Sequence analysis of three canine adipokine genes revealed an association between TNF polymorphisms and obesity in Labrador dogs

Animal Genetics

Volumn 47, Issue 2, 2016, Pages 245-249

  Mankowska, M ^a   Stachowiak, M ^a   Graczyk, A ^a   Ciazynska, P ^a   Gogulski, M ^a   Nizanski, W ^b   Switonski, M ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

^b WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

adiposity; cytokine; IL6; interleukin 6; resistin; RETN; TNF; tumor necrosis factor

Indexed keywords

ADIPOCYTOKINE; INTERLEUKIN 6; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; BREEDING; DNA SEQUENCE; DOG; GENETICS; GENOTYPE; HAPLOTYPE; OBESITY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOKINES; ANIMALS; BREEDING; DOGS; GENOTYPE; HAPLOTYPES; INTERLEUKIN-6; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RESISTIN; SEQUENCE ANALYSIS, DNA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84952342923     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/age.12390     Document Type: Article

References (24)

1. Apalasamy Y.D., Rampal S., Salim A., Moy F.M., Su T.T., Majid H.A., Bulgiba A., &, Mohamed Z., (2015) Polymorphisms of the resistin gene and their association with obesity and resistin levels in malaysian malays. Biochemical Genetics 53, 120-31.
2. Armstrong P.J., &, Lusby A.L., (2011) Clinical importance of canine and feline obesity. In: Practical Weight Management in Dogs and Cats (Ed. by, T.L. Towell,), p. 6. John Wiley & Sons, Inc, Hoboken.
3. Corbee R.J., (2013) Obesity in show dogs. Journal of Animal Physiology and Animal Nutrition 97, 904-10.
4. Dassi E., &, Quattrone A., (2012) Tuning the engine: an introduction to resources on post-transcriptional regulation of gene expression. RNA Biology 9, 1224-32.
5. El-Shal A.S., Pasha H.F., &, Rashad N.M., (2013) Association of resistin gene polymorphisms with insulin resistance in Egyptian obese patients. Gene 515, 233-8.
6. Gómez-Hernández A., Perdomo L., de las Heras N., et al,. (2014) Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage. Cardiovascular Diabetology 13, 108.
7. Grzes M., Szczerbal I., Fijak-Nowak H., Szydlowski M., &, Switonski M., (2011) Two candidate genes (FTO and INSIG2) for fat accumulation in four canids: chromosome mapping, gene polymorphisms and association studies of body and skin weight of red foxes. Cytogenetic and Genome Research 135, 25-32.
8. Li G., Klein R.L., Matheny M., King M.A., Meyer E.M., &, Scarpace P.J., (2002) Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 115, 879-89.
9. Li L., Yang G., Shi S., Yang M., Liu H., &, Boden G., (2009) The adipose triglyceride lipase, adiponectin and visfatin are downregulated by tumor necrosis factor-alpha (TNF-alpha) in vivo. Cytokine 45, 12-9.
10. Loftus J.P., &, Wakshlag J.J., (2015) Canine and feline obesity: a review of pathophysiology, epidemiology, and clinical management. Veterinary Medicine: Research and Reports 6, 49-60.
11. Lund E.M., Armstrong P.J., Kirk C.A., &, Klausner J.S., (2006) Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. International Journal of Applied Research in Veterinary Medicine 4, 177-86.
12. Miyabe M., Gin A., Onozawa E., et al,. (2015) Genetic variants of the unsaturated fatty acid receptor GPR120 relating to obesity in dogs. Journal of Veterinary Medical Science 77, 1201-6.
13. Moleres A., Rendo-Urteaga T., Azcona C., Martínez J.A., Gómez-Martínez S., Ruiz J.R., Moreno L.A., Marcos A., Marti A., & AVENA group. (2009) Il6 gene promoter polymorphism (-174G/C) influences the association between fat mass and cardiovascular risk factors. Journal of Physiology and Biochemistry 65, 405-13.
14. Osto M., &, Lutz T.A., (2015) Translational value of animal models of obesity-focus on dogs and cats. European Journal of Pharmacology 759, 240-52.
15. Probert L., (2015) TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects. Neuroscience 302, 2-22.
16. Proenca A.R., Sertié R.A., Oliveira A.C., Campaña A.B., Caminhotto R.O., Chimin P., &, Lima F.B., (2014) New concepts in white adipose tissue physiology. Brazilian Journal of Medical and Biological Research 47, 192-205.
17. Sassek M., Pruszynska-Oszmalek E., Nowacka-Woszuk J., Szczerbal I., Szczepankiewicz D., Kaczmarek P., Kolodziejski P.A., Switonski M., &, Mackowiak P., (2013) Resistin-from gene expression to development of diabetes. Journal of Biological Regulators and Homeostatic Agents 27, 647-54.
18. Skorczyk A., Stachowiak M., Szczerbal I., Klukowska-Roetzler J., Schelling C., Dolf G., &, Switonski M., (2007) Polymorphism and chromosomal location of the MC4R (melanocortin-4 receptor) gene in the dog and red fox. Gene 392, 247-52.
19. Skorczyk A., Flisikowski K., Szydlowski M., Cieslak J., Fries R., &, Switonski M., (2011) Association of MC3R gene polymorphisms with body weight in the red fox and comparative gene organization in four canids. Animal Genetics 42, 104-7.
20. Switonski M., &, Mankowska M., (2013) Dog obesity-the need for identifying predisposing genetic markers. Research in Veterinary Science 95, 831-6.
21. Van den Berg L., van den Berg S.M., Martens E.E., Hazewinkel H.A., Dijkshoorn N.A., Delemarre-van de Waal H.A., Heutink P., Leegwater P.A., &, Heuven H.C., (2010) Analysis of variation in the melanocortin-4 receptor gene (MC4R) in Golden Retriever dogs. Animal Genetics 41, 557.
22. Watanabe M., Tanaka K., Takizawa T., Segawa K., Neo S., Tsuchiya R., Murata M., Murakami M., &, Hisasue M., (2014) Characterization of a canine tetranucleotide microsatellite marker located in the first intron of the tumor necrosis factor alpha gene. Journal of Veterinary Medical Science 76, 119-22.
23. Yu Z., Han S., Cao X., Zhu C., Wang X., &, Guo X., (2012) Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis. Obesity 20, 396-406.
24. Zeng R., Zhang Y., &, Du P., (2014) The SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs. Experimental Animals 63, 73-8.