Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells

Oncology Reports

Volumn 35, Issue 6, 2016, Pages 3248-3256

  Park, Sun Young ^a   Chae, Seon Yeong ^a   Park, Jin Oh ^a   Lee, Kyu Jin ^a   Park, Geuntae ^a  

^a Pusan National University   (South Korea)

Author keywords

Gold nanoparticles; Invasion; MMP 9; Resveratrol; TPA

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE B; GOLD NANOPARTICLE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESVERATROL; RESVERATROL CAPPED GOLD NANOPARTICLE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; GOLD; HMOX1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MMP9 PROTEIN, HUMAN; NANOCONJUGATE; PTGS2 PROTEIN, HUMAN; STILBENE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL MIGRATION; CELL NUCLEUS TRANSPLANTATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MCF 7 CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR INVASION; CELL MOTION; DRUG EFFECTS; MCF-7 CELL LINE; METABOLISM;

CELL MOVEMENT; CYCLOOXYGENASE 2; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GOLD; HEME OXYGENASE-1; HUMANS; MATRIX METALLOPROTEINASE 9; MCF-7 CELLS; NANOCONJUGATES; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; STILBENES;

EID: 84964857929     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.4716     Document Type: Article

References (26)

1. Gnerlich JL, Deshpande AD, Jeffe DB, Seelam S, Kimbuende E and Margenthaler JA: Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration. Ann Surg Oncol 18: 1837-1844, 2011.
2. Bertolini F: Adipose tissue and breast cancer progression: A link between metabolism and cancer. Breast 22 (Suppl 2): S48-S49, 2013.
3. Song J, Su H, Zhou YY and Guo LL: Prognostic value of matrix metalloproteinase 9 expression in breast cancer patients: A metaanalysis. Asian Pac J Cancer Prev 14: 1615-1621, 2013.
4. Yang S and Han H: Effect of cycloxygenase-2 silencing on the malignant biological behavior of MCF-7 breast cancer cells. Oncol Lett 8: 1628-1634, 2014.
5. Jin ML, Park SY, Kim YH, Park G and Lee SJ: Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9. Int J Oncol 44: 309-318, 2014.
6. Liao YF, Rao YK and Tzeng YM: Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells. Food Chem Toxicol 50: 2930-2936, 2012.
7. Kim YS, Sull JW and Sung HJ: Suppressing effect of resveratrol on the migration and invasion of human metastatic lung and cervical cancer cells. Mol Biol Rep 39: 8709-8716, 2012.
8. Chakraborty A, Gupta N, Ghosh K and Roy P: In vitro evaluation of the cytotoxic, anti-proliferative and anti-oxidant properties of pterostilbene isolated from Pterocarpus marsupium. Toxicol In Vitro 24: 1215-1228, 2010.
9. Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S and Aggarwal BB: Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int J Cancer 127: 257-268, 2010.
10. Amri A, Chaumeil JC, Sfar S and Charrueau C: Administration of resveratrol: What formulation solutions to bioavailability limitations? J Control Release 158: 182-193, 2012.
11. Pangeni R, Sahni JK, Ali J, Sharma S and Baboota S: Resveratrol: Review on therapeutic potential and recent advances in drug delivery. Expert Opin Drug Deliv 11: 1285-1298, 2014.
12. Nicol JR, Dixon D and Coulter JA: Gold nanoparticle surface functionalization: A necessary requirement in the development of novel nanotherapeutics. Nanomedicine 10: 1315-1326, 2015.
13. Park H, Tsutsumi H and Mihara H: Cell penetration and cell-selective drug delivery using α-helix peptides conjugated with gold nanoparticles. Biomaterials 34: 4872-4879, 2013.
14. Karuppaiya P, Satheeshkumar E, Chao WT, Kao LY, Chen EC and Tsay HS: Anti-metastatic activity of biologically synthesized gold nanoparticles on human fibrosarcoma cell line HT-1080. Colloids Surf B Biointerfaces 110: 163-170, 2013.
15. Suganya KS, Govindaraju K, Kumar VG, Dhas TS, Karthick V, Singaravelu G and Elanchezhiyan M: Blue green alga mediated synthesis of gold nanoparticles and its antibacterial efficacy against Gram positive organisms. Mater Sci Eng C 47: 351-356, 2015.
16. Sanna V, Pala N, Dessì G, Manconi P, Mariani A, Dedola S, Rassu M, Crosio C, Iaccarino C and Sechi M: Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities. Int J Nanomedicine 9: 4935-4951, 2014.
17. Kondath S, Srinivas Raghavan B, Anantanarayanan R and Rajaram R: Synthesis and characterisation of morin reduced gold nanoparticles and its cytotoxicity in MCF-7 cells. Chem Biol Interact 224C: 78-88, 2014.
18. Barathmanikanth S, Kalishwaralal K, Sriram M, Pandian SR, Youn HS, Eom S and Gurunathan S: Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice. J Nanobiotechnology 8: 16, 2010.
19. Khan HA, Abdelhalim MA, Alhomida AS and Al Ayed MS: Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles. Genet Mol Res 12: 5851-5857, 2013.
20. Kumar CG, Poornachandra Y and Mamidyala SK: Green synthesis of bacterial gold nanoparticles conjugated to resveratrol as delivery vehicles. Colloids Surf B Biointerfaces 123: 311-317, 2014.
21. Chao CY, Lii CK, Hsu YT, Lu CY, Liu KL, Li CC and Chen HW: Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells. Carcinogenesis 34: 1843-1851, 2013.
22. Lee CW, Yen FL, Huang HW, Wu TH, Ko HH, Tzeng WS and Lin CC: Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways. J Agric Food Chem 60: 4662-4671, 2012.
23. Li J, Wang X, Wang C, Chen B, Dai Y, Zhang R, Song M, Lv G and Fu D: The enhancement effect of gold nanoparticles in drug delivery and as biomarkers of drug-resistant cancer cells. ChemMedChem 2: 374-378, 2007.
24. Correard F, Maximova K, Estève MA, Villard C, Roy M, Al-Kattan A, Sentis M, Gingras M, Kabashin AV and Braguer D: Gold nanoparticles prepared by laser ablation in aqueous biocompatible solutions: Assessment of safety and biological identity for nanomedicine applications. Int J Nanomedicine 9: 5415-5430, 2014.
25. Lee WY, Chen YC, Shih CM, Lin CM, Cheng CH, Chen KC and Lin CW: The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide. Toxicol Appl Pharmacol 274: 55-62, 2014.
26. Lin CW, Shen SC, Hou WC, Yang LY and Chen YC: Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9. Mol Cancer Ther 7: 1195-1206, 2008.