Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses

PLoS Pathogens

Volumn 12, Issue 4, 2016, Pages

  Harvey, William T ^a   Benton, Donald J ^b,c   Gregory, Victoria ^b,c   Hall, James P J ^d,g   Daniels, Rodney S ^b,c   Bedford, Trevor ^e   Haydon, Daniel T ^a   Hay, Alan J ^b,c   McCauley, John W ^b,c   Reeve, Richard ^a,f  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e USA   (United States)

^f INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^g UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; GENE SEQUENCE; HEMAGGLUTINATION INHIBITION; IMMUNOGENICITY; INFLUENZA A (H1N1); MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENY; TRAINING; VIRUS MUTANT; AMINO ACID SUBSTITUTION; ANIMAL; ANTIGENIC VARIATION; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS (H1N1); ORTHOMYXOVIRUS INFECTION; VIROLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENIC VARIATION; ANTIGENS, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; ORTHOMYXOVIRIDAE INFECTIONS; PHYLOGENY;

EID: 84964838655     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005526     Document Type: Article

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