The Relationship between Endothelial Nitric Oxide Synthase Gene (NOS3) Polymorphisms, NOS3 Expression, and Varicocele

Genetic Testing and Molecular Biomarkers

Volumn 20, Issue 4, 2016, Pages 191-196

  Kahraman, Cigdem Yuce ^a   Tasdemir, Sener ^b   Sahin, Ibrahim ^b   Marzioglu Ozdemir, Ebru ^a   Yarall, Oguzhan ^a   Ziypak, Tevfik ^b   Adanur, Senol ^b   Kahraman, Mustafa ^a   Tatar, Abdulgani ^b  

^a Erzurum Regional and Training Hospital ^*  (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GENOMIC DNA; MESSENGER RNA; NOS3 PROTEIN, HUMAN;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; VARICOCELE; BIOSYNTHESIS; CASE CONTROL STUDY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; RISK FACTOR;

ADULT; ALLELES; CASE-CONTROL STUDIES; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; VARICOCELE;

EID: 84964829678     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2015.0294     Document Type: Article

References (55)

1. Aksoy H, Aksoy Y, Ozbey I, et al. (2000) The relationship between varicocele and semen nitric oxide concentrations. Urol Res 28:357-359.
2. Aladag MA, Turkoz Y, Ozerol IH (2000) Nitrik oksit ve nörofizyopatolojik etkileri. T Klin J 20:107-111.
3. Alfadhli S (2013) Influence of endothelial nitric oxide synthase gene intron-4 27bp repeat polymorphism on its expression in autoimmune diseases. Dis Markers 34:349-359.
4. Bauersachs J, Bouloumie A, Mulsch A, et al. (1998) Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production. Cardiovasc Res 37:772-779.
5. Bianco B, Ghirelli-Filho M, Cavalheiro CM, et al. (2013) Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men. Gene 519:13-17.
6. Bolotina VM, Najibi S, Palacino JJ, et al. (1994) Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 368:850-853.
7. Buldreghini E, Mahfouz RZ, Vignini A, et al. (2010) Single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp variant) in infertile men with asthenozoospermia. J Androl 31:482-488.
8. Cattaruzza M, Guzik TJ, Slodowski W, et al. (2004) Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res 95:841-847.
9. Crabos M, Coste P, Paccalin M, et al. (1997) Reduced basal NO-mediated dilation and decreased endothelial NO-synthase expression in coronary vessels of spontaneously hypertensive rats. J Mol Cell Cardiol 29:55-65.
10. Doshi AA, Ziolo MT, Wang H, et al. (2010) A promoter polymorphism of the endothelial nitric oxide synthase gene is associated with reduced mRNA and protein expression in failing human myocardium. J Card Fail 16:314-319.
11. Eisenberg ML, Lipshultz LI (2011) Varicocele-induced infertility: newer insights into its pathophysiology. Indian J Urol 27:58-64.
12. Erkan E, Toktas G, Unluer E, et al. (2012) Expression of NOS isoforms in internal spermatic veins of infertile men with varicocele. Syst Biol Reprod Med 58:268-273.
13. Eroz R, Bahadir A, Dikici S, et al. (2014) Association of endothelial nitric oxide synthase gene polymorphisms (894G/T,-786T/C, G10T) and clinical findings in patients with migraine. Neuromolecular Med 16:587-593.
14. Fish JE, Marsden PA (2006) Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium. Cell Mol Life Sci 63:144-162.
15. Fujisawa M, Yamanaka K, Tanaka H, et al. (2001) Expression of endothelial nitric oxide synthase in the Sertoli cells of men with infertility of various causes. BJU Int 87:85-88.
16. Garcia SR, Izzard AS, Heagerty AM, et al. (1997) Myogenic tone in coronary arteries from spontaneously hypertensive rats. J Vasc Res 34:109-116.
17. Geller DA, Billiar TR (1998) Molecular biology of nitric oxide synthases. Cancer Metastasis Rev 17:7-23.
18. Godfrey V, Chan SL, Cassidy A, et al. (2007) The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers. Cardiovasc Drug Rev 25:280-288.
19. Huang PL, Huang Z, Mashimo H, et al. (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377:239-242.
20. Joshi MS, Mineo C, Shaul PW, et al. (2007) Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear. FASEB J 21:2655-2663.
21. Kanner J, Harel S, Granit R (1991) Nitric oxide as an antioxidant. Arch Biochem Biophys 289:130-136.
22. Karatas A, Eroz R, Bahadir A, et al. (2014) Endothelial nitric oxide synthase gene polymorphisms (promoter-786T/C, exon 894 G/T and intron G10T) in unexplained female infertility. Gynecol Obstet Invest 77:89-93.
23. Kisa U, Basar MM, Ferhat M, et al. (2004) Testicular tissue nitric oxide and thiobarbituric acid reactive substance levels: evaluation with respect to the pathogenesis of varicocele. Urol Res 32:196-199.
24. Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J 298(Pt 2):249-258.
25. Lacchini R, Silva PS, Tanus-Santos JE (2010)Apharmacogeneticsbased approach to reduce cardiovascular mortality with the prophylactic use of statins. Basic Clin Pharmacol Toxicol 106: 357-361.
26. Levy AS, Chung JC, Kroetsch JT, et al. (2009) Nitric oxide and coronary vascular endothelium adaptations in hypertension. Vasc Health Risk Manag 5:1075-1087.
27. Li H, Forstermann U (2000) Nitric oxide in the pathogenesis of vascular disease. J Pathol 190:244-254.
28. Li J, Wu X, Li X, et al. (2010) The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis. Cardiology 116:271-278.
29. Malinski T (2000) The vital role of nitric oxide. Oakland J 1:47-56.
30. Marangoni K, Neves AF, Cardoso AM, et al. (2006) The endothelial nitric oxide synthase Glu-298-Asp polymorphism and its mRNA expression in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia. Cancer Detect Prev 30:7-13.
31. Marroni AS, Metzger IF, Souza-Costa DC, et al. (2005) Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms. Nitric Oxide 12:177-182.
32. Mitropoulos D, Deliconstantinos G, Zervas A, et al. (1996) Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction. J Urol 156:1952-1958.
33. Miyamoto Y, Saito Y, Nakayama M, et al. (2000) Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a-786T/C mutation associated with coronary spastic angina. Hum Mol Genet 9:2629-2637.
34. Nakayama M, Yasue H, Yoshimura M, et al. (1999) T-786/C mutation in the 5¢-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:2864-2870.
35. Nava E, Noll G, Luscher TF (1995) Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension. Circulation 91:2310-2313.
36. Niu W, Qi Y (2011) An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension. PLoS One 6:e24266.
37. Noske HD, Weidner W (1999) Varicocele-a historical perspective. World J Urol 17:151-157.
38. Ozbek E, Turkoz Y, Gokdeniz R, et al. (2000) Increased nitric oxide production in the spermatic vein of patients with varicocele. Eur Urol 37:172-175.
39. Romeo C, Ientile R, Impellizzeri P, et al. (2003) Preliminary report on nitric oxide-mediated oxidative damage in adolescent varicocele. Hum Reprod 18:26-29.
40. Romeo C, Ientile R, Santoro G, et al. (2001) Nitric oxide production is increased in the spermatic veins of adolescents with left idiophatic varicocele. J Pediatr Surg 36:389-393.
41. Safarinejad MR, Shafiei N, Safarinejad S (2010) The role of endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms in the risk of idiopathic male infertility. Mol Reprod Dev 77:720-727.
42. Shiraishi K, Naito K (2007) Nitric oxide produced in the testis is involved in dilatation of the internal spermatic vein that compromises spermatogenesis in infertile men with varicocele. BJU Int 99:1086-1090.
43. Sinici I, Karahan S, Atalar E (2009) Distribution of endothelial nitric oxide synthase gene polymorphisms in Turkish population. J Investig Med 57:769-776.
44. Susic D, Nunez E, Hosoya K, et al. (1998) Coronary hemodynamics in aging spontaneously hypertensive and normotensive Wistar-Kyoto rats. J Hypertens 16:231-237.
45. Tanus-Santos JE, Desai M, Deak LR, et al. (2002) Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics 12:407-413.
46. Tanus-Santos JE, Desai M, Flockhart DA (2001) Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 11:719-725.
47. Tian GX, Zeng XT, Wang XB, et al. (2013) Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a metaanalysis of 39 casecontrol studies. Mol Med Rep 7:1310-1318.
48. Venturelli E, Galimberti D, Lovati C, et al. (2005) The T-786C NOS3 polymorphism in Alzheimer's disease: association and influence on gene expression. Neurosci Lett 382:300-303.
49. Wang XL, Wang J (2000) Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 70:241-251.
50. Xu Y, Xu QY, Yang BH, Zhu XM, Peng YF (2008) Relationship of nitric oxide and nitric oxide synthase with varicocele infertility. Zhonghua Nan Ke Xue 14:414-417.
51. Yun YJ, Park JH, Song SH, et al. (2008) The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men. Fertil Steril 90:1126-1131.
52. Zhang K, Bai P, Shi S, et al. (2012) The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis. Thromb Res 130:192-197.
53. Zhang MX, Zhang C, Shen YH, et al. (2008a) Effect of 27nt small RNA on endothelial nitric-oxide synthase expression. Mol Biol Cell 19:3997-4005.
54. Zhang MX, Zhang C, Shen YH, et al. (2008b) Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene. J Biol Chem 283:14685-14693.
55. Zintzaras E, Kitsios G, Stefanidis I (2006) Endothelial NO synthase gene polymorphisms and hypertension: a metaanalysis. Hypertension 48:700-710.