메뉴 건너뛰기




Volumn 8, Issue 5, 2016, Pages 248-253

Prenatal developmental toxicity evaluation of low molecular weight galactomannans based standardized fenugreek seed extract during organogenesis period of pregnancy in rats

Author keywords

Developmental toxicity; Low molecular weight galactomannans; OECD Test No. 414; Rat; Reproductive system; Standardized fenugreek seed extract

Indexed keywords


EID: 84964899844     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (46)
  • 1
    • 0141922881 scopus 로고    scopus 로고
    • Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements
    • Schilter B, Andersson C, Anton R, Constable A, Kleiner J, O’Brien J, et al. Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food Chem Toxicol 2003;41:1625-49.
    • (2003) Food Chem Toxicol , vol.41 , pp. 1625-1649
    • Schilter, B.1    Ersson, C.2    Anton, R.3    Constable, A.4    Kleiner, J.5    O’Brien, J.6
  • 2
    • 1842817412 scopus 로고    scopus 로고
    • Criteria for risk assessment of botanical food supplements
    • Walker R. Criteria for risk assessment of botanical food supplements. Toxicol Lett 2004;149(1-3):187-95.
    • (2004) Toxicol Lett , vol.149 , Issue.1-3 , pp. 187-195
    • Walker, R.1
  • 5
    • 0141517488 scopus 로고    scopus 로고
    • Systematic review: Hepatotoxic events associated with herbal medicinal products
    • Pittler M, Ernst E. Systematic review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther 2003;18:451-71.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 451-471
    • Pittler, M.1    Ernst, E.2
  • 8
    • 84864674482 scopus 로고    scopus 로고
    • Survey of lactation instructors on folk traditions in breastfeeding
    • Schaffir J, Czapla C. Survey of lactation instructors on folk traditions in breastfeeding. Breastfeed Med 2012;7:230-3.
    • (2012) Breastfeed Med , vol.7 , pp. 230-233
    • Schaffir, J.1    Czapla, C.2
  • 9
    • 0036987064 scopus 로고    scopus 로고
    • New legume sources as therapeutic agents
    • Madar Z, Stark AH. New legume sources as therapeutic agents. Br J Nutr 2002;88 Suppl 3:S287-92.
    • (2002) Br J Nutr , vol.88 , pp. S287-S292
    • Madar, Z.1    Stark, A.H.2
  • 10
    • 0023025947 scopus 로고
    • Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects
    • Sharma R. Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects. Nutr Res 1986;6:1353-64.
    • (1986) Nutr Res , vol.6 , pp. 1353-1364
    • Sharma, R.1
  • 11
    • 0025284666 scopus 로고
    • Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes
    • Sharma R, Raghuram T, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
    • (1990) Eur J Clin Nutr , vol.44 , pp. 301-306
    • Sharma, R.1    Raghuram, T.2    Rao, N.S.3
  • 12
    • 84890543148 scopus 로고    scopus 로고
    • A review on the functional properties, nutritional content, medicinal utilization and potential application of fenugreek
    • Meghwal M, Goswami T. A review on the functional properties, nutritional content, medicinal utilization and potential application of fenugreek. J Food Process Technol 2012:3:181.
    • (2012) J Food Process Technol , vol.3 , pp. 181
    • Meghwal, M.1    Goswami, T.2
  • 13
    • 0001126459 scopus 로고
    • Polysaccharide composition of a gel fraction derived from fenugreek and its effect on starch digestion and bile acid absorption in rats
    • Madar Z, Shomer I. Polysaccharide composition of a gel fraction derived from fenugreek and its effect on starch digestion and bile acid absorption in rats. J Agric Food Chem 1990;38:1535-9.
    • (1990) J Agric Food Chem , vol.38 , pp. 1535-1539
    • Madar, Z.1    Shomer, I.2
  • 14
    • 0034740870 scopus 로고    scopus 로고
    • Trigonella foenum graecum (Fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes
    • Raju J, Gupta D, Rao AR, Yadava PK, Baquer NZ. Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 2001;224(1-2):45-51.
    • (2001) Mol Cell Biochem , vol.224 , Issue.1-2 , pp. 45-51
    • Raju, J.1    Gupta, D.2    Rao, A.R.3    Yadava, P.K.4    Baquer, N.Z.5
  • 15
    • 84884415039 scopus 로고    scopus 로고
    • Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus
    • Kamble H, Kandhare A, Bodhankar S, Mohan V, Thakurdesai PA. Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol 2013;3:145-51.
    • (2013) Biomed Aging Pathol , vol.3 , pp. 145-151
    • Kamble, H.1    Kandhare, A.2    Bodhankar, S.3    Mohan, V.4    Thakurdesai, P.A.5
  • 16
    • 34047254102 scopus 로고    scopus 로고
    • Soluble dietary fiber fraction of Trigonella foenum-graecum (Fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action
    • Hannan JM, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, et al. Soluble dietary fiber fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr 2007;97:514-21.
    • (2007) Br J Nutr , vol.97 , pp. 514-521
    • Hannan, J.M.1    Ali, L.2    Rokeya, B.3    Khaleque, J.4    Akhter, M.5    Flatt, P.R.6
  • 17
    • 0034767317 scopus 로고    scopus 로고
    • In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A
    • Al-Habori M, Raman A, Lawrence MJ, Skett P. In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. Int J Exp Diabesity Res 2001;2:91-9.
    • (2001) Int J Exp Diabesity Res , vol.2 , pp. 91-99
    • Al-Habori, M.1    Raman, A.2    Lawrence, M.J.3    Skett, P.4
  • 18
    • 33947496078 scopus 로고    scopus 로고
    • Hypolipidaemic effect of chemically different mucilages in rats: A comparative study
    • Boban PT, Nambisan B, Sudhakaran PR. Hypolipidaemic effect of chemically different mucilages in rats: a comparative study. Br J Nutr 2006;96:1021-9.
    • (2006) Br J Nutr , vol.96 , pp. 1021-1029
    • Boban, P.T.1    Nambisan, B.2    Sudhakaran, P.R.3
  • 19
    • 33846701894 scopus 로고    scopus 로고
    • A fibre cocktail of fenugreek, guar gum, and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats
    • Venkatesan N, Devaraj SN, Devaraj H. A fibre cocktail of fenugreek, guar gum, and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats. Mol Cell Biochem 2007;294(1-2):145-53.
    • (2007) Mol Cell Biochem , vol.294 , Issue.1-2 , pp. 145-153
    • Venkatesan, N.1    Devaraj, S.N.2    Devaraj, H.3
  • 20
    • 78149498174 scopus 로고    scopus 로고
    • Study of galactomannan on androgenic and anabolic activity in male rats
    • Aswar U, Mohan V, Bhaskaran S, Bodhankar SL. Study of galactomannan on androgenic and anabolic activity in male rats. Pharmacologyonline 2008;2:56-65.
    • (2008) Pharmacologyonline , vol.2 , pp. 56-65
    • Aswar, U.1    Mohan, V.2    Bhaskaran, S.3    Bodhankar, S.L.4
  • 21
    • 84926388778 scopus 로고    scopus 로고
    • Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat-diet-induced insulin resistance in C57BL/6 mice
    • Kandhare A, Bodhankar SL, Mohan V, Thakurdesai PA. Prophylactic efficacy and possible mechanisms of oligosaccharides based standardized fenugreek seed extract on high-fat-diet-induced insulin resistance in C57BL/6 mice. J Appl Pharm Sci 2015;5:35-45.
    • (2015) J Appl Pharm Sci , vol.5 , pp. 35-45
    • Kandhare, A.1    Bodhankar, S.L.2    Mohan, V.3    Thakurdesai, P.A.4
  • 22
    • 77958515756 scopus 로고    scopus 로고
    • The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males
    • Poole C, Bushey B, Foster C, Campbell B, Willoughby D, Kreider R, et al. The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males. J Int Soc Sports Nutr 2010;7:34.
    • (2010) J Int Soc Sports Nutr , vol.7 , pp. 34
    • Poole, C.1    Bushey, B.2    Foster, C.3    Campbell, B.4    Willoughby, D.5    Kreider, R.6
  • 23
    • 0032822825 scopus 로고    scopus 로고
    • Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat
    • Narasimhamurthy K, Viswanatha S, Ramesh B. Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 1999;37:831-8.
    • (1999) Food Chem Toxicol , vol.37 , pp. 831-838
    • Narasimhamurthy, K.1    Viswanatha, S.2    Ramesh, B.3
  • 24
    • 83755196683 scopus 로고    scopus 로고
    • Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats
    • Muraki E, Hayashi Y, Chiba H, Tsunoda N, Kasono K. Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats. Lipids Health Dis 2011;10:240.
    • (2011) Lipids Health Dis , vol.10 , pp. 240
    • Muraki, E.1    Hayashi, Y.2    Chiba, H.3    Tsunoda, N.4    Kasono, K.5
  • 26
    • 0003479926 scopus 로고    scopus 로고
    • Section 4: Health Effects. Paris: OECD Publishing
    • OECD. Test No. 414: Prenatal Development Toxicity Study. OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects. Paris: OECD Publishing; 2001.
    • (2001) OECD Guidelines for the Testing of Chemicals
  • 28
    • 34250974627 scopus 로고
    • Färbemethode zum makroskopischen nachweis von Implantationsstellen am Uterus der ratte
    • Salewski E. Färbemethode zum makroskopischen nachweis von Implantationsstellen am Uterus der ratte. Naunyn-Schmiedeberg’s Arch Pharmacol 1964;247:367.
    • (1964) Naunyn-Schmiedeberg’s Arch Pharmacol , vol.247 , pp. 367
    • Salewski, E.1
  • 31
    • 32044461974 scopus 로고    scopus 로고
    • Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits
    • Kassem A, Al-Aghbari A, Molham AH, Al-Mamary M. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception 2006;73:301-6.
    • (2006) Contraception , vol.73 , pp. 301-306
    • Kassem, A.1    Al-Aghbari, A.2    Molham, A.H.3    Al-Mamary, M.4
  • 32
    • 77956265149 scopus 로고    scopus 로고
    • Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice
    • Khalki L, M’hamed SB, Bennis M, Chait A, Sokar Z. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice. J Ethnopharmacol 2010;131:321-5.
    • (2010) J Ethnopharmacol , vol.131 , pp. 321-325
    • Khalki, L.1    M’Hamed, S.B.2    Bennis, M.3    Chait, A.4    Sokar, Z.5
  • 33
    • 0004327149 scopus 로고
    • Effect of fenugreek (Trigonella foenum graecum) seed based diets on the birth outcome in albino rats
    • Mital N, Gopaldas T. Effect of fenugreek (Trigonella foenum graecum) seed based diets on the birth outcome in albino rats. Nutr Rep Int 1986;33:363-9.
    • (1986) Nutr Rep Int , vol.33 , pp. 363-369
    • Mital, N.1    Gopaldas, T.2
  • 34
    • 84856005997 scopus 로고    scopus 로고
    • The neurobehavioral developmental effects of fenugreek seeds on prenatally exposed mice
    • Khalki L, Bennis M, Sokar Z, Ba-M’hamed S. The neurobehavioral developmental effects of fenugreek seeds on prenatally exposed mice. J Ethnopharmacol 2012;139:672-7.
    • (2012) J Ethnopharmacol , vol.139 , pp. 672-677
    • Khalki, L.1    Bennis, M.2    Sokar, Z.3    Ba-M’hamed, S.4
  • 35
    • 0027403577 scopus 로고
    • Efficacy of the steroidal fraction of fenugreek seed extract on fertility of male albino rats
    • Kamal R, Yadav R, Sharma J. Efficacy of the steroidal fraction of fenugreek seed extract on fertility of male albino rats. Phytother Res 1993;7:134-8.
    • (1993) Phytother Res , vol.7 , pp. 134-138
    • Kamal, R.1    Yadav, R.2    Sharma, J.3
  • 36
    • 77956261920 scopus 로고    scopus 로고
    • Malformations associées à la prise de fenugrec au cours de la grossesse
    • Skalli S. Malformations associées à la prise de fenugrec au cours de la grossesse. Bulletin d’informations de pharmacovigilance; 2006. p. 3.
    • (2006) Bulletin d’informations De Pharmacovigilance , pp. 3
    • Skalli, S.1
  • 37
    • 0004327149 scopus 로고
    • Effect of fenugreek (Trigonella foenum graceum) seeds based on the birth outcome in albino rats
    • Mittal N, Gopaldas T. Effect of fenugreek (Trigonella foenum graceum) seeds based on the birth outcome in albino rats. Nutr Reproduction Int 1986;33:362-9.
    • (1986) Nutr Reproduction Int , vol.33 , pp. 362-369
    • Mittal, N.1    Gopaldas, T.2
  • 38
    • 0347897113 scopus 로고
    • Effect of fenugreek (Trigonella foenum-graecum) seed based diets on the lactational performance in albino rats
    • Mittal N, Gopaldas T. Effect of fenugreek (Trigonella foenum-graecum) seed based diets on the lactational performance in albino rats. Nutr Report Int 1986;33:477-84.
    • (1986) Nutr Report Int , vol.33 , pp. 477-484
    • Mittal, N.1    Gopaldas, T.2
  • 39
    • 45949085901 scopus 로고    scopus 로고
    • Rebaudioside a: Two-generation reproductive toxicity study in rats
    • Curry LL, Roberts A, Brown N. Rebaudioside a: two-generation reproductive toxicity study in rats. Food Chem Toxicol 2008;46:S21-S30.
    • (2008) Food Chem Toxicol , vol.46 , pp. S21-S30
    • Curry, L.L.1    Roberts, A.2    Brown, N.3
  • 40
    • 85045228549 scopus 로고
    • Contraceptive properties of Stevia rebaudiana
    • Planas GM, Kuć J. Contraceptive properties of Stevia rebaudiana. Science 1968;162:1007.
    • (1968) Science , vol.162 , pp. 1007
    • Planas, G.M.1    Kuć, J.2
  • 41
    • 0033203620 scopus 로고    scopus 로고
    • Effect of crude extract of Stevia rebaudiana on renal water and electrolytes excretion
    • Melis MS. Effect of crude extract of Stevia rebaudiana on renal water and electrolytes excretion. Phytomedicine 1999;6:247-50.
    • (1999) Phytomedicine , vol.6 , pp. 247-250
    • Melis, M.S.1
  • 42
    • 0032852968 scopus 로고    scopus 로고
    • Effects of chronic administration of Stevia rebaudiana on fertility in rats
    • Melis MS. Effects of chronic administration of Stevia rebaudiana on fertility in rats. J Ethnopharmacol 1999;67:157-61.
    • (1999) J Ethnopharmacol , vol.67 , pp. 157-161
    • Melis, M.S.1
  • 43
    • 0029008328 scopus 로고
    • Chronic administration of aqueous extract of Stevia rebaudiana in rats: Renal effects
    • Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34.
    • (1995) J Ethnopharmacol , vol.47 , pp. 129-134
    • Melis, M.S.1
  • 44
    • 0029955183 scopus 로고    scopus 로고
    • A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats
    • Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
    • (1996) Braz J Med Biol Res , vol.29 , pp. 669-675
    • Melis, M.S.1
  • 46
    • 33748319204 scopus 로고    scopus 로고
    • Guidance for Industry: Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers
    • Center for Drug Evaluation and Research. Guidance for Industry: Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. US Department of Health and Human Services, Food and Drug Administration; 2005.
    • (2005) US Department of Health and Human Services, Food and Drug Administration


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.