Eculizumab for atypical hemolytic uremic syndrome in pregnancy

Obstetrics and Gynecology

Volumn 122, Issue 2 PART2, 2013, Pages 487-489

  Ardissino, Gianluigi ^a,b,c   Ossola, Manuela Wally ^a,b   Baffero, Giulia Maria ^a,b   Rigotti, Angelo ^a,b   Cugno, Massimo ^a,b  

^a Obstetrics and Gynecology Department   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; CREATININE; ECULIZUMAB; FRESH FROZEN PLASMA; HAPTOGLOBIN; HEPARIN; LACTATE DEHYDROGENASE; METHYLDOPA; PROSTAGLANDIN E2;

ADULT; ALLERGIC REACTION; ANTIBIOTIC THERAPY; ARTICLE; BLOOD EXAMINATION; CASE REPORT; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT HEMOLYSIS TEST; DIALYSIS; DRUG TOLERABILITY; FEMALE; GENE MUTATION; GESTATIONAL AGE; HEADACHE; HEMOLYTIC UREMIC SYNDROME; HOMOZYGOTE; HUMAN; HYPERTENSION; KIDNEY FAILURE; LABORATORY TEST; LEUKOPENIA; NEISSERIA MENINGITIDIS; PLASMAPHERESIS; PREGNANCY; PRIORITY JOURNAL; PROTEINURIA; RELAPSE; REMISSION; THROMBOCYTE COUNT; THROMBOTIC THROMBOCYTOPENIC PURPURA; VACCINATION;

ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; COMPLEMENT FACTOR H; FEMALE; HEMOLYTIC-UREMIC SYNDROME; HOMOZYGOTE; HUMANS; LIVE BIRTH; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC;

EID: 84880958391     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1097/AOG.0b013e31828e2612     Document Type: Article

References (8)

1. Loirat C, Frémeaux-Bacchi V. Atypical hemolytic uremic syndrome. Orphanet J Rare Dis 2011;6:60.
2. Kavanagh D, Goodship T. Genetics and complement in atypical HUS. Pediatr Nephrol 2010;25:2431-42.
3. Fakhouri F, Roumenina L, Provot F, Sallée M, Caillard S, Couzi L, et al. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol 2010;21:859-67.
4. Clark WF. Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange. Semin Dial 2012;25:214-9.
5. Thomas TC, Rollins SA, Rother RP, Giannoni MA, Hartman SL, Elliott EA, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol 1996;33: 1389-401.
6. Nürnberger J, Philipp T, Witzke O, Opazo Saez A, Vester U, Baba HA, et al. Eculizumab for atypical hemolytic uremic syndrome. N Engl J Med 2009;360:542-4.
7. Kelly R, Arnold L, Richards S, Hill A, Bomken C, Hanley J, et al. The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab. Br J Haematol 2010;149:446-50.
8. Marasca R, Coluccio V, Santachiara R, Leonardi G, Torelli G, Notaro R, et al. Pregnancy in PNH: another eculizumab baby. Br J Haematol 2010;150:707-8.