Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer

British Journal of Cancer

Volumn 109, Issue 4, 2013, Pages 872-881

  Reddy, S M ^a   Sadim, M ^a   Li, J ^b   Yi, N ^b   Agarwal, S ^a   Mantzoros, C S ^c   Kaklamani, V G ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; AROMATASE INHIBITOR; TAMOXIFEN; TAXANE DERIVATIVE;

ADIPOQ GENE; ADIPORT1 GENE; ADULT; AGED; ARTICLE; BODY MASS; BREAST CANCER; CLINICAL ASSESSMENT; DEMOGRAPHY; FAT MASS; GENE; GENETICS; GENOTYPE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; OBESITY ASSOCIATED PROTEIN GENE; PREDICTION; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT GAIN;

ADIPONECTIN; ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA; FEMALE; HUMANS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; RECEPTORS, ADIPONECTIN; RETROSPECTIVE STUDIES; RISK ASSESSMENT; ROC CURVE; WEIGHT GAIN;

EID: 84883154966     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.441     Document Type: Article

References (82)

1. Aslani A, Smith RC, Allen BJ, Pavlakis N, Levi JA (1999) Changes in body composition during breast cancer chemotherapy with the CMF-regimen. Breast Cancer Res Treat 57(3): 285-290.
2. Becker T, Schumacher J, Cichon S, Baur MP, Knapp M (2005) Haplotype interaction analysis of unlinked regions. Genet Epidemiol 29(4): 313-322.
3. Caan BJ, Emond JA, Natarajan L, Castillo A, Gunderson EP, Habel L, Jones L, Newman VA, Rock CL, SlatteryML, StefanickML, Sternfeld B, Thomson CA, Pierce JP (2006) Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat 99(1): 47-57.
4. Camoriano JK, Loprinzi CL, Ingle JN, Therneau TM, Krook JE, Veeder MH (1990) Weight change in women treated with adjuvant therapy or observed following mastectomy for node-positive breast cancer. J Clin Oncol 8(8): 1327-1334.
5. Campbell KL, Lane K, Martin AD, Gelmon KA, McKenzie DC (2007) Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer. Cancer Nurs 30(2): 95-100.
6. Campbell KL, Van Patten CL, Neil SE, Kirkham AA, Gotay CC, Gelmon KA, McKenzie DC (2012) Feasibility of a lifestyle intervention on body weight and serum biomarkers in breast cancer survivors with overweight and obesity. J Acad Nutr Diet 112(4): 559-567.
7. Chlebowski RT, Aiello E, McTiernan A (2002) Weight loss in breast cancer patient management. J Clin Oncol 20(4): 1128-1143.
8. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, Hudis C, Butler J, Merkel D, Kristal A, Caan B, Michaelson R, Vinciguerra V, Del Prete S, Winkler M, Hall R, Simon M, Winters BL, Elashoff RM (2006) Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst 98(24): 1767-1776.
9. Cordell HJ (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Human Mol Genet 11(20): 2463-2468.
10. Costa LJ, Varella PC, del Giglio A (2002) Weight changes during chemotherapy for breast cancer. Sao Paulo Med J 120(4): 113-117.
11. Day R, Ganz PA, Costantino JP, Cronin WM, Wickerham DL, Fisher B (1999) Health-related quality of life and tamoxifen in breast cancer prevention: a report from the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Clin Oncol 17(9): 2659-2669.
12. De Waard F, Ramlau R, Mulders Y, De Vries T, Van Waveren S (1993) A feasibility study on weight reduction in obese postmenopausal breast cancer patients. Eur J Cancer Prevent 2(3): 233-238.
13. Demark-Wahnefried W, Hars V, Conaway MR, Havlin K, Rimer BK, McElveen G, Winer EP (1997a) Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. Am J Clin Nutr 65(5): 1495-1501.
14. Demark-Wahnefried W, Rimer BK, Winer EP (1997b) Weight gain in women diagnosed with breast cancer. J Am Diet Assoc 97(5): 519-526,529; quiz 527-8.
15. Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Williams SM, Signorello LB, Blot WJ, Matthews CE (2012) HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am J Epidemiol 175(1): 11-21.
16. Ilippi E, Sentinelli F, Romeo S, Arca M, Berni A, Tiberti C, Verrienti A, Fanelli M, Fallarino M, Sorropago G, Baroni MG (2005) The adiponectin gene SNP\+276G4T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age oor 50 years). J Mol Med 83(9): 711-719.
17. Fox CS, Heard-Costa NL, Vasan RS, Murabito JM, D'Agostino Sr. RB, Atwood LD, Framingham Heart S (2005) Genomewide linkage analysis of weight change in the Framingham Heart Study. J Clin Endocrinol Metab 90(6): 3197-3201.
18. Freedman RJ, Aziz N, Albanes D, Hartman T, Danforth D, Hill S, Sebring N, Reynolds JC, Yanovski JA (2004) Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab 89(5): 2248-2253.
19. Gelman A, Jakulin A, Pittau MG, Su YS (2008) A weakly informative default prior distribution for logistic and other regression models. Ann Appl Stat 2(4): 1360-1383.
20. Gloeckler Ries LA, Reichman ME, Lewis DR, Hankey BF, Edwards BK (2003) Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program. The oncologist 8(6): 541-552.
21. Goodwin P, Esplen MJ, Butler K, Winocur J, Pritchard K, Brazel S, Gao J, Miller A (1998) Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat 48(1): 53-64.
22. Goodwin PJ, Ennis M, Pritchard KI, McCready D, Koo J, Sidlofsky S, Trudeau M, Hood N, Redwood S (1999) Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol 17(1): 120-129.
23. Grant SF, Li M, Bradfield JP, Kim CE, Annaiah K, Santa E, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Shaner JL, Smith RM, Imielinski M, Eckert AW, Chiavacci RM, Berkowitz RI, Hakonarson H (2008) Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 3(3): e1746.
24. Gu K, Chen X, Zheng Y, Chen Z, Zheng W, Lu W, Shu XO (2010) Weight change patterns among breast cancer survivors: results from the Shanghai breast cancer survival study. Cancer Causes Control 21(4): 621-629.
25. Han HS, Lee KW, Kim JH, Kim SW, Kim IA, Oh DY, Im SA, Bang SM, Lee JS (2009) Weight changes after adjuvant treatment in Korean women with early breast cancer. Breast Cancer Res Treat 114(1): 147-153.
26. Han LY, Wu QH, Jiao ML, Hao YH, Liang LB, Gao LJ, Legge DG, Quan H, Zhao MM, Ning N, Kang Z, Sun H (2011) Associations between singlenucleotide polymorphisms (\+45T4G, \+276G4T,-11377C4G,-11391G4A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-Analysis. Diabetologia 54(9): 2303-2314.
27. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51(2): 536-540.
28. Harris MN, Swift DL, Myers VH, Earnest CP, Johannsen NM, Champagne CM, Parker BD, Levy E, Cash KC, Church TS (2012) Cancer Survival Through Lifestyle Change (CASTLE): a Pilot Study of Weight Loss. Int J Behav Med; e-pub ahead of print 26 April 2012.
29. He B, Pan Y, Zhang Y, Bao Q, Chen L, Nie Z, Gu L, Xu Y, Wang S (2011) Effects of genetic variations in the adiponectin pathway genes on the risk of colorectal cancer in the Chinese population. BMC Med Genet 12: 94.
30. Hegener HH, Lee IM, Cook NR, Ridker PM, Zee RY (2006) Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. Clin Chem 52(11): 2021-2027.
31. Heid IM, Wagner SA, Gohlke H, Iglseder B, Mueller JC, Cip P, Ladurner G, Reiter R, Stadlmayr A, Mackevics V, Illig T, Kronenberg F, Paulweber B (2006) Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes 55(2): 375-384.
32. Heideman WH, Russell NS, Gundy C, Rookus MA, Voskuil DW (2009) The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors. Eur J Cancer 45(1): 119-126.
33. Hein R, Beckmann L, Chang-Claude J (2009) Comparison of different haplotype-based association methods for gene-environment (GxE) interactions in case-control studies when haplotype-phase is ambiguous. Hum Hered 68(4): 252-267.
34. Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, Muller TD, Grallert H, Illig T, Wichmann HE, Rief W, Schafer H, Hebebrand J (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2(12): e1361.
35. Hoy MK, Winters BL, Chlebowski RT, Papoutsakis C, Shapiro A, Lubin MP, Thomson CA, Grosvenor MB, Copeland T, Falk E, Day K, Blackburn GL (2009) Implementing a low-fat eating plan in the Women's Intervention Nutrition Study. J Am Diet Assoc 109(4): 688-696.
36. Hsiao TJ, Wu LS, Huang SY, Lin E (2010) A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity. Clin Pharmacol 2: 105-110.
37. Ingram C, Brown JK (2004) Patterns of weight and body composition change in premenopausal women with early stage breast cancer: has weight gain been overestimated? Cancer Nurs 27(6): 483-490.
38. Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R (2005) Changes in body fat and weight after a breast cancer diagnosis: influence of demographic, prognostic, and lifestyle factors. J Clin Oncol 23(4): 774-782.
39. Janssens AC, Moonesinghe R, Yang Q, Steyerberg EW, van Duijn CM, Khoury MJ (2007) The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 9(8): 528-535.
40. Jen KL, Djuric Z, DiLaura NM, Buison A, Redd JN, Maranci V, Hryniuk WM (2004) Improvement of metabolism among obese breast cancer survivors in differing weight loss regimens. Obes Res 12(2): 306-312.
41. Kaklamani V, Yi N, Sadim M, Siziopikou K, Zhang K, Xu Y, Tofilon S, Agarwal S, Pasche B, Mantzoros C (2011a) The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet 12: 52.
42. Kaklamani V, Yi N, Zhang K, Sadim M, Offit K, Oddoux C, Ostrer H, Mantzoros C, Pasche B (2011b) Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Metabolism 60(9): 1234-1243.
43. Kaklamani VG, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, Ahsan H, Pasche B, Mantzoros C (2008a) Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res 68(9): 3178-3184.
44. Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B (2008b) Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA 300(13): 1523-1531.
45. Kao CH, Zeng ZB (2002) Modeling epistasis of quantitative trait loci using Cockerham's model. Genetics 160(3): 1243-1261.
46. Kroenke CH, Chen WY, Rosner B, Holmes MD (2005) Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol 23(7): 1370-1378.
47. Kumar NB, Allen K, Cantor A, Cox CE, Greenberg H, Shah S, Lyman GH (1997) Weight gain associated with adjuvant tamoxifen therapy in stage I and II breast cancer: fact or artifact? Breast Cancer Res Treat 44(2): 135-143.
48. Kutynec CL, McCargar L, Barr SI, Hislop TG (1999) Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc 99(10): 1222-1227.
49. Kwee LC, Epstein MP, Manatunga AK, Duncan R, Allen AS, Satten GA (2007) Simple methods for assessing haplotype-environment interactions in case-only and case-control studies. Genet Epidemiol 31(1): 75-90.
50. Lake SL, Lyon H, Tantisira K, Silverman EK, Weiss ST, Laird NM, Schaid DJ (2003) Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered 55(1): 56-65.
51. Lankester KJ, Phillips JE, Lawton PA (2002) Weight gain during adjuvant and neoadjuvant chemotherapy for breast cancer: an audit of 100 women receiving FEC or CMF chemotherapy. Clin Oncol 14(1): 64-67.
52. Litton JK, Gonzalez-Angulo AM, Warneke CL, Buzdar AU, Kau SW, Bondy M, Mahabir S, Hortobagyi GN, Brewster AM (2008) Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer. J Clin Oncol 26(25): 4072-4077.
53. Liu F, He Z, Deng S, Zhang H, Li N, Xu J (2011) Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population. Mol Biol Rep 38(3): 1983-1988.
54. Loi S, Milne RL, FriedlanderML, McCredieMR,Giles GG,Hopper JL, Phillips KA (2005) Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 14(7): 1686-1691.
55. Loos RJ, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C (2007) Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Am J Clin Nutr 85(1): 26-34.
56. Loprinzi CL, Athmann LM, Kardinal CG, O'Fallon JR, See JA, Bruce BK, Dose AM, Miser AW, Kern PS, Tschetter LK, Rayson S (1996) Randomized trial of dietician counseling to try to prevent weight gain associated with breast cancer adjuvant chemotherapy. Oncology 53(3): 228-232.
57. Mather KJ, Christophi CA, Jablonski KA, KnowlerWC, Goldberg RB, Kahn SE, Spector T, Dastani Z, Waterworth D, Richards JB, Funahashi T, Pi-Sunyer FX, Pollin TI, Florez JC, Franks PW. for the Diabetes Prevention Program Research G (2012) Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program. Diabet Med 29(12): 1579-1588.
58. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A (2002) A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 51(7): 2306-2312.
59. Mtiraoui N, Ezzidi I, Turki A, Chaieb A, Mahjoub T, Almawi WY (2012) Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs. Diab Res Clin Pract 97(2): 290-297.
60. Rampersaud E, Mitchell BD, Pollin TI, Fu M, Shen H, O'Connell JR, Ducharme JL, Hines S, Sack P, Naglieri R, Shuldiner AR, Snitker S (2008) Physical activity and the association of common FTO gene variants with body mass index and obesity. Arch Int Med 168(16): 1791-1797.
61. Rock CL, Demark-Wahnefried W (2002) Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J Clin Oncol 20(15): 3302-3316.
62. Saquib N, Flatt SW, Natarajan L, Thomson CA, Bardwell WA, Caan B, Rock CL, Pierce JP (2007) Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women's healthy eating and living (WHEL) study. Breast Cancer Res Treat 105(2): 177-186.
63. Schwartz AL (2000) Exercise and weight gain in breast cancer patients receiving chemotherapy. Cancer Pract 8(5): 231-237.
64. Segal R, Evans W, Johnson D, Smith J, Colletta S, Gayton J, Woodard S, Wells G, Reid R (2001) Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol 19(3): 657-665.
65. Siitonen N, Pulkkinen L, Mager U, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M (2006) Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia 49(8): 1795-1805.
66. Silventoinen K, Kaprio J (2009) Genetics of tracking of body mass index from birth to late middle age: evidence from twin and family studies. Obes Facts 2(3): 196-202.
67. Soccio T, Zhang YY, Bacci S, Mlynarski W, Placha G, Raggio G, Di Paola R, Marucci A, Johnstone MT, Gervino EV, Abumrad NA, Klein S, Trischitta V, Doria A (2006) Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes 55(10): 2763-2770.
68. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F, Haring H (2002) Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51(1): 37-41.
69. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41(1): 18-24.
70. Ukkola O, Santaniemi M, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bergman R, Kesaniemi YA, Bouchard C (2005) Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study. Ann Med 37(2): 141-150.
71. van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, Hofman A, Sijbrands EJ, Janssens AC (2008) Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes 57(11): 3122-3128.
72. Vance V, Mourtzakis M, McCargar L, Hanning R (2011) Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev 12(4): 282-294.
73. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11(21): 2607-2614.
74. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R (2008) Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 93(9): 3640-3643.
75. Williamson DF (1993) Descriptive epidemiology of body weight and weight change in U.S. adults. Ann Int Med 119(7 Pt 2): 646-649.
76. Williamson DF, Kahn HS, Byers T (1991) The 10-y incidence of obesity and major weight gain in black and white US women aged 30-55 y. Am J Clin Nutr 53(6 Suppl): 1515S-1518S.
77. Yang WS, Chuang LM (2006) Human genetics of adiponectin in the metabolic syndrome. J Mol Med 84(2): 112-121.
78. Yang Y, Zhang F, Ding R, Wang Y, Lei H, Hu D (2012) Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-Analysis based on 12 465 subjects. Thrombosis Res 130(1): 58-64.
79. Yi NJ, Banerjee S (2009) Hierarchical Generalized Linear Models for Multiple Quantitative Trait Locus Mapping. Genetics 181(3): 1101-1113.
80. Yi NJ, Xu SH (2008) Bayesian LASSO for quantitative trait loci mapping. Genetics 179(2): 1045-1055.
81. Zhang H, Mo X, Hao Y, Gu D (2012) Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-Analysis. BMC Med Genet 13: 40.
82. Zhao J, Bradfield JP, Li M, Wang K, Zhang H, Kim CE, Annaiah K, Glessner JT, Thomas K, Garris M, Frackelton EC, Otieno FG, Shaner JL, Smith RM, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF (2009) The role of obesity-Associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity 17(12): 2254-2257. Diseases Diseases Diseases