Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development

Biology Open

Volumn 1, Issue 8, 2012, Pages 693-704

  Chakrabarty, Koushik ^a   Von Oerthel, Lars ^a,b   Hellemons, Anita ^a   Clotman, Frédéric ^c   Espana, Agnès ^c   Koerkamp, Marian Groot ^d   Holstege, Frank C P ^d   Pasterkamp, R Jeroen ^a   Smidt, Marten P ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Development; Neuronal; Nurr1; Onecut; Pitx3

Indexed keywords

EID: 84964870632     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20121230     Document Type: Article

References (36)

1. Alves dos Santos, M. T. and Smidt, M. P. (2011). En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev. 6, 23.
2. Azam, L., Chen, Y. and Leslie, F. M. (2007). Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons. Neuroscience 144, 1347-1360.
3. Barzilai, A. and Melamed, E. (2003). Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease. Trends Mol. Med. 9, 126-132.
4. Berke, J. D. and Hyman, S. E. (2000). Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25, 515-532.
5. Champtiaux, N., Han, Z. Y., Bessis, A., Rossi, F. M., Zoli, M., Marubio, L., McIntosh, J. M. and Changeux, J. P. (2002). Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J. Neurosci. 22, 1208-1217.
6. Champtiaux, N., Gotti, C., Cordero-Erausquin, M., David, D. J., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F. M., Le Novère, N. et al. (2003). Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J. Neurosci. 23, 7820-7829.
7. Di Salvio, M., Di Giovannantonio, L. G., Acampora, D., Prosperi, R., Omodei, D., Prakash, N., Wurst, W. and Simeone, A. (2010). Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat. Neurosci. 13, 1481-1488.
8. Drenan, R. M., Grady, S. R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J. M., Bupp, S., Heintz, N., McIntosh, J. M., Bencherif, M. et al. (2008). In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron 60, 123-136.
9. Espana, A. and Clotman, F. (2012). The Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. J. Comp. Neurol. 520, 1424-1441.
10. Exley, R., Maubourguet, N., David, V., Eddine, R., Evrard, A., Pons, S., Marti, F., Threlfell, S., Cazala, P., McIntosh, J. M. et al. (2011). Distinct contributions of nicotinic acetylcholine receptor subunit α4 and subunit α6 to the reinforcing effects of nicotine. Proc. Natl. Acad. Sci. USA 108, 7577-7582.
11. Fenstermaker, A. G., Prasad, A. A., Bechara, A., Adolfs, Y., Tissir, F., Goffinet, A., Zou, Y. and Pasterkamp, R. J. (2010). Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J. Neurosci. 30, 16053-16064.
12. Freed, C. R., Greene, P. E., Breeze, R. E., Tsai, W. Y., DuMouchel, W., Kao, R., Dillon, S., Winfield, H., Culver, S., Trojanowski, J. Q. et al. (2001). Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344, 710-719.
13. Gotti, C., Zoli, M. and Clementi, F. (2006). Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol. Sci. 27, 482-491.
14. Hamatani, T., Carter, M. G., Sharov, A. A. and Ko, M. S. (2004). Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 6, 117-131.
15. Hoft, N. R., Corley, R. P., McQueen, M. B., Huizinga, D., Menard, S. and Ehringer, M. A. (2009). SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. Genes Brain Behav. 8, 631-637.
16. Jacobs, F. M. J., Smits, S. M., Noorlander, C. W., von Oerthel, L., van der Linden, A. J. A., Burbach, J. P. H. and Smidt, M. P. (2007). Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development 134, 2673-2684.
17. Jacobs, F.M., van Erp, S., van der Linden, A. J., von Oerthel, L., Burbach, J. P. and Smidt, M. P. (2009a). Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development 136, 531-540.
18. Jacobs, F. M., van der Linden, A. J., Wang, Y., von Oerthel, L., Sul, H. S., Burbach, J. P. and Smidt, M. P. (2009b). Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development 136, 2363-2373.
19. Keath, J. R., Iacoviello, M. P., Barrett, L. E., Mansvelder, H. D. and McGehee, D. S. (2007). Differential modulation by nicotine of substantia nigra versus ventral tegmental area dopamine neurons. J. Neurophysiol. 98, 3388-3396.
20. Klink, R., de Kerchove d'Exaerde, A., Zoli, M. and Changeux, J. P. (2001). Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21, 1452-1463.
21. Kolk, S. M., Gunput, R. A., Tran, T. S., van den Heuvel, D. M., Prasad, A. A., Hellemons, A. J., Adolfs, Y., Ginty, D. D., Kolodkin, A. L., Burbach, J. P. et al. (2009). Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. J. Neurosci. 29, 12542-12557.
22. Millar, N. S. and Harkness, P. C. (2008). Assembly and trafficking of nicotinic acetylcholine receptors (Review). Mol. Membr. Biol. 25, 279-292.
23. Olanow, C. W., Kordower, J. H., Lang, A. E. and Obeso, J. A. (2009). Dopaminergic transplantation for Parkinson's disease: current status and future prospects. Ann. Neurol. 66, 591-596.
24. Peng, X., Wood, C. L., Blalock, E. M., Chen, K. C., Landfield, P.W. and Stromberg, A. J. (2003). Statistical implications of pooling RNA samples for microarray experiments. BMC Bioinformatics 4, 26.
25. Prakash, N. and Wurst, W. (2006). Genetic networks controlling the development of midbrain dopaminergic neurons. J. Physiol. 575, 403-410.
26. Saucedo-Cardenas, O., Quintana-Hau, J. D., Le, W. D., Smidt, M. P., Cox, J. J., De Mayo, F., Burbach, J. P. and Conneely, O. M. (1998). Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
27. Sesack, S. R. and Carr, D. B. (2002). Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia. Physiol. Behav. 77, 513-517.
28. Simon, H. H., Saueressig, H., Wurst, W., Goulding, M. D. and O'Leary, D. D. (2001). Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J. Neurosci. 21, 3126-3134.
29. Smidt, M. P. and Burbach, J. P. (2007). How to make a mesodiencephalic dopaminergic neuron. Nat. Rev. Neurosci. 8, 21-32.
30. Smidt, M. P., van Schaick, H. S., Lanctôt, C., Tremblay, J. J., Cox, J. J., van der Kleij, A. A., Wolterink, G., Drouin, J. and Burbach, J. P. (1997). A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc. Natl. Acad. Sci. USA 94, 13305-13310.
31. Smidt, M. P., Smits, S. M., Bouwmeester, H., Hamers, F. P., van der Linden, A. J., Hellemons, A. J., Graw, J. and Burbach, J. P. (2004). Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131, 1145-1155.
32. Smits, S. M., Ponnio, T., Conneely, O. M., Burbach, J. P. and Smidt, M. P. (2003). Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur. J. Neurosci. 18, 1731-1738.
33. Smits, S. M., Burbach, J. P. and Smidt, M. P. (2006). Developmental origin and fate of meso-diencephalic dopamine neurons. Prog. Neurobiol. 78, 1-16.
34. Thorgeirsson, T. E., Gudbjartsson, D. F., Surakka, I., Vink, J. M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S. et al.; ENGAGE Consortium. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat. Genet. 42, 448-453.
35. Wong, A. H. and van Tol, H. H. (2003). Schizophrenia: from phenomenology to neurobiology. Neurosci. Biobehav. Rev. 27, 269-306.
36. Wu, F., Sapkota, D., Li, R. and Mu, X. (2012). Onecut 1 and Onecut 2 are potential regulators of mouse retinal development. J. Comp. Neurol. 520, 952-969.