosal immune barrier with physiological and clinical implications
    • Yarbrough, V.L., Winkle, S. & Herbst-Kralovetz, M.M. Antimicrobial peptides in the female reproductive tract: A critical component of the mucosal immune barrier with physiological and clinical implications. Hum. Reprod. Update. 21, 353-377 (2014).
    • (2014) Hum. Reprod. Update. , vol.21 , pp. 353-377
    • Yarbrough, V.L.1    Winkle, S.2    Herbst-Kralovetz, M.M.3
  • 13
    • 85032972492 scopus 로고    scopus 로고
    • Genital tract immunological markers in Sub-Saharan African women with relevance to HIV risk and prevention
    • Kyongo, J.K. et al. Genital tract immunological markers in Sub-Saharan African women with relevance to HIV risk and prevention. AIDS Res. Hum. Retroviruses 30, A233 (2014).
    • (2014) AIDS Res. Hum. Retroviruses , vol.30 , pp. A233
    • Kyongo, J.K.1
  • 14
    • 84925382154 scopus 로고    scopus 로고
    • Correlates of the molecular vaginal microbiota composition of African women
    • Gautam, R. et al. Correlates of the molecular vaginal microbiota composition of African women. BMC Infect. Dis. 15, 86 (2015).
    • (2015) BMC Infect. Dis. , vol.15 , pp. 86
    • Gautam, R.1
  • 15
    • 80655129298 scopus 로고    scopus 로고
    • Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers
    • Burgener, A. et al. Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers. J. Proteome Res. 10, 5139-5149 (2011).
    • (2011) J. Proteome Res. , vol.10 , pp. 5139-5149
    • Burgener, A.1
  • 16
    • 84886243224 scopus 로고    scopus 로고
    • Proteome profiles of vaginal fluids fromwomen affected by bacterial vaginosis and healthy controls: Outcomes of rifaximin treatment
    • Cruciani, F. et al. Proteome profiles of vaginal fluids fromwomen affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment. J. Antimicrob. Chemother. 68, 2648-2659 (2013).
    • (2013) J. Antimicrob. Chemother. , vol.68 , pp. 2648-2659
    • Cruciani, F.1
  • 17
    • 77953915771 scopus 로고    scopus 로고
    • Noninvasive diagnosis of intraamniotic infection: Proteomic biomarkers in vaginal fluid
    • Hitti, J. et al. Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid. Am. J. Obstet. Gynecol. 203, 32.e1-e8 (2010).
    • (2010) Am. J. Obstet. Gynecol. , vol.203 , pp. 32e1-32e8
    • Hitti, J.1
  • 18
    • 84874056131 scopus 로고    scopus 로고
    • Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes
    • Liong, S. et al. Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes. Reproduction 145, 137-147 (2013).
    • (2013) Reproduction , vol.145 , pp. 137-147
    • Liong, S.1
  • 19
    • 34248196045 scopus 로고    scopus 로고
    • Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid
    • Pereira, L. et al. Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid. J. Proteome Res. 6, 1269-1276 (2007).
    • (2007) J. Proteome Res. , vol.6 , pp. 1269-1276
    • Pereira, L.1
  • 20
    • 65549103789 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples
    • Zegels, G., Van Raemdonck, G.A., Coen, E.P., Tjalma,W.A. & Van Ostade, X.W. Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples. Proteome Sci. 7, 17 (2009).
    • (2009) Proteome Sci. , vol.7 , pp. 17
    • Zegels, G.1    Van Raemdonck, G.A.2    Coen, E.P.3    Tjalma, W.A.4    Van Ostade, X.W.5
  • 21
    • 84906942139 scopus 로고    scopus 로고
    • Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women
    • Borgdorff, H. et al. Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women. ISME J. 8, 1781-1793 (2014).
    • (2014) ISME J. , vol.8 , pp. 1781-1793
    • Borgdorff, H.1
  • 22
    • 0030947113 scopus 로고    scopus 로고
    • Mucin genes expressed by human female reproductive tract epithelia
    • Gipson, I.K. et al. Mucin genes expressed by human female reproductive tract epithelia. Biol. Reprod. 56, 999-1011 (1997).
    • (1997) Biol. Reprod. , vol.56 , pp. 999-1011
    • Gipson, I.K.1
  • 23
    • 84899816777 scopus 로고    scopus 로고
    • Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion
    • Chen, A. et al. Transient antibody-mucin interactions produce a dynamic molecular shield against viral invasion. Biophys. J. 106, 2028-2036 (2014).
    • (2014) Biophys. J. , vol.106 , pp. 2028-2036
    • Chen, A.1
  • 24
    • 0037334692 scopus 로고    scopus 로고
    • Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis
    • Olmsted, S.S., Meyn, L.A., Rohan, L.C. & Hillier, S.L. Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. Sex. Transm. Dis. 30, 257-261 (2003).
    • (2003) Sex. Transm. Dis. , vol.30 , pp. 257-261
    • Olmsted, S.S.1    Meyn, L.A.2    Rohan, L.C.3    Hillier, S.L.4
  • 25
    • 84877653478 scopus 로고    scopus 로고
    • Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model
    • Radtke, A.L., Quayle, A.J. & Herbst-Kralovetz, M.M. Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model. Biol. Reprod. 87, 132 (2012).
    • (2012) Biol. Reprod. , vol.87 , pp. 132
    • Radtke, A.L.1    Quayle, A.J.2    Herbst-Kralovetz, M.M.3
  • 26
    • 84900525927 scopus 로고    scopus 로고
    • Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner
    • Doerflinger, S.Y., Throop, A.L. & Herbst-Kralovetz, M.M. Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner. J. Infect. Dis. 209, 1989-1999 (2014).
    • (2014) J. Infect. Dis. , vol.209 , pp. 1989-1999
    • Doerflinger, S.Y.1    Throop, A.L.2    Herbst-Kralovetz, M.M.3
  • 27
    • 84926676917 scopus 로고    scopus 로고
    • Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1
    • Koning, N. et al. Human Milk Blocks DC-SIGN-Pathogen Interaction via MUC1. Front. Immunol. 6, 112 (2015).
    • (2015) Front. Immunol. , vol.6 , pp. 112
    • Koning, N.1
  • 28
    • 40649127911 scopus 로고    scopus 로고
    • MUC1 mucin is a negative regulator of toll-like receptor signaling
    • Ueno, K. et al. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am. J. Respir. Cell Mol. Biol. 38, 263-268 (2008).
    • (2008) Am. J. Respir. Cell Mol. Biol. , vol.38 , pp. 263-268
    • Ueno, K.1
  • 29
    • 77957278004 scopus 로고    scopus 로고
    • Cytoskeletal regulation of epithelial barrier function during inflammation
    • Ivanov, A.I., Parkos, C.A. & Nusrat, A. Cytoskeletal regulation of epithelial barrier function during inflammation. Am. J. Pathol. 177, 512-524 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 512-524
    • Ivanov, A.I.1    Parkos, C.A.2    Nusrat, A.3
  • 30
    • 78650969022 scopus 로고    scopus 로고
    • Innate immunity and inflammatory response to Trichomonas vaginalis and bacterial vaginosis: Relationship to HIV acquisition
    • Thurman, A.R. & Doncel, G.F. Innate immunity and inflammatory response to Trichomonas vaginalis and bacterial vaginosis: relationship to HIV acquisition. Am. J. Reprod. Immunol. 65, 89-98 (2011).
    • (2011) Am. J. Reprod. Immunol. , vol.65 , pp. 89-98
    • Thurman, A.R.1    Doncel, G.F.2
  • 31
    • 84873539965 scopus 로고    scopus 로고
    • A multi-omic systems-based approach reveals metabolic markers of bacterial vaginosis and insight into the disease
    • Yeoman, et al. A multi-omic systems-based approach reveals metabolic markers of bacterial vaginosis and insight into the disease. PLoS One 8, e56111 (2013).
    • (2013) PLoS One , vol.8 , pp. e56111
    • Yeoman1
  • 32
    • 84879769779 scopus 로고    scopus 로고
    • Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis
    • Macklaim, J.M., Fernandes, A.D., Di Bella, J.M., Hammond, J.A., Reid, G. & Gloor, G.B. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome 1, 12 (2013).
    • (2013) Microbiome , vol.1 , pp. 12
    • Macklaim, J.M.1    Fernandes, A.D.2    Di Bella, J.M.3    Hammond, J.A.4    Reid, G.5    Gloor, G.B.6
  • 33
    • 44149099717 scopus 로고    scopus 로고
    • The human keratins: Biology and pathology
    • Moll, R., Divo, M. & Langbein, L. The human keratins: biology and pathology. Histochem. Cell Biol. 129, 705-733 (2008).
    • (2008) Histochem. Cell Biol. , vol.129 , pp. 705-733
    • Moll, R.1    Divo, M.2    Langbein, L.3
  • 34
    • 56449112645 scopus 로고    scopus 로고
    • Extracellular, circulating proteasomes and ubiquitin-incidence and relevance
    • Sixt, S.U. & Dahlmann, B. Extracellular, circulating proteasomes and ubiquitin-incidence and relevance. Biochim. Biophys. Acta. 1782, 817-823 (2008).
    • (2008) Biochim. Biophys. Acta. , vol.1782 , pp. 817-823
    • Sixt, S.U.1    Dahlmann, B.2
  • 35
    • 1042278905 scopus 로고    scopus 로고
    • Proteasome and peptidase function in MHC-class-I-mediated antigen presentation
    • Kloetzel, P.M. & Ossendorp, F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol. 16, 76-81 (2004).
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 76-81
    • Kloetzel, P.M.1    Ossendorp, F.2
  • 36
    • 84891373742 scopus 로고    scopus 로고
    • T lymphocytes export proteasomes by way of microparticles: A possible mechanism for generation of extracellular proteasomes
    • Bochmann, I. et al. T lymphocytes export proteasomes by way of microparticles: A possible mechanism for generation of extracellular proteasomes. J. Cell Mol. Med. 18, 59-68 (2014).
    • (2014) J. Cell Mol. Med. , vol.18 , pp. 59-68
    • Bochmann, I.1
  • 37
    • 33749237882 scopus 로고    scopus 로고
    • Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis
    • Valore, E.V., Wiley, D.J. & Ganz, T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect. Immun. 74, 5693-5702 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 5693-5702
    • Valore, E.V.1    Wiley, D.J.2    Ganz, T.3
  • 38
    • 77958179336 scopus 로고    scopus 로고
    • Psoriasin (S100A7) is amajor Escherichia coli-cidal factor of the female genital tract
    • Mildner,M. et al. Psoriasin (S100A7) is amajor Escherichia coli-cidal factor of the female genital tract. Mucosal Immunol. 3, 602-609 (2010).
    • (2010) Mucosal Immunol. , vol.3 , pp. 602-609
    • Mildner, M.1
  • 39
    • 84901193479 scopus 로고    scopus 로고
    • Exploitation of the host ubiquitin system by human bacterial pathogens
    • Ashida, H., Kim, M. & Sasakawa, C. Exploitation of the host ubiquitin system by human bacterial pathogens. Nat. Rev. Microbiol. 12, 399-413 (2014).
    • (2014) Nat. Rev. Microbiol. , vol.12 , pp. 399-413
    • Ashida, H.1    Kim, M.2    Sasakawa, C.3
  • 40
    • 33750682358 scopus 로고    scopus 로고
    • Beyond the walls of the nucleus: The role of histones in cellular signaling and innate immunity
    • Parseghian, M.H. & Luhrs, K.A. Beyond the walls of the nucleus: The role of histones in cellular signaling and innate immunity. Biochem. Cell Biol. 84, 589-604 (2006).
    • (2006) Biochem. Cell Biol. , vol.84 , pp. 589-604
    • Parseghian, M.H.1    Luhrs, K.A.2
  • 41
    • 33745264884 scopus 로고    scopus 로고
    • Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer
    • Makarov, A., Denisov, E., Lange, O. & Horning, S. Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer. J. Am. Soc. Mass Spectrom. 17, 977-982 (2006).
    • (2006) J. Am. Soc. Mass Spectrom. , vol.17 , pp. 977-982
    • Makarov, A.1    Denisov, E.2    Lange, O.3    Horning, S.4
  • 42
    • 0036720455 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1
    • Williams, S.B. et al. Human immunodeficiency virus (HIV)-specific antibody in cervicovaginal lavage specimens obtained from women infected with HIV type 1. Clin. Infect. Dis. 35, 611-617 (2002).
    • (2002) Clin. Infect. Dis. , vol.35 , pp. 611-617
    • Williams, S.B.1
  • 43
    • 3042550239 scopus 로고    scopus 로고
    • Vaginal lactobacilli in adolescents: Presence and relationship to local and systemic immunity, and to bacterial vaginosis
    • Alvarez-Olmos,M.I. et al. Vaginal lactobacilli in adolescents: presence and relationship to local and systemic immunity, and to bacterial vaginosis. Sex. Transm. Dis. 31, 393-400 (2004).
    • (2004) Sex. Transm. Dis. , vol.31 , pp. 393-400
    • Alvarez-Olmos, M.I.1
  • 45
    • 0031593946 scopus 로고    scopus 로고
    • Impairment of the mucosal immune system: IgA and IgM cleavage detected in vaginal washings of a subgroup of patients with bacterial vaginosis
    • Cauci, S., Monte, R., Driussi, S., Lanzafame, P. & Quadrifoglio, F. Impairment of the mucosal immune system: IgA and IgM cleavage detected in vaginal washings of a subgroup of patients with bacterial vaginosis. J. Infect. Dis. 178, 1698-1706 (1998).
    • (1998) J. Infect. Dis. , vol.178 , pp. 1698-1706
    • Cauci, S.1    Monte, R.2    Driussi, S.3    Lanzafame, P.4    Quadrifoglio, F.5
  • 46
    • 79954790658 scopus 로고    scopus 로고
    • High human immunodeficiency virus incidence in a cohort of Rwandan female sex workers
    • Braunstein, S.L. et al. High human immunodeficiency virus incidence in a cohort of Rwandan female sex workers. Sex. Transm. Dis. 38, 385-394 (2011).
    • (2011) Sex. Transm. Dis. , vol.38 , pp. 385-394
    • Braunstein, S.L.1
  • 47
    • 79953267321 scopus 로고    scopus 로고
    • Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis
    • Dols, J.A. et al. Microarray-based identification of clinically relevant vaginal bacteria in relation to bacterial vaginosis. Am. J. Obstet. Gynecol. 204, 305 (2011).
    • (2011) Am. J. Obstet. Gynecol. , vol.204 , pp. 305
    • Dols, J.A.1
  • 48
    • 84907958775 scopus 로고    scopus 로고
    • Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites
    • Armstrong, S.D. et al. Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites. Mol. Cell Proteomics 13, 2527-2544 (2014).
    • (2014) Mol. Cell Proteomics , vol.13 , pp. 2527-2544
    • Armstrong, S.D.1
  • 49
    • 84891796097 scopus 로고    scopus 로고
    • ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination
    • Vizcaíno, J.A. et al. ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination. Nat. Biotechnol. 30, 223-226 (2014).
    • (2014) Nat. Biotechnol. , vol.30 , pp. 223-226
    • Vizcaíno, J.A.1
  • 50
    • 0345269981 scopus 로고    scopus 로고
    • Lactate dehydrogenase and its isoenzymes in vaginal fluid in vaginitis/vaginosis cases and in healthy controls
    • Niklasson, O., Skude, G. & Mardh, P.A. Lactate dehydrogenase and its isoenzymes in vaginal fluid in vaginitis/vaginosis cases and in healthy controls. Int. J. STD AIDS 14, 270-273 (2003).
    • (2003) Int. J. STD AIDS , vol.14 , pp. 270-273
    • Niklasson, O.1    Skude, G.2    Mardh, P.A.3
  • 52
    • 84891783174 scopus 로고    scopus 로고
    • Activities at the Universal Protein Resource (UniProt)
    • UniProt Consortium. Activities at the Universal Protein Resource (UniProt). Nucleic Acids Res. 42, D191-D198 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D191-D198
  • 53
    • 84867000608 scopus 로고    scopus 로고
    • Complement genetics, deficiencies, and disease associations
    • Mayilyan, K.R. Complement genetics, deficiencies, and disease associations. Protein Cell 3, 487-496 (2012).
    • (2012) Protein Cell , vol.3 , pp. 487-496
    • Mayilyan, K.R.1
  • 54
    • 77951223173 scopus 로고    scopus 로고
    • Maspin (SERPINB5) is an obligate intracellular serpin
    • Teoh, S.S., Whisstock, J.C. & Bird, P.I. Maspin (SERPINB5) is an obligate intracellular serpin. J. Biol. Chem. 285, 10862-10869 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 10862-10869
    • Teoh, S.S.1    Whisstock, J.C.2    Bird, P.I.3
  • 55
    • 0030016595 scopus 로고    scopus 로고
    • Structure and functions of the 20S and 26S proteasomes
    • Coux, O., Tanaka, K. & Goldberg, A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65, 801-847 (1996).
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 801-847
    • Coux, O.1    Tanaka, K.2    Goldberg, A.L.3
  • 56
    • 0021993033 scopus 로고
    • A Wilcoxon-type test for trend
    • Cuzick, J. A Wilcoxon-type test for trend. Stat. Med. 4, 87-90 (1985).
    • (1985) Stat. Med. , vol.4 , pp. 87-90
    • Cuzick, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.