Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles

Genetics and Molecular Research

Volumn 12, Issue 4, 2013, Pages 5851-5857

  Khan, H A ^a   Abdelhalim, M A K ^a   Alhomida, A S ^a   Al Ayed, M S ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Indexed keywords

GOLD NANOPARTICLE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DISEASE SEVERITY; EXPOSURE; GENE EXPRESSION; INFLAMMATION; INTERLEUKIN 1BETA GENE; INTERLEUKIN 6 GENE; MALE; NONHUMAN; PARTICLE SIZE; RAT; REAL TIME POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR ALPHA GENE;

ANIMALS; GOLD; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIVER; MALE; METAL NANOPARTICLES; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888357014     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.November.22.12     Document Type: Article

References (23)

1. Auger F, Gendron MC, Chamot C, Marano F, et al. (2006). Responses of well-differentiated nasal epithelial cells exposed to particles: role of the epithelium in airway inflammation. Toxicol. Appl. Pharmacol. 215: 285-294.
2. Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, et al. (2008). Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J. Phys. Chem. B 112: 13608-13619.
3. Chen YS, Hung YC, Liau I and Huang GS (2009). Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res. Lett. 4: 858-864.
4. Cui Y, Liu H, Zhou M, Duan Y, et al. (2011). Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles. J. Biomed. Mater. Res. A 96: 221-229.
5. Fischer HC and Chan WC (2007). Nanotoxicity: the growing need for in vivo study. Curr. Opin. Biotechnol. 18: 565-571.
6. Gojova A, Guo B, Kota RS, Rutledge JC, et al. (2007). Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ. Health Perspect. 115: 403-409.
7. Han SG, Andrews R, Gairola CG and Bhalla DK (2008). Acute pulmonary effects of combined exposure to carbon nanotubes and ozone in mice. Inhal. Toxicol. 20: 391-398.
8. Heng BC, Zhao X, Tan EC, Khamis N, et al. (2011). Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles. Arch. Toxicol. 85: 1517-1528.
9. Higashitsuji H, Arii S, Furutani M, Mise M, et al. (1995). Expression of cytokine genes during liver regeneration after partial hepatectomy in rats. J. Surg. Res. 58: 267-274.
10. Martínez-Gutierrez F, Thi EP, Silverman JM, de Oliveira CC, et al. (2012). Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine 8: 328-336.
11. Nishanth RP, Jyotsna RG, Schlager JJ, Hussain SM, et al. (2011). Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: role of ROS-NFκB signaling pathway. Nanotoxicology 5: 502-516.
12. Park EJ and Park K (2009). Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol. Lett. 184: 18-25.
13. Park EJ, Kim H, Kim Y and Park K (2010). Intratracheal instillation of platinum nanoparticles may induce inflammatory responses in mice. Arch. Pharm. Res. 33: 727-735.
14. Park EJ, Choi K and Park K (2011). Induction of inflammatory responses and gene expression by intratracheal instillation of silver nanoparticles in mice. Arch. Pharm. Res. 34: 299-307.
15. Renwick LC, Brown D, Clouter A and Donaldson K (2004). Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup. Environ. Med. 61: 442-447.
16. Ronis MJ, Butura A, Sampey BP, Shankar K, et al. (2005). Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic. Biol. Med. 39: 619-630.
17. Rothen-Rutishauser B, Mühlfeld C, Blank F, Musso C, et al. (2007). Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol. 4: 9.
18. Salazar-Montes A, Delgado-Rizo V and Armendáriz-Borunda J (2000). Differential gene expression of pro-inflammatory and anti-inflammatory cytokines in acute and chronic liver injury. Hepatol. Res. 16: 181-194.
19. Sato M, Sasaki M and Hojo H (1995). Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. Arch. Biochem. Biophys. 316: 738-744.
20. Wang J, Liu Y, Jiao F, Lao F, et al. (2008). Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology 254: 82-90.
21. Wilson MR, Foucaud L, Barlow PG, Hutchison GR, et al. (2007). Nanoparticle interactions with zinc and iron: implications for toxicology and inflammation. Toxicol. Appl. Pharmacol. 225: 80-89.
22. Yen HJ, Hsu SH and Tsai CL (2009). Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 5: 1553-1561.
23. Zhang Q, Hitchins VM, Schrand AM, Hussain SM, et al. (2011). Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators. Nanotoxicology 5: 284-295.