Nonstructural protein NP1 of human bocavirus 1 plays a critical role in the expression of viral capsid proteins

Journal of Virology

Volumn 90, Issue 9, 2016, Pages 4658-4669

  Zou, Wei ^a   Cheng, Fang ^a   Shen, Weiran ^a   Engelhardt, John F ^b   Yan, Ziying ^b   Qiu, Jianming ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; NONSTRUCTURAL PROTEIN NP1; PLASMID DNA; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3; SMALL CYTOPLASMIC RNA; UNCLASSIFIED DRUG; VIRUS VECTOR; POLYADENYLIC ACID; RNA SPLICE SITE; START CODON; VIRAL PROTEIN; VIRUS RNA;

5' UNTRANSLATED REGION; ARTICLE; CODON; CONTROLLED STUDY; DNA FLANKING REGION; DNA PACKAGING; GENE DELETION; GENE EXPRESSION REGULATION; HEK293 CELL LINE; HUMAN BOCAVIRUS; HUMAN BOCAVIRUS 1; INTRON; MOLECULAR SYSTEMATICS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PLASMID; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; RIBONUCLEASE PROTECTION ASSAY; RNA SPLICING; SILENT MUTATION; TRANSCRIPTION INITIATION SITE; VIRUS CAPSID; VIRUS EXPRESSION; VIRUS GENOME; VIRUS TRANSCRIPTION; WESTERN BLOTTING; ALTERNATIVE RNA SPLICING; CELL LINE; GENE INACTIVATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; RNA SPLICE SITE; START CODON; TRANSCRIPTION INITIATION;

ALTERNATIVE SPLICING; BASE SEQUENCE; CAPSID PROTEINS; CELL LINE; CODON, INITIATOR; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, VIRAL; GENE KNOCKOUT TECHNIQUES; GENOME, VIRAL; HUMAN BOCAVIRUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; POLY A; RNA SPLICE SITES; RNA, MESSENGER; RNA, VIRAL; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84964961862     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02964-15     Document Type: Article

References (31)

1. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. 2005. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A 102:12891-12896 http://dx.doi.org/10.1073/pnas.0504666102.
2. Cotmore SF, Agbandje-McKenna M, Chiorini JA, Mukha DV, Pintel DJ, Qiu J, Soderlund-Venermo M, Tattersall P, Tijssen P, Gatherer D, Davison AJ. 2014. The family Parvoviridae. Arch Virol 159:1239-1247. http://dx.doi.org/10.1007/s00705-013-1914-1.
3. Johnson FB, Qiu J. 2011. Bocavirus, Parvoviridae, Parvovirinae, p 1209-1215. In Tidona C, Darai G (ed), The Springer index of viruses, 2nd ed. Springer, New York, NY.
4. Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, Vuorinen T, Waris M, Bjerkner A, Tiveljung-Lindell A, van den Hoogen BG, Hyypia T, Ruuskanen O. 2007. Human bocavirus and acute wheezing in children. Clin Infect Dis 44:904-910. http://dx.doi.org/10.1086/512196.
5. Lin F, Zeng A, Yang N, Lin H, Yang E, Wang S, Pintel D, Qiu J. 2007. Quantification of human bocavirus in lower respiratory tract infections in China. Infect Agent Cancer 2:3. http://dx.doi.org/10.1186/1750-9378-2-3.
6. Christensen A, Nordbo SA, Krokstad S, Rognlien AG, Dollner H. 2010. Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection. J Clin Virol 49:158-162. http://dx.doi.org/10.1016/j.jcv.2010.07.016.
7. Deng Y, Gu X, Zhao X, Luo J, Luo Z, Wang L, Fu Z, Yang X, Liu E. 2012. High viral load of human bocavirus correlates with duration of wheezing in children with severe lower respiratory tract infection. PLoS ONE 7:e34353. http://dx.doi.org/10.1371/journal.pone.0034353.
8. Don M, Soderlund-Venermo M, Valent F, Lahtinen A, Hedman L, Canciani M, Hedman K, Korppi M. 2010. Serologically verified human bocavirus pneumonia in children. Pediatr Pulmonol 45:120-126. http://dx.doi.org/10.1002/ppul.21151.
9. Edner N, Castillo-Rodas P, Falk L, Hedman K, Soderlund-Venermo M, Allander T. 2012. Life-threatening respiratory tract disease with human bocavirus-1 infection in a four-year-old child. J Clin Microbiol 50:531-532. http://dx.doi.org/10.1128/JCM.05706-11.
10. Kantola K, Hedman L, Allander T, Jartti T, Lehtinen P, Ruuskanen O, Hedman K, Soderlund-Venermo M. 2008. Serodiagnosis of human bocavirus infection. Clin Infect Dis 46:540-546. http://dx.doi.org/10.1086/526532.
11. Martin ET, Kuypers J, McRoberts JP, Englund JA, Zerr DM. 2015. Human bocavirus-1 primary infection and shedding in infants. J Infect Dis 212:516-524. http://dx.doi.org/10.1093/infdis/jiv044.
12. Dijkman R, Koekkoek SM, Molenkamp R, Schildgen O, van der Hoek L. 2009. Human bocavirus can be cultured in differentiated human airway epithelial cells. J Virol 83:7739-7748. http://dx.doi.org/10.1128/JVI.00614-09.
13. Huang Q, Deng X, Yan Z, Cheng F, Luo Y, Shen W, Lei-Butters DC, Chen AY, Li Y, Tang L, Soderlund-Venermo M, Engelhardt JF, Qiu J. 2012. Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. PLoS Pathog 8:e1002899. http://dx.doi.org/10.1371/journal.ppat.1002899.
14. Deng X, Yan Z, Luo Y, Xu J, Cheng Y, Li Y, Engelhardt J, Qiu J. 2013. In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia. J Virol 87:4097-4102. http://dx.doi.org/10.1128/JVI.03132-12.
15. Deng X, Li Y, Qiu J. 2014. Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively. J Virol Methods 195:112-119. http://dx.doi.org/10.1016/j.jviromet.2013.10.012.
16. Chen AY, Cheng F, Lou S, Luo Y, Liu Z, Delwart E, Pintel D, Qiu J. 2010. Characterization of the gene expression profile of human bocavirus. Virology 403:145-154. http://dx.doi.org/10.1016/j.virol.2010.04.014.
17. Shen W, Deng X, Zou W, Cheng F, Engelhardt JF, Yan Z, Qiu J. 2015. Identification and functional analysis of novel non-structural proteins of human bocavirus 1. J Virol 89:10097-10109. http://dx.doi.org/10.1128/JVI.01374-15.
18. Sun Y, Chen AY, Cheng F, Guan W, Johnson FB, Qiu J. 2009. Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses. J Virol 83:3956-3967. http://dx.doi.org/10.1128/JVI.02569-08.
19. Yan Z, Keiser NW, Song Y, Deng X, Cheng F, Qiu J, Engelhardt JF. 2013. A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia. Mol Ther 21:2181-2194. http://dx.doi.org/10.1038/mt.2013.92.
20. Yan Z, Zhang Y, Duan D, Engelhardt JF. 2000. Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy. Proc Natl Acad Sci U S A 97:6716-6721. http://dx.doi.org/10.1073/pnas.97.12.6716.
21. Chen AY, Kleiboeker S, Qiu J. 2011. Productive parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIF alpha. PLoS Pathog 7:e1002088. http://dx.doi.org/10.1371/journal.ppat.1002088.
22. Qiu J, Nayak R, Tullis GE, Pintel DJ. 2002. Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses. J Virol 76:12435-12447. http://dx.doi.org/10.1128/JVI.76.24.12435-12447.2002.
23. Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. 2009. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clin Vaccine Immunol 16:597-604. http://dx.doi.org/10.1128/CVI.00470-08.
24. Zarudnaya MI, Kolomiets IM, Potyahaylo AL, Hovorun DM. 2003. Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures. Nucleic Acids Res 31:1375-1386. http://dx.doi.org/10.1093/nar/gkg241.
25. Huang Q, Deng X, Best SM, Bloom ME, Li Y, Qiu J. 2012. Internal polyadenylation of parvoviral precursormRNAlimits progeny virus production. Virology 426:167-177. http://dx.doi.org/10.1016/j.virol.2012.01.031.
26. Lederman M, Patton JT, Stout ER, Bates RC. 1984. Virally coded noncapsid protein associated with bovine parvovirus infection. J Virol 49:315-318.
27. Qiu J, Cheng F, Johnson FB, Pintel D. 2007. The transcription profile of the bocavirus bovine parvovirus is unlike those of previously characterized parvoviruses. J Virol 81:12080-12085. http://dx.doi.org/10.1128/JVI.00815-07.
28. Mihaylov IS, Cotmore SF, Tattersall P. 2014. Complementation for an essential ancillary non-structural protein function across parvovirus genera. Virology 468-470:226-237. http://dx.doi.org/10.1016/j.virol.2014.07.043.
29. Sukhu L, Fasina O, Burger L, Rai A, Qiu J, Pintel DJ. 2013. Characterization of the non-structural proteins of the bocavirus minute virus of canine (MVC). J Virol 87:1098-1104. http://dx.doi.org/10.1128/JVI.02627-12.
30. Fasina OO, Dong Y, Pintel DJ. 2015. NP1 protein of the bocaparvovirus minute virus of canines controls access to the viral capsid genes via its role in RNA processing. J Virol 90:1718-1728. http://dx.doi.org/10.1016/j.virol.2014.07.043.
31. Bentley DL. 2014. Coupling mRNA processing with transcription in time and space. Nat Rev Genet 15:163-175. http://dx.doi.org/10.1038/nrg3662.