Pregnancy-related thrombotic microangiopathies: Clues from complement biology

Transfusion and Apheresis Science

Volumn 54, Issue 2, 2016, Pages 199-202

  Fakhouri, Fadi ^a  

^a INSERM   (France)

Author keywords

Complement; HELLP; Hemolytic uremic syndrome; Pregnancy; Thrombotic microangiopathy

Indexed keywords

ECULIZUMAB; IMMUNOSUPPRESSIVE AGENT; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; EMTRICITABINE PLUS RILPIVIRINE PLUS TENOFOVIR DISOPROXIL;

COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; FEMALE; GENE MUTATION; HELLP SYNDROME; HEMOLYTIC UREMIC SYNDROME; HUMAN; PREGNANCY; PREGNANCY COMPLICATION; PUERPERIUM; REMISSION; REVIEW; THIRD TRIMESTER PREGNANCY; THROMBOTIC THROMBOCYTOPENIC PURPURA; BLOOD; HEMOLYTIC-UREMIC SYNDROME; PATHOLOGY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PURPURA, THROMBOTIC THROMBOCYTOPENIC; THROMBOTIC MICROANGIOPATHIES;

EMTRICITABINE, RILPIVIRINE, TENOFOVIR DRUG COMBINATION; FEMALE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PURPURA, THROMBOTIC THROMBOCYTOPENIC; THROMBOTIC MICROANGIOPATHIES;

EID: 84964765602     PISSN: 14730502     EISSN: 18781683     Source Type: Journal    
DOI: 10.1016/j.transci.2016.04.009     Document Type: Review

References (26)

1. Furlan M, Robles R, Galbusera M, Remuzzi G, Kyrle PA, Brenner B, et al. von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med 1998, 339(22):1578-1584.
2. Tsai HM, Lian EC Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med 1998, 339(22):1585-1594.
3. Scully M, Starke R, Lee R, Mackie I, Machin S, Cohen H Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura. Blood Coagul Fibrinolysis 2006, 17(6):459-463.
4. Mannucci PM, Canciani MT, Forza I, Lussana F, Lattuada A, Rossi E Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood 2001, 98(9):2730-2735.
5. Moatti-Cohen M, Garrec C, Wolf M, Boisseau P, Galicier L, Azoulay E, et al. Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura. Blood 2012, 119(24):5888-5897.
6. Freméaux-Bacchi V, Miller EC, Liszewski MK, Strain L, Blouin J, Brown AL, et al. Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood 2008, 112(13):4948-4952.
7. Fremeaux-Bacchi V, Moulton EA, Kavanagh D, Dragon-Durey MA, Blouin J, Caudy A, et al. Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J Am Soc Nephrol 2006, 17(7):2017-2025.
8. Noris M, Remuzzi G Atypical hemolytic-uremic syndrome. N Engl J Med 2009, 361(17):1676-1687.
9. Fremeaux-Bacchi V, Fakhouri F, Garnier A, Bienaimé F, Dragon-Durey MA, Ngo S, et al. Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults. Clin J Am Soc Nephrol 2013, 8(4):554-562.
10. Fakhouri F, Roumenina L, Provot F, Sallée M, Caillard S, Couzi L, et al. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol 2010, 21(5):859-867.
11. Regal JF, Gilbert JS, Burwick RM The complement system and adverse pregnancy outcomes. Mol Immunol 2015, 67(1):56-70.
12. Holmes CH, Simpson KL, Wainwright SD, Tate CG, Houlihan JM, Sawyer IH, et al. Preferential expression of the complement regulatory protein decay accelerating factor at the fetomaternal interface during human pregnancy. J Immunol 1990, 144(8):3099-3105.
13. Petitbarat M, Durigutto P, Macor P, Bulla R, Palmioli A, Bernardi A, et al. Critical role and therapeutic control of the lectin pathway of complement activation in an abortion-prone mouse mating. J Immunol 2015, 195(12):5602-5607.
14. Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 2013, 368(23):2169-2181.
15. Zuber J, Fakhouri F, Roumenina LT, Loirat C, Fremeaux-Bacchi V Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol 2012, 8(11):643-657.
16. Ardissino G, Wally Ossola M, Baffero GM, Rigotti A, Cugno M Eculizumab for atypical hemolytic uremic syndrome in pregnancy. Obstet Gynecol 2013, 122(2 Pt 2):487-489.
17. Zschiedrich S, Prager EP, Kuehn EW Successful treatment of the postpartum atypical hemolytic uremic syndrome with eculizumab. Ann Intern Med 2013, 159(1):76.
18. Barton JR, Riely CA, Adamec TA, Shanklin DR, Khoury AD, Sibai BM Hepatic histopathologic condition does not correlate with laboratory abnormalities in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Am J Obstet Gynecol 1992, 167(6):1538-1543.
19. Abraham KA, Kennelly M, Dorman AM, Walshe JJ Pathogenesis of acute renal failure associated with the HELLP syndrome: a case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 2003, 108(1):99-102.
20. Abraham KA, Connolly G, Farrell J, Walshe JJ The HELLP syndrome, a prospective study. Ren Fail 2001, 23(5):705-713.
21. Fakhouri F, Jablonski M, Lepercq J, Blouin J, Benachi A, Hourmant M, et al. Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. Blood 2008, 112(12):4542-4545.
22. Crovetto F, Borsa N, Acaia B, Nishimura C, Frees K, Smith RJ, et al. The genetics of the alternative pathway of complement in thepathogenesis of HELLP syndrome. J Matern Fetal Neonatal Med 2012, 25(11):2322-2325.
23. Hertig A, Fort J, Lefevre G, Chabbert-Buffet N, Uzan M, Rondeau E, et al. Soluble endoglin in preeclamptic patients with or without HELLP syndrome. Am J Obstet Gynecol 2010, 202(6):594. e1-4.
24. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006, 12(6):642-649.
25. Salmon JE, Heuser C, Triebwasser M, Liszewski MK, Kavanagh D, Roumenina L, et al. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med 2011, 8(3):e1001013.
26. Frimat M, Decambron M, Lebas C, Moktefi A, Lemaitre L, Gnemmi V, et al. Renal cortical necrosis in postpartum hemorrhage: a case series. Am J Kidney Dis 2016, Epub 16 Jan 2016. 10.1053/j.ajkd.2015.11.022.