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Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 12, 2016, Pages 2817-2820

Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA

(9) Prakash, Thazha P a Kinberger, Garth A a Murray, Heather M a Chappell, Alfred a Riney, Stan a Graham, Mark J a Lima, Walt F a Swayze, Eric E a Seth, Punit P a

a ISIS PHARMACEUTICALS (United States)

Author keywords

3 GalNAc cluster; 5 Vinylphosphonate siRNA; Alternating F OMe siRNA; Fully modified siRNA; siRNA phosphorothioates

Indexed keywords

5' VINYLPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE; PHOSPHOROTHIOIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VINYL DERIVATIVE; N ACETYLGALACTOSAMINE; PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, MOUSE; VINYLPHOSPHONIC ACID;

ARTICLE; CELL CULTURE; CHEMICAL MODIFICATION; CONJUGATION; DRUG POTENCY; DRUG TARGETING; METABOLIC STABILITY; MOUSE; NONHUMAN; PHARMACOKINETIC PARAMETERS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; HUMAN; LIVER; METABOLISM; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

ACETYLGALACTOSAMINE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; ORGANOPHOSPHONATES; PHOSPHATES; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 84964940266 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2016.04.063 Document Type: Article

Times cited : (44)

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