-
1
-
-
0142092389
-
Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
-
Guadalupe, M. et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77, 11708-11717 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 11708-11717
-
-
Guadalupe, M.1
-
2
-
-
79751468870
-
Pathogenic mechanisms of HIV disease
-
Moir, S., Chun, T.W. & Fauci, A.S. Pathogenic mechanisms of HIV disease. Annu. Rev. Pathol. 6, 223-248 (2011).
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 223-248
-
-
Moir, S.1
Chun, T.W.2
Fauci, A.S.3
-
3
-
-
76949087872
-
Th17 cells, HIV and the gut mucosal barrier
-
Dandekar, S., George, M.D. & Baumler, A.J. Th17 cells, HIV and the gut mucosal barrier. Curr. Opin. HIV AIDS 5, 173-178 (2010).
-
(2010)
Curr. Opin. HIV AIDS
, vol.5
, pp. 173-178
-
-
Dandekar, S.1
George, M.D.2
Baumler, A.J.3
-
4
-
-
37349078686
-
Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration
-
Sankaran, S. et al. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J. Virol. 82, 538-545 (2008).
-
(2008)
J. Virol.
, vol.82
, pp. 538-545
-
-
Sankaran, S.1
-
5
-
-
84904438190
-
HIV infection: Epidemiology, pathogenesis, treatment, and prevention
-
Maartens, G., Celum, C. & Lewin, S.R. HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet 384, 258-271 (2014).
-
(2014)
Lancet
, vol.384
, pp. 258-271
-
-
Maartens, G.1
Celum, C.2
Lewin, S.R.3
-
6
-
-
33746791047
-
Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection
-
Guadalupe, M. et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J. Virol. 80, 8236-8247 (2006).
-
(2006)
J. Virol.
, vol.80
, pp. 8236-8247
-
-
Guadalupe, M.1
-
7
-
-
84871703067
-
Microbial translocation, immune activation, and HIV disease
-
Klatt, N.R., Funderburg, N.T. & Brenchley, J.M. Microbial translocation, immune activation, and HIV disease. Trends Microbiol. 21, 6-13 (2013).
-
(2013)
Trends Microbiol.
, vol.21
, pp. 6-13
-
-
Klatt, N.R.1
Funderburg, N.T.2
Brenchley, J.M.3
-
8
-
-
3843056825
-
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
-
Deeks, S.G. et al. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 104, 942-947 (2004).
-
(2004)
Blood
, vol.104
, pp. 942-947
-
-
Deeks, S.G.1
-
10
-
-
54449084622
-
Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
-
Macal, M. et al. Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol. 1, 475-488 (2008).
-
(2008)
Mucosal Immunol.
, vol.1
, pp. 475-488
-
-
Macal, M.1
-
11
-
-
84880540665
-
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
-
Vujkovic-Cvijin, I. et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci. Transl. Med. 5, 193ra191 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 193ra191
-
-
Vujkovic-Cvijin, I.1
-
12
-
-
84895733084
-
A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
-
Mutlu, E.A. et al. A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects. PLoS Pathog. 10, e1003829 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1003829
-
-
Mutlu, E.A.1
-
13
-
-
84883855720
-
Alterations in the gut microbiota associated with HIV-1 infection
-
Lozupone, C.A. et al. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe 14, 329-339 (2013).
-
(2013)
Cell Host Microbe
, vol.14
, pp. 329-339
-
-
Lozupone, C.A.1
-
14
-
-
84879369738
-
Commensal bacteria at the interface of host metabolism and the immune system
-
Brestoff, J.R. & Artis, D. Commensal bacteria at the interface of host metabolism and the immune system. Nat. Immunol. 14, 676-684 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 676-684
-
-
Brestoff, J.R.1
Artis, D.2
-
15
-
-
84867208167
-
The gutmicrobiota in IBD
-
Manichanh, C., Borruel, N., Casellas, F. & Guarner, F. The gutmicrobiota in IBD. Nat. Rev. Gastroenterol. Hepatol. 9, 599-608 (2012).
-
(2012)
Nat. Rev. Gastroenterol. Hepatol.
, vol.9
, pp. 599-608
-
-
Manichanh, C.1
Borruel, N.2
Casellas, F.3
Guarner, F.4
-
16
-
-
84900493012
-
An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia
-
Dillon, S.M. et al. An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. Mucosal Immunol. 7, 983-994 (2014).
-
(2014)
Mucosal Immunol.
, vol.7
, pp. 983-994
-
-
Dillon, S.M.1
-
17
-
-
84929633864
-
Dysbiotic bacteria translocate in progressive SIV infection
-
Klase, Z. et al. Dysbiotic bacteria translocate in progressive SIV infection. Mucosal Immunol. 8, 1009-1020 (2015).
-
(2015)
Mucosal Immunol.
, vol.8
, pp. 1009-1020
-
-
Klase, Z.1
-
18
-
-
84896704747
-
Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection
-
Ocon, S. et al. Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection. PLoS One 8, e80863 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e80863
-
-
Ocon, S.1
-
19
-
-
84883860231
-
SIV-induced instability of the chimpanzee gut microbiome
-
Moeller, A.H. et al. SIV-induced instability of the chimpanzee gut microbiome. Cell Host Microbe 14, 340-345 (2013).
-
(2013)
Cell Host Microbe
, vol.14
, pp. 340-345
-
-
Moeller, A.H.1
-
20
-
-
41949101136
-
Antiviral therapy during primary simian immunodeficiency virus infection fails to prevent acute loss of CD4+ T cells in gut mucosa but enhances their rapid restoration through central memory Tcells
-
Verhoeven, D., Sankaran, S., Silvey, M. & Dandekar, S. Antiviral therapy during primary simian immunodeficiency virus infection fails to prevent acute loss of CD4+ T cells in gut mucosa but enhances their rapid restoration through central memory Tcells. J. Virol. 82, 4016-4027 (2008).
-
(2008)
J. Virol.
, vol.82
, pp. 4016-4027
-
-
Verhoeven, D.1
Sankaran, S.2
Silvey, M.3
Dandekar, S.4
-
21
-
-
0024362349
-
Rhesus macaques inoculated with molecularly cloned simian immunodeficiency virus
-
Marthas, M.L. et al. Rhesus macaques inoculated with molecularly cloned simian immunodeficiency virus. J. Med. Primatol. 18, 311-319 (1989).
-
(1989)
J. Med. Primatol.
, vol.18
, pp. 311-319
-
-
Marthas, M.L.1
-
22
-
-
0027935344
-
Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus
-
Lackner, A.A., Vogel, P., Ramos, R.A., Kluge, J.D. & Marthas, M. Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus. Am. J. Pathol. 145, 428-439 (1994).
-
(1994)
Am. J. Pathol.
, vol.145
, pp. 428-439
-
-
Lackner, A.A.1
Vogel, P.2
Ramos, R.A.3
Kluge, J.D.4
Marthas, M.5
-
23
-
-
13944258421
-
Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration
-
George, M.D., Reay, E., Sankaran, S. & Dandekar, S. Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration. J. Virol. 79, 2709-2719 (2005).
-
(2005)
J. Virol.
, vol.79
, pp. 2709-2719
-
-
George, M.D.1
Reay, E.2
Sankaran, S.3
Dandekar, S.4
-
24
-
-
84881013177
-
RIG-I activation inhibits HIV replication in macrophages
-
Wang, Y., Wang, X., Li, J., Zhou, Y. & Ho, W. RIG-I activation inhibits HIV replication in macrophages. J. Leukoc. Biol. 94, 337-341 (2013).
-
(2013)
J. Leukoc. Biol.
, vol.94
, pp. 337-341
-
-
Wang, Y.1
Wang, X.2
Li, J.3
Zhou, Y.4
Ho, W.5
-
25
-
-
84899874803
-
Toll-like receptor agonists are potent inhibitors of human immunodeficiency virus-type 1 replication in peripheral blood mononuclear cells
-
Buitendijk, M., Eszterhas, S.K. & Howell, A.L. Toll-like receptor agonists are potent inhibitors of human immunodeficiency virus-type 1 replication in peripheral blood mononuclear cells. AIDS Res. Hum. Retroviruses 30, 457-467 (2014).
-
(2014)
AIDS Res. Hum. Retroviruses
, vol.30
, pp. 457-467
-
-
Buitendijk, M.1
Eszterhas, S.K.2
Howell, A.L.3
-
26
-
-
0033143105
-
Virulence factors of Actinobacillus actinomycetemcomitans
-
Fives-Taylor, P.M., Meyer, D.H., Mintz, K.P. & Brissette, C. Virulence factors of Actinobacillus actinomycetemcomitans. Periodontology 2000 20, 136-167 (1999).
-
(1999)
Periodontology 2000
, vol.20
, pp. 136-167
-
-
Fives-Taylor, P.M.1
Meyer, D.H.2
Mintz, K.P.3
Brissette, C.4
-
27
-
-
22244451393
-
Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors
-
Sankaran, S. et al. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc. Natl. Acad. Sci. USA 102, 9860-9865 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9860-9865
-
-
Sankaran, S.1
-
28
-
-
41849142985
-
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
-
Raffatellu, M. et al. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 14, 421-428 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 421-428
-
-
Raffatellu, M.1
-
29
-
-
0032540418
-
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
-
Veazey, R.S. et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280, 427-431 (1998).
-
(1998)
Science
, vol.280
, pp. 427-431
-
-
Veazey, R.S.1
-
30
-
-
0031925896
-
Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes
-
Smit-McBride, Z.,Mattapallil, J.J., McChesney,M., Ferrick, D. & Dandekar, S. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J. Virol. 72, 6646-6656 (1998).
-
(1998)
J. Virol.
, vol.72
, pp. 6646-6656
-
-
Smit-McBride, Z.1
Mattapallil, J.J.2
McChesney, M.3
Ferrick, D.4
Dandekar, S.5
-
31
-
-
84897478663
-
Enhanced innate antiviral gene expression, IFN-alpha, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection
-
Verhoeven, D. et al. Enhanced innate antiviral gene expression, IFN-alpha, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection. J. Immunol. 192, 3308-3318 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 3308-3318
-
-
Verhoeven, D.1
-
32
-
-
0027755134
-
Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques
-
Heise, C., Vogel, P., Miller, C.J., Halsted, C.H. & Dandekar, S. Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques. Functional, pathological, and morphological changes. Am. J. Pathol. 142, 1759-1771 (1993).
-
(1993)
Functional, Pathological, and Morphological Changes. Am. J. Pathol.
, vol.142
, pp. 1759-1771
-
-
Heise, C.1
Vogel, P.2
Miller, C.J.3
Halsted, C.H.4
Dandekar, S.5
-
33
-
-
84927639135
-
Innate immune pattern recognition: A cell biological perspective
-
Brubaker, S.W., Bonham, K.S., Zanoni, I. & Kagan, J.C. Innate immune pattern recognition: A cell biological perspective. Annu. Rev. Immunol. 33, 257-290 (2015).
-
(2015)
Annu. Rev. Immunol.
, vol.33
, pp. 257-290
-
-
Brubaker, S.W.1
Bonham, K.S.2
Zanoni, I.3
Kagan, J.C.4
-
34
-
-
84911139963
-
Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques
-
Sang, M., Liu, J.B., Dai, M., Wu, J.G. & Ho, W.Z. Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques. Antiviral Res. 112, 103-112 (2014).
-
(2014)
Antiviral Res.
, vol.112
, pp. 103-112
-
-
Sang, M.1
Liu, J.B.2
Dai, M.3
Wu, J.G.4
Ho, W.Z.5
-
35
-
-
84923096458
-
TLR7 induces anergy in human CD4(+) T cells
-
Dominguez-Villar, M., Gautron, A.S., de Marcken,M., Keller, M.J. & Hafler, D.A. TLR7 induces anergy in human CD4(+) T cells. Nat. Immunol. 16, 118-128 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 118-128
-
-
Dominguez-Villar, M.1
Gautron, A.S.2
De Marcken, M.3
Keller, M.J.4
Hafler, D.A.5
-
36
-
-
84930974237
-
Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption
-
Hirao, L.A. et al. Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption. PLoS Pathog. 10, e1004311 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1004311
-
-
Hirao, L.A.1
-
37
-
-
84939213978
-
HIV-1 tat protein induces production of proinflammatory cytokines by human dendritic cells and monocytes/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-kappaB pathway
-
Ben Haij, N. et al. HIV-1 tat protein induces production of proinflammatory cytokines by human dendritic cells and monocytes/macrophages through engagement of TLR4-MD2-CD14 complex and activation of NF-kappaB pathway. PLoS One 10, e0129425 (2015).
-
(2015)
PLoS One
, vol.10
, pp. e0129425
-
-
Ben Haij, N.1
-
38
-
-
72849132344
-
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
-
Bosinger, S.E. et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J. Clin. Invest. 119, 3556-3572 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3556-3572
-
-
Bosinger, S.E.1
-
39
-
-
77951288057
-
HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
-
Gringhuis, S.I. et al. HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells. Nat. Immunol. 11, 419-426 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 419-426
-
-
Gringhuis, S.I.1
-
40
-
-
84908131727
-
Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3
-
Ellegard, R. et al. Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3. J. Immunol. 193, 4590-4601 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 4590-4601
-
-
Ellegard, R.1
-
41
-
-
0028072532
-
Cytokine gene expression in HIV-infected intestinal mucosa
-
McGowan, I., Radford-Smith, G. & Jewell, D.P. Cytokine gene expression in HIV-infected intestinal mucosa. Aids 8, 1569-1575 (1994).
-
(1994)
AIDS
, vol.8
, pp. 1569-1575
-
-
McGowan, I.1
Radford-Smith, G.2
Jewell, D.P.3
-
42
-
-
84883373112
-
Chronic HIV infection enhances the responsiveness of antigen presenting cells to commensal Lactobacillus
-
Nagy, L.H. et al. Chronic HIV infection enhances the responsiveness of antigen presenting cells to commensal Lactobacillus. PLoS One 8, e72789 (2013).
-
(2013)
PLoS One
, vol.8
, pp. e72789
-
-
Nagy, L.H.1
-
43
-
-
77953679372
-
Innate immune recognition and activation during HIV infection
-
Mogensen, T.H., Melchjorsen, J., Larsen, C.S. & Paludan, S.R. Innate immune recognition and activation during HIV infection. Retrovirology 7, 54 (2010).
-
(2010)
Retrovirology
, vol.7
, pp. 54
-
-
Mogensen, T.H.1
Melchjorsen, J.2
Larsen, C.S.3
Paludan, S.R.4
-
44
-
-
84905565097
-
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
-
Whitney, J.B. et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74-77 (2014).
-
(2014)
Nature
, vol.512
, pp. 74-77
-
-
Whitney, J.B.1
-
45
-
-
0029296083
-
Differences in viral distribution and cell-adhesion molecule expression in the intestinal-tract of rhesus macaques infected with pathogenic and nonpathogenic SIV
-
Stone, J.D., Heise, C.C., Canfield, D.R., Elices, M.J. & Dandekar, S. Differences in viral distribution and cell-adhesion molecule expression in the intestinal-tract of rhesus macaques infected with pathogenic and nonpathogenic SIV. J. Med. Primatol. 24, 132-140 (1995).
-
(1995)
J. Med. Primatol.
, vol.24
, pp. 132-140
-
-
Stone, J.D.1
Heise, C.C.2
Canfield, D.R.3
Elices, M.J.4
Dandekar, S.5
-
46
-
-
84902124658
-
Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication
-
Kristoff, J. et al. Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. J. Clin. Invest. 124, 2802-2806 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 2802-2806
-
-
Kristoff, J.1
-
47
-
-
84912144937
-
Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection
-
Sandler, N.G. et al. Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection. J. Infect. Dis. 210, 1549-1554 (2014).
-
(2014)
J. Infect. Dis.
, vol.210
, pp. 1549-1554
-
-
Sandler, N.G.1
-
48
-
-
84876501381
-
The dynamics of gut-associated microbial communities during inflammation
-
Winter, S.E., Lopez, C.A. & Baumler, A.J. The dynamics of gut-associated microbial communities during inflammation. EMBO Rep. 14, 319-327 (2013).
-
(2013)
EMBO Rep.
, vol.14
, pp. 319-327
-
-
Winter, S.E.1
Lopez, C.A.2
Baumler, A.J.3
-
49
-
-
79956311926
-
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
-
Round, J.L. et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332, 974-977 (2011).
-
(2011)
Science
, vol.332
, pp. 974-977
-
-
Round, J.L.1
-
50
-
-
84858698108
-
Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation
-
Edwards, L.A. et al. Enterotoxin-producing staphylococci cause intestinal inflammation by a combination of direct epithelial cytopathy and superantigen-mediated T-cell activation. Inflamm. Bowel Dis. 18, 624-640 (2012).
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 624-640
-
-
Edwards, L.A.1
|