Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis

Journal of the National Cancer Institute

Volumn 107, Issue 12, 2015, Pages

  Playdon, Mary C ^a   Bracken, Michael B ^a   Sanft, Tara B ^b   Ligibel, Jennifer A ^c   Harrigan, Maura ^a   Irwin, Melinda L ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE CANCER CENTER   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ALL CAUSE MORTALITY; BODY WEIGHT; BODY WEIGHT CHANGE; BREAST CANCER; CANCER RECURRENCE; CINAHL; DISEASE SPECIFIC SURVIVAL; EMBASE; HUMAN; MEDLINE; META ANALYSIS; MORTALITY; MORTALITY RATE; NEWCASTLE-OTTAWA SCALE; OBESITY; REVIEW; SYSTEMATIC REVIEW; WEB OF SCIENCE; ADULT; AGED; BODY MASS; BREAST NEOPLASMS; CANCER STAGING; CAUSE OF DEATH; COMPLICATION; FEMALE; MIDDLE AGED; ODDS RATIO; PATHOLOGY; PROGNOSIS; RISK FACTOR; WEIGHT GAIN;

ADULT; AGED; BODY MASS INDEX; BREAST NEOPLASMS; CAUSE OF DEATH; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM STAGING; OBESITY; ODDS RATIO; OVERWEIGHT; PROGNOSIS; RISK FACTORS; WEIGHT GAIN;

EID: 84964912488     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv275     Document Type: Review

References (93)

1. American Cancer Society. Cancer Facts & Figures 2013. In. Atlanta, GA; 2013.
2. Society AC. Breast Cancer Facts & Figures 2013–2014. In. Atlanta; 2013.
3. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975–2010, National Cancer Institute. In: Bethesda, MD: National Cancer Institute; 2013.
4. Kamineni A, Anderson ML, White E, et al. Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population. Cancer Causes Control. 2013;24(2):305–312.
5. Niraula S, Ocana A, Ennis M, et al. Body size and breast cancer prognosis in relation to hormone receptor and menopausal status: a meta-analysis. Breast Cancer Res Treat. 2012;134(2):769–781.
6. Cheraghi Z, Poorolajal J, Hashem T, et al. Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis. PLoS One. 2012;7(12):e51446.
7. Kwan ML, Chen WY, Kroenke CH, et al. Pre-diagnosis body mass index and survival after breast cancer in the After Breast Cancer Pooling Project. Breast Cancer Res Treat. 2012;132(2):729–739.
8. Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat. 2010;123(3):627–635.
9. Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–578.
10. Azrad M, Demark-Wahnefried W. The association between adiposity and breast cancer recurrence and survival: A review of the recent literature. Curr Nutr Rep. 2014;3(1):9–15.
11. Kwan ML, John EM, Caan BJ, et al. Obesity and mortality after breast cancer by race/ethnicity: The California Breast Cancer Survivorship Consortium. Am J Epidemiol. 2014;179(1):95–111.
12. Schmitz KH, Neuhouser ML, Agurs-Collins T, et al. Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst. 2013;105(18):1344–1354.
13. Vrieling A, Buck K, Kaaks R, et al. Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis. Breast Cancer Res Treat. 2010;123(3):641–649.
14. Ahn J, Schatzkin A, Lacey JV Jr, et al. Adiposity, adult weight change, and postmenopausal breast cancer risk. Arch Intern Med. 2007;167(19):2091–2102.
15. Eliassen AH, Colditz GA, Rosner B, et al. Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006;296(2):193–201.
16. Harvie M, Howell A, Vierkant RA, et al. Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women’s health study. Cancer Epidemiol Biomarkers Prev. 2005;14(3):656–661.
17. Lahmann PH, Schulz M, Hoffmann K, et al. Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). Br J Cancer. 2005;93(5):582–589.
18. Chan DS, Vieira AR, Aune D, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 2014;25(10):1901–1914.
19. Pierobon M, Frankenfeld CL. Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;137(1):307–314.
20. Anderson GL, Neuhouser ML. Obesity and the risk for premenopausal and postmenopausal breast cancer. Cancer Prev Res (Phila). 2012;5(4):515–521.
21. Yang XR, Chang-Claude J, Goode EL, et al. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst. 2011;103(3):250–263.
22. Pan H GR. Abstract 503: Effect of obesity in premenopausal ER+ early breast cancer: EBCTCG data on 80,000 patients in 70 trials. J Clin Oncol. 2014;32(5s).
23. Goodwin PJ, Ennis M, Pritchard KI, et al. Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol. 1999;17(1):120–129.
24. Vance V, Mourtzakis M, McCargar L, et al. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev. 2011;12(4):282–294.
25. Harvie MN, Campbell IT, Baildam A, et al. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. Breast Cancer Res Treat. 2004;83(3):201–210.
26. Irwin ML, McTiernan A, Baumgartner RN, et al. Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors. J Clin Oncol. 2005;23(4):774–782.
27. Demark-Wahnefried W, Peterson BL, Winer EP, et al. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol. 2001;19(9):2381–2389.
28. Caan BJ, Kwan ML, Shu XO, et al. Weight change and survival after breast cancer in the after breast cancer pooling project. Cancer Epidemiol Biomarkers Prev. 2012;21(8):1260–1271.
29. Kroenke CH, Chen WY, Rosner B, et al. Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol. 2005;23(7):1370–1378.
30. Thivat E, Therondel S, Lapirot O, et al. Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer. 2010;10:648.
31. Nichols HB, Trentham-Dietz A, Egan KM, et al. Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1403–1409.
32. Caan BJ, Kwan ML, Hartzell G, et al. Pre-diagnosis body mass index, postdiagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control. 2008;19(10):1319–1328.
33. Caan BJ, Emond JA, Natarajan L, et al. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat. 2006;99(1):47–57.
34. Chen X, Lu W, Zheng W, et al. Obesity and weight change in relation to breast cancer survival. Breast Cancer Res Treat. 2010;122(3):823–833.
35. Howard-Anderson J, Ganz PA, Bower JE, et al. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386–405.
36. Vagenas D, DiSipio T, Battistutta D, et al. Weight and weight change following breast cancer: evidence from a prospective, population-based, breast cancer cohort study. BMC Cancer. 2015;15(1):28.
37. Sestak I, Harvie M, Howell A, et al. Weight change associated with anastrozole and tamoxifen treatment in postmenopausal women with or at high risk of developing breast cancer. Breast Cancer Res Treat. 2012;134(2):727–734.
38. Makari-Judson G JCH, Mertens W C. Longitudinal patterns of weight gain after breast cancer diagnosis: observations beyond the first year. Breast J. 2007;13:258–265.
39. Schmitz KH, Speck RM, Rye SA, et al. Prevalence of breast cancer treatment sequelae over 6 years of follow-up: the Pulling Through Study. Cancer. 2012;118(8 Suppl):2217–2225.
40. Zhao G, Li C, Okoro CA, et al. Trends in modifiable lifestyle-related risk factors following diagnosis in breast cancer survivors. J Cancer Surviv. 2013;7(4):563–569.
41. Sedjo RL, Hines LM, Byers T, et al. Long-term weight gain among Hispanic and non-Hispanic White women with and without breast cancer. Nutr Cancer. 2013;65(1):34–42.
42. American Joint Committee on Cancer. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer; 2010.
43. Stevens J, Truesdale KP, McClain JE, et al. The definition of weight maintenance. Int J Obes (Lond). 2006;30(3):391–399.
44. Black WC, Haggstrom DA, Welch HG. All-cause mortality in randomized trials of cancer screening. J Natl Cancer Inst. 2002;94(3):167–173.
45. von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453–1457.
46. Higgins JPT GS. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. In: 13.5.2.3 Tools for assessing methodological quality or risk of bias in non-randomized studies: The Cochrane Collaboration; 2011.
47. Wells GA OCD, Peterson J, Welch J, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed January 4, 2014.
48. Borenstein M HL, Higgins JPT, Rothstein HR. Introduction to Meta-Analysis. Chichester, West Sussex: John Wiley & Sons, Ltd.; 2009.
49. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–560.
50. Jeon YW, Lim ST, Choi HJ, et al. Weight change and its impact on prognosis after adjuvant TAC (docetaxel-doxorubicin-cyclophosphamide) chemotherapy in Korean women with node-positive breast cancer. Med Oncol. 2014;31(3):849.
51. Fedele P, Orlando L, Schiavone P, et al. BMI variation increases recurrence risk in women with early-stage breast cancer. Future Oncol. 2014;10(15):2459–2468.
52. Bradshaw PT, Ibrahim JG, Stevens J, et al. Postdiagnosis change in bodyweight and survival after breast cancer diagnosis. Epidemiology. 2012;23(2):320–327.
53. Camoriano JK, Loprinzi CL, Ingle JN, et al. Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer. J Clin Oncol. 1990;8(8):1327–1334.
54. Goodwin PJ, Panzarella T, Boyd NF. Weight gain in women with localized breast cancer-a descriptive study. Breast Cancer Res Treat. 1988;11(1):59–66.
55. Levine E, Raczynski, JM, Carpenter, JT. Weight Gain With Breast Cancer Adjuvant Treatment. Cancer. 1990;67:1954–1958.
56. Tom SE, Cooper R, Patel KV, et al. Menopausal characteristics and physical functioning in older adulthood in the National Health and Nutrition Examination Survey III. Menopause. 2012;19(3):283–289.
57. Chlebowski RT, Weiner JM, Reynolds R, et al. Long-term survival following relapse after 5-FU but not CMF adjuvant breast cancer therapy. Breast Cancer Res Treat. 1986;7(1):23–30.
58. Costa LJ, Varella PC, del Giglio A. Weight changes during chemotherapy for breast cancer. Sao Paulo Med J. 2002;120(4):113–117.
59. Bao J, Borja N, Rao M, et al. Impact of weight change during neoadjuvant chemotherapy on pathologic response in triple-negative breast cancer. Cancer Med. 2015;4(4):500–506.
60. Cleveland RJ, Eng SM, Abrahamson PE, et al. Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(9):1803–1811.
61. Kumar NB, Cantor A, Allen K, et al. Android obesity at diagnosis and breast carcinoma survival: Evaluation of the effects of anthropometric variables at diagnosis, including body composition and body fat distribution and weight gain during life span,and survival from breast carcinoma. Cancer. 2000;88(12):2751–2757.
62. Trentham-Dietz A, Newcomb PA, Nichols HB, et al. Breast cancer risk factors and second primary malignancies among women with breast cancer. Breast Cancer Res Treat. 2007;105(2):195–207.
63. Hellmann SS, Thygesen LC, Tolstrup JS, et al. Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Eur J Cancer Prev. 2010;19(5):366–373.
64. Johnson J LB, Mills A, Watkins PL, Chaudhary V, Bharadwaj J, Dufan TA, Watkins JM. The Impact of Weight Change During and After Post-Operative Chemotherapy on Breast Cancer Control in Node-Positive Patients Treated With Trimodality Therapy. Cancer Clin Oncol. 2014;3(2):16–26.
65. Verrill M. Chemotherapy for early-stage breast cancer: a brief history. Br J Cancer. 2009;101(Suppl 1):S2–S5.
66. Kenez X MA, Simonsson M, Ingvar C, Rose C, Jernstrom HC. Abstract 2171: Weight change in relation to early breast cancer events in breast cancer patients. Cancer Res. 2014;74(19 Suppl).
67. Myrskylä M, Chang VW. Weight change, initial BMI, and mortality among middle- and older-aged adults. Epidemiology. 2009;20(6):840–848.
68. Chen X, Lu W, Gu K, et al. Weight change and its correlates among breast cancer survivors. Nutr Cancer. 2011;63(4):538–548.
69. Reddy SM, Sadim M, Li J, et al. Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer. Br J Cancer. 2013;109(4):872–881.
70. Demark-Wahnefried W, Winer EP, Rimer BK. Why women gain weight with adjuvant chemotherapy for breast cancer. J Clin Oncol. 1993;11(7):1418–1429.
71. Cheney CL, Mahloch J, Freeny P. Computerized tomography assessment of women with weight changes associated with adjuvant treatment for breast cancer. Am J Clin Nutr. 1997;66(1):141–146.
72. Wang JS, Cai H, Wang CY, et al. Body weight changes in breast cancer patients following adjuvant chemotherapy and contributing factors. Mol Clin Oncol. 2014;2(1):105–110.
73. Niravath P. Aromatase inhibitor-induced arthralgia: a review. Ann Oncol. 2013;24(6):1443–1449.
74. Yaw YH, Shariff ZM, Kandiah M, et al. Diet and physical activity in relation to weight change among breast cancer patients. Asian Pac J Cancer Prev. 2014;15(1):39–44.
75. Demark-Wahnefried W, Campbell KL, Hayes SC. Weight management and its role in breast cancer rehabilitation. Cancer. 2012;118(8 Suppl):2277–2287.
76. Irwin ML, Crumley D, McTiernan A, et al. Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer. 2003;97(7):1746–1757.
77. Irwin ML, McTiernan A, Manson JE, et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women’s health initiative. Cancer Prev Res (Phila). 2011;4(4):522–529.
78. Howe LR, Subbaramaiah K, Hudis CA, et al. Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res. 2013;19(22):6074–6083.
79. Roberts DL, Dive C, Renehan AG. Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med. 2010;61:301–316.
80. Goodwin PJ, Ennis M, Pritchard KI, et al. Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes. Breast Cancer Res Treat. 2002;74(1):65–76.
81. Dowsett M, Folkerd E. Reduced progesterone levels explain the reduced risk of breast cancer in obese premenopausal women: a new hypothesis. Breast Cancer Res Treat. 2015;149(1):1–4.
82. Reeves GK, Pirie K, Beral V, et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335(7630):1134.
83. Sheean PM, Hoskins K, Stolley M. Body composition changes in females treated for breast cancer: a review of the evidence. Breast Cancer Res Treat. 2012;135(3):663–680.
84. Douchi T, Yonehara Y, Kawamura Y, et al. Difference in segmental lean and fat mass components between pre- and postmenopausal women. Menopause. 2007;14(5):875–878.
85. Newman AB, Lee JS, Visser M, et al. Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study. Am J Clin Nutr. 2005;82(4):872–878; quiz 915–916.
86. Stenholm S, Harris TB, Rantanen T, et al. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008;11(6):693–700.
87. Villasenor A, Ballard-Barbash R, Baumgartner K, et al. Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Surviv. 2012;6(4):398–406.
88. George SM, Bernstein L, Smith AW, et al. Central adiposity after breast cancer diagnosis is related to mortality in the Health, Eating, Activity, and Lifestyle study. Breast Cancer Res Treat. 2014;146(3):647–655.
89. Chubak J, Boudreau DM, Wirtz HS, et al. Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival. J Natl Cancer Inst. 2013;105(19):1456–1462.
90. Patnaik JL, Byers T, DiGuiseppi C, et al. Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study. Breast Cancer Res. 2011;13(3):R64.
91. Colzani E, Liljegren A, Johansson AL, et al. Prognosis of patients with breast cancer: causes of death and effects of time since diagnosis, age, and tumor characteristics. J Clin Oncol. 2011;29(30):4014–4021.
92. Tao MH, Shu XO, Ruan ZX, et al. Association of overweight with breast cancer survival. Am J Epidemiol. 2006;163(2):101–107.
93. Johnson CJ, Weir HK, Fink AK, et al. The impact of National Death Index linkages on population-based cancer survival rates in the United States. Cancer Epidemiol. 2013;37(1):20–28.